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  3. Repoitin 4000IU Injection 1's

Repoitin 4000IU Injection 1's, Pack of 1 INJECTION
Repoitin 4000IU Injection 1's, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Repoitin 4000IU Injection is used to treat anaemia in cancer, chronic kidney disease, and HIV. It contains Epoetin alfa which works by stimulating the bone marrow to make more red blood cells. In some cases, this medicine may cause side effects such as diarrhoea, vomiting, fever, feeling sick, stuffy nose and sore throat. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions
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Composition :

EPOETIN ALFA-4000I.U

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Repoitin 4000IU Injection

Repoitin 4000IU Injection belongs to the class of medication called 'blood-forming agent'  primarily used to treat anaemia (low red blood cell count) in persons with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells' cancer). Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.

Repoitin 4000IU Injection contains a human-made protein known as 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells (RBCs). Repoitin 4000IU Injection helps to reverse anaemia and reduce the need for blood transfusion. Repoitin 4000IU Injection is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Repoitin 4000IU Injection stimulates the production of this protein in the bone marrow. 

Repoitin 4000IU Injection will be administered by a healthcare professional; do not self-administer. The most common side effects of Repoitin 4000IU Injection are shortness of breath,  cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these side effects of Repoitin 4000IU Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to epoetin alfa or darbepoetin alfa, please inform your doctor before taking Repoitin 4000IU Injection to avoid any complications. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be a sign that the body has stopped responding to Repoitin 4000IU Injection. It is not known whether Repoitin 4000IU Injection will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant and breastfeeding before starting treatment with this medicine. Repoitin 4000IU Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might be lost. Do not store in the freezer or the fridge.

Uses of Repoitin 4000IU Injection

Treatment of Anemia in cancer, Anemia in chronic kidney disease, Anemia in HIV.

Directions for Use

Repoitin 4000IU Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Repoitin 4000IU Injection is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn causes low red blood cells count causing anemia.  This medicine is primarily indicated for treating anemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease, persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells cancer, and persons taking zidovudine to treat HIV(human immunodeficiency virus). Repoitin 4000IU Injection is also used to reduce the need for red blood cell transfusions in adults having certain types of surgery. Repoitin 4000IU Injection contains a protein 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. 

How Repoitin 4000IU Injection Works

Repoitin 4000IU Injection contains a human-made protein known as 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells (RBCs). Repoitin 4000IU Injection helps to reverse anaemia and reduce the need for blood transfusion. Repoitin 4000IU Injection is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Repoitin 4000IU Injection stimulates the production of this protein in the bone marrow.

Storage

Store in a cool and dry place away from sunlight
Side effects of Repoitin 4000IU Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.

What if I have taken an overdose of Repoitin 4000IU Injection

Since Repoitin 4000IU Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as a fast or racing heartbeat.

Drug Warnings

Repoitin 4000IU Injection can enhance the risk of blood clots and serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may speed up tumor growth, or shorten remission or survival time in some people with certain types of cancer. Inform your doctor before taking Repoitin 4000IU Injection if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take Repoitin 4000IU Injection if you are pregnant or breastfeeding unless prescribed by the doctor. Repoitin 4000IU Injection should not be given to children below 1 month of age, as safety and effectiveness have not been established. Do not use Repoitin 4000IU Injection from a multi-dose vial when giving medicine to a baby. The multi-dose vial contains an ingredient (benzyl alcohol) that can cause serious side effects or death in very young infants or premature babies. Repoitin 4000IU Injection may affect a person's ability to drive as it may cause convulsions during the initial days of treatment, so a person taking Repoitin 4000IU Injection should avoid driving or operating any machine. Avoid consuming alcohol along with Repoitin 4000IU Injection as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

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ErythropoietinLenalidomide
Severe
ErythropoietinPomalidomide
Severe

Drug-Drug Interactions

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ErythropoietinLenalidomide
Severe
How does the drug interact with Repoitin 4000IU Injection:
Combining Repoitin 4000IU Injection with Lenalidomide can increase the risk of Thrombosis(formation of a blood clot ).

How to manage the interaction:
Although there is an interaction between Repoitin 4000IU Injection and Lenalidomide, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
ErythropoietinPomalidomide
Severe
How does the drug interact with Repoitin 4000IU Injection:
Pomalidomide can cause serious blood clots and taking it alongside Repoitin 4000IU Injection may enhance the risk.

How to manage the interaction:
Co-administration of Repoitin 4000IU Injection with Pomalidomide can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ErythropoietinThalidomide
Severe
How does the drug interact with Repoitin 4000IU Injection:
Taking thalidomide with Repoitin 4000IU Injection may increase the risk or severity of thromboembolism(a circulating blood clot that gets stuck and causes an obstruction).

How to manage the interaction:
Although taking Repoitin 4000IU Injection and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ErythropoietinCarfilzomib
Severe
How does the drug interact with Repoitin 4000IU Injection:
Carfilzomib can cause serious blood clots and taking it alongside Repoitin 4000IU Injection may enhance the risk.

How to manage the interaction:
Co-administration of Repoitin 4000IU Injection with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Limit the consumption of fluids, salt, potassium, phosphorous, and other electrolytes.
  • Eat a low-protein diet, and get enough calories from the foods if you are losing weight.
  • Eat foods that are high in vitamin B12, iron, and folic acid can fulfill the deficiencies of happed in kidney disease.
  • Include a little number of healthy fats in your diet that gives you enough energy to be active during the day; however, try to limit fats that make you fat. Try to include olive oil, peanut oil, and corn oil in your diet.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ERYTHROPOIESIS STIMULATING AGENTS (ESAs)

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Repoitin 4000IU Injection as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Repoitin 4000IU Injection if you are pregnant unless prescribed by a doctor as Repoitin 4000IU Injection is a pregnancy category B drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks. If prescribed use only single-dose vials (the benzyl alcohol-free formulation) in pregnant women.

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Breast Feeding

Caution

Consult your doctor before taking Repoitin 4000IU Injection; your doctor will decide whether Repoitin 4000IU Injection can be taken by breastfeeding mothers or not.

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Driving

Caution

Repoitin 4000IU Injection causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Repoitin 4000IU Injection should not be given to neonates as the safety and efficacy have not been established.

Have a query?

FAQs

Repoitin 4000IU Injection is used to treat anaemia (low red blood cell count) in people with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells cancer).

Repoitin 4000IU Injection contains a protein "Epoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.

A person who is allergic to any chemical compound present in Repoitin 4000IU Injection or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.

It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.

It is suggested to store the Repoitin 4000IU Injection in the refrigerator between 2 and 8 ℃ and protect it from light. However, a person should not freeze it.

The common side-effects of Repoitin 4000IU Injection are headache and pain, redness at the injection site. These side-effects are usually mild and temporary. However, inform your doctor immediately if any of these side-effects persist or get worse.

Repoitin 4000IU Injection will be administered subcutaneously (under the skin) or intravenously (through the vein) by the doctor or nurse based on individual considerations.

Since Repoitin 4000IU Injection will be administered by the doctor it is unlikely to exceed the recommended dose. However, seek medical attention if you experience symptoms of overdose such as a fast or racing heartbeat.

Yes, Repoitin 4000IU Injection will be given to children by the doctor if needed. However, it should not be given to children under 1 month of age, as its safety and effectiveness have not been established for this age group. Consult the doctor if you have any concerns.

Yes, Repoitin 4000IU Injection may cause hypertension (high blood pressure). The doctor will control high blood pressure before and during treatment. However, it is not recommended for people with uncontrolled hypertension. Let the doctor know if you have hypertension before starting treatment with Repoitin 4000IU Injection.

Country of origin

INDIA

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - REP0083

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Keep Refrigerated. Do not freeze.

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.drugs.com/mtm/epoetin-alfa.html
  2. https://www.medicines.org.uk/emc/files/pil.1193.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103234s5363s5366lbl.pdf
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