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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Ryzodeg 100IU/ml Penfill 3 ml is used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children. It contains Insulin Aspart and Insulin Degludec, which help lower blood sugar levels after food intake. It confirms rapid and stable sugar control by helping reuptake of sugar in fat cells and muscle and suppressing sugar production in the liver. It may cause side effects such as rash, injection site allergic reaction, weight gain, oedema (tissue swelling or fluid overload), lipodystrophy (skin thickening or pits at the injection site), hypoglycemia (low blood glucose level), and itching. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions. Along with this medicine, you should take a healthy diet, do regular exercise, and maintain healthy weight for effective results.

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Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Ryzodeg 100IU/ml Penfill 3 ml

Ryzodeg 100IU/ml Penfill 3 ml used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children. In Type 1 Diabetes Mellitus, the body does not produce enough insulin to regulate blood sugar levels. In type 2 diabetes mellitus, either the body stops producing enough insulin (a hormone that helps lower blood sugar levels) or there is resistance to the action of insulin. As a result, insulin is produced in large quantities, but it is unable to function properly on the body's organs.

Ryzodeg 100IU/ml Penfill 3 ml is a combination medicine that works by promoting the recovery of sugar in muscle and fat cells and suppressing sugar production in the liver. Together, Ryzodeg 100IU/ml Penfill 3 ml confirms rapid and stable sugar control.

Not everyone who is taking Ryzodeg 100IU/ml Penfill 3 ml will get these side effects. You may experience rash, injection site allergic reaction, weight gain, edema (tissue swelling or fluid overload), skin thickening at the injection site, low blood glucose levels, and itching. Most of these side effects of Ryzodeg 100IU/ml Penfill 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Ryzodeg 100IU/ml Penfill 3 ml should be taken before food or advised by your doctor. It should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks) only. Your doctor will explain how to inject the medicine by your own. However, if it is difficult to inject the medicine, ask a healthcare professional to administer it. Along with Ryzodeg 100IU/ml Penfill 3 ml, you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor. 

Inform your doctor if you are allergic to Ryzodeg 100IU/ml Penfill 3 ml. Do not take Ryzodeg 100IU/ml Penfill 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs. Try not to stop receiving Ryzodeg 100IU/ml Penfill 3 ml of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Ryzodeg 100IU/ml Penfill 3 ml is a cold chain medicine, and so it must be stored in the refrigerator between 2-8 degrees Celsius, or else its efficiency might get lost. Do not store in the freezer or the fridge.

Uses of Ryzodeg 100IU/ml Penfill 3 ml

Ryzodeg 100IU/ml Penfill 3 ml is used in the treatment of Diabetes (type 1 diabetes mellitus and type 2 diabetes mellitus). The detailed uses of Ryzodeg 100IU/ml Penfill 3 ml are as follows:
• Diabetes Management: Ryzodeg 100IU/ml Penfill 3 ml is primarily used to regulate blood glucose levels in individuals with diabetes mellitus, helping to keep them within a healthy range.
• Postprandial Blood Sugar Control: Ryzodeg 100IU/ml Penfill 3 ml effectively manages postprandial (after meal) blood sugar spikes through its combination of intermediate and short-acting insulin.
• Type 1 and Type 2 Diabetes Treatment: Ryzodeg 100IU/ml Penfill 3 ml is prescribed for patients with Type 1 and Type 2 diabetes who are unable to achieve adequate glycemic control with oral hypoglycemic agents alone.

Directions for Use

• Follow your doctor's instructions regarding the dosage and duration of treatment. • Ryzodeg 100IU/ml Penfill 3 ml should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks). • It should never be administered intravenously or in the vein. • If you are not well trained to self-administer it, ask a healthcare professional to administer it.

Medicinal Benefits

  • Ryzodeg 100IU/ml Penfill 3 ml is an antidiabetic medicine primarily used for the treatment of both type 1 and type 2 diabetes mellitus.
  • Ryzodeg 100IU/ml Penfill 3 ml works by ensuring rapid and consistent sugar control. It typically begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). Together, they confirm rapid and stable sugar control by facilitating the reuptake of sugar in fat and muscle cells and suppressing the production of sugar in the liver.
  • It prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells, thereby suppressing sugar production in the liver.
  • Ryzodeg 100IU/ml Penfill 3 ml helps improve glycaemic control, which in turn decreases the risk of complications of diabetes, such as damage to the retina (retinopathy), damage to the kidneys (nephropathy), impairment of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcers, and others.
  • Ryzodeg 100IU/ml Penfill 3 ml can also be safely prescribed to the diabetic mother during pregnancy and lactation.

How Ryzodeg 100IU/ml Penfill 3 ml Works

Ryzodeg 100IU/ml Penfill 3 ml is a combination of two drugs, namely, Insulin Aspart and Insulin Degludec. Insulin aspart helps lower blood sugar levels after food intake. Insulin degludec begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). Ryzodeg 100IU/ml Penfill 3 ml stimulates the recovery of sugar in muscle and fat cells and suppresses sugar production in the liver. Together, Ryzodeg 100IU/ml Penfill 3 ml confirms rapid and stable sugar control by helping reuptake of sugar in fat cells and muscle and suppressing the creation of sugar in the liver.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Ryzodeg 100IU/ml Penfill 3 ml

Do not take more than the prescribed dose of Ryzodeg 100IU/ml Penfill 3 ml as it may cause overdose resulting in hypoglycemia (low blood sugar). If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Inform your doctor if you are allergic to Ryzodeg 100IU/ml Penfill 3 ml. Do not take Ryzodeg 100IU/ml Penfill 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs. Try not to stop receiving Ryzodeg 100IU/ml Penfill 3 ml of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Ryzodeg 100IU/ml Penfill 3 ml may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death.

Ryzodeg 100IU/ml Penfill 3 ml is for subcutaneous (under the skin) use only. If you are switching to a different insulin brand or using a different method of injection, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first symptoms of hyperglycemia (high blood sugar levels) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and an acetone odour in the breath. You should closely monitor these symptoms.

It is advisable not to consume alcohol, as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. Ryzodeg 100IU/ml Penfill 3 ml is a cold chain medicine, and therefore it must be stored in the refrigerator at a temperature between 2-8 degrees Celsius, or else its efficiency may be compromised. Do not store in the freezer or the fridge.

Keep the medicine out of reach of children. Please do not inject more than the recommended dose of medicine, as it can cause undesirable effects. It is always important to check the expiry date of the medicine. Discard the medicine if it reaches the expiry date. Ryzodeg 100IU/ml Penfill 3 ml should not be administered intravenously (into the vein).

Drug-Drug Interactions

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Insulin aspartTrovafloxacin
Severe

Drug-Drug Interactions

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How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with norfloxacin affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia have been reported.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and norfloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremors, nausea, hunger, weakness, sweating, palpitation, rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin aspartTrovafloxacin
Severe
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with Trovafloxacin affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia have been reported.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and Trovafloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Severe
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with cinoxacin affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia(low blood glucose).

How to manage the interaction:
Although there is a interaction between Ryzodeg 100IU/ml Penfill 3 ml and Cinoxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, symptoms of hyperglycemia, which include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with carvedilol may increase the therapeutic efficacy of carvedilol.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and carvedilol but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience any unusual symptoms like shaking, palpitations, rapid heartbeat. Do not stop any medications without consulting a doctor.
Insulin aspartGrepafloxacin
Severe
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with Grepafloxacin affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia have been reported.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and grepafloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with Gatifloxacin affects blood glucose levels, hyperglycemia (high blood glucose) and, less frequently, hypoglycemia.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and gatifloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to a doctor.
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with nalidixic acid affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia have been reported.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and Nalidixic acid but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with Sparfloxacin affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia have been reported.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and Sparfloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with ciprofloxacin affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia(low blood glucose).

How to manage the interaction:
Although taking ciprofloxacin and Ryzodeg 100IU/ml Penfill 3 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor if you experience headaches, dizziness, sleepiness, anxiety, disorientation, tremors, nausea, hunger, weakness, increased sweat, and a rapid heartbeat, increased hunger, thirst, and urine. It is recommended to maintain blood glucose levels.
Insulin aspartLomefloxacin
Severe
How does the drug interact with Ryzodeg 100IU/ml Penfill 3 ml:
Taking Ryzodeg 100IU/ml Penfill 3 ml with Lomefloxacin affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia have been reported.

How to manage the interaction:
There could be a possible interaction between Ryzodeg 100IU/ml Penfill 3 ml and lomefloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercise may lower your body’s need for insulin during and for some time after the physical activity.
  • Exercise may also speed up the insulin dose effect, especially if the exercise involves the injection site area (for example, the leg should not be used for injection just before running).
  • Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise.
  • Avoid eating sugary food and prefer food cooked food low in calories.
  • When travelling across more than 2 time zones, you should talk to your doctor about your insulin schedule adjustments.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Ryzodeg 100IU/ml Penfill 3 ml Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Ryzodeg 100IU/ml Penfill 3 ml to avoid unpleasant side-effects. Alcohol may either decrease or increase the blood sugar level which can be fatal.

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Pregnancy

Safe if prescribed

Ryzodeg 100IU/ml Penfill 3 ml can be used during pregnancy. Your insulin dose may need to be changed during pregnancy and after delivery.

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Breast Feeding

Safe if prescribed

Ryzodeg 100IU/ml Penfill 3 ml can be given safely to nursing mothers but only under the supervision of a doctor.

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Driving

Unsafe

Drive with caution, Ryzodeg 100IU/ml Penfill 3 ml usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycemia (low blood sugar).

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Liver

Caution

Ryzodeg 100IU/ml Penfill 3 ml to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Ryzodeg 100IU/ml Penfill 3 ml to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

bannner image

Children

Consult your doctor

Ryzodeg 100IU/ml Penfill 3 ml can be given in children only if recommended by the physician.

Have a query?

FAQs

Ryzodeg 100IU/ml Penfill 3 ml is used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children.

Ryzodeg 100IU/ml Penfill 3 ml can be given to treat both the condition of type 1 and type 2 diabetes mellitus. However, your doctor will decide whether Ryzodeg 100IU/ml Penfill 3 ml can be given to you or not depending on your present condition. Ryzodeg 100IU/ml Penfill 3 ml should be avoided in patients who are allergic to Ryzodeg 100IU/ml Penfill 3 ml or other forms of insulin, patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycemia), and low potassium level (hypokalaemia).

Cold sweat, cool pale skin, headache; rapid heartbeat, feeling sick, feeling very hungry, temporary vision changes, drowsiness, unusual tiredness and weakness, nervousness or tremor, feeling anxious, feeling confused, difficulty in concentrating are some of the common signs of the low blood sugar level in an individual.

If you experience low blood sugar, eat glucose tablets or another high sugar snack (e.g. sweets, biscuits, fruit juice). Measure your blood sugar if possible and rest. Always carry glucose tablets or high sugar snacks with you. You should give a call to any of your family members if you are feeling dizziness or drowsiness. Consult a doctor immediately.

It is advised to tell all the medicines that you are using to your doctor like pioglitazone or rosiglitazone as taking other diabetes medicines may increase the risk of serious heart problems.

Local allergic reactions (pain, redness, hives, inflammation, bruising, swelling, and itching) at the injection site may occur. These usually disappear after a few weeks of taking your insulin. If they do not disappear, or if they spread throughout your body, talk to your doctor immediately.

Ryzodeg 100IU/ml Penfill 3 ml does not help in weight loss. It is used to control blood sugar levels in people with diabetes.

Ryzodeg 100IU/ml Penfill 3 ml may cause side effects such as rash, injection site allergic reaction, weight gain, oedema (tissue swelling or fluid overload), lipodystrophy (skin thickening or pits at the injection site), hypoglycaemia (low blood glucose level), and itching. Most of these side effects of Ryzodeg 100IU/ml Penfill 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Ryzodeg 100IU/ml Penfill 3 ml is not typically used for weight loss. In fact, insulin therapy can sometimes lead to weight gain due to increased insulin levels and improved glucose uptake in the body. If you have any concerns regarding weight loss, consult your doctor.

Ryzodeg 100IU/ml Penfill 3 ml is a combination of two insulins. One (Insulin Aspart) works quickly to lower blood sugar after meals, and the other (Insulin Degludec) works slowly to control blood sugar throughout the day. Together, they help your body use sugar properly and reduce sugar production in the liver. This leads to better blood sugar control.

Ryzodeg 100IU/ml Penfill 3 ml is used to treat adults with type 1 or type 2 diabetes, helping to control blood sugar levels in addition to diet and exercise. However, it should only be used under the guidance of a physician, who will assess your overall health, medical history, and age before prescribing it.

Use Ryzodeg 100IU/ml Penfill 3 ml precisely as prescribed. Inject it once daily, at the same time, with or without meals. Remember to rotate injection sites to avoid any skin issues. Also, monitor your blood sugar levels regularly and follow your doctor's instructions for best results.

No, do not mix Ryzodeg 100IU/ml Penfill 3 ml with any other insulins. Please consult your doctor if you have any concerns.

Store Ryzodeg 100IU/ml Penfill 3 ml between 36° to 46°F (2° and 8°C). Keep it away from the freezer and the refrigerator's cooling element. Never freeze it, and don't use it if it’s frozen. Also, keep it out of reach of children.

Ryzodeg 100IU/ml Penfill 3 ml is safe to use during pregnancy and breastfeeding if prescribed by the doctor.

If you take too much of Ryzodeg 100IU/ml Penfill 3 ml, it can cause a severe overdose and low blood sugar. Symptoms include confusion, dizziness, and shaking. If you think you've taken too much, get medical help immediately. Always follow the prescribed dosage to stay safe.

It is not known if Ryzodeg 100IU/ml Penfill 3 ml is safe and effective in children under 18 years of age. Please consult the doctor if you have any concerns.

It is essential to monitor your blood sugar levels while using Ryzodeg 100IU/ml Penfill 3 ml. Regular blood sugar monitoring helps you understand how your body responds to the medication, allows you to make informed decisions about your diet and activity, and helps your healthcare provider adjust your treatment plan if needed.

If you experience an allergic reaction to Ryzodeg 100IU/ml Penfill 3 ml, seek medical attention immediately. Symptoms of an allergic reaction may include hives, itching, swelling, difficulty breathing, and rapid heartbeat. Call emergency services or go to the nearest hospital if you experience severe symptoms. Inform your healthcare provider about the allergic reaction, as they may need to adjust your treatment plan.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - RYZ0004

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