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  1. Home
  2. Medicine

  3. Rex 50mg/500mg Tablet

Prescription drug
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Rex 50mg/500mg Tablet, Pack of 1 Tablet
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Extra 15% Off with Bank Offers

Composition :

DIACEREIN-50MG + GLUCOSAMINE-500MG

Manufacturer/Marketer :

Biochemix Health Care Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Rex 50mg/500mg Tablet

Rex 50mg/500mg Tablet is used to reduce the pain of osteoarthritis (OA) in specific large and small joints. Osteoarthritis is a chronic (lifelong) joint condition in which glucosamine sulfate (a chemical found in the human body, especially in joints) is reduced. The body uses this fluid to produce other chemicals required to form ligaments, cartilage, tendons, and the thick fluid that surrounds joints.

Rex 50mg/500mg Tablet comprises diacerein and glucosamine. Diacerein inhibits the action of a protein responsible for causing inflammation and cartilage destruction, thereby alleviating symptoms of osteoarthritis. Glucosamine produces various chemicals responsible for building ligaments, cartilage, tendons, and the thick fluid surrounding joints.

Sometimes, you may experience certain common side effects such as headache, tiredness, nausea, abdominal pain, indigestion, diarrhoea, constipation, and wind. Most of these side effects do not require medical attention and resolve gradually over time. However, talk to your doctor if you experience these undesirable effects persistently.

Inform your doctor if you are allergic to it. Rex 50mg/500mg Tablet is not allowed to be used by children younger than 18. Consult your doctor if you have ever had blood clots or circulation problems in your legs or if you are pregnant or planning to be pregnant, as this may harm an unborn baby. Tell your doctor if you are breastfeeding, as it may not be safe to breastfeed a baby while taking Rex 50mg/500mg Tablet.

Uses of Rex 50mg/500mg Tablet

Rex 50mg/500mg Tablet is used in the treatment of osteoarthritis. The detailed uses of Rex 50mg/500mg Tablet are as follows:

  • Manages Osteoarthritis: Rex 50mg/500mg Tablet helps to rebuild and protect cartilage (the cushioning tissue in joints), reducing wear and tear caused by osteoarthritis.
  • Reduces joint pain and inflammation: Rex 50mg/500mg Tablet helps relieve symptoms such as joint pain, stiffness, and swelling, thereby improving mobility and comfort.
  • Slows joint damage: Rex 50mg/500mg Tablet helps to slow the progression of joint degeneration and improve long-term joint health.

Have a query?

Directions for Use

  • Take Rex 50mg/500mg Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Rex 50mg/500mg Tablet comprises two medicines, namely diacerein and glucosamine.
  • Diacerein restricts the action of a protein responsible for causing inflammation and destruction of cartilage, a process known as osteoarthritis.
  • Glucosamine sulfate is a natural protein found in the body used by the body to produce a variety of chemicals responsible for building ligaments, cartilage, tendons, and the thick fluid surrounding joints.
  • Rex 50mg/500mg Tablet may either enhance the cartilage and fluid surrounding joints or prevent the breakdown of both components.
  • In combination, both help form cartilage (the soft tissue that cushions the joints) and make the joints lubricated for better movement and flexibility.
  • Rex 50mg/500mg Tablet relieves pain, thereby improving joint function and helping individuals restore their quality of life.
  • It also increases the cushioning and lubrication of joints, provides relief from pain, and makes physical activity easier.

How Rex 50mg/500mg Tablet Works

Rex 50mg/500mg Tablet compromises two medicines, namely Diacerein and Glucosamine. Diacerein restricts the action of a protein responsible for causing inflammation and destruction of cartilage or osteoarthritis. At the same time, Glucosamine sulfate is a natural protein found in the body used by the body to produce various chemicals responsible for building ligaments, cartilage, tendons, and the thick fluid surrounding joints. Taking Rex 50mg/500mg Tablet may either enhance the cartilage and fluid surrounding joints or prevent the breakdown of both components. In combination, both help form cartilage (the soft tissue that cushions the joints) and make the joints lubricated for better movement and flexibility.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Rex 50mg/500mg Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Rex 50mg/500mg Tablet

Do not take more than the prescribed dose of Rex 50mg/500mg Tablet as it may cause serious side effects. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to any of its components.
  • Consumption of alcohol should be avoided during the treatment with Rex 50mg/500mg Tablet as it may lead to an increased risk of liver damage.
  • Patients with blood clots or leg circulation problems should not take Rex 50mg/500mg Tablet.
  • Although it is generally a safe medicine to use, it should be avoided in patients with liver and kidney disease as the Rex 50mg/500mg Tablet may harm the liver and renal functions.
  • Use Rex 50mg/500mg Tablet in pregnancy and breastfeeding only if recommended by the physician.
  • Although Rex 50mg/500mg Tablet provides symptomatic relief in conditions like arthritis and may reduce the inflammation caused by these conditions, it is strongly recommended to remain physically active as much as your condition allows to achieve the best results.
  • Adopting a healthy lifestyle and a diet containing high protein is the mainstay for managing arthritic conditions.

Drug-Drug Interactions

verifiedApollotooltip
GlucosamineWarfarin
Moderate
GlucosamineDicoumarol
Moderate

Drug-Drug Interactions

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GlucosamineWarfarin
Moderate
How does the drug interact with Rex 50mg/500mg Tablet:
The combined use of Rex 50mg/500mg Tablet and warfarin can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Rex 50mg/500mg Tablet and warfarin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
GlucosamineDicoumarol
Moderate
How does the drug interact with Rex 50mg/500mg Tablet:
The combined use of Dicoumarol and Rex 50mg/500mg Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of dicoumarol and Rex 50mg/500mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
  • Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscles by lifting light weights.
  • Including fish like salmon, trout, tuna, and sardines in your daily diet. These fish are enriched with omega-3 fatty acids with a minimum level of chemicals called cytokines, which ramp up inflammation.
  • Your sitting posture is important, especially when you have a painful and inflammatory condition. Try to sit as little as possible and only for a short time (10-15 min). Use a back support like a rolled-up towel to minimise pain in the curve of your back. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESICS

Rex 50mg/500mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Rex 50mg/500mg Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Rex 50mg/500mg Tablet should not be taken in pregnancy as the safety and effectiveness of Rex 50mg/500mg Tablet have not been established. Please consult your doctor.

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Breast Feeding

Unsafe

Rex 50mg/500mg Tablet should not be taken in breastfeeding mothers as the safety and effectiveness of Rex 50mg/500mg Tablet have not been established.

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Driving

Caution

In some cases, Rex 50mg/500mg Tablet may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.

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Liver

Caution

Rex 50mg/500mg Tablet should be used with caution in persons dealing with any liver disorders. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

Rex 50mg/500mg Tablet should be used with caution in persons dealing with kidney disorders. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Rex 50mg/500mg Tablet can not be given to persons younger than 18 years of age, as the safety and effectiveness of Rex 50mg/500mg Tablet have not been established.

FAQs

Rex 50mg/500mg Tablet is used to relieve pain associated with osteoarthritis. It helps form cartilage (the soft tissue that cushions the joints) and makes the joints lubricated for better movement and flexibility.

Rex 50mg/500mg Tablet is not suggested in patients having liver problems. Rex 50mg/500mg Tablet is also not administered to patients with known allergies to Rex 50mg/500mg Tablet.

The safety and effectiveness of Rex 50mg/500mg Tablet in joints other than the knee have not been established. So its use in parts other than the knee joint should be avoided.

Glucosamine sulfate is a natural protein found in the body used by the body to produce a variety of chemicals responsible for building ligaments, cartilage, tendons, and the thick fluid surrounding joints. Taking Rex 50mg/500mg Tablet may either enhance the cartilage and fluid surrounding joints or prevent both components' breakdown.

You are advised to tell your doctor if you have diabetes, high cholesterol or triglycerides (a type of fat in the blood), cancer, liver disease, asthma, or other breathing disorder if you are allergic to shellfish, or you have taken a blood thinner (warfarin, Coumadin, Jantoven).

Some research suggests that the presence of Glucosamine in Rex 50mg/500mg Tablet may affect antidiabetic drugs; it can also increase the sugar level in the blood in type 2 diabetes. This is why it is suggested to go for regular checkups of blood sugar with type 2 diabetes.

Rex 50mg/500mg Tablet may increase the risk of bleeding in people taking Warfarin, so it is advised to tell your doctor if you are taking Warfarin or any other medicine.

Some research suggests that glucosamine sulfate may enhance insulin levels in the body which can increase blood pressure. To be safer side, go for regular blood checks and closely monitor your blood pressure.

It has been noticed that Rex 50mg/500mg Tablet may cause allergic reactions in persons who are sensitive to shellfish. Glucosamine is produced synthetically from shells of shrimp, lobster, and crabs.

Some research suggests that Rex 50mg/500mg Tablet may increase pressure inside the eye and may worsen glaucoma. So if you have glaucoma then tell to your doctor.

No, Rex 50mg/500mg Tablet is not a steroid. This combination medication supports joint health by pairing Diacerein, which reduces inflammation and cartilage damage, with Glucosamine, which helps build and maintain joint cushioning. Together, they improve joint flexibility, reduce pain, and enhance movement.

Rex 50mg/500mg Tablet works by reducing inflammation and protecting cartilage from damage. Diacerein blocks specific proteins that trigger joint inflammation, while Glucosamine promotes the production of cartilage and joint fluid. Together, they improve joint lubrication, reduce pain, and enhance mobility.

The optimal timing for taking Rex 50mg/500mg Tablet is typically with meals, preferably breakfast or lunch, to enhance absorption and minimise gastrointestinal discomfort. However, it is crucial to adhere to the specific dosing instructions provided by your healthcare provider or pharmacist.

The common side effects of Rex 50mg/500mg Tablet may include gastrointestinal issues such as nausea, abdominal pain, indigestion, diarrhoea, constipation, wind, and general symptoms like tiredness and headache. Most of these side effects are mild and temporary, resolving on their own over time. However, if they persist or worsen, it's essential to consult your doctor for proper evaluation and guidance.

Rex 50mg/500mg Tablet is generally safe for most people, but if you have diabetes, you should use it with caution. Glucosamine may slightly affect blood sugar levels, so regular monitoring is crucial. Therefore, please consult the doctor before taking Rex 50mg/500mg Tablet to ensure it’s safe for your condition and does not interfere with your diabetes management.

Rex 50mg/500mg Tablet may take time to show noticeable effects. Diacerein usually starts working within 8 to 12 weeks, while the impact of Glucosamine may vary among individuals. Therefore, consistently following your doctor’s prescribed duration is key to achieving the best results.

Before taking Rex 50mg/500mg Tablet, it's essential to inform your doctor if you have any pre-existing medical conditions, such as blood clots, circulation problems, pregnancy, breastfeeding, or plans to become pregnant. Additionally, disclose any joint infections, skin diseases, diabetes, kidney or liver problems, heart disease, or asthma. It's also essential to avoid drinking alcohol while taking this medication and note that it's not recommended for children under 18.

Rex 50mg/500mg Tablet should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.

There is no specific evidence that Rex 50mg/500mg Tablet increases the risk of developing glaucoma. However, some studies suggest that Glucosamine may raise intraocular pressure (IOP), a glaucoma risk factor. Therefore, please consult the doctor if you have glaucoma before using Rex 50mg/500mg Tablet.

Country of origin

India
Other Info - RE53563

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Oct 13, 2025 | 8:53 AM IST

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Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/2171814.PA1521_003_002.cb4ba0a2-1887-4c40-afe6-e19cea656342.000001750mg%20PIL%20.160824.pdf
  2. https://www.drugs.com/mtm/glucosamine.html
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