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  1. Home
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  3. Proluton Depot 250 mg Injection 1 ml

Prescription drug
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Proluton Depot 250 mg Injection 1 ml, Pack of 1 Injection
Proluton Depot 250 mg Injection 1 ml, Pack of 1 Injection
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Composition :

HYDROXYPROGESTERONE-250MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Proluton Depot 250 mg Injection 1 ml

Proluton Depot 250 mg Injection 1 ml is used to prevent premature labour. Premature labour can start before 37 completed weeks of pregnancy and can be caused by premature rupture of membranes, high blood pressure during pregnancy (pre-eclampsia), and poor diet. Preterm labour symptoms include leaking fluid or bleeding from the vagina, the feeling of pressure in the pelvis, and cramps that feel like menstrual cramps regularly.

Proluton Depot 250 mg Injection 1 ml contains 'Hydroxyprogesterone', which modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Proluton Depot 250 mg Injection 1 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour. 

In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhea, gradually resolve over time. Talk to your doctor if you feel any discomfort while taking Proluton Depot 250 mg Injection 1 ml.

Before starting Proluton Depot 250 mg Injection 1 ml, please inform your doctor if you have an allergy to any medicines, have unusual vaginal bleeding related to your pregnancy, liver disease, severe hypertension (high blood pressure), or a history of breast cancer, uterus or vagina. Inform your doctor about all medicines you are taking and about your health condition to rule out any unpleasant side effects.

Uses of Proluton Depot 250 mg Injection 1 ml

Proluton Depot 250 mg Injection 1 ml used in the treatment of Premature labor. The detailed uses of Proluton Depot 250 mg Injection 1 ml are as follows:

  • Premature Labor: Proluton Depot 250 mg Injection 1 ml reduces the risk of preterm birth in women with a history of singleton spontaneous preterm birth, delaying or preventing premature labor and its complications.
  • Miscarriage Prevention: Proluton Depot 250 mg Injection 1 ml prevents miscarriage by modulating the immune response, allowing the embryo to attach to the uterus, and supporting a healthy pregnancy.

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Directions for Use

  • Follow your doctor's recommendations on the dosage and timing of this medication to achieve optimal results.
  • Proluton Depot 250 mg Injection 1 ml will be administered by a healthcare professional.
  • Do not self-administer.

Medicinal Benefits

  • Proluton Depot 250 mg Injection 1 ml contains “Hydroxyprogesterone” a progestin (female hormones) that is used in pregnant women who have delivered a baby too early (preterm) in the past.
  • It works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus.
  • Proluton Depot 250 mg Injection 1 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had a past premature delivery.

How Proluton Depot 250 mg Injection 1 ml Works

Proluton Depot 250 mg Injection 1 ml contains 'Hydroxyprogesterone', a progestin (female hormones) that modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Proluton Depot 250 mg Injection 1 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Proluton Depot 250 mg Injection 1 ml
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

What if I have taken an overdose of Proluton Depot 250 mg Injection 1 ml

The overdose of Proluton Depot 250 mg Injection 1 ml is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Proluton Depot 250 mg Injection 1 ml, please inform your doctor immediately.

Drug Warnings

  • You should not take Proluton Depot 250 mg Injection 1 ml without a doctor's advice.
  • Before starting Proluton Depot 250 mg Injection 1 ml, please inform your doctor if you have an allergy to any medicines.
  • Do not take Proluton Depot 250 mg Injection 1 ml if you have unusual vaginal bleeding that is not related to your pregnancy, liver disease, severe hypertension (high blood pressure), or history of cancer of the breast, uterus or vagina.
  • Tell your doctor before using Proluton Depot 250 mg Injection 1 ml if you have had preeclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clot form in the blood), diabetes, depression, or epilepsy.
  • Do not take Proluton Depot 250 mg Injection 1 ml on your own. Proluton Depot 250 mg Injection 1 ml can cause dizziness and drowsiness.
  • Use caution while driving a motor vehicle, as dizziness or drowsiness may occur.
  • Let your doctor know if you are a breastfeeding mother. Your doctor will weigh the benefits and any potential risks before prescribing them to you.
  • Proluton Depot 250 mg Injection 1 ml is not recommended for children younger than 16 years old. Proluton Depot 250 mg Injection 1 ml is not intended for use in the first trimester of pregnancy.
  • Avoid alcohol consumption to prevent unpleasant side effects.

Drug-Drug Interactions

verifiedApollotooltip
HydroxyprogesteroneNicotine
Severe
HydroxyprogesteroneItraconazole
Severe

Drug-Drug Interactions

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HydroxyprogesteroneNicotine
Severe
How does the drug interact with Proluton Depot 250 mg Injection 1 ml:
Coadministration of Nicotine and Proluton Depot 250 mg Injection 1 ml may reduce the blood levels and effects of nicotine.

How to manage the interaction:
Using Nicotine and Proluton Depot 250 mg Injection 1 ml together can lead to an interaction, they can be taken if advised by your doctor. Consult your doctor if your symptoms do not improve or worsen. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneItraconazole
Severe
How does the drug interact with Proluton Depot 250 mg Injection 1 ml:
Coadministration of Itraconazole and Proluton Depot 250 mg Injection 1 ml can cause an increase in the levels of Proluton Depot 250 mg Injection 1 ml.

How to manage the interaction:
Using Itraconazole and Proluton Depot 250 mg Injection 1 ml together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or vaginal bleeding, consult the doctor . Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneRifabutin
Severe
How does the drug interact with Proluton Depot 250 mg Injection 1 ml:
Coadministration of Rifabutin and Proluton Depot 250 mg Injection 1 ml may reduce the blood levels and effects of Proluton Depot 250 mg Injection 1 ml.

How to manage the interaction:
Using Rifabutin and Proluton Depot 250 mg Injection 1 ml together can lead to an interaction; they can be taken if your doctor advises. However, if you experience any abnormal bleeding, or pain, swelling, itching, bruising, or a lump at the injection site, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneTirzepatide
Moderate
How does the drug interact with Proluton Depot 250 mg Injection 1 ml:
Proluton Depot 250 mg Injection 1 ml may interfere with blood glucose control and decrease the effectiveness of diabetic treatments.

How to manage the interaction:
Inform doctor about all other medications administering, including vitamins and herbs, is crucial. Consult doctor before stopping any medications.

Drug-Food Interactions

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HYDROXYPROGESTERONE-250MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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HYDROXYPROGESTERONE-250MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu, Grapefruit Juice, Grapefruit

How to manage the interaction:
Proluton Depot 250 mg Injection 1 ml may reduce the blood levels and effects of caffeine. Grapefruit juice may increase the blood levels of Proluton Depot 250 mg Injection 1 ml. Avoid or limit taking caffeine and grape juice while taking Proluton Depot 250 mg Injection 1 ml as it can lead to interaction.

Diet & Lifestyle Advise

  • Eat a healthy and balanced diet rich in vegetables, fruits, and whole grains to reduce the risk of preterm delivery.
  • Try to incorporate heart-healthy, omega-3 fatty acid-containing foods and drinks into your daily diet. You can also use low-fat cooking oils, such as olive oil, soybean oil, canola oil, and coconut oil.
  • I prefer whole foods and grains to processed ones. I avoid processed foods and foods high in sugar and fat.
  • Avoid stress, as it can increase the chances of preterm delivery. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Regular physical activity and yoga help keep you fit, improve blood circulation, and regulate the oxygen supply, thereby increasing your chances of carrying your baby to full term.
  • Quitting smoking is the best strategy to lower the risk of premature delivery.
  • Keep your weight under control.
  • Try to avoid alcohol as it can affect your stomach and intestines, and limit the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

HORMONES

Proluton Depot 250 mg Injection 1 ml Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

There is not enough scientific data available for Proluton Depot 250 mg Injection 1 ml interaction with alcohol, hence it is best to consult a doctor.

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Pregnancy

Safe if prescribed

Proluton Depot 250 mg Injection 1 ml can be used during pregnancy if prescribed by the doctor.

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Breast Feeding

Consult your doctor

Please consult your doctor before using Proluton Depot 250 mg Injection 1 ml during breastfeeding.

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Driving

Caution

It is advised to drive with caution after taking Proluton Depot 250 mg Injection 1 ml as it may interfere with driving capabilities. It can make you feel drowsy.

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Liver

Caution

Proluton Depot 250 mg Injection 1 ml should be taken with caution, especially if you have a history of liver diseases. Your doctor may have to adjust the dose.

bannner image

Kidney

Caution

Proluton Depot 250 mg Injection 1 ml should be taken with caution, especially if you have a history of kidney diseases. Your doctor may have to adjust the dose.

bannner image

Children

Unsafe

Proluton Depot 250 mg Injection 1 ml not indicated for use in children. Safety and effectiveness in pediatric patients less than 16 years of age have not been established.

FAQs

Proluton Depot 250 mg Injection 1 ml is used to prevent premature labour. It prevents miscarriage and helps lower the risk of premature birth in pregnant women.

Proluton Depot 250 mg Injection 1 ml may cause weight gain. It can be due to water retention. If you feel that you are gaining a lot of weight while taking Proluton Depot 250 mg Injection 1 ml, please consult your doctor.

Proluton Depot 250 mg Injection 1 ml works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus.

Proluton Depot 250 mg Injection 1 ml should be taken in the dose and duration as prescribed by the doctor.

Progesterone is an endogenous steroid and progestogen sex hormone secreted by the female reproductive part in the second half of the menstrual cycle to prepare for the release of the egg in the uterus. It is also necessary for the implantation of the fertilized egg in the uterus, for maintaining pregnancy and in hormonal replacement therapy in women deficient in progesterone.

Some of the common side effects of Proluton Depot 250 mg Injection 1 ml include nausea, vomiting, itching, hives (skin rashes), swelling of the face, lips, tongue, or throat, and diarrhea.

You should stop using Proluton Depot 250 mg Injection 1 ml and tell a doctor before using Proluton Depot 250 mg Injection 1 ml if you have uncontrolled high blood pressure (hypertension), unusual vaginal bleeding, liver disease, liver cancer, jaundice during pregnancy, circulation problems or bleeding problems, stroke, blood clot problems, breast cancer, uterus/cervix/vaginal cancer.

Since Proluton Depot 250 mg Injection 1 ml is administered by a doctor, it's unlikely you will stop taking Proluton Depot 250 mg Injection 1 ml on your own. Complete the duration of treatment as prescribed by the doctor.

Proluton Depot 250 mg Injection 1 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour.

You should stop using Proluton Depot 250 mg Injection 1 ml if you have uncontrolled high blood pressure (hypertension), unusual vaginal bleeding, liver disease, liver cancer, jaundice during pregnancy, circulation problems or bleeding problems, stroke, blood clot problems, breast cancer, uterus/cervix/vaginal cancer.

Proluton Depot 250 mg Injection 1 ml is a synthetic progesterone female hormone called progestin used to prevent premature labour.

Proluton Depot 250 mg Injection 1 ml will be administered by a doctor. The doctor will determine the dose based on your condition.

Since Proluton Depot 250 mg Injection 1 ml is administered by a doctor, it's unlikely for you to miss a dose. Consult the doctor if you think you have missed a dose.

You should not receive Proluton Depot 250 mg Injection 1 ml if you are allergic to any of its components, if you have blood clotting problems, uncontrolled high blood pressure, or breast cancer.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015, Gujarat, India.
Other Info - PRO0027

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 30, 2025 | 1:28 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf
  2. https://www.drugs.com/mtm/hydroxyprogesterone-injection.html

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