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  3. Spexib 150 mg Capsule 10's

Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Spexib Capsule is used to manage or treat a type of lung cancer called non-small cell lung cancer. It contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply, which helps slow or stop the spread of cancer cells. Common side effects of this medication include diarrhoea, feeling or being sick, abdominal pain, vomiting, fatigue (feeling overtired), decreased appetite, and weight loss.

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Composition :

CERITINIB-150MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Spexib Capsule

Spexib Capsule is used to manage or treat a type of lung cancer called non-small cell lung cancer that is ALK-positive, and you have already had treatment with a drug. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Take Spexib Capsule as prescribed. Follow your doctor's instructions to get the maximum benefit. Sometimes, you may experience certain common side effects, such as diarrhoea, feeling or being sick, abdominal pain, vomiting, fatigue (feeling overtired), decreased appetite, and weight loss. You are advised to talk to your doctor if you persistently experience any of these side effects.

Before taking the Spexib Capsule, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Spexib Capsule can cause fetal harm when in pregnancy. Contact your doctor immediately if you or your partner becomes pregnant while you are on treatment. Breastfeeding is not recommended during the treatment. Do not consume alcohol during treatment with this medicine. The safety and effectiveness of Spexib Capsule in children have not been established.

Uses of Spexib Capsule

Spexib Capsule is used in the treatment of Non-small cell lung cancer (NSCLC). The detailed uses of Spexib Capsule are as follows:<br/>• Non-small cell lung cancer (NSCLC): Spexib Capsule is used for the treatment of ALK-positive (anaplastic lymphoma kinase-positive) metastatic NSCLC. It is especially used in patients who have either not responded to or cannot tolerate previous treatments like crizotinib.<br/>• Targeted cancer therapy: Spexib Capsule works by inhibiting the ALK protein, which plays a role in the growth and spread of cancer cells. By blocking this protein, it helps slow or stop tumor progression.<br/>

Directions for Use

• Spexib Capsule should be taken with meals to reduce stomach upset and improve absorption.• It is usually taken once a day; however, follow your doctor's advice regarding the dosage and duration.• Swallow the capsule as a whole with a glass of water.• Do not crush, chew or break Spexib Capsule.

Medicinal Benefits

Spexib Capsule contains Ceritinib, which belongs to a class of protein kinase inhibitors primarily used to manage or treat Non-small cell lung cancer (NSCLC) that is ALK-positive, and you have already had treatment with a drug. Ceritinib blocks proteins in cancer cells that encourage the cancer to grow. In some cases, if you have advanced NSCLC and have not received any other treatments, you may be prescribed Ceritinib.  If you haven't had any prior therapies, you may have Ceritinib.

How Spexib Capsule Works

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Spexib Capsule out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Spexib 150 mg Capsule
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.

What if I have taken an overdose of Spexib Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause poisoning or serious side effects. If you suspect that you may have overdosed of Spexib Capsule or observe any side effects, please go to the emergency department of the closest hospital or nursing home.

Drug Warnings

Before taking the Spexib Capsule, let your doctor know about all your medical conditions (especially liver disease, heart problems, QT interval prolongation, hyperglycemia, bradycardia, stomach problems and/or pancreatitis), sensitivities or allergic conditions, and all medications you are using. Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. Effective birth control is required throughout treatment and at least six months after treatment for women and at least three months after treatment for males. You should not breastfeed while taking this medication for two weeks after your last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements.

Drug-Drug Interactions

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CeritinibHalofantrine
Critical
CeritinibPhenytoin
Critical

Drug-Drug Interactions

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CeritinibHalofantrine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Halofantrine can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Halofantrine is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
CeritinibPhenytoin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with phenytoin may significantly reduce the blood levels and effectiveness of Spexib 150 mg Capsule.

How to manage the interaction:
Taking Phenytoin with Spexib 150 mg Capsule is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
CeritinibIvabradine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Coadministration of ivabradine with Spexib 150 mg Capsule can increase the levels and effects of ivabradine.

How to manage the interaction:
Taking Ivabradine with Spexib 150 mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CeritinibSilodosin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Co-administration of Spexib 150 mg Capsule and Silodosin together can increase the effect of Silodosin and increase the risk for side effects.

How to manage the interaction:
Taking Silodosin and Spexib 150 mg Capsule together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
CeritinibRanolazine
Critical
How does the drug interact with Spexib 150 mg Capsule:
When Spexib 150 mg Capsule is taken with Ranolazine, may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Taking Ranolazine with Spexib 150 mg Capsule together can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any side effects like lightheadedness, fainting, dizziness, or fast or pounding heartbeats, consult a doctor. Do not discontinue any medications without consulting a doctor.
CeritinibSaquinavir
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Saquinavir may increase the risk of irregular heart rhythm and side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Saquinavir is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CeritinibMesoridazine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with mesoridazine can increase the risk of irregular heart rhythms.

How to manage the interaction:
Although there is a interaction between Spexib 150 mg Capsule with mesoridazine it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CeritinibErgotamine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking ergotamine with Spexib 150 mg Capsule can significantly increase the blood levels and effects of ergotamine.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Ergotamine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and trouble speaking. Do not discontinue any medications without consulting a doctor.
CeritinibSimvastatin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Combining Spexib 150 mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Spexib 150 mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
CeritinibConivaptan
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking conivaptan with Spexib 150 mg Capsule can significantly increase the blood levels and effects of conivaptan.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Conivaptan is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience difficulty swallowing, speaking, muscle weakness, controlling body movements, confusion, mood changes, and seizures(fits). Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Spexib Capsule.

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Pregnancy

Unsafe

Spexib Capsule should not be used during pregnancy as it may cause embryo-fetal toxicity. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

You should not breastfeed during the treatment with Spexib Capsule and for two weeks after your last dose of this medication.

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Driving

Caution

Spexib Capsule may cause tiredness and weakness (fatigue), impacting the ability to drive or use machines.

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Liver

Caution

Spexib Capsule might harm the liver. During the treatment, your doctor may perform blood tests at least once a month to monitor your liver. Notify your physician straight away if you experience any of the following symptoms: Fatigue, skin itchiness, yellowing of the skin or the whites of your eyes, nausea, vomiting, decreased appetite, right-side stomach pain, dark or brown (tea-coloured) urine, and an increased propensity to bleed or bruise.

bannner image

Kidney

Consult your doctor

It is not known how Spexib Capsule affects when used in kidney-impaired patients. Please consult your doctor if you have kidney problems or a disease history.

bannner image

Children

Unsafe

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

Have a query?

FAQs

Spexib Capsule is used to treat a type of lung cancer called non-small cell lung cancer.

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

While taking Spexib Capsule, visit your doctor at all the appointments to ensure treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Spexib Capsule.

Elevations of lipase and/or amylase and pancreatitis can occur during treatment. Your doctor monitors lipase and amylase prior to treatment and periodically thereafter, as clinically indicated. If clinically insignificant values are observed, your doctor either withholds them or reduces the Spexib Capsule.

In some cases, Spexib Capsule can cause bradycardia. Monitoring heart rate and blood pressure regularly is recommended. If this condition persists, Withhold the dose or permanently discontinue Spexib Capsule and consult the doctor immediately.

Spexib Capsule can cause hyperglycemia. Your doctor monitors fasting glucose prior to treatment and periodically after that. Your doctor may prescribe anti-hyperglycemic medications, reduce the dose, or permanently discontinue Spexib Capsule if required.

Spexib Capsule is an anti-cancer agent (kinase inhibitor) indicated for the treatment of metastatic non-small cell lung cancer (NSCLC).

ALK-positive lung cancer is a specific type of non-small cell lung cancer (NSCLC) that has a mutation in the ALK (Anaplastic lymphoma kinase) gene, resulting in uncontrolled cell replication- cancer.

Spexib Capsule should be swallowed as a whole with water. Take it at least 1 hour before or at least 2 hours after meals.

Lab tests will help you know the body’s response to Spexib Capsule. Keep taking Spexib Capsule for the duration advised by the doctor.

Spexib Capsule may cause serious side effects like stomach and gastrointestinal problems, liver injury, pneumonitis (lung inflammation), and abnormal heartbeats. Consult the doctor if you experience any unusual symptoms.

Spexib Capsule may cause liver problems such as liver injury. The doctor will advise regular blood tests to check for liver health during the treatment. Consult the doctor if you experience symptoms such as tiredness, itchy skin, nausea, vomiting, yellowing of eyes, decreased appetite, dark or brown urine, bleeding or bruising easily than usual, and pain on the right side of the stomach.

Spexib Capsule may cause severe or life-threatening lung inflammation (pneumonitis). Seek medical attention if you experience chest pain, fever, cough with or without mucous, shortness of breath or trouble breathing.

Eat non-spicy food and drink enough fluids if you have diarrhoea. You can take anti-diarrhoeal medicines if advised by the doctor.

Spexib Capsule may cause vision problems. Do not drive, operate machinery or do any work that requires alertness until you know how the medicine affects you. Consult the doctor if you notice any vision problems.

Spexib Capsule might cause itchy skin or rash. Use moisturiser and wear loose cotton clothes if you experience this. Consult the doctor if you notice yellow skin as this could be a sign of liver problems.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SPE0179

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.novartis.com/us-en/sites/novartis_us/files/zykadia.pdf
  2. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/ceritinib
  3. https://medlineplus.gov/druginfo/meds/a614027.html
  4. https://reference.medscape.com/drug/zykadia-ceritinib-999936
  5. https://chemocare.com/druginfo/ceritinib
  6. https://www.macmillan.org.uk/cancer-information-and-support/lung-cancer/non-small-cell-lung-cancer
  7. https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7397
  8. https://www.drugs.com/drug-interactions/ceritinib.html

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