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  3. Spexib 150 mg Capsule 10's

Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Spexib Capsule is used to treat non-small cell lung cancer. It contains Ceritinib, which works by slowing or stopping the spread of cancer cells. Common side effects of this medication include diarrhoea, nausea, vomiting, abdominal pain, fatigue, decreased appetite, and weight loss. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Composition :

CERITINIB-150MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Spexib Capsule

Spexib Capsule is used to treat a type of lung cancer called non-small cell lung cancer that is ALK-positive. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues.

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Sometimes, Spexib Capsule may cause side effects, such as diarrhoea, nausea, abdominal pain, vomiting, fatigue, decreased appetite, and weight loss. You are advised to talk to your doctor if you persistently experience any of these side effects.

Do not take Spexib Capsule if you are allergic to any of its components. Contact your doctor immediately if you or your partner becomes pregnant while you are on treatment with Spexib Capsule. Spexib Capsule is not recommended during pregnancy and breastfeeding.

Uses of Spexib Capsule

Spexib Capsule is used in the treatment of Non-small cell lung cancer (NSCLC). The detailed uses of Spexib Capsule are as follows:

  • Non-small cell lung cancer (NSCLC): Spexib Capsule is used for the treatment of ALK-positive (anaplastic lymphoma kinase-positive) metastatic NSCLC. It is especially used in patients who have either not responded to or cannot tolerate previous treatments like crizotinib.
  • Targeted cancer therapy: Spexib Capsule works by inhibiting the ALK protein, which plays a role in the growth and spread of cancer cells. By blocking this protein, it helps slow or stop tumour progression.

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Directions for Use

  • Spexib Capsule should be taken with meals to reduce stomach upset and improve absorption.
  • It is usually taken once a day; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow the capsule as a whole with a glass of water.
  • Do not crush, chew or break Spexib Capsule.

Medicinal Benefits

  • Spexib Capsule is used to treat ALK-Positive Non-Small Cell Lung Cancer (NSCLC). It is specifically designed to treat NSCLC caused by an abnormal ALK gene, which is a known driver of cancer cell growth.
  • It is used when the cancer has spread to other parts of the body, helping to slow down or stop tumour growth.
  • Spexib Capsule works by blocking ALK proteins in cancer cells, which are responsible for promoting cell division and tumour progression.
  • It helps delay the progression of lung cancer.

How Spexib Capsule Works

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Spexib Capsule out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Spexib 150 mg Capsule
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.

What if I have taken an overdose of Spexib Capsule

Using more medication will not improve your symptoms; instead, it may cause poisoning or serious side effects. If you suspect that you may have overdosed on Spexib Capsule or observe any side effects, please seek immediate medical attention.

Drug Warnings

  • Do not take Spexib Capsule if you are allergic to any of its components.
  • Inform your doctor if you have liver problems, diabetes, heart problems (long QT syndrome), pancreas inflammation, are pregnant or breastfeeding.
  • Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication.
  • Effective birth control is required throughout treatment and at least six months after treatment for women and at least three months after treatment for males.
  • You should not breastfeed while taking this medication for two weeks after your last dose.
  • Inform your doctor about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

Drug-Drug Interactions

verifiedApollotooltip
CeritinibSilodosin
Critical
CeritinibMidazolam
Critical

Drug-Drug Interactions

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CeritinibSilodosin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Co-administration of Spexib 150 mg Capsule and Silodosin together can increase the effect of Silodosin and increase the risk for side effects.

How to manage the interaction:
Taking Silodosin and Spexib 150 mg Capsule together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
CeritinibMidazolam
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule and midazolam may significantly increase the blood levels and effects of midazolam.

How to manage the interaction:
Although taking Spexib 150 mg Capsule and midazolam together may result in an interaction, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
CeritinibCisapride
Critical
How does the drug interact with Spexib 150 mg Capsule:
Coadministration of Spexib 150 mg Capsule with cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Spexib 150 mg Capsule with cisapride is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CeritinibZiprasidone
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Ziprasidone is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CeritinibVenetoclax
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Venetoclax may increase the risk of side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Venetoclax is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like nausea; vomiting; diarrhea; weakness; and pain while urinating, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CeritinibIvabradine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Coadministration of ivabradine with Spexib 150 mg Capsule can increase the levels and effects of ivabradine.

How to manage the interaction:
Taking Ivabradine with Spexib 150 mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CeritinibIsavuconazole
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with isavuconazole may significantly increase the blood levels of isavuconazole.

How to manage the interaction:
Taking Isavuconazole with Spexib 150 mg Capsule is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CeritinibPimozide
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Pimozide may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pimozide with Spexib 150 mg Capsule is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CeritinibAlprazolam
Critical
How does the drug interact with Spexib 150 mg Capsule:
Co-administration of Alprazolam with Spexib 150 mg Capsule may considerably increase the blood levels and effects of Alprazolam.

How to manage the interaction:
Although there is a interaction between Alprazolam and Spexib 150 mg Capsule, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
CeritinibLomitapide
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking lomitapide with Spexib 150 mg Capsule may significantly increase the blood levels of lomitapide.

How to manage the interaction:
Although there is a interaction between Spexib 150 mg Capsule with lomitapide, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Spexib Capsule.

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Pregnancy

Unsafe

Spexib Capsule should not be used during pregnancy as it may cause embryo-fetal toxicity. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking this medication.

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Breast Feeding

Unsafe

You should not breastfeed during the treatment with Spexib Capsule and for two weeks after your last dose of this medication.

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Driving

Caution

Spexib Capsule may cause tiredness and weakness (fatigue), impacting the ability to drive or use machines.

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Liver

Caution

Spexib Capsule may cause liver problems. Please consult your doctor if you have liver problems before starting Spexib Capsule.

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Kidney

Consult your doctor

It is not known how Spexib Capsule affects when used in kidney-impaired patients. Please consult your doctor if you have kidney problems.

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Children

Unsafe

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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Heart

If you have a history of heart disease, please inform the doctor before receiving Spexib Capsule.

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Geriatrics

Caution

Spexib Capsule can be used in the elderly when prescribed by a doctor. If you have any concerns about using Spexib Capsule, please consult a doctor.

FAQs

Spexib Capsule is used to treat a type of lung cancer called non-small cell lung cancer.

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

While taking Spexib Capsule, visit your doctor at all the appointments to ensure treatment works. Regular monitoring of blood and lipid tests and weight checks is required. An effective method of contraception should be used by both men and women while taking Spexib Capsule.

Elevations of lipase and/or amylase and pancreatitis can occur during treatment. Your doctor monitors lipase and amylase prior to treatment and periodically thereafter, as clinically indicated. If clinically insignificant values are observed, your doctor either withholds them or reduces the Spexib Capsule.

In some cases, Spexib Capsule can cause bradycardia. Monitoring heart rate and blood pressure regularly is recommended. If this condition persists, consult your doctor immediately.

Spexib Capsule can cause hyperglycemia. Your doctor monitors fasting glucose prior to treatment and periodically after that. Your doctor may prescribe anti-hyperglycemic medications, reduce the dose, or permanently discontinue Spexib Capsule if required.

Spexib Capsule is an anti-cancer agent (kinase inhibitor) indicated for the treatment of metastatic non-small cell lung cancer (NSCLC).

ALK-positive lung cancer is a specific type of non-small cell lung cancer (NSCLC) that has a mutation in the ALK (Anaplastic lymphoma kinase) gene, resulting in uncontrolled cell replication-cancer.

Spexib Capsule should be swallowed as a whole with water.

Lab tests will help you know the body’s response to Spexib Capsule. Keep taking Spexib Capsule for the duration advised by the doctor for effective results.

Spexib Capsule may cause serious side effects like stomach and gastrointestinal problems, liver injury, pneumonitis (lung inflammation), and abnormal heartbeats. Consult the doctor if you experience any unusual symptoms.

Spexib Capsule may cause liver problems such as liver injury. The doctor will advise regular blood tests to check for liver health during the treatment. Consult the doctor if you experience symptoms such as tiredness, itchy skin, nausea, vomiting, yellowing of eyes, decreased appetite, dark or brown urine, bleeding or bruising easily than usual, and pain on the right side of the stomach.

Spexib Capsule may cause severe or life-threatening lung inflammation (pneumonitis). Seek medical attention if you experience chest pain, fever, cough with or without mucous, shortness of breath or trouble breathing.

Eat non-spicy food and drink enough fluids if you have diarrhoea. You can take anti-diarrhoeal medicines if advised by the doctor.

Spexib Capsule may cause vision problems. Do not drive, operate machinery or do any work that requires alertness until you know how the medicine affects you. Consult the doctor if you notice any vision problems.

Spexib Capsule might cause itchy skin or rash. Use moisturiser and wear loose cotton clothes if you experience this. Consult the doctor if you notice yellow skin as this could be a sign of liver problems.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SPE0179

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:50 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.novartis.com/us-en/sites/novartis_us/files/zykadia.pdf
  2. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/ceritinib
  3. https://medlineplus.gov/druginfo/meds/a614027.html
  4. https://reference.medscape.com/drug/zykadia-ceritinib-999936
  5. https://chemocare.com/druginfo/ceritinib
  6. https://www.macmillan.org.uk/cancer-information-and-support/lung-cancer/non-small-cell-lung-cancer
  7. https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7397
  8. https://www.drugs.com/drug-interactions/ceritinib.html

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