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Premarin Vaginal Cream is used as hormone replacement therapy (HRT) to treat symptoms associated with menopause. During menopause, the estrogen levels decrease, which leads to hot flushes. It is also used to relieve moderate to severe pain during sexual intercourse due to menopause.
Premarin Vaginal Cream contains conjugated estrogens, which work by replacing the estrogen hormone in menopausal women. It also regulates the secretions of hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Premarin Vaginal Cream may cause side effects such as vaginal discharge, pain and swelling in the breasts, discharge from the nipples, changes in breast tissue, feeling or being sick, bloating, abdominal pain, or headache. Talk to your doctor if any of the side effects persist or worsen.
Premarin Vaginal Cream should be avoided if you are allergic to any of its ingredients. Inform your doctor about your current medical history. Premarin Vaginal Cream is not recommended for use in pregnant and breastfeeding women.
Premarin Vaginal Cream is used in the treatment of moderate to severe hot flashes, changes in and around the vagina, and other symptoms of menopause or low estrogen levels (hypoestrogenism). The detailed uses of Premarin Vaginal Cream are as follows:
Caution
Avoid consumption of alcohol as it may worsen your condition by increasing the risk of side effects.
Unsafe
Premarin Vaginal Cream is a category X drug. This medicine is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before using Premarin Vaginal Cream. Your doctor may prescribe an alternative based on the medical condition.
Unsafe
Premarin Vaginal Cream may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before using Premarin Vaginal Cream. Your doctor may suggest you stop feeding while on treatment with this medicine.
Safe if prescribed
It is not known whether Premarin Vaginal Cream will affect your ability to drive. Hence, consult your doctor.
Unsafe
Premarin Vaginal Cream should not be used in patients with liver diseases. Hence, inform your doctor if you have liver problems before using this medicine.
Caution
Premarin Vaginal Cream should be used with caution in patients with severe kidney diseases. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor before using Premarin Vaginal Cream. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.
Unsafe
Premarin Vaginal Cream is not recommended for use in children.
Consult your doctor
Please consult your doctor if you have heart problems before using Premarin Vaginal Cream.
Consult your doctor
Please consult a doctor if you have any concerns regarding the use of Premarin Vaginal Cream in elderly patients.

Have a query?
The time required for Premarin Vaginal Cream to start to work: The time required for Premarin Vaginal Cream to show its action is unknown.
The time for which the effects of Premarin Vaginal Cream last: The duration of action for Premarin Vaginal Cream is unknown.
Drug-Drug Interactions: Premarin Vaginal Cream may interact with anticonvulsants (phenobarbital, phenytoin, carbamazepine), medicines used to treat HIV (nevirapine, efavirenz, ritonavir, nelfinavir), antibiotics (erythromycin, clarithromycin), antifungal medicines (ketoconazole, itraconazole), a herbal preparation such as St. John’s wort (Hypericum perforatum), a medicine used to treat Cushing’s syndrome (metyrapone), a drug used to treat stomach ulcers (cimetidine) and corticosteroids (dexamethasone).
Drug-Food Interactions: Avoid alcohol and tobacco use along with Premarin Vaginal Cream, as it may increase the risk of side effects.
Drug-Disease Interactions: Premarin Vaginal Cream is contraindicated in conditions such as breast cancer, endometrial cancer (cancer of the lining of the womb), unexplained vaginal bleeding, untreated endometrial hyperplasia (thickening of the womb lining), having a blood clot in the veins (thrombosis), in the legs (deep vein thrombosis), or the lungs (pulmonary embolism), blood clotting disorder, heart attack or angina (chest pain), inherited porphyria (a blood disorder), or liver disease.
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Premarin Vaginal Cream is used as hormone replacement therapy (HRT) to treat symptoms associated with menopause. It is also used to relieve moderate to severe pain during sexual intercourse due to menopause.
Premarin Vaginal Cream works by replacing the deficient estrogen hormone in menopausal women. It effectively reduces the symptoms and improves health conditions.
Premarin Vaginal Cream does not act as a contraceptive. You may need an additional contraceptive agent to prevent pregnancy if you have not had a menstrual period in less than 12 months or are under 50 years old. So, consult your doctor for advice.
Your doctor will decide the dose of Premarin Vaginal Cream based on your health condition. Do not use more than the recommended dose of Premarin Vaginal Cream.
Premarin Vaginal Cream increases the risk of breast cancer. However, the risk increases when given only HRT (hormone replacement therapy) and longer durations.
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