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compositionComposition:DASATINIB-25MG
prescription
Prescription Medicine
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Rytstat 25 mg Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia and acute lymphoblastic leukaemia. It contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce their further spread to other parts of the body.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DASATINIB-25MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rytstat 25 mg Tablet

Rytstat 25 mg Tablet is an oral prescription medication used to treat specific types of blood cancers, including chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL). It is prescribed to slow down or stop the growth of abnormal cancer cells in the bone marrow. This medication helps manage these complex blood conditions in both adults and, in some cases, children.

For the best results, you must take Rytstat 25 mg Tablet consistently at the same time every day. You can take this tablet with or without food, but you should stick to the same routine daily. Making healthy lifestyle choices, such as eating a well-balanced diet and drinking plenty of fluids, can help support your body during this treatment.

While taking Rytstat 25 mg Tablet, you may experience some common side effects, which are usually manageable. However, you must contact your doctor immediately if you experience serious symptoms, such as sudden shortness of breath, unexplained swelling, or unusual bleeding. Regular medical follow-ups and blood tests are required to ensure the medication is working safely.

Do not take this if you are allergic to any of its ingredients. Before starting Rytstat 25 mg Tablet, tell your doctor if you have a history of heart disease, liver damage, low potassium or magnesium levels in your blood, or a personal or family history of long QT syndrome. Pregnant women must not take this medication, as it can cause harm to an unborn baby.

Rytstat 25 mg Tablet can interact with several common medications, including stomach-acid reducers and certain antibiotics, which can prevent it from working properly. You should avoid drinking alcohol while taking this medicine as it may increase the risk of side effects, and talk to your doctor if you smoke. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, consult your doctor to discuss the risks and benefits of this treatment.

Uses of Rytstat 25 mg Tablet

Rytstat 25 mg Tablet is used to treat specific types of blood cancers. The detailed uses of Rytstat 25 mg Tablet are as follows:

  • Chronic Myeloid Leukaemia (CML): Rytstat 25 mg Tablet helps by targeting and blocking abnormal proteins that send signals to cancer cells to multiply, helping to control the overproduction of abnormal white blood cells.
  • Philadelphia Chromosome-Positive Acute Lymphoblastic Leukaemia (Ph+ ALL): Rytstat 25 mg Tablet stops the rapid growth of abnormal leukaemia cells, allowing the bone marrow to produce healthier, normally functioning blood cells.
     

Key Benefits

Rytstat 25 mg Tablet provides targeted action directly against the proteins causing cancer cell growth, which offers several practical benefits for patients:

  • Disease Control: It helps slow down or halt the progression of leukaemia, allowing many patients to achieve and maintain remission.
  • Symptom Relief: By reducing the number of abnormal white blood cells, it helps relieve common leukaemia symptoms like severe fatigue, night sweats, and bone pain, allowing you to feel stronger and more active.
  • Oral Convenience: Because it is taken as a simple daily tablet, it allows you to manage your treatment at home without requiring frequent, lengthy hospital stays for intravenous therapies.
Side effects of Rytstat 25 mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.

Directions for Use

  • Rytstat 25 mg Tablet can be taken with or without food, as food does not affect its absorption or effectiveness.
  • It is usually taken once a day, or as prescribed by your doctor.
  • Swallow Rytstat 25 mg Tablet as a whole with water.
  • Do not crush, chew or break Rytstat 25 mg Tablet.

How Rytstat 25 mg Tablet Works

Rytstat 25 mg Tablet contains dasatinib, which belongs to a class of medications called tyrosine kinase inhibitors. In certain leukaemias, an abnormal gene creates a protein that signals white blood cells to grow out of control. This medication works by specifically binding to and blocking these abnormal proteins. By cutting off these growth signals, Rytstat 25 mg Tablet stops the leukaemia cells from multiplying and surviving, which helps your bone marrow regain its normal balance of healthy blood cells.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Rytstat 25 mg Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

When given to a pregnant woman, Rytstat 25 mg Tablet may cause fetal harm. There have been no sufficient and well-controlled investigations of Rytstat 25 mg Tablet in pregnant women. Women of reproductive potential should avoid becoming pregnant while undergoing treatment with this medicine.

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Breast Feeding

Unsafe

It is not known if Rytstat 25 mg Tablet passes into your breast milk. Inform your doctor if you are breastfeeding. You should not breastfeed while taking this medicine and for 2 weeks of the treatment with Rytstat 25 mg Tablet. Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Rytstat 25 mg Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Rytstat 25 mg Tablet or until you become alert.

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Liver

Caution

Use Rytstat 25 mg Tablet with caution if you have liver disease. Your doctor may monitor your liver function while taking this medicine. No dose adjustments are necessary in patients with liver impairment.

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Kidney

Caution

There are presently no clinical investigations with Rytstat 25 mg Tablet in patients with compromised renal function. If you have kidney problems, inform your doctor before taking this medicine.

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Children

Consult your doctor

Rytstat 25 mg Tablet is safe for use in children above one year of age if prescribed by the doctor.

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Heart

Caution

Rytstat 25 mg Tablet may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Rytstat 25 mg Tablet.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Rytstat 25 mg Tablet to geriatric patients. Your doctor will prescribe Rytstat 25 mg Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Rytstat 25 mg Tablet

If you accidentally take more than your prescribed dose, seek immediate medical attention. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking Rytstat 25 mg Tablet, as it can dangerously increase the levels of the medicine in your body.
  • Manage infection risk: Wash your hands frequently and avoid close contact with people who have active infections, as this medicine can temporarily lower your white blood cell count.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys flush out waste products as tumour cells break down.
  • Track your weight: Weigh yourself regularly and report any sudden, unexplained weight gain to your doctor, as this can be an early sign of fluid retention.
health query

Have a query?

How Soon It Starts Working

The time required for Rytstat 25 mg Tablet to start to work: Rytstat 25 mg Tablet ideally shows its action within few hours after administration. The time for which the effects of Rytstat 25 mg Tablet last: The effect of Rytstat 25 mg Tablet lasts for 24 hours.

What if you forget to take Rytstat 25 mg Tablet

If you miss a dose, skip the missed dose and take your next dose at your regularly scheduled time. Do not take a double dose to make up for the missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store Rytstat 25 mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Never crush or break Rytstat 25 mg Tablet tablets. If a tablet is broken, pregnant women must avoid handling it, as the active drug can be absorbed through the skin and harm an unborn baby.
  • Always carry a list of all your current medicines, vitamins, and herbal supplements, and show it to any doctor or dentist before receiving new treatments.
  • Check your body daily for any unusual bruising, red spots on your skin, or dark stools, and report these to your doctor immediately.
  • Make sure to attend all scheduled laboratory appointments so your doctor can check your blood counts and monitor your liver and heart health.

 

Drug-Drug Interactions

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Drug-Drug Interaction Summary:

  • Acid-reducers: Medicines like proton pump inhibitors (e.g., omeprazole) and H2 blockers can significantly lower the absorption of Rytstat 25 mg Tablet, making it less effective.
  • Blood thinners: Taking this medicine with anticoagulants (like warfarin) or antiplatelet drugs (like aspirin) can increase your risk of severe bleeding.
  • CYP3A4 inhibitors and inducers: Certain antibiotics, antifungals, and anti-seizure medicines can change how quickly your liver breaks down Rytstat 25 mg Tablet, causing levels to become dangerously high or too low.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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Drug-Food Interaction Summary:

  • Grapefruit: Consuming grapefruit or its juice can block the enzymes that break down Rytstat 25 mg Tablet, leading to a high buildup of the medicine in your blood and increasing the risk of serious side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Rytstat 25 mg Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Rytstat 25 mg Tablet contains Dasatinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.
Rytstat 25 mg Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.
Take antacids such as aluminium hydroxide/magnesium hydroxide, calcium carbonate, calcium carbonate, and magnesium 2 hours before or after taking Rytstat 25 mg Tablet as antacids may alter the absorption of this medicine.
Yes, you can take Rytstat 25 mg Tablet either with or without food. However, try to be consistent with how you take it each day to help keep drug levels steady in your body. Talk to your doctor if you have questions.
Contact your healthcare team immediately. A fever can be a sign of a serious infection, which requires prompt medical evaluation since this medicine can lower your white blood cell count. Talk to your doctor right away.
No, you must avoid grapefruit and grapefruit juice entirely while taking this medication. Grapefruit can dramatically increase the drug levels in your body, leading to severe side effects. Talk to your doctor if you have dietary concerns.
No, you must not crush, cut, or chew the tablets. They must be swallowed whole. If you have difficulty swallowing pills, talk to your doctor or pharmacist for alternative guidance.
Some patients may experience thinning of the hair or mild hair loss while taking Rytstat 25 mg Tablet, though it is usually temporary. If this concern is affecting your well-being, talk to your doctor or pharmacist for supportive care advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Therapeutic Class

[ANTINEOPLASTIC]

Habit Forming

No
Other Info - RYT0028
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