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compositionComposition:RANOLAZINE-1000MG
prescription
Prescription Medicine
info
Randear 1000mg Tablet ER

Randear 1000mg Tablet ER is used alone or with other medicines to treat angina pectoris. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines. In some cases, it may cause side effects such as constipation, dizziness, headache, or feeling sick. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RANOLAZINE-1000MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Randear 1000mg Tablet ER

Randear 1000mg Tablet ER is a prescription oral medication primarily used to treat chronic chest pain, also known as angina. It is prescribed for long-term management to help reduce the frequency of chest pain episodes. This medication is not intended to treat sudden, acute attacks of angina.

To work effectively, Randear 1000mg Tablet ER must be taken consistently every day, usually twice daily, as directed by your doctor. You can take this medication with or without food, but it is important to be consistent with whichever method you choose. Combining this treatment with heart-healthy lifestyle habits, such as eating a balanced diet and engaging in light, doctor-approved physical activity, can significantly improve your overall outcomes.

While taking this medicine, some patients may experience mild side effects like dizziness, headache, nausea, or constipation. If you experience serious symptoms such as an irregular heartbeat, severe lightheadedness, or shortness of breath, you should contact your doctor immediately.

Do not take this if you have moderate to severe liver damage, as your body will not be able to process the medicine safely. Before starting, tell your healthcare provider if you have kidney problems or a family history of heart rhythm issues.

Randear 1000mg Tablet ER can interact with certain medications, grapefruit juice, and alcohol, which can increase the risk of side effects like dizziness or heart rhythm changes. Pregnant women, breastfeeding mothers, and elderly patients should consult their doctor before starting this medicine to ensure it is safe for their specific circumstances.

Uses of Randear 1000mg Tablet ER

The following are the primary therapeutic uses of Randear 1000mg Tablet ER:

  • Chronic Angina: Randear 1000mg Tablet ER helps by preventing and reducing the frequency of ongoing chest pain in patients with coronary artery disease, allowing for improved daily functioning.

Key Benefits

When taken as prescribed, Randear 1000mg Tablet ER offers several benefits for people managing chronic angina:

  • Reduces angina episodes: Helps decrease the frequency of chest pain attacks, improving day-to-day comfort.
  • Supports physical activity: Enables patients to perform routine activities with less angina-related discomfort.
  • Does not significantly lower heart rate: Suitable for patients who may not tolerate medications that slow the heart excessively.
  • Has minimal impact on blood pressure: Can be a useful option for individuals with low blood pressure or those sensitive to blood pressure-lowering effects.
  • Improves quality of life: Helps patients maintain a more active and independent lifestyle by providing better symptom control.

Directions for Use

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can release the medication too quickly and increase the risk of side effects.
  • Take it at the same times every day to maintain a steady level of the medicine in your body.
  • You may take this medicine with or without food, but keep your routine consistent.

Always follow your doctor's exact instructions regarding how and when to take this medication.

How Randear 1000mg Tablet ER Works

Randear 1000mg Tablet ER works by targeting the electrical and chemical processes inside the heart muscle cells. During chronic chest pain, heart cells can experience an abnormal buildup of sodium. This excess sodium leads to an overload of calcium, which prevents the heart muscle from fully relaxing between beats. By selectively blocking these late sodium channels, Randear 1000mg Tablet ER prevents calcium buildup. This allows the heart muscle to relax properly, improving blood flow and oxygen delivery to the heart without altering your normal resting heart rate or blood pressure.
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Alcohol

Safe if prescribed

Randear 1000mg Tablet ER does not have any reported interaction; hence, if you experience any difficulty, discuss with your doctor.

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Pregnancy

Unsafe

Randear 1000mg Tablet ER should not be used when pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Randear 1000mg Tablet ER.

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Breast Feeding

Consult your doctor

Randear 1000mg Tablet ER should not be used in nursing mothers. Please consult the doctor if you have any concerns regarding this.

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Driving

Safe if prescribed

Randear 1000mg Tablet ER does not have any reported interaction; hence, in case you experience any difficulty, discuss with your doctor.

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Liver

Caution

Randear 1000mg Tablet ER to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Randear 1000mg Tablet ER to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Randear 1000mg Tablet ER is not recommended for children below the age of 18. The safety and effectiveness of Randear 1000mg Tablet ER have not been established in children due to limited testing of this drug on children by competent authorities worldwide.

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Heart

Consult your doctor

Please consult your physician if you have any heart-related problems before taking Randear 1000mg Tablet ER.

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Geriatrics

Consult your doctor

Your doctor will recommend Randear 1000mg Tablet ER if needed in the geriatric population. Please consult your doctor.

What if I have taken an overdose of Randear 1000mg Tablet ER

Do not take more than the prescribed dose of Randear 1000mg Tablet ER as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid Grapefruit: Do not drink grapefruit juice or eat grapefruit while taking this medicine, as it can dangerously increase the levels of the drug in your system.
  • Monitor Salt Intake: Adopt a low-sodium diet to help manage underlying coronary artery disease and reduce strain on your cardiovascular system.
  • Stay Hydrated: Drink adequate amounts of water to help prevent constipation, which is a common side effect of this medication.
  • Engage in Gentle Exercise: Participate in moderate, doctor-approved activities like walking to support heart health without overexerting yourself.

Have a query?

How Soon It Starts Working

The time required for Randear 1000mg Tablet ER to start to work: The time required for Randear 1000mg Tablet ER to show its action is not clinically established. The time for which the effects of Randear 1000mg Tablet ER last: The effect of Randear 1000mg Tablet ER lasts for 21 days.

What if you forget to take Randear 1000mg Tablet ER

Take the missed dose as soon as you remember. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for your missed dose.

Storage

• Store Randear 1000mg Tablet ER tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the medication in its original container to protect it from moisture and direct light.

Drug Warnings

  • Avoid driving initially: Do not drive or operate machinery until you know how Randear 1000mg Tablet ER affects you, as it commonly causes dizziness.
  • Check other prescriptions: Always let your doctor know about all other medications, supplements, or herbal products you are taking to prevent dangerous interactions.
  • Do not stop suddenly: Keep taking this medication even if you feel well; stopping it abruptly can cause your chest pain to return.
  • Stand up slowly: To reduce the risk of dizziness or fainting, rise slowly from sitting or lying positions.

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Drug-Drug Interactions

The following medicines may interact with Randear 1000mg Tablet ER and affect its safety or effectiveness:

  • Strong CYP3A inhibitors: These medicines can increase the level of Randear 1000mg Tablet ER in your blood, raising the risk of side effects.
  • Strong CYP3A inducers: These drugs can reduce the effectiveness of Randear 1000mg Tablet ER by lowering its concentration in the body.
  • Heart rhythm medications: Taking these with Randear 1000mg Tablet ER may increase the risk of abnormal heart rhythms.
  • Tuberculosis medications: Certain TB treatments can alter how Randear 1000mg Tablet ER is metabolised, affecting its effectiveness.
  • Anti-seizure medications: These medicines may interfere with the blood levels and action of Randear 1000mg Tablet ER.


Drug-Food Interactions

Certain foods and beverages may affect how Randear 1000mg Tablet ER works in your body:

  • Grapefruit and grapefruit juice: Avoid these completely, as they can increase the amount of Randear 1000mg Tablet ER in your bloodstream to unsafe levels.
  • Alcohol: Limiting alcohol intake is advised, as it may worsen dizziness and other side effects.


Drug-Disease Interactions

Some existing medical conditions may affect whether Randear 1000mg Tablet ER is suitable for you:

  • Severe liver disease (cirrhosis): Do not take Randear 1000mg Tablet ER if you have severe liver impairment, as it may lead to harmful drug accumulation.
  • Moderate-to-severe kidney disease: Use with caution, as impaired kidney function may affect how the medicine is processed.
  • Long QT syndrome: If you have a personal or family history of this heart rhythm disorder, Randear 1000mg Tablet ER may increase the risk of serious cardiac complications.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIANGINALS]

FAQs

Randear 1000mg Tablet ER is used alone or with other medicines to treat angina pectoris.
The active substance in Randear 1000mg Tablet ER is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Randear 1000mg Tablet ER is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.
No, Randear 1000mg Tablet ER does not stop acute attacks (sudden attacks) of angina, but Randear 1000mg Tablet ER helps prevent a new attack.
No, alcohol should not be taken with Randear 1000mg Tablet ER as it may lead to unwanted side effects and increase angina attacks.
Yes, smoking (tobacco) decreases the efficacy of Randear 1000mg Tablet ER, especially when taken for angina (chest pain), so it should be avoided while taking Randear 1000mg Tablet ER.
Yes, Randear 1000mg Tablet ER can cause an upset stomach when taken empty stomach. So, to avoid it, Randear 1000mg Tablet ER should be taken with a meal for best results.
Yes, Randear 1000mg Tablet ER can cause drowsiness. If you feel excessively sleepy, please consult your doctor for better advice.
Some major side effects include a rapid, pounding, or irregular heartbeat, difficulty breathing, and fainting. If you encounter any of these symptoms, contact your doctor immediately.
Do not take more than the prescribed dose of Randear 1000mg Tablet ER as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.
Randear 1000mg Tablet ER may increase the blood levels and effects of metoprolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.
Randear 1000mg Tablet ER might raise metformin levels, increasing the risk of lactic acidosis. If you are prescribed ranolazine while taking metformin, discuss it with a healthcare physician. They may offer a lesser dose of metformin as a safer alternative.
You can take it if prescribed by the doctor. However, limit simvastatin to 20 mg once daily in individuals taking any dose of Randear 1000mg Tablet ER.
No, you should never crush, chew, or split Randear 1000mg Tablet ER tablets. They are designed as extended-release tablets to slowly release the medicine into your body over time. Breaking them can cause too much medication to be absorbed at once. Talk to your doctor if you have trouble swallowing tablets.
Dizziness is a common side effect, especially when starting the medication. Try to sit or lie down until the feeling passes, and rise slowly when standing up. If the dizziness is severe or does not improve, talk to your doctor.
Unlike many other chronic chest pain medications, Randear 1000mg Tablet ER does not significantly lower your blood pressure or slow your heart rate. This makes it a useful option for patients who already have low blood pressure or a slow pulse. Talk to your doctor for more details.
No, you should avoid grapefruit and grapefruit juice entirely while taking Randear 1000mg Tablet ER. Grapefruit blocks enzymes that break down the drug, which can lead to dangerously high levels of the medicine in your body. Talk to your doctor or pharmacist if you have questions about foods to avoid.
Randear 1000mg Tablet ER starts working within a few days, but it may take several weeks of consistent use to notice a significant reduction in your chest pain episodes. Keep taking it daily even if you do not feel immediate relief. Talk to your doctor if your symptoms do not improve.
The safety of Randear 1000mg Tablet ER during pregnancy and breastfeeding is not fully established. You should only use this medication if the potential benefit justifies the potential risk. Talk to your doctor to discuss safer alternatives.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - RA69972
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