Pyrimethamine 25 mg Tablet 100's

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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Pyrimethamine 25 mg Tablet is used to treat malaria. It contains Pyrimethamine, which belongs to the class of antimalarial/antiparasitic drugs. It works by increasing the harmful, toxic and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading. In this way, it is used to prevent malaria relapse caused by parasites. Pyrimethamine 25 mg Tablet may cause side effects such as nausea, dizziness, vomiting, headache, diarrhoea, body pain, stomach discomfort, and injection site reactions.

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About Pyrimethamine 25 mg Tablet

Pyrimethamine 25 mg Tablet is an antimalarial medicine used in the treatment of malaria. Malaria is a parasitic disease caused by the plasmodium species. The infection occurs when the mosquito bites and enters the human body. Symptoms may include chills, on-and-off fever, and sweating. This medicine is only used to treat the infection. It is not recommended to prevent or treat severe conditions (where the infection is spread to the brain, kidneys, or lungs). Pyrimethamine 25 mg Tablet is also used in the treatment of toxoplasmosis (infection caused by parasites toxoplasma gondii) and also in chemoprophylaxis of malaria.

Pyrimethamine 25 mg Tablet contains Pyrimethamine, which belongs to the class of antimalarial/antiparasitic drugs. It works by increasing the harmful, toxic and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading. In this way, Pyrimethamine 25 mg Tablet is used for the prevention of relapse of malaria caused by parasites.

Pyrimethamine 25 mg Tablet may cause certain side effects such as nausea, dizziness, vomiting, headache, diarrhoea, body pain, stomach discomfort, and injection site reactions. These side effects usually disappear without any medical attention. However, if these side effects persist, inform your doctor immediately. Pyrimethamine 25 mg Tablet should be taken as advised by your doctor. Your doctor will decide the dose of the medicine based on the severity of your disease. Always take the medicine on time without skipping any dose.

Pyrimethamine 25 mg Tablet should be avoided if you are allergic to it or any other artemisinin derivatives. It is contraindicated in patients with megaloblastic anemia. Inform your doctor if you have/had any conditions such as anemia, liver/kidney disease, heart problem, or taking any other medicines before taking Pyrimethamine 25 mg Tablet as it may cause serious side effects under these conditions. If you are pregnant or breastfeeding, inform your doctor before taking Pyrimethamine 25 mg Tablet . This medicine is used in combination with other medicines for the treatment of malaria.

Uses of Pyrimethamine 25 mg Tablet

Pyrimethamine 25 mg Tablet is used to treat and prevent certain parasitic infections. The detailed uses of Pyrimethamine 25 mg Tablet are as follows:<br/>• Treats malaria: Pyrimethamine 25 mg Tablet is used with other fast-acting antimalarial drugs like chloroquine or quinine to manage malaria infections.<br/>• Helps prevent malaria: Pyrimethamine 25 mg Tablet is used in some cases to prevent malaria, although not typically preferred for travel-related prevention.<br/>• Treats toxoplasmosis: Pyrimethamine 25 mg Tablet is effective against infections caused by the Toxoplasma parasite.<br/>

Directions for Use

• Pyrimethamine 25 mg Tablet should be taken after meals to prevent stomach upset or as advised by your doctor.• It is usually taken once daily; however, follow your doctor's advice regarding the dosage and duration.• Swallow the tablet as a whole with a glass of water.• Do not break, chew or crush Pyrimethamine 25 mg Tablet .

Medicinal Benefits

Pyrimethamine 25 mg Tablet contains Pyrimethamine, which belongs to the class of antimalarial/ antiparasitic drugs. It works by increasing the harmful, toxic and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading. In this way, Pyrimethamine 25 mg Tablet is used for the prevention of relapse of malaria caused by plasmodium species. Pyrimethamine 25 mg Tablet is in combination with other antimalarial medicines such as chloroquine or quinine for the treatment of malarial infection.

How Pyrimethamine 25 mg Tablet Works

Pyrimethamine 25 mg Tablet contains Pyrimethamine, which belongs to the class of antimalarial/antiparasitic drugs. It works by increasing the harmful, toxic and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading. In this way, Pyrimethamine 25 mg Tablet is used for the prevention of relapse of malaria caused by parasites.

Storage

• Store in a cool and dry place away from sunlight.• Keep Pyrimethamine 25 mg Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Pyrimethamine 25 mg Tablet

Toxic epidermal necrolysis (Lyell's syndrome) (A Life-Threatening Skin Condition That Causes The Top Layer Of Skin To Detach From The Lower Layers)

Eat foods rich in vitamins C and E, and healthy fats.
Consider soft foods like smoothies, soups, and scrambled eggs.
Take supplements like vitamins C and E, zinc, and omega-3 fatty acids under medical supervision.
Include anti-inflammatory foods like omega-3 rich foods, berries, leafy greens, and spices.
Avoid allergens and consider an elimination diet.
Practice gentle skin care with non-irritating cleansers and moisturizers.
Keep skin well-moisturized with fragrance-free products.
Monitor for complications like infection and temperature regulation.

Red Patches Evolving Into Target Lesions Typically On Both Hands

Let your doctor know if there are unsual symptoms after taking the medication, such as red patches on your skin.
Your doctor may change your medication, lower the dose, or stop the treatment to help manage the symptoms.
Avoid heavy physical activity and get plenty of rest to prevent further worsening of the symptoms.
Apply cold packs to the affected areas for relief.
Keep yourself hydrated or take supplements to get enough vitamins.
Over-the-counter pain relievers can help with discomfort.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Low White Blood Cell Count

Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
Get sufficient sleep and manage stress which helps in improving white blood cell count.
Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Severe Allergic Reaction

If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
Your doctor will evaluate the severity of the reaction and determine the best course of action.
To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Blood In Urine

Staying hydrated helps prevent hematuria by increasing urine production. You should drink about eight glasses of fluid per day, and more in hot weather.
Avoiding smoking as it is linked to urinary tract cancers.
Eat berries like Cranberries, blueberries, and raspberries can help promote urinary tract health and protect against infection.
Taking Vitamin C can help treat urinary tract infections.
Avoid irritants that can contribute to hematuria.
Empty the bladder regularly, as it can helps in preventing hematuria.

What if I have taken an overdose of Pyrimethamine 25 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs of an overdose of Pyrimethamine 25 mg Tablet may include abdominal pain, nausea, severe and repeated vomiting, possibly including hematemesis, generalized and prolonged convulsions, respiratory depression, circulatory collapse, and death. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Avoid using Pyrimethamine 25 mg Tablet if you are allergic to it or any other artemisinin derivatives. Inform your doctor if you have/had any conditions such as liver/kidney disease, heart problem, or taking any other medicines before receiving Pyrimethamine 25 mg Tablet as it may cause serious side effects under these conditions. Pyrimethamine 25 mg Tablet is recommended for use in children only if prescribed by the paediatrician, and if administered, proper care and dosing should be checked. This medicine is used alone or in combination with other medicines for the treatment of malaria.

Drug-Drug Interactions

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

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Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

It is important to allow the patient to eat regularly in small amounts to tolerate the food.
Try to add protein to your diet for malaria-induced weight loss.
Eating at the right time and taking proper rest is important for the patient to recover.
Avoid eating fried and processed foods, and junk oily and spicy foods can aggravate nausea and disturb the body's digestion process.
Eat nutritious food that helps to improve malaria-induced weakness
Keep your area and surroundings mosquito-free.
Use mosquito-repellent products to avoid the recurrence of infections and any other further complications.

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Alcohol

Consult your doctor

The interaction of Pyrimethamine 25 mg Tablet with alcohol is unknown. Avoiding alcohol consumption is advised.

Pregnancy

Caution

In pregnant women, there are no favourable or well-controlled trials. Pyrimethamine 25 mg Tablet should only be used during pregnancy if the possible benefit outweighs the risk to the fetus. Concurrent use of folinic acid is strongly advised while treating toxoplasmosis during pregnancy.

Breast Feeding

Caution

Pyrimethamine is excreted in human milk. Because of the risk of serious adverse reactions in nursing infants from pyrimethamine and concurrent use of a sulfonamide with Pyrimethamine 25 mg Tablet for the treatment of some patients with toxoplasmosis, a decision should be made whether to discontinue nursing or the drug, taking into account the benefits of the drug to the mother.

Driving

Caution

Pyrimethamine 25 mg Tablet may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery after taking Pyrimethamine 25 mg Tablet until you are alert.

Liver

Caution

Pyrimethamine 25 mg Tablet should be used with caution if you have a pre-existing or a history of liver disease. Your doctor may adjust the dose based on your condition.

Kidney

Caution

Pyrimethamine 25 mg Tablet should be used with caution if you have a pre-existing or a history of kidney diseases. Your doctor may adjust the dose based on your condition.

Children

Safe if prescribed

Please consult your doctor. Your child's doctor will decide the dose of this medicine based on the age and condition of the child.

Have a query?

FAQs

What is the use of Pyrimethamine 25 mg Tablet ?

Pyrimethamine 25 mg Tablet is used to treat Malaria and Toxoplasmosis.

How does Pyrimethamine 25 mg Tablet work?

Pyrimethamine 25 mg Tablet contains Pyrimethamine, which belongs to the class of antimalarial/ antiparasitic drugs. It works by increasing the harmful, toxic, and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading.

Can I stop taking Pyrimethamine when I feel better?

No, do not stop taking Pyrimethamine 25 mg Tablet . It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve. Failure to do so might result in drug resistance, and treating any subsequent infection with the same medicine would be very difficult.

What are the side-effects of Pyrimethamine 25 mg Tablet ?

The common side-effects of Pyrimethamine 25 mg Tablet are nausea, vomiting, dizziness, diarrhoea, headache and injection site reactions. These side effects usually do not require any medical attention.

Country of origin

India

Manufacturer/Marketer address

Firozpur Jhirka, Haryana 122104

Other Info - PYR0191

Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:20 PM IST

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