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  3. RCINEX R CIN + INH 450MG CAPSULE

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RCINEX R CIN + INH 450MG CAPSULE, Pack of 10
RCINEX R CIN + INH 450MG CAPSULE, Pack of 10
RCINEX R CIN + INH 450MG CAPSULE, Pack of 10
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axis icici
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

RCINEX R CIN + INH 450MG CAPSULE is used to treat tuberculosis in children. It contains Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, they kill Mycobacterium tuberculosis, which causes TB (tuberculosis). Common side effects of RCINEX R CIN + INH 450MG CAPSULE are nausea, vomiting, diarrhoea, stomach pain, and loss of appetite.

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Composition :

ISONIAZID-300MG + RIFAMPICIN-450MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About RCINEX R CIN + INH 450MG CAPSULE

RCINEX R CIN + INH 450MG CAPSULE is used to treat tuberculosis in children. Tuberculosis is an infectious disease that mainly affects the lungs but can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.
 
RCINEX R CIN + INH 450MG CAPSULE contains Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, RCINEX R CIN + INH 450MG CAPSULE kills Mycobacterium tuberculosis which causes TB (tuberculosis).
 
In some cases, RCINEX R CIN + INH 450MG CAPSULE may cause side effects such as nausea, vomiting, diarrhoea, stomach pain, and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.
 
Let your doctor know if your child is allergic to any of the components in RCINEX R CIN + INH 450MG CAPSULE. Keep your doctor informed about your child's health condition and medications to rule out any side effects/interactions.

Uses of RCINEX R CIN + INH 450MG CAPSULE

RCINEX R CIN + INH 450MG CAPSULE is used in the treatment of Tuberculosis. The detailed uses of RCINEX R CIN + INH 450MG CAPSULE are as follows:<br/>• Treatment of Active Tuberculosis (TB): RCINEX R CIN + INH 450MG CAPSULE is used in combination therapy to treat active TB infections in children. Rifampicin and Isoniazid work synergistically to kill Mycobacterium tuberculosis by disrupting bacterial protein synthesis and cell wall formation, helping reduce symptoms like persistent cough, fever, and weight loss.<br/>• Latent Tuberculosis Infection (LTBI): RCINEX R CIN + INH 450MG CAPSULE is used in children who have been exposed to TB but do not yet show symptoms. It helps prevent the progression from latent to active TB, especially in high-risk groups such as those with weakened immune systems.<br/>• Tuberculous Meningitis and Disseminated TB: RCINEX R CIN + INH 450MG CAPSULE may be part of a broader regimen to treat severe forms of TB, such as TB meningitis or miliary TB, due to its ability to penetrate the central nervous system and systemic circulation effectively.<br/>• Preventive Therapy in High-Risk Pediatric Contacts: RCINEX R CIN + INH 450MG CAPSULE is used as a prophylactic treatment for children who have been in close contact with TB-positive individuals, aiming to stop the infection before it becomes active.<br/>

Directions for Use

• RCINEX R CIN + INH 450MG CAPSULE should be administered one hour before or two hours after meals, or as directed by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Administer the prescribed dose to the child using the measuring cup/dosing syringe.• Shake well before use.

Medicinal Benefits

RCINEX R CIN + INH 450MG CAPSULE belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. RCINEX R CIN + INH 450MG CAPSULE contains two anti-mycobacterial agents, Rifampicin and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, RCINEX R CIN + INH 450MG CAPSULE kills Mycobacterium tuberculosis which causes TB (tuberculosis).

How RCINEX R CIN + INH 450MG CAPSULE Works

RCINEX R CIN + INH 450MG CAPSULE contains Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, RCINEX R CIN + INH 450MG CAPSULE kills Mycobacterium tuberculosis which causes TB (tuberculosis).

Storage

• Store in a cool and dry place away from sunlight.
• Keep RCINEX R CIN + INH 450MG CAPSULE out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Rcinex R Cin + Inh 450mg Capsule
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Avoid rubbing your eyes, which can exacerbate the issue.
  • Lubricate your eyes using artificial tears or eye drops.
  • Wear sunglasses while you are out in the sun to protect your eyes from sun and wind.
  • Avoid irritants like smoke, dust, and strong chemicals.
  • Get enough rest and sleep to help your eyes recover.
  • Inform your doctor about changes in saliva levels. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of RCINEX R CIN + INH 450MG CAPSULE

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of RCINEX R CIN + INH 450MG CAPSULE may include altered sensorium, generalized tonic-clonic seizures, renal and hepatic dysfunctions, and severe metabolic acidosis. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not give RCINEX R CIN + INH 450MG CAPSULE to the child if he/she is allergic to any of the components in RCINEX R CIN + INH 450MG CAPSULE, if he/she has acute liver disease, drug-induced liver disease, if the child has experienced liver damage linked to rifampicin or isoniazid, or if the child is taking anti-fungal (voriconazole) or medicines for HIV infection (protease inhibitors). RCINEX R CIN + INH 450MG CAPSULE may cause liver damage; consult your doctor if the child experiences symptoms such as unexplained loss of appetite, nausea, vomiting, jaundice, dark urine, persistent fatigue for more than 3 days, abdominal pain and tenderness. Consult a doctor if your child gets flu-like symptoms such as headache, fever, or muscle ache. Inform the doctor if your child has HIV infection, epilepsy, psychiatric disorder, diabetes, porphyria, phenylketonuria (metabolic disorder), peripheral neuropathy (tingling sensation in hands and feet), kidney or liver problems, if your child is allergic to ethionamide or niacin (nicotinic acid), or if your child is taking cortisone or any cortisone-like drug. 

Drug-Drug Interactions

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RifampicinSaquinavir
Critical
RifampicinIndinavir
Critical

Drug-Drug Interactions

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RifampicinSaquinavir
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
Taking saquinavir with Rcinex R Cin + Inh 450mg Capsule can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Rcinex R Cin + Inh 450mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
When Indinavir is taken with Rcinex R Cin + Inh 450mg Capsule, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Rcinex R Cin + Inh 450mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinDarunavir
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
Taking darunavir with Rcinex R Cin + Inh 450mg Capsule can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Rcinex R Cin + Inh 450mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
Taking Voriconazole with Rcinex R Cin + Inh 450mg Capsule can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with Rcinex R Cin + Inh 450mg Capsule, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
When ranolazine is taken with Rcinex R Cin + Inh 450mg Capsule, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Rcinex R Cin + Inh 450mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinPirfenidone
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
Taking pirfenidone with Rcinex R Cin + Inh 450mg Capsule can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and Rcinex R Cin + Inh 450mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsoniazidRegorafenib
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
When Rcinex R Cin + Inh 450mg Capsule is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Rcinex R Cin + Inh 450mg Capsule is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLomitapide
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
When Lomitapide is taken with Rcinex R Cin + Inh 450mg Capsule, Rcinex R Cin + Inh 450mg Capsule may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Rcinex R Cin + Inh 450mg Capsule with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidLovastatin
Critical
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
When Lovastatin is taken with Rcinex R Cin + Inh 450mg Capsule, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Rcinex R Cin + Inh 450mg Capsule with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
RifampicinDabigatran etexilate
Severe
How does the drug interact with Rcinex R Cin + Inh 450mg Capsule:
Taking dabigatran etexilate with Rcinex R Cin + Inh 450mg Capsule can decrease the blood levels of dabigatran etexilate, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between dabigatran etexilate and Rcinex R Cin + Inh 450mg Capsule, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ISONIAZID-300MG+RIFAMPICIN-450MGTyramine-containing food
Moderate

Drug-Food Interactions

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ISONIAZID-300MG+RIFAMPICIN-450MGTyramine-containing food
Moderate
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Coadministration of Rcinex R Cin + Inh 450mg Capsule with foods containing tyramine increases the risk of side effects such as headache, sweating, diarrhea, nausea, vomiting, fast heartbeats, difficulty breathing, and low blood pressure. Avoid foods containing tyramine while being treated with Rcinex R Cin + Inh 450mg Capsule , as it can lead to side effects.

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from a cough.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

-

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Breast Feeding

Not applicable

-

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Driving

Not applicable

-

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Liver

Consult your doctor

Please consult the doctor if your child has a liver impairment or if you have any concerns regarding this.

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Kidney

Consult your doctor

Please consult the doctor if your child has kidney problems.

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Children

Safe if prescribed

RCINEX R CIN + INH 450MG CAPSULE is safe for children if prescribed by the doctor. Your doctor may prescribe the dose and duration based on the child's condition and age.

Have a query?

FAQs

RCINEX R CIN + INH 450MG CAPSULE is used to treat Tuberculosis.

RCINEX R CIN + INH 450MG CAPSULE works by killing Mycobacterium tuberculosis which causes TB (tuberculosis).

RCINEX R CIN + INH 450MG CAPSULE may cause reddish-orange discolouration of body fluids such as tears, sputum and urine; this is not harmful and does not require medical attention. However, consult your doctor if you have any concerns.

RCINEX R CIN + INH 450MG CAPSULE might stain soft contact lenses. The child should use spectacles and avoid wearing contact lens while taking RCINEX R CIN + INH 450MG CAPSULE.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - RCI0006

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicinesforchildren.org.uk/medicines/isoniazid-and-rifampicin-combination-for-latent-tuberculosis/
  2. https://extranet.who.int/pqweb/sites/default/files/TB302Part3_0.pdf
  3. https://www.sahpra.org.za/wp-content/uploads/2020/02/Rimactazid-Paed-60-60_PIL_Sandoz_MCC-format-01-October-2018.pdf

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