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  3. Solpar 25mg/325mg Tablet

Solpar 25mg/325mg Tablet, Pack of 1 Tablet
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Solpar 25mg/325mg Tablet is used to treat mild to moderate pain, including headache, backache, migraine, rheumatic and muscle pain, toothache and period pain. It also relieves discomfort associated with colds, influenza, and sore throats, and helps reduce fever. It contains Paracetamol (acetaminophen) and Caffeine, which inhibit the release of these enzymes and reduce pain. It may cause common side effects such as agitation, nervousness, and insomnia. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Synonym :

ACETAMINOPHEN+CAFFEINE

Composition :

CAFFEINE-25MG + PARACETAMOL-325MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Solpar 25mg/325mg Tablet

Solpar 25mg/325mg Tablet is used to treat mild to moderate pain, including headache, backache, migraine, rheumatic and muscle pain, toothache and period pain. Pain is caused by the activation of pain receptors due to the release of certain chemicals or enzymes.

Solpar 25mg/325mg Tablet contains paracetamol and caffeine. Paracetamol inhibits the release of these enzymes and alleviates pain. Caffeine increases the efficacy of paracetamol by improving its absorption, thereby prolonging analgesic action.

The common side effects of Solpar 25mg/325mg Tablet include agitation, nervousness, and insomnia. Everyone does not need to experience the above side effects, as they vary for each person depending on their health, underlying conditions, age, weight, and gender. In case of any discomfort, speak with a doctor.

Do not take Solpar 25mg/325mg Tablet if you're allergic to any ingredient in it. Solpar 25mg/325mg Tablet is not recommended for use during pregnancy or breastfeeding. Ask your healthcare professional for advice if you have any concerns. Do not use Solpar 25mg/325mg Tablet in more than the prescribed doses or for a longer duration, as it may cause adverse effects.

Uses of Solpar 25mg/325mg Tablet

Solpar 25mg/325mg Tablet is used in the treatment of Pain relief. The detailed uses of Solpar 25mg/325mg Tablet are as follows:

  • Mild to Moderate Pain Relief: Solpar 25mg/325mg Tablet relieves headache, backache, migraine, rheumatic and muscle pain, toothache, and period pain, providing effective pain management for various conditions.
  • Fever Reduction: Solpar 25mg/325mg Tablet helps reduce high temperature associated with various conditions accompanied by pain.

Directions for Use

  • Take Solpar 25mg/325mg Tablet with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Solpar 25mg/325mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Solpar 25mg/325mg Tablet is a combination medication containing paracetamol (acetaminophen) and caffeine.
  • Solpar 25mg/325mg Tablet effectively treats mild to moderate pain, including headache, backache, migraine, rheumatic and muscle pain, toothache and period pain.
  • On the other hand, it also relieves discomfort associated with colds, influenza, and sore throats, and helps reduce fever.
  • Paracetamol inhibits the release of these enzymes and alleviates pain. It also has an antipyretic effect, reducing body temperature in cases of fever.
  • Caffeine increases the efficacy of paracetamol by improving its absorption, thereby prolonging analgesic action.

How Solpar 25mg/325mg Tablet Works

Solpar 25mg/325mg Tablet contains paracetamol (acetaminophen) and caffeine. Paracetamol inhibits the release of these enzymes and alleviates pain. Caffeine increases the efficacy of paracetamol by improving its absorption, thereby prolonging analgesic action. Paracetamol also has an antipyretic effect and can reduce body temperature in cases of fever.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Solpar 25mg/325mg Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Identify the medicine causing acidosis and talk to your doctor whether it can be discontinued or substituted with other medicine.
  • If you experience symptoms of acidosis like rapid breathing, confusion, overtiredness or nausea, contact your doctor immediately.
  • Your doctor may recommend dietary changes like changes in potassium intake based on the type of acidosis.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

What if I have taken an overdose of Solpar 25mg/325mg Tablet

Do not take more than the prescribed dose of Solpar 25mg/325mg Tablet as it may cause overdose and increase the risk of irreversible liver damage. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Consult your doctor immediately if you have any allergic reactions such as skin rash, swelling of the face/lips/tongue/throat, wheezing, or shortness of breath.
  • Do not take it if you have any known allergy to paracetamol (acetaminophen) or caffeine.
  • People with kidney, liver, alcohol dependence, heart disease, or persistent headaches should avoid taking Solpar 25mg/325mg Tablet unless instructed by the doctor.
  • Inform your doctor if you are taking any other prescribed or over-the-counter medications before taking this medicine.
  • Do not increase your dose or duration of the medicine without consulting the doctor.

Drug-Drug Interactions

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CaffeineLinezolid
Critical
CaffeineIsocarboxazid
Critical

Drug-Drug Interactions

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CaffeineLinezolid
Critical
How does the drug interact with Solpar 25mg/325mg Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Solpar 25mg/325mg Tablet with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Solpar 25mg/325mg Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Solpar 25mg/325mg Tablet with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Solpar 25mg/325mg Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Solpar 25mg/325mg Tablet with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineTranylcypromine
Critical
How does the drug interact with Solpar 25mg/325mg Tablet:
Coadministration of tranylcypromine with Solpar 25mg/325mg Tablet can in cause severe high blood pressure.

How to manage the interaction:
Taking Solpar 25mg/325mg Tablet with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with Solpar 25mg/325mg Tablet:
Co-administration of Teriflunomide with Solpar 25mg/325mg Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Solpar 25mg/325mg Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Solpar 25mg/325mg Tablet:
Co-administration of Solpar 25mg/325mg Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Solpar 25mg/325mg Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Solpar 25mg/325mg Tablet:
Co-administration of Lomitapide and Solpar 25mg/325mg Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Solpar 25mg/325mg Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolKetamine
Severe
How does the drug interact with Solpar 25mg/325mg Tablet:
Co-administration of ketamine and Solpar 25mg/325mg Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Solpar 25mg/325mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolLeflunomide
Severe
How does the drug interact with Solpar 25mg/325mg Tablet:
Co-administration of Solpar 25mg/325mg Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Solpar 25mg/325mg Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Solpar 25mg/325mg Tablet:
Co-administration of Mipomersen with Solpar 25mg/325mg Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Solpar 25mg/325mg Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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CAFFEINE-25MG+PARACETAMOL-325MGFruit juices
Mild

Drug-Food Interactions

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CAFFEINE-25MG+PARACETAMOL-325MGFruit juices
Mild
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consumption of grape juice increases the effect of caffeine. Avoid taking grape juice with caffeine, as it causes an interaction. If you experience any symptoms, consult the doctor immediately.

Diet & Lifestyle Advise

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids such as soy, berries, broccoli, grapes and green tea help in reducing inflammation.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Practice relaxation techniques that help to calm down the mind and reduce pain levels.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

Solpar 25mg/325mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Solpar 25mg/325mg Tablet is unsafe with alcohol as it may cause gastrointestinal side effects such as abdominal pain and vomiting.

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Pregnancy

Consult your doctor

Paracetamol presnet in Solpar 25mg/325mg Tablet is a Category B pregnancy medicine, but caffeine use is limited during pregnancy. So, it should be used during pregnancy only if the doctor has prescribed it.

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Breast Feeding

Consult your doctor

Solpar 25mg/325mg Tablet should not be used in nursing mothers unless clearly necessary. So, inform your doctor if you are a nursing mother.

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Driving

Safe if prescribed

Solpar 25mg/325mg Tablet may not affect your ability to drive or operate machinery.

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Liver

Caution

Solpar 25mg/325mg Tablet is to be taken with caution, especially if you have a history of liver diseases such as alcoholic liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Solpar 25mg/325mg Tablet is to be taken with caution, especially if you have a history of kidney diseases. You may require dose adjustments based on your health condition.

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Children

Consult your doctor

The dose of Solpar 25mg/325mg Tablet needs to be adjusted, and its use should be recommended by a child specialist only.

Have a query?

FAQs

Solpar 25mg/325mg Tablet belongs to the class of analgesic medication. It is primarily used to treat mild to moderate pain, including headache, backache, migraine, rheumatic and muscle pain, toothache and period pain.

Solpar 25mg/325mg Tablet contains paracetamol (acetaminophen) and caffeine. Paracetamol inhibits the release of these enzymes and alleviates pain. Caffeine increases the efficacy of paracetamol by improving its absorption, thereby prolonging analgesic action. Paracetamol also has an antipyretic effect and can reduce body temperature in cases of fever.

The dose of Solpar 25mg/325mg Tablet depends on your condition and severity. Consult a doctor to know the exact dose and duration.

Take the missed dose as soon as you remember, if the next dose is not due within a few hours. Do not double the next dose. Take your next doses at the fixed time.

If there is an overdose, you may experience signs of liver damage such as nausea, vomiting, loss of appetite, rash, or dark urine. Consult a doctor immediately if you have any discomfort.

Solpar 25mg/325mg Tablet is recommended to use not more than 2 to 3 days per week. Prolonged use may lead to medicine-overuse (rebound) headaches.

Country of origin

India
Other Info - SO63557

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Sep 8, 2025 | 9:10 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.7416.pdf
  2. https://www.drugs.com/cdi/acetaminophen-and-caffeine.html
  3. https://india-consumer.gsk.com/media/861691/crocin-pain-relief.pdf
  4. https://www.medicines.org.uk/emc/files/pil.7416.pdf
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