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  3. Safeflam P Tablet

Safeflam P Tablet, Pack of 1
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Safeflam P Tablet is used to reduce pain and inflammation. It helps in relieving pain from conditions like headaches, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It contains Aceclofenac and Paracetamol, which work by blocking the chemical messengers responsible for causing pain, inflammation, and fever. In some cases, it may cause side effects like dizziness, nausea, digestion problems (constipation, flatulence, diarrhoea) and skin reactions (like rashes and hives). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ACECLOFENAC-100MG + PARACETAMOL-325MG

Manufacturer/Marketer :

Accilex Nutricorp

Consume Type :

ORAL

Return Policy :

Not Returnable

About Safeflam P Tablet

Safeflam P Tablet is used to reduce pain and inflammation. The pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Inflammation is a localized physical condition in which part of the body becomes reddened, swollen, hot and often painful.

Safeflam P Tablet is composed of aceclofenac and paracetamol. Aceclofenac and Paracetamol both work by blocking the chemical messengers responsible for causing pain, inflammation, and fever.

Safeflam P Tablet may cause side effects like dizziness, nausea, constipation, flatulence, diarrhoea, rashes and hives. Most of the side effects of Safeflam P Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Avoid taking Safeflam P Tablet if you are allergic to any of the ingredients present in it. Taking more than the daily prescribed dose of Safeflam P Tablet may cause liver damage or allergic reactions like swelling of the mouth, face, throat, difficulty in breathing, skin rash, itching, gastrointestinal bleeding and/or ulcer. 

Uses of Safeflam P Tablet

Safeflam P Tablet is used in the treatment of Pain, Inflammation, and fever. The detailed uses of Safeflam P Tablet are as follows:

  • Pain Relief: Safeflam P Tablet is used to relieve pain, by its analgesic effects, which block pain signals and reduce discomfort.
  • Inflammation: Safeflam P Tablet helps to reduce inflammation and swelling associated with conditions like arthritis, osteoarthritis, and rheumatoid arthritis.
  • Fever Reduction: Safeflam P Tablet is used to bring down elevated body temperature, providing relief from discomfort associated with fever.

Directions for Use

  • Safeflam P Tablet can be taken with or without food, preferably with a meal.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Safeflam P Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Safeflam P Tablet helps to reduce pain and inflammation caused by various complications or conditions.
  • It significantly works on providing relief from pain for extended hours.
  • It contains paracetamol, which is less irritant to the stomach than other painkillers. Hence, it is well tolerated by patients who have an allergy to aspirin or a risk of gastrointestinal bleeding or ulcer formation.
  • Besides this, it does not affect bleeding time and also helps in reducing fever due to pain or swelling.

How Safeflam P Tablet Works

Safeflam P Tablet is composed of two medicines: Aceclofenac (pain reducer) and Paracetamol (fever reducer). Safeflam P Tablet helps in relieving pain from conditions like headaches, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Aceclofenac and Paracetamol both work by blocking the chemical messengers responsible for causing pain, inflammation, and fever.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Safeflam P Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

What if I have taken an overdose of Safeflam P Tablet

Do not take more than the prescribed dose of Safeflam P Tablet as it may cause adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Safeflam P Tablet if you are allergic to it or its components.
  • Taking more than the daily prescribed dose of Safeflam P Tablet may cause liver damage or allergic reactions like swelling of the mouth, face, throat, difficulty in breathing, skin rash or itching.
  • Most of the cases of liver injury are associated with the use of paracetamol. 
  • Gastrointestinal bleeding and ulcer formation are commonly observed with the use of Safeflam P Tablet, so the doctor may prescribe you the lowest dose available.
  • Do not take Safeflam P Tablet if you have asthma or allergies to painkillers, heart, kidney and liver conditions.
  • Safeflam P Tablet should not be taken during pregnancy or by breastfeeding mothers as it may affect the baby.
  • The components of Safeflam P Tablet can cause stomach upset. Thus, it is recommended to consume Safeflam P Tablet with meals to minimize gastric side effects. If you have a diagnosis of peptic ulcer, Safeflam P Tablet is best avoided unless prescribed by your doctor.
  • Although Safeflam P Tablet provides symptomatic relief, it is strongly recommended to remain physically active as much as your condition allows.
  • Adopting a healthy lifestyle, coupled with a healthy diet containing high proteins, is the mainstay of the management of arthritic conditions.

Drug-Drug Interactions

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AceclofenacAtenolol
Severe
ParacetamolLeflunomide
Severe

Drug-Drug Interactions

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AceclofenacAtenolol
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Atenolol with Safeflam P Tablet could increase the risk of low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Safeflam P Tablet, you can take these medicines together if prescribed by a doctor. Consult a doctor if you experience excessive sweating, shortness of breath, palpitations, or chest discomfort. Do not discontinue any medications without consulting a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Safeflam P Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Safeflam P Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Lomitapide and Safeflam P Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Safeflam P Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolKetoconazole
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Safeflam P Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Safeflam P Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Safeflam P Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Safeflam P Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Safeflam P Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Safeflam P Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Mipomersen with Safeflam P Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Safeflam P Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolKetamine
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of ketamine and Safeflam P Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Safeflam P Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with Safeflam P Tablet:
Co-administration of Teriflunomide with Safeflam P Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Safeflam P Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulphate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
  • Do not go for heavy exercise as it may increase your joint pain and arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.
  • In chronic arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that have a minimum level of chemicals called cytokines, which ramp up inflammation.
  • Your sitting posture is important, especially when you have pain and inflammation conditions. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

Safeflam P Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Safeflam P Tablet as it contains paracetamol which can together damage your liver severely.

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Pregnancy

Consult your doctor

The safety of this medicine for use during pregnancy is not known. Hence, it is not recommended for use in pregnancy unless considered essential by your doctor.

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Breast Feeding

Consult your doctor

Safeflam P Tablet should not be used without consultation with your doctor if you are breast-feeding. It is not known if this medicine passes into breast milk. It is not recommended for use during breast-feeding unless considered essential by your doctor.

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Driving

Unsafe

Safeflam P Tablet usually causes dizziness, drowsiness and visual disturbances which may affect their ability to drive or operate machinery. Make sure you are not affected before driving or operating machinery.

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Liver

Caution

Safeflam P Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Safeflam P Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

bannner image

Children

Unsafe

The safety and efficacy of Safeflam P Tablet in children have not been established. Safeflam P Tablet is not recommended in children.

Have a query?

FAQs

Safeflam P Tablet is used to reduce pain and inflammation.

No, Safeflam P Tablet does not cure Rheumatoid arthritis but instead, it helps in reducing the pain and inflammation caused by it as it a pain killer.

Yes, Safeflam P Tablet is may cause nausea or vomiting in some people. In order to avoid the same, you should take Safeflam P Tablet with milk or food. In case you are still experiencing excessive nausea while consuming Safeflam P Tablet, speak with your doctor right away.

No, do not suddenly stop taking Safeflam P Tablet. If you want to stop taking this medicine, consult your doctor and he might gradually reduce the dose to avoid an unwanted increase in pain or inflammation.

No, Safeflam P Tablet should ideally not be taken for stomach pain without consulting a physician. This medication can increase the secretion of stomach acid, which may worsen gastritis or an unknown underlying stomach ulcer.

Patients with mild to moderate renal impairment should be kept under surveillance. The lowest effective dose should be used and renal function monitored regularly. Effects on renal function are usually reversible on withdrawal of Safeflam P Tablet.

Yes, let your doctor know if you are taking any other medicine for pain, arthritis or fever. If you experience dark stools, blood in vomit, or stomach pain, stop taking Safeflam P Tablet and consult your doctor immediately, as these could be signs of bleeding in your stomach or intestine. Take Safeflam P Tablet only for the duration as prescribed by your doctor. Do not take more than the prescribed dose, as it may cause an overdose.

Safeflam P Tablet already contains Paracetamol and Aceclofenac. So, avoid taking additional paracetamol. If your pain does not subside, consult your doctor so that they may increase the dose or add another medicine depending on your condition.

Yes, Safeflam P Tablet is a painkiller. It contains Aceclofenac and Paracetamol, which helps to relieve pain.

You are recommended to consult your doctor before taking Safeflam P Tablet with antibiotics to avoid drug interactions.

Safeflam P Tablet is safe if used as advised by the doctor. Follow your doctor’s instructions.

Yes, the use of Safeflam P Tablet can cause dizziness (feeling faint, lightheaded, unsteady, or weak) in some patients. If you feel dizzy or lightheaded, take rest for sometime and resume once you feel better.

Safeflam P Tablet is contraindicated in patients with known allergy to any of its ingredients or in patients or other painkillers (NSAIDs). Patients with a history of stomach ulcers or active, recurrent stomach ulcer/bleeding should ideally avoid taking Safeflam P Tablet. Additionally, patients with a history of high blood pressure, heart failure, and kidney or liver disease, should also avoid taking Safeflam P Tablet.

Yes, Safeflam P Tablet be taken with vitamin B-complex as it helps to treat vitamin deficiency that may be the cause of underlying pain. However, please consult your doctor before using Safeflam P Tablet with other medicines or supplements.

No, taking higher dose of Safeflam P Tablet than recommended may cause serious liver damage or allergic reactions such as swelling of the mouth, face and throat; itching; rash or difficulty in breathing. If the pain is not relieved or if you are experience increased severity of pain by the recommended doses, please consult your doctor.

Store Safeflam P Tablet at room temperature in a dry place. Protect from sunlight. Keep it out of reach of children.

Safeflam P Tablet may take about 1.5 to 3 hours after oral administration to show its effect. However, the time may vary with every individual patient to get the desired results.

The dosage of Safeflam P Tablet will be decided by your doctor. Follow doctor’s instructions. Do not take more than the recommended dose.

No, you are not recommended to take Safeflam P Tablet along with other painkiller tablets as it may cause unwanted side effects such as stomach ulcers or pain. Therefore, please consult your doctor before taking Safeflam P Tablet with other medicines.

Safeflam P Tablet is not recommended for children as the safety and efficacy have not been established.

Safeflam P Tablet contains Aceclofenac (pain reducer) and Paracetamol (fever reducer) which work by blocking the chemical messengers responsible for causing pain, inflammation, and fever.

Take Safeflam P Tablet as advised by your doctor. Swallow it as whole with a glass of water. Do not crush, chew or break it.

Safeflam P Tablet may cause side effects such as nausea, dizziness, diarrhoea, flatulence, or constipation. If these side effects persist or worsen, please consult your doctor.

You are preferably advised to take Safeflam P Tablet after meals, as food helps to prevent any potential gastric irritation the drug might cause when taken on an empty stomach. Follow doctor’s instructions.

If you forget to take a dose of Safeflam P Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

You are recommended to consult your doctor before taking other medicines with Safeflam P Tablet to avoid drug interactions.

Other Info - SA55732

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 18, 2025 | 1:05 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.4240.pdf
  2. https://www.medicines.org.uk/emc/files/pil.10548.pdf
  3. https://www.ciplamed.com/content/voltanec-pr-tablets
  4. https://www.medicineindia.org/pharmacology-for-generic/177/aceclofenac-paracetamol
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