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  3. Sayana Press 104mg/0.65ml Injection

Sayana Press 104mg/0.65ml Injection, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Sayana Press 104mg/0.65ml Injection is used in the treatment of amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding. It is also used for the Prevention of endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen. It contains medroxyprogesterone acetate (DMPA), which is similar to (but not the same as) the natural hormone progesterone produced in the ovaries during the second half of your menstrual cycle. During your menstrual cycle, it prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm.
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Synonym :

DEPOT MEDROXYPROGESTERONE ACETATE

Composition :

MEDROXYPROGESTERONE ACETATE-104MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Sayana Press 104mg/0.65ml Injection

Sayana Press 104mg/0.65ml Injection belongs to a group of medicines called progestogens used as a long-acting contraceptive. Contraception is a procedure that aims to prevent unwanted pregnancy for safe family planning.

Sayana Press 104mg/0.65ml Injection contains medroxyprogesterone acetate (DMPA), which is similar to (but not the same as) the natural hormone progesterone, which is produced in the ovaries during the second half of your menstrual cycle. During your menstrual cycle, Sayana Press 104mg/0.65ml Injection prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm and result in pregnancy.

Sayana Press 104mg/0.65ml Injection will be administered by your doctor or healthcare professional. In some cases, you may have nervousness, headache, stomach pain or discomfort, weight increase or decrease, libido decreased (reduced sex drive), dizziness, and feeling sick and depressed. Most of these side effects of Sayana Press 104mg/0.65ml Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Let your doctor know before prescribing Sayana Press 104mg/0.65ml Injection if you have, or had migraine headaches, diabetes, Severe pain or swelling in the calf, eye disorders, depression, liver or kidney disorders, osteoporosis, asthma, or epilepsy. And also inform your doctor if you are pregnant or expecting pregnancy or breastfeeding or taking if you are using certain medicines such as high-dose glucocorticoids (steroids).

Uses of Sayana Press 104mg/0.65ml Injection

i. Treatment of amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding.ii. Prevention of endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen

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Directions for Use

• The timing and frequency of Sayana Press 104mg/0.65ml Injection will be determined by your doctor, based on your medical condition and response to treatment.• This medication should only be administered by a qualified healthcare provider. Do not attempt self-administration of the injection.• Follow your healthcare provider's instructions about the medication and any steps to track your progress or precautions during treatment.

Medicinal Benefits

Sayana Press 104mg/0.65ml Injection contains medroxyprogesterone acetate (DMPA), which is close to (but not the same as) progesterone, a natural hormone secreted in the ovaries during the second half of your menstrual cycle. Sayana Press 104mg/0.65ml Injection prevents an egg from fully developing and being released from the ovaries during your menstrual cycle. An egg that is not released cannot be fertilised by sperm and result in pregnancy. On the other hand, it also induces changes in the lining of your womb, making conception less likely. It also thickens the mucus at the womb's opening, making sperm entry more difficult.

How Sayana Press 104mg/0.65ml Injection Works

Sayana Press 104mg/0.65ml Injection contains medroxyprogesterone acetate (DMPA), which is similar to (but not the same as) the natural hormone progesterone, which is produced in the ovaries during the second half of your menstrual cycle. During your menstrual cycle, Sayana Press 104mg/0.65ml Injection prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm and result in pregnancy.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Sayana Press 104mg/0.65ml Injection out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Sayana Press 104mg/0.65ml Injection

As Sayana Press 104mg/0.65ml Injection is a parenteral formulation, the chance of overdose may be less. However, keep track of your medicine as an overdose of Sayana Press 104mg/0.65ml Injection may cause serious side effects. Symptoms may include breathing problems, nausea, vomiting, and altered mental status. Seek immediate medical attention if you observe any of these side effects.

Drug Warnings

Sayana Press 104mg/0.65ml Injection should not be used if you are allergic to any of its components. Inform your doctor if you are allergic to any of the substances. Before taking Sayana Press 104mg/0.65ml Injection, inform your healthcare provider if you have or have had migraine headaches, vaginal bleeding, blood disorders (such as deep vein thrombosis), diabetes, severe pain or swelling in the calf, eye diseases, depression, liver (such as jaundice) or kidney disorders, osteoporosis, asthma, or epilepsy and hormone-dependent cancer of the breast or sex organs. Also, tell your doctor if you are pregnant, expecting a pregnancy, breastfeeding, or using certain medications, such as high-dose glucocorticoids (steroids).

Drug-Drug Interactions

verifiedApollotooltip
MedroxyprogesteroneAcitretin
Critical
MedroxyprogesteroneEtretinate
Critical

Drug-Drug Interactions

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MedroxyprogesteroneAcitretin
Critical
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Coadministration of Acitretin with Sayana Press 104mg/0.65ml Injection can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Sayana Press 104mg/0.65ml Injection together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneEtretinate
Critical
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Taking Sayana Press 104mg/0.65ml Injection and Etretinate may cause severe birth defects if the mother takes the medication during pregnancy.

How to manage the interaction:
Using etretinate and Sayana Press 104mg/0.65ml Injection together is not recommended, but can be taken if prescribed by a doctor. However, if you experience unusual symptoms contact your doctor. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneTranexamic acid
Critical
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Taking Sayana Press 104mg/0.65ml Injection acetate with Tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Sayana Press 104mg/0.65ml Injection with Tranexamic acid is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
MedroxyprogesteroneMycophenolic acid
Severe
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Coadministration of Sayana Press 104mg/0.65ml Injection with mycophenolic acid may decrease the levels and effects of Sayana Press 104mg/0.65ml Injection.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Sayana Press 104mg/0.65ml Injection, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
MedroxyprogesteroneGriseofulvin
Severe
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Taking griseofulvin with Sayana Press 104mg/0.65ml Injection may reduce blood levels and the effects of Sayana Press 104mg/0.65ml Injection.

How to manage the interaction:
There may be a possibility of interaction between Griseofulvin and Sayana Press 104mg/0.65ml Injection, but it can be taken if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, or if you think you might be pregnant while using birth control, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneBrigatinib
Severe
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Taking Sayana Press 104mg/0.65ml Injection and Brigatinib may, reduce the blood levels and effects of Sayana Press 104mg/0.65ml Injection.

How to manage the interaction:
Although taking Sayana Press 104mg/0.65ml Injection and brigatinib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.
MedroxyprogesteroneTopiramate
Severe
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
When Sayana Press 104mg/0.65ml Injection acetate is taken with Topiramate, it reduces the blood levels and effects of Sayana Press 104mg/0.65ml Injection.

How to manage the interaction:
Co-administration of Sayana Press 104mg/0.65ml Injection with Topiramate can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing symptoms like hot flashes, vaginal dryness, or abnormal bleeding, contact your doctor. Do not stop using any medications without talking to your doctor.
MedroxyprogesteroneBoceprevir
Severe
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Taking boceprevir and Sayana Press 104mg/0.65ml Injection may, decrease the blood levels and effects of Sayana Press 104mg/0.65ml Injection.

How to manage the interaction:
Although taking Sayana Press 104mg/0.65ml Injection and Boceprevir together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneBexarotene
Severe
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Taking Sayana Press 104mg/0.65ml Injection with bexarotene may decrease the effectiveness of Sayana Press 104mg/0.65ml Injection.

How to manage the interaction:
Although taking Sayana Press 104mg/0.65ml Injection and Bexarotene together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneFosamprenavir
Severe
How does the drug interact with Sayana Press 104mg/0.65ml Injection:
Taking Sayana Press 104mg/0.65ml Injection together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Although there is a possible interaction between Sayana Press 104mg/0.65ml Injection and Fosamprenavir, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Including heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
  • Do regular exercise to maintain weight fluctuations caused due to Sayana Press 104mg/0.65ml Injection.
  • Avoid chronic stress and exercise like running, as it might increase vaginal bleeding.
  • Try to be stress-free to improve your mood swings due to hormonal fluctuations. 
  • Monitor your blood pressure daily and if there is too much fluctuation, immediately contact your doctor.
  • Monitor your blood sugar level and blood pressure regularly to avoid any complications.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.

Habit Forming

No

Therapeutic Class

HORMONES
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Alcohol

Caution

It is not known whether it is safe to consume alcohol with Sayana Press 104mg/0.65ml Injection. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Unsafe

Sayana Press 104mg/0.65ml Injection must not be taken if you are pregnant as hormonal medicines can affect the developing baby.

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Breast Feeding

Safe if prescribed

Sayana Press 104mg/0.65ml Injection can be safely used by nursing mothers. Your doctor or healthcare professional may advise that you wait until at least 6 weeks after your baby has been born before you start using Sayana Press 104mg/0.65ml Injection for contraception.

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Driving

Caution

Sayana Press 104mg/0.65ml Injection usually does not impact your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving the Sayana Press 104mg/0.65ml Injection if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving the Sayana Press 104mg/0.65ml Injection if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Sayana Press 104mg/0.65ml Injection is not recommended for children below 12 years of age.

FAQs

Sayana Press 104mg/0.65ml Injection is used to treat amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding. Besides that, it can also use to prevent endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen.

Sayana Press 104mg/0.65ml Injection prevents an egg from fully developing and being released from the ovaries during your menstrual cycle. An egg that is not released cannot be fertilised by sperm and result in pregnancy. On the other hand, it also induces changes in the lining of your womb, making conception less likely. It also thickens the mucus at the womb's opening, making sperm entry more difficult.

It is recommended not to take any other contraceptives with Sayana Press 104mg/0.65ml Injection without a doctor's prescription.

Yes, the Sayana Press 104mg/0.65ml Injection may cause hair loss. If you feel that you are experiencing a lot of hall falls while taking Sayana Press 104mg/0.65ml Injection, please consult your doctor.

Do not use Sayana Press 104mg/0.65ml Injection if you are allergic to medroxyprogesterone acetate, or any other similar hormonal medicines, if you have/had breast cancer, a blood clotting disorder such as deep vein thrombosis (blood clot in the legs) or pulmonary embolism (blood clot in the lung), severe liver disease such as jaundice, unexplained vaginal bleeding or if you are pregnant or think you may be pregnant or If you have not yet started your periods.

Sayana Press 104mg/0.65ml Injection can be used for just one or two occasions in a few cases such as if your partner is having a vasectomy, Sayana Press 104mg/0.65ml Injection can be used to protect you until the vasectomy takes place, or if you are being immunised against rubella, to prevent conception during the virus's active phase, or if you are awaiting sterilisation.

Sayana Press 104mg/0.65ml Injection is not primarily used as a contraceptive, but Medroxyprogesterone injections are commonly used as contraception.

Weight gain is a possible side effect of Sayana Press 104mg/0.65ml Injection, but it can often be managed with diet and exercise. The weight gain can vary from person to person, and it's more likely to occur with higher doses. By maintaining a healthy lifestyle, you can minimize the impact of weight gain while taking Sayana Press 104mg/0.65ml Injection.

Sayana Press 104mg/0.65ml Injection is a generally safe and effective medication when used as directed. However, as with any medication, it may not be suitable for everyone and can cause side effects in some individuals. To ensure safe and effective use, following your healthcare provider's instructions is essential.

Withdrawal bleeding usually occurs within 3 to 7 days after you stop taking Sayana Press 104mg/0.65ml Injection. Consult your doctor if your condition does not improve or if it worsens.

Take Sayana Press 104mg/0.65ml Injection at the same time every day, with or without food as directed, and swallow it whole with water. Don't crush, break, or chew it.

If you miss to take a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not take a double dose.

The common side effects of Sayana Press 104mg/0.65ml Injection include headache, nausea, dizziness, hair loss, acne, and unusual vaginal bleeding or spotting. Most of these side effects of Sayana Press 104mg/0.65ml Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051
Other Info - SAY0022

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:23 AM IST

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Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/0e9c77a8-7b8a-4e83-8b7b-2d5ee2a0f7d7.pdf
  2. https://www.drugs.com/drug-interactions/medroxyprogesterone.html

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