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compositionComposition:BASILIXIMAB-20MG
prescriptionPrescription Medicine
Simulect 20 mg Injection 1's

Simulect 20 mg Injection 1's is used to prevent rejection of a kidney transplant. It contains Basiliximab, which decreases the production of white blood cells in the body that normally attack foreign invaders and defends the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in transplant patients. Simulect 20 mg Injection 1's may cause common side effects such as diarrhoea, constipation, nausea, weight gain, headache, high blood pressure, pain, and swelling of hands, ankles or feet.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BASILIXIMAB-20MG

Manufacturer/Marketer :

NOVARTIS HEALTHCARE PVT LTD

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

Simulect 20 mg Injection 1's belongs to a class of drugs called immunosuppressants used to prevent rejection of a kidney transplant. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Simulect 20 mg Injection 1's contains Basiliximab, which decreases the production of white blood cells in the body that normally attack foreign invaders and defends the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in transplant patients. Simulect 20 mg Injection 1's is used with other medicines, such as ciclosporin (immunosuppressant) and corticosteroids.

Simulect 20 mg Injection 1's will be administered by a healthcare professional. Do not self-administer. Simulect 20 mg Injection 1's may cause certain common side effects such as diarrhoea, constipation, nausea, weight gain, headache, high blood pressure, pain, and swelling of hands, ankles or feet. Most of these side effects of Simulect 20 mg Injection 1's do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor. 

If you are allergic to Basiliximab, or any other ingredients, tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to inform your doctor before receiving Simulect 20 mg Injection 1's. Women are advised to use effective contraceptive measures before starting treatment with Simulect 20 mg Injection 1's, during treatment and for 16 weeks after stopping treatment with Simulect 20 mg Injection 1's. Simulect 20 mg Injection 1's may increase the risk of infections or cancer as it lowers the body’s immune defence system.

Uses of Simulect 20 mg Injection 1's

Simulect 20 mg Injection 1's is used in prevention of kidney transplant rejection. The detailed uses of Simulect 20 mg Injection 1's are as follows:

  • Prevention of acute organ rejection: Simulect 20 mg Injection 1's is used in the prevention of acute organ rejection in patients undergoing renal (kidney) transplantation.
  • Enhance immunosuppression: Simulect 20 mg Injection 1's is used in combination to enhance immunosuppression.

Key Benefits

Simulect 20 mg Injection 1's contains Basiliximab, an immunosuppressant used to prevent organ rejection after a kidney transplant. Simulect 20 mg Injection 1's is combined with other medications, such as corticosteroids and immunosuppressants. It inhibits the body's production of white blood cells, which normally attack foreign invaders and protect the body from foreign cells and infection. As a result, it prevents organ rejection in transplanted patients and aids the body's acceptance of the new organ.

Side effects of Simulect 20mg 1vial
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.

Directions for Use

  • Typically, it is given in two doses: one 2 hours before transplant surgery and the second 4 days after; however, your doctor will determine the dosage and duration based on your condition.
  • Simulect 20 mg Injection 1's will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.
Simulect 20 mg Injection 1's contains Basiliximab, which decreases the production of white blood cells in the body that normally attack foreign invaders and defends the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in transplant patients. Simulect 20 mg Injection 1's is used with other medicines, such as ciclosporin (immunosuppressant) and corticosteroids.
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Alcohol

Consult your doctor

The interaction of alcohol with Simulect 20 mg Injection 1's is unknown. If you have any concerns regarding this, please discuss with your doctor.

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Pregnancy

Consult your doctor

Simulect 20 mg Injection 1's should be used in pregnant women only when the potential benefit outweighs the potential risk to the fetus. You are recommended to use effective contraception before beginning treatment with Simulect 20 mg Injection 1's, during therapy, and for 4 months after completion of therapy.

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Breast Feeding

Consult your doctor

It is unknown whether Basiliximab is excreted in human milk. Based on the importance of drug to the mother, a decision should be made whether to discontinue nursing or to discontinue Simulect 20 mg Injection 1's.

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Driving

Safe

Simulect 20 mg Injection 1's does not affect the ability to drive or operate machinery.

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Liver

Caution

If you have any concerns regarding the use of Simulect 20 mg Injection 1's in patients with liver problems, discuss with your doctor.

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Kidney

Safe if prescribed

Simulect 20 mg Injection 1's may be safe to use in patients with kidney problems if prescribed by a doctor.

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Children

Safe if prescribed

Simulect 20 mg Injection 1's may be safe for children if prescribed by a doctor.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems before using Simulect 20 mg Injection 1's. Your doctor will prescribe Simulect 20 mg Injection 1's if the benefits outweigh the risk.

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Geriatrics

Safe if prescribed

Simulect 20 mg Injection 1's is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

As Simulect 20 mg Injection 1's is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Diet & Lifestyle Advise

  • Make sure you eat fruits and vegetables every day.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Eat dark chocolate that contains at least 70% cocoa.

Have a query?

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Keep Refrigerated. Do not freeze.

Drug Warnings

If you are allergic to Basiliximab, or any other ingredients, tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to inform your doctor before receiving Simulect 20 mg Injection 1's. Women are advised to use effective contraceptive measures before starting treatment with Simulect 20 mg Injection 1's, during treatment and for 4 months after stopping treatment with Simulect 20 mg Injection 1's. Do not take any vaccinations without discussing with your doctor. Simulect 20 mg Injection 1's may increase the risk of infections or cancer as it lowers the body’s immune defence system. Inform your doctor if you have ever had a transplant that failed after only a short period or if you have ever been in the operating room for a transplant that was not performed in the end.

Drug-Drug Interactions

verifiedApollotooltip
BasiliximabBaricitinib
Severe
BasiliximabInfliximab
Severe

Drug-Drug Interactions

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BasiliximabBaricitinib
Severe
How does the drug interact with Simulect 20mg 1vial:
Combining baricitinib and Simulect 20mg 1vial can raise your risk of developing certain types of cancer as well as serious, sometimes harmful infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Simulect 20mg 1vial if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BasiliximabInfliximab
Severe
How does the drug interact with Simulect 20mg 1vial:
Combining Infliximab with Simulect 20mg 1vial can increase the risk or severity of developing infections.

How to manage the interaction:
Taking Simulect 20mg 1vial with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, contact a doctor right away. Do not stop using any medications without talking to a doctor.
BasiliximabEtanercept
Severe
How does the drug interact with Simulect 20mg 1vial:
When Etanercept is used with Simulect 20mg 1vial, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Simulect 20mg 1vial can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
BasiliximabTofacitinib
Severe
How does the drug interact with Simulect 20mg 1vial:
Simulect 20mg 1vial can enhance the immune-suppressing effects of Tofacitinib which increases risk of infections.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Simulect 20mg 1vial, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
BasiliximabLeflunomide
Severe
How does the drug interact with Simulect 20mg 1vial:
Combining Simulect 20mg 1vial with Leflunomide can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Simulect 20mg 1vial with Leflunomide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination, contact your doctor right away. Do not discontinue any medications without consulting your doctor.
BasiliximabCladribine
Severe
How does the drug interact with Simulect 20mg 1vial:
Combining Simulect 20mg 1vial with Cladribine can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Simulect 20mg 1vial with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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No
[IMMUNOSUPPRESSANTS]

FAQs

Simulect 20 mg Injection 1's is used to prevent rejection of a kidney transplant.

Simulect 20 mg Injection 1's contains Basiliximab, which works by inhibiting the body's production of white blood cells, which normally attack foreign invaders and protect the body from foreign cells and infection. As a result, it prevents organ rejection in transplanted patients and aids the body's acceptance of the new organ.

Simulect 20 mg Injection 1's may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as sore throat or fever.

If you are about to receive any vaccinations, especially live vaccines, inform your doctor that you are on treatment with Simulect 20 mg Injection 1's because it may decrease the effect of the vaccine and increase the risk of infection.

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Veda MaddalaDoctor badge

Written By

  • Veda Maddala

    M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

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