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  3. Silodal M 25 Combikit 1's

Silodal M 25 Combikit 1's, Pack of 1 Tablet
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Silodal M 25 Combikit is used for the treatment of Benign prostatic hyperplasia (BPH), a condition in men that causes the enlargement of the prostate gland. It contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

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Composition :

MIRABEGRON-25MG + SILODOSIN-8MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Silodal M 25 Combikit

Silodal M 25 Combikit is used for the treatment of Benign prostatic hyperplasia (BPH), a condition in men that causes the enlargement of the prostate gland. It is complicated by an overactive bladder and symptoms of urge urinary incontinence (involuntary leakage of urine), urgency, and frequency.

Silodal M 25 Combikit contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

Take Silodal M 25 Combikit as prescribed. Your doctor will advise you on how often you should take it based on your medical condition. Silodal M 25 Combikit may cause common side effects such as abnormal ejaculation, increased heart rate, dizziness, nausea, constipation, urinary tract infections, and runny or blocked nose. Most of these side effects of Silodal M 25 Combikit do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Mirabegron, Silodosin, or any other medicines, please tell your doctor. Silodal M 25 Combikit is not recommended for children and adolescents under 18 years of age. Drive only if you are alert after taking Silodal M 25 Combikit, as it may cause dizziness. If you are about to undergo cataract eye surgery, inform your eye specialist that you are taking Silodal M 25 Combikit, as it may cause complications during the surgery.

Uses of Silodal M 25 Combikit

Silodal M 25 Combikit is used in the treatment of Benign prostatic hyperplasia (BPH). The detailed uses of Silodal M 25 Combikit are as follows:<br/>• Management of benign prostatic hyperplasia (BPH): Silodal M 25 Combikit is primarily used to manage benign prostatic hyperplasia (BPH) with symptoms of overactive bladder (OAB).<br/>• Relieve symptoms: Silodal M 25 Combikit help relieve bothersome urinary symptoms like frequent urination, urgency, weak stream, and incomplete bladder emptying.<br/>

Directions for Use

• Silodal M 25 Combikit can be taken with or without food, as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow the whole Silodal M 25 Combikit with a glass of water.• Do not chew, crush, or break it.

Medicinal Benefits

Silodal M 25 Combikit contains Mirabegron and Silodosin. Mirabegron is a bladder muscle relaxant which works by reducing the activity of an overactive bladder and treats related symptoms such as frequent urination, urgency incontinence (an uncontrollable urge to urinate) and sudden need to empty the bladder. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms such as incomplete bladder emptying, frequent urination at night and difficulty urinating. Thus, together, they help treat benign prostatic hyperplasia (BPH) symptoms.

How Silodal M 25 Combikit Works

Silodal M 25 Combikit contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

Storage

• Store in a cool and dry place away from sunlight.• Keep Silodal M 25 Combikit out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Silodal M 25 Combikit
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Silodal M 25 Combikit

Do not take more than the prescribed dose. Using more medication will not improve symptoms; instead, they may cause serious adverse effects such as Increased pulse rate, systolic blood pressure, and hypotension. If you suspect that you or anyone else who may have overdosed of Silodal M 25 Combikit, please go to the emergency department of the closest hospital.

Drug Warnings

If you are allergic to Mirabegron, Silodosin or any other medicines, please tell your doctor. Silodal M 25 Combikit is not recommended for children and adolescents below 18 years of age. Drive only if you are alert after taking Silodal M 25 Combikit as it may cause dizziness. If you are about to undergo cataract eye surgery, inform your eye specialist that you are taking Silodal M 25 Combikit as it may cause complications during the surgery. Inform your doctor if you take other medicines for overactive bladder treatment. If you get headaches, especially sudden, migraine-like (throbbing) headaches, tell your doctor, as these may be signs of severe high blood pressure.

Drug-Drug Interactions

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MirabegronEliglustat
Critical
SolifenacinPotassium chloride
Critical

Drug-Drug Interactions

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MirabegronEliglustat
Critical
How does the drug interact with Silodal M 25 Combikit:
Coadministration of Eliglustat and Silodal M 25 Combikit can significantly increase the blood levels of eliglustat. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Silodal M 25 Combikit with Eliglustat is not recommended, it should be taken only when advised by a doctor. You should seek immediate medical help if you develop symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, irregular heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without a doctor's advice.
SolifenacinPotassium chloride
Critical
How does the drug interact with Silodal M 25 Combikit:
Taking Silodal M 25 Combikit and Potassium chloride together can increase the risk of stomach ulcers, bleeding, and stomach injury.

How to manage the interaction:
Taking Silodal M 25 Combikit with Potassium chloride is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
SolifenacinItraconazole
Critical
How does the drug interact with Silodal M 25 Combikit:
The blood levels and effects of Silodal M 25 Combikit may be greatly increased when combined with itraconazole.

How to manage the interaction:
Silodal M 25 Combikit and Itraconazole may interact, however, if recommended by a physician, they are safe to consume. Consult a doctor if you feel sleepy, or uneasy, have an irregular heartbeat, have blurry vision, have trouble urinating, have a dry mouth, a headache, have digestive problems, or have constipation. Without consulting a doctor, never stop taking any medication.
SolifenacinMesoridazine
Critical
How does the drug interact with Silodal M 25 Combikit:
Using Mesoridazine together with Silodal M 25 Combikit can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Silodal M 25 Combikit is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations call a doctor.
MirabegronBrexpiprazole
Severe
How does the drug interact with Silodal M 25 Combikit:
A combined use of Silodal M 25 Combikit and Brexpiprazole may increase the level of Brexpiprazole in blood. This can increase the risk or severity of side effects.

How to manage the interaction:
There could be a possible interaction between Silodal M 25 Combikit and Brexpipraole, it can be taken together if your doctor has advised them. However, if you experience drowsiness, fatigue, seizure, chest pain or tightness, irregular heart rates, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramp, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronAripiprazole
Severe
How does the drug interact with Silodal M 25 Combikit:
Combining Aripiprazole with Silodal M 25 Combikit can increase the levels of Aripiprazole in the body. This can lead to increased risk or severity of side effects.

How to manage the interaction:
Although taking Silodal M 25 Combikit and Aripiprazole together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs like feeling sleepy, having seizures, unusual muscle movements, low blood pressure, feeling confused, muscle spasms, twitching in your jaw, shaking or jerking in your arms and legs, feeling nervous or restless, dizziness, lightheaded, or fainting contact the doctor right away. Do not stop using any medications without a doctor's advice.
MirabegronTamoxifen
Severe
How does the drug interact with Silodal M 25 Combikit:
Coadministration of Silodal M 25 Combikit and Tamoxifen may reduce the effects of tamoxifen.

How to manage the interaction:
Taking Silodal M 25 Combikit and Tamoxifen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience painful urination, constipation, dry mouth, headache, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronVenetoclax
Severe
How does the drug interact with Silodal M 25 Combikit:
Coadministration of Silodal M 25 Combikit and Venetoclax may significantly increase the blood levels and effects of Venetoclax. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possible interaction between Silodal M 25 Combikit and Venetoclax, but they can be taken together if your doctor has prescribed them. However, if you experience nausea, vomiting, diarrhea, fatigue, fever, chills, bleeding problems, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronThioridazine
Severe
How does the drug interact with Silodal M 25 Combikit:
Combine use of Silodal M 25 Combikit and thioridazine may raise the blood levels of thioridazine. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Silodal M 25 Combikit and thioridazine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience stomach pain, diarrhea, dehydration, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronPimozide
Severe
How does the drug interact with Silodal M 25 Combikit:
Combined use of Silodal M 25 Combikit and Pimozide may increase the level of pimozide in the blood. This can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Silodal M 25 Combikit and Pimozide may lead to an interaction but they can be taken together if your doctor has prescribed them. However, if you experience drowsiness, blurred vision, dry mouth, constipation, low blood pressure, tremors, trembling of hands, arms, legs, jaw and face, balance and Speech difficulty, or abnormal muscle movements consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid caffeine and alcohol, especially in the hours after dinner.
  • Urinate as soon as you feel the urge.
  • Go to the washroom even when you don’t feel the urge.
  • Reduce your stress levels, as nervousness may increase urination frequency.
  • Keep yourself warm since being cold may worsen symptoms.
     

Habit Forming

No

Therapeutic Class

BPH AGENTS

Silodal M 25 Combikit Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of Silodal M 25 Combikit with alcohol is unknown. If you have any concerns, discuss them with your doctor.

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Pregnancy

Not applicable

Silodal M 25 Combikit is recommended for use in men.

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Breast Feeding

Not applicable

Silodal M 25 Combikit is recommended for use in men.

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Driving

Caution

Silodal M 25 Combikit may cause dizziness in some people. Therefore, avoid driving if you feel dizzy after taking Silodal M 25 Combikit.

bannner image

Liver

Consult your doctor

If you are suffering from liver diseases or conditions, inform your doctor before taking Silodal M 25 Combikit. Your doctor may adjust the dose as necessary.

bannner image

Kidney

Consult your doctor

If you are suffering from kidney diseases or conditions, inform your doctor before taking Silodal M 25 Combikit. Your doctor may adjust the dose as necessary.

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Children

Unsafe

Silodal M 25 Combikit is not recommended for children and adolescents below 18 years as there is no relevant use for this age group.

Have a query?

FAQs

Silodal M 25 Combikit is used for the treatment of Benign prostatic hyperplasia (BPH) complicated by overactive bladder with symptoms of urge urinary incontinence (involuntary leakage of urine), urgency, and frequency.

Silodal M 25 Combikit contains Mirabegron and Silodosin. Mirabegron reduces the activity of an overactive bladder and treats related symptoms. Silodosin relaxes the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

Low blood pressure, especially when starting to take Silodal M 25 Combikit, may cause dizziness when standing up suddenly from a sitting or lying position. Therefore, to avoid such effects, it is advised to stand up slowly from a sitting or lying position. Regular blood pressure monitoring is recommended at the beginning of therapy to reduce the possibility of such effects.

The best time to take Silodal M 25 Combikit may vary based on the health condition of an individual. However, take Silodal M 25 Combikit at the same time each day for best results as advised by the doctor.

Consult the doctor before taking Silodal M 25 Combikit if you have any history of kidney disease as dose adjustment may be necessary.

The side effects of Silodal M 25 Combikit include constipation, nausea, dizziness, increased heart rate, abnormal ejaculation, urinary tract infections, and runny or blocked nose. Most of these side effects resolve gradually over time on their own. However, consult the doctor if any of these side effects persist or worsen.

Silodal M 25 Combikit is primarily intended to treat symptoms of Benign Prostatic Hyperplasia (BPH). While it may have a secondary effect on blood pressure, it is not intended to manage blood pressure. Please check with your doctor for information or to discuss your blood pressure treatment plan.

Do not stop taking Silodal M 25 Combikit without consulting your doctor, even if you feel better. Stopping Silodal M 25 Combikit abruptly may cause symptoms of Benign Prostatic Hyperplasia (BPH) to recur or worsen. Therefore, always follow your doctor’s instructions to treat your medical condition effectively.

You should take sildenafil along with Silodal M 25 Combikit with caution, as both medications can cause low blood pressure (hypotension), leading to fainting, dizziness, or light-headedness. It’s important to consult your doctor before using them together to avoid potential interactions.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - SIL0764

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:08 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.msnlabs.com/img/RxList/MFLL0042-00.pdf

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