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  3. Sildura 4 Capsule Combipack

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Sildura 4 Capsule Combipack, Pack of 1 CAPSULE
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Sildura 4 Capsule Combipack is used to treat the symptoms of an enlarged prostate gland (benign prostatic hyperplasia - BPH) in men. It contains Silodosin, which works by relaxing the muscles of the bladder and prostate gland. This helps in relieving the symptoms of benign prostatic hyperplasia and makes it easier to pass water, thereby increasing urine output and flow. In some cases, it may cause common side effects such as ejaculation disorders (orgasm with reduced or no sperm), dizziness, diarrhoea, stuffy nose (nasal congestion), and orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). Before taking this medicine, you should tell your doctor if you are allergic to any of its components and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SILODOSIN-4MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Sildura 4 Capsule Combipack

Sildura 4 Capsule Combipack is used to treat the symptoms of an enlarged prostate gland (benign prostatic hyperplasia - BPH) in men. Benign prostatic hyperplasia (BPH) is a condition in which there is an enlargement of the prostate gland due to the multiplication of the cells, mostly in men above 50 years of age.

Sildura 4 Capsule Combipack contains ‘Silodosin’ that works by blocking the receptors (alpha 1) located in the prostate, bladder and urethra (urine pipe), thereby relaxing the muscles of the bladder and prostate gland. 

Sildura 4 Capsule Combipack may cause side effects such as dizziness, diarrhoea, stuffy nose, and sudden lowering in blood pressure. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You are advised to take Sildura 4 Capsule Combipack for as long as your doctor has prescribed it for you, depending on your medical condition. Take this medication by mouth with or as directed by your doctor. Your physician will decide the dose of the medicine based on the severity of your condition.

Avoid taking Sildura 4 Capsule Combipack if you are allergic to it. Inform your doctor if you have low blood pressure or liver or kidney disease. Sildura 4 Capsule Combipack is intended for use in men only; women should not take Sildura 4 Capsule Combipack, especially pregnant or breastfeeding women. Sildura 4 Capsule Combipack should not be given to children as safety and efficacy have not been established. Sildura 4 Capsule Combipack may cause dizziness, so drive with caution. Avoid alcohol consumption along with Sildura 4 Capsule Combipack as it could lead to increased dizziness.

Uses of Sildura 4 Capsule Combipack

Sildura 4 Capsule Combipack is used in the treatment of Benign Prostatic Hyperplasia (BPH) in men. The detailed uses of Sildura 4 Capsule Combipack are as follows:

  • Treatment of Benign Prostatic Hyperplasia (BPH): Sildura 4 Capsule Combipack helps reduce prostate size by blocking the production of hormones responsible for its growth, and also improves urinary flow, reducing symptoms such as difficulty urinating, frequent urges, and a weak urine stream.
  • Relaxation of Bladder and Prostate Muscles: Sildura 4 Capsule Combipack works by relaxing the muscles in the bladder and prostate, making urination easier and helping relieve urinary discomfort associated with an enlarged prostate.
  • Prevention of Urinary Blockage: Sildura 4 Capsule Combipack reduces the risk of complete urinary obstruction, which can occur if BPH is left untreated and helps maintain normal urinary function over time.

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Directions for Use

  • Take Sildura 4 Capsule Combipack with food or as advised by your doctor.
  • It is advised to take Sildura 4 Capsule Combipack once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Sildura 4 Capsule Combipack as a whole with a glass of water.
  • Do not crush, chew or break it.

Medicinal Benefits

  • Sildura 4 Capsule Combipack belongs to the group of medicines called alpha-blockers used to treat enlarged prostate (benign prostatic hyperplasia).
  • Sildura 4 Capsule Combipack helps alleviate the symptoms of benign prostatic hyperplasia, making it easier to pass urine and thereby increasing urine output and flow. 

How Sildura 4 Capsule Combipack Works

Sildura 4 Capsule Combipack contains ‘Silodosin’ that works by blocking the receptors (alpha 1) located in the prostate, bladder and urethra (urine pipe), thereby relaxing the muscles of the bladder and prostate gland. This helps in relieving the symptoms of benign prostatic hyperplasia and makes it easier to pass water, thereby increasing urine output and flow.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Sildura 4 Capsule Combipack
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.

What if I have taken an overdose of Sildura 4 Capsule Combipack

Do not take more than the prescribed dose of Sildura 4 Capsule Combipack as it may cause overdose. The symptoms of overdose include fainting, dizziness, blurred vision or lightheadedness. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Sildura 4 Capsule Combipack if you are allergic to it, any alpha 1 blockers or any of the components in Sildura 4 Capsule Combipack.
  • Inform your doctor if you have low blood pressure, liver or kidney disease.
  • It is advised to talk to your doctor before taking Sildura 4 Capsule Combipack if you are undergoing eye surgery (cataract surgery) as cases of intraoperative floppy iris syndrome (IFIS) have been found.
  • Sildura 4 Capsule Combipack is intended for use in men only; women should not take Sildura 4 Capsule Combipack, especially pregnant women or breastfeeding mothers.
  • Sildura 4 Capsule Combipack should not be given to children as safety and efficacy have not been established.
  • Sildura 4 Capsule Combipack may cause dizziness, so avoid or limit alcohol consumption and driving, as it could lead to increased dizziness.
  • It is always important to check the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

verifiedApollotooltip
SilodosinFosamprenavir
Critical
SilodosinSaquinavir
Critical

Drug-Drug Interactions

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SilodosinFosamprenavir
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Co-administration of Fosamprenavir and Sildura 4 Capsule Combipack together can increase the effect of Sildura 4 Capsule Combipack which may lead to side effects including extremely low blood pressure, increased heart rate.

How to manage the interaction:
Taking Fosamprenavir with Sildura 4 Capsule Combipack together i not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
SilodosinSaquinavir
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Coadministration of Saquinavir and Sildura 4 Capsule Combipack may increase the effects of Sildura 4 Capsule Combipack which may lead to side effects including extremely low blood pressure and increased heart rate.

How to manage the interaction:
Taking Saquinavir with Sildura 4 Capsule Combipack together is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However consult the doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, priapism (prolonged and painful erection unrelated to sexual activity) may also increase, nasal congestion, heart palpitation. Do not discontinue any medications without consulting a doctor.
SilodosinClarithromycin
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Taking Sildura 4 Capsule Combipack with Clarithromycin may significantly increase the blood levels and effects of Sildura 4 Capsule Combipack, this may cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position.

How to manage the interaction:
Co-administration of Clarithromycin and Sildura 4 Capsule Combipack is not recommended as it can lead to an interaction, but it can be taken if advised by a doctor. However, consult a doctor immediately if you experience any symptoms like dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not stop using any medications without a doctor's advice.
SilodosinNefazodone
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Co-administration of Nefazodone and Sildura 4 Capsule Combipack together can increase the effect of Sildura 4 Capsule Combipack which may lead to side effects including extremely low blood pressure, increased heart rate.

How to manage the interaction:
Taking Nefazodone with Sildura 4 Capsule Combipack together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
SilodosinItraconazole
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Coadministration of Itraconazole with Sildura 4 Capsule Combipack can increase the blood levels and effects of Sildura 4 Capsule Combipack, which may lead to side effects including extremely low blood pressure and increased heart rate.

How to manage the interaction:
Taking Itraconazole with Sildura 4 Capsule Combipack together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
SilodosinAtazanavir
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Co-administration of Atazanavir and Sildura 4 Capsule Combipack together can increase the effectiveness of Sildura 4 Capsule Combipack which may lead to side effects including extremely low blood pressure, increased heart rate.

How to manage the interaction:
Taking Atazanavir and Sildura 4 Capsule Combipack together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
SilodosinCeritinib
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Co-administration of Ceritinib and Sildura 4 Capsule Combipack together can increase the effect of Sildura 4 Capsule Combipack and increase the risk for side effects.

How to manage the interaction:
Taking Sildura 4 Capsule Combipack and Ceritinib together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
SilodosinPosaconazole
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Coadministration of Sildura 4 Capsule Combipack and posaconazole may significantly increase the blood levels and effects of Sildura 4 Capsule Combipack.

How to manage the interaction:
Although there is an interaction between Posaconazole and Sildura 4 Capsule Combipack, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, nasal congestion, and headache. Do not discontinue any medications without consulting a doctor.
SilodosinNelfinavir
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Coadministration of Nelfinavir and Sildura 4 Capsule Combipack can increase the effect of Sildura 4 Capsule Combipack which may lead to side effects including extremely low blood pressure, increased heart rate.

How to manage the interaction:
Taking Nelfinavir and Sildura 4 Capsule Combipack together is not recommended but it can be taken if prescribed by a doctor. If you notice any of these signs - like dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitation-call a doctor right away. Do not stop using any medications without a doctor's advice.
SilodosinBoceprevir
Critical
How does the drug interact with Sildura 4 Capsule Combipack:
Co-administration of Boceprevir and Sildura 4 Capsule Combipack together can increase the effect of Sildura 4 Capsule Combipack which may lead to side effects including extremely low blood pressure, increased heart rate.

How to manage the interaction:
Taking Boceprevir and Sildura 4 Capsule Combipack together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Urinate as soon as you feel the urge.
  • Avoid excess caffeine and alcohol consumption.
  • Maintain a healthy diet and exercise regularly.
  • Practice kegel exercises to strengthen pelvic muscles.
  • Reduce stress levels by doing yoga or meditation. Nervousness can increase the frequency of urination.

Habit Forming

No

Therapeutic Class

BPH AGENTS

Sildura 4 Capsule Combipack Substitute

Substitutes safety advice
bannner image

Alcohol

Unsafe

You are recommended to avoid or limit alcohol consumption while taking Sildura 4 Capsule Combipack as it may cause increased dizziness.

bannner image

Pregnancy

Not applicable

Sildura 4 Capsule Combipack is intended for use in men only; women should not take Sildura 4 Capsule Combipack, especially pregnant women.

bannner image

Breast Feeding

Not applicable

Sildura 4 Capsule Combipack is intended for use in men only; women should not take Sildura 4 Capsule Combipack, especially breastfeeding women.

bannner image

Driving

Unsafe

Sildura 4 Capsule Combipack may cause dizziness. Do not drive or operate heavy machinery if you experience dizziness.

bannner image

Liver

Consult your doctor

Sildura 4 Capsule Combipack should not be used if you have severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Consult your doctor

Dose adjustment may be necessary. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Sildura 4 Capsule Combipack should not be given to children as the safety and efficacy have not been established.

FAQs

Sildura 4 Capsule Combipack is used to treat the symptoms of an enlarged prostate gland (benign prostatic hyperplasia - BPH) in men.

Sildura 4 Capsule Combipack works by blocking the receptors (alpha 1) on the prostate gland, bladder and urethra (urine pipe), thereby relaxing the muscles of the bladder and prostate. This helps in relieving the symptoms of benign prostatic hyperplasia and makes it easier to pass urine.

Sildura 4 Capsule Combipack may cause dizziness and drowsiness in rare cases. So, drive only if you are alert and avoid driving and operating machinery if you feel dizzy or drowsy.

Sildura 4 Capsule Combipack may affect fertility as it causes ejaculation disorders such as retrograde ejaculation (orgasm with less or no semen) and anejaculation (inability to ejaculate semen). However, this is a temporary effect as is reversible on discontinuation of Sildura 4 Capsule Combipack. Talk to your doctor if you have any concerns.

Diarrhoea might be a side-effect of Sildura 4 Capsule Combipack. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience excess diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Orthostatic hypotension could be a side-effect of Sildura 4 Capsule Combipack. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Sildura 4 Capsule Combipack are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.

Do not take Sildura 4 Capsule Combipack after expiry. Expiry refers to the last date the manufacturer guarantees the potency (strength) of the medicine. Check the expiry date regularly and dispose of the medicine properly post expiry date.

Sildura 4 Capsule Combipack causes ejaculation disorders which could result in decreased erectile function. Talk to the doctor if you have any concerns.

No, Sildura 4 Capsule Combipack does not cause high blood pressure. In some cases, it might cause low blood pressure leading to dizziness on standing up suddenly.

Let your doctor know if you have had cataract surgery or are due to undergo cataract surgery, as Sildura 4 Capsule Combipack may affect the pupil of the eye during cataract surgery. In some cases, intraoperative floppy iris syndrome (IFIS, loss of muscle tone in the iris) has been found.

Sildura 4 Capsule Combipack should be taken as prescribed by the doctor. Take Sildura 4 Capsule Combipack with a meal at around the same time daily.

It is advised to take Sildura 4 Capsule Combipack for as long as your doctor has prescribed it for you, depending on your medical condition.

Sildura 4 Capsule Combipack may cause hypotension (low blood pressure), especially during the initial doses. Regularly monitor blood pressure and be cautious while driving or operating machinery.

Sildura 4 Capsule Combipack contains Silodosin, which belongs to the group of medicines called alpha-blockers used to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia).

Consult the doctor before taking sildenafil with Sildura 4 Capsule Combipack as combining these two medicines can lower the blood pressure and increase the risk of lightheadedness, dizziness, fainting, headache, flushing and nasal congestion.

Side effects of Sildura 4 Capsule Combipack include ejaculation disorders (orgasm with reduced or no sperm), dizziness, diarrhoea, stuffy nose (nasal congestion), and orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). Talk to your doctor if any of the side effects persist or worsen.

Country of origin

INDIA

Manufacturer/Marketer address

463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA
Other Info - SIL0282

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 11:23 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/43c4ae37-d929-4bb5-b0eb-84a7405b8d2c.pdf
  2. https://medlineplus.gov/druginfo/meds/a609002.html
  3. https://www.drugs.com/cdi/silodosin.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022206s012lbl.pdf

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