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  3. PROSTODIN 125MG AMPULE 1ML

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PROSTODIN 125MG AMPULE 1ML, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
PROSTODIN 125MG AMPULE 1ML is used for the initiation or improvement of uterine contraction and producing uterine contraction during the third stage of labour. Besides this, it also controls postpartum bleeding or haemorrhage after childbirth. PROSTODIN 125MG AMPULE 1ML is also used for the medical termination of the pregnancy between the 13th to 20th week of pregnancy (second trimester of the pregnancy).
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Composition :

CARBOPROST-125MCG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About PROSTODIN 125MG AMPULE 1ML

PROSTODIN 125MG AMPULE 1ML belongs to the class of medication called 'oxytocic' or 'uterotonic', primarily used for the initiation or improvement of uterine contraction (antepartum) and producing uterine contraction during the third stage of labour (postpartum). Besides this, it also controls postpartum bleeding or haemorrhage after childbirth. PROSTODIN 125MG AMPULE 1ML is also used for the medical termination of the pregnancy between the 13th to 20th week of pregnancy (second trimester of the pregnancy) after the first day of the last menses period.

PROSTODIN 125MG AMPULE 1ML contains a synthetic prostaglandin (a chemical messenger) analogue ‘Carboprost’ with oxytocic properties. PROSTODIN 125MG AMPULE 1ML stimulates uterine muscles and increases uterus contractions. It also increases the production of a natural substance called prostaglandins (PGs), increasing contractions and controlling postpartum bleeding. In addition, it is also used to produce an abortion by causing uterine contractions.

PROSTODIN 125MG AMPULE 1ML administered by a doctor only in hospitals in which intensive care and surgical facilities are available. The most common side effects of PROSTODIN 125MG AMPULE 1ML are nausea, vomiting, and headache in some cases. Most of these side effects of PROSTODIN 125MG AMPULE 1ML do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

You should not receive PROSTODIN 125MG AMPULE 1ML if you are allergic to it, have active pelvic inflammatory disease, have a lung disorder or breathing problem, or have heart disease, kidney disease or liver disease. PROSTODIN 125MG AMPULE 1ML is not recommended to children below 18 years of age as safety and effectiveness have not been established. Do not do strenuous activities like running, heavy exercise or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete, as no bleeding does not mean that abortion is complete. Although the incidence of cervical trauma is extremely small, the cervix (lower portion of the uterus) should always be carefully examined immediately post-abortion with PROSTODIN 125MG AMPULE 1ML. PROSTODIN 125MG AMPULE 1ML is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees celsius else its efficacy might get lost. Do not store in the freezer or the fridge.

Uses of PROSTODIN 125MG AMPULE 1ML

Used in the treatment of Postpartum haemorrhage, Medical Abortion.

Directions for Use

• Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.• PROSTODIN 125MG AMPULE 1ML will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

PROSTODIN 125MG AMPULE 1ML contains ‘Carboprost’, a synthetic prostaglandin (a chemical messenger) analogue of PGF2α with oxytocic properties. It is used to treat severe bleeding after childbirth (postpartum). In addition to this, is also used to produce an abortion by causing uterine contractions. It is usually given between the 13th and 20th weeks (2nd trimester) of pregnancy. PROSTODIN 125MG AMPULE 1ML stimulates uterine muscles and increases the contractions in the uterus. Also, it increases the production of prostaglandins, which further increases the contractions and hence control post-delivery bleeding. PROSTODIN 125MG AMPULE 1ML is often used when another method of abortion has not completely emptied the uterus or when a pregnancy complication would cause the baby to be born too early to survive. PROSTODIN 125MG AMPULE 1ML is more effective in preventing postpartum bleeding in high-risk patients undergoing cesarean delivery than oxytocin.

How PROSTODIN 125MG AMPULE 1ML Works

PROSTODIN 125MG AMPULE 1ML contains a synthetic prostaglandin (a chemical messenger) analogue ‘Carboprost’ with oxytocic properties. PROSTODIN 125MG AMPULE 1ML stimulates uterine muscles and increases uterus contractions. It also increases the production of a natural substance called prostaglandins (PGs), increasing contractions and controlling postpartum bleeding.

Storage

Keep PROSTODIN 125MG AMPULE 1ML out of the sight and reach of children.
Side effects of Prostodin 125mg Ampule 1ml
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.

What if I have taken an overdose of PROSTODIN 125MG AMPULE 1ML

The overdose of PROSTODIN 125MG AMPULE 1ML is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with PROSTODIN 125MG AMPULE 1ML, please inform your doctor immediately.

Drug Warnings

Do not take PROSTODIN 125MG AMPULE 1ML if you are allergic to PROSTODIN 125MG AMPULE 1ML or its ingredients. Increasing the dose of PROSTODIN 125MG AMPULE 1ML can be harmful if your womb already has too strong contractions, any obstructions in the pathway that might prevent the delivery or if the baby is not receiving a sufficient oxygen supply. If you have been given prostaglandins, do not use PROSTODIN 125MG AMPULE 1ML within 6 hours. If taken together, can increase the contractions. PROSTODIN 125MG AMPULE 1ML should not be used for a prolonged time if the contractions do not increase or if you have severe pre-eclamptic toxaemia (high blood pressure, protein in the urine, and swelling) of blood or heart circulation problem. A professional should always administer PROSTODIN 125MG AMPULE 1ML at a hospital, do not practice self-administration. It should also not be given as a rapid injection into a vein as it might cause hypotension (low blood pressure) or suddenly increased heart rate.  Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by ultrasonography to confirm if the abortion is complete. Confirmation of fetal death is imperative before administration when used for missed abortion or intrauterine fetal death. You should not receive PROSTODIN 125MG AMPULE 1ML if you have an active pelvic inflammatory disease, a breathing disorder, heart disease, liver or kidney disease.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Long walks can help to relieve stress, keep your body strong and help in easy delivery.
  • Please take a little bit of Castrol oil as it is known to stimulate prostaglandin, which ripens the cervix and gets labour started.
  • For some food like dates, raspberry tea leaves are known to ripen the cervix and get labour started.
  • Acupressure also stimulates labour and helps in delivery.
  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.
  • Avoid chronic stress and physical exercise like running, as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, immediately contact your doctor.
  • Get an ultrasound done to check if the abortion is done completely to avoid any unwanted complications.
  • Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

OXYTOCIC, UTEROTONIC, ECBOLIC

PROSTODIN 125MG AMPULE 1ML Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid or limit consumption of alcohol after taking PROSTODIN 125MG AMPULE 1ML as it may cause serious side effects.

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Pregnancy

Safe if prescribed

PROSTODIN 125MG AMPULE 1ML is used to induce contractions in the uterus. Hence, it is considered safe to be used during pregnancy. PROSTODIN 125MG AMPULE 1ML is also used for medical termination of pregnancy.

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Breast Feeding

Caution

It is unknown whether PROSTODIN 125MG AMPULE 1ML passes into breast milk or if it could harm a nursing baby. If you are breastfeeding, inform your doctor before taking PROSTODIN 125MG AMPULE 1ML.

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Driving

Unsafe

Patients should refrain from driving until they know that PROSTODIN 125MG AMPULE 1ML does not affect their ability to drive or use machines.

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Liver

Caution

If you have a history or a pre-existing liver disease, inform your doctor before receiving this injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition. PROSTODIN 125MG AMPULE 1ML is contraindicated in patients with severe active hepatic disease.

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Kidney

Caution

PROSTODIN 125MG AMPULE 1ML to be taken with caution, especially if you have a history of kidney diseases. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

PROSTODIN 125MG AMPULE 1ML is not recommended for children under the age of 18. The safety and effectiveness of PROSTODIN 125MG AMPULE 1ML have not been established in children due to limited testing of this drug on children by competent authorities worldwide.

Have a query?

FAQs

PROSTODIN 125MG AMPULE 1ML is used for the initiation or improvement of uterine contraction (antepartum) and producing uterine contraction during the third stage of labour. Besides this, it also controls postpartum bleeding or haemorrhage after childbirth. It is also used for the medical termination of the pregnancy between the 13th to 20th week of pregnancy (second trimester of the pregnancy).

PROSTODIN 125MG AMPULE 1ML contains carboprost that stimulates contraction of the uterine muscles, helping to control post-delivery bleeding.

If you have a previous premature delivery or a c-section, or cervical surgery, please inform your doctor before starting PROSTODIN 125MG AMPULE 1ML. Also, mention a detailed medical history to your doctor to avoid complications.

No, PROSTODIN 125MG AMPULE 1ML is not known to affect any future chances of fertility. PROSTODIN 125MG AMPULE 1ML is used for medical abortion of pregnancy.

You should not receive PROSTODIN 125MG AMPULE 1ML, if you have a pelvic inflammatory disease, breathing disorder, heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking PROSTODIN 125MG AMPULE 1ML in these conditions can cause life-threatening conditions in an individual. Please inform your doctor, your doctor will decide whether to give PROSTODIN 125MG AMPULE 1ML.

After taking PROSTODIN 125MG AMPULE 1ML, you may or may not experience vaginal bleeding, which is not an indication of complete abortion. Your doctor will examine by ultrasonography to confirm if the abortion is complete.

The most common side effects of PROSTODIN 125MG AMPULE 1ML include nausea, vomiting, headache, diarrhoea, and increased or decreased blood pressure. You might also feel increased uterine contractions for some time, but these are manageable under medical supervision.

PROSTODIN 125MG AMPULE 1ML will be administered by a healthcare professional under medical supervision. Do not self-administer.

The dose of PROSTODIN 125MG AMPULE 1ML can vary depending on the individual medical condition. Your doctor will decide the dose based on your medical condition.

Country of origin

India

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - PRO0174

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Keep Refrigerated. Do not freeze.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:46 AM IST

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Reference

  1. https://www.drugs.com/mtm/carboprost.html
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017989s019lbl.pdf
  3. https://www.glowm.com/resources/glowm/cd/pages/drugs/c013.html

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