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compositionComposition:CLARITHROMYCIN-500MG
prescriptionPrescription Medicine
Synclar 500mg Infusion
Synclar 500mg Infusion
Synclar 500mg Infusion

Synclar 500mg Infusion is an antibiotic used in treating bacterial infections. It contains Clarithromycin, which stops the growth of bacteria. It may cause side effects like injection site reactions, nausea, and vomiting. Inform your doctor if you are pregnant, breasfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

CLARITHROMYCIN-500MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Synclar 500mg Infusion

Synclar 500mg Infusion belongs to the group of medicines known as macrolide antibiotics, used to treat infections caused by bacteria such as bronchitis, pneumonia, throat, sinus, skin and soft tissue infections. It is prescribed for treating severe infections or when oral therapy is ineffective.

Synclar 500mg Infusion contains 'Clarithromycin', which works by killing the bacteria that cause the infection by preventing the synthesis of essential proteins necessary for the survival of the bacteria. Thereby, it effectively treats bacterial infections.

You may experience injection site reactions (redness, swelling, and pain), headache, nausea or vomiting, stomach pain, and diarrhoea. Most of these side effects do not require medical attention and resolve over time. Please consult your doctor if these side effects become troublesome.

Inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby or if you are breastfeeding. Let your doctor know about your medical condition and the medications you are taking to avoid any interactions.

Uses of Synclar 500mg Infusion

Synclar 500mg Infusion is used to treat a wide range of bacterial infections. The detailed uses of Synclar 500mg Infusion include:

  • Treatment of respiratory tract infections: Synclar 500mg Infusion is effective in managing infections such as bronchitis, sinusitis, and pneumonia.
  • Treatment of throat and tonsil infections: Synclar 500mg Infusion helps relieve bacterial infections affecting the throat and tonsils, including pharyngitis and tonsillitis.
  • Treatment of skin and soft tissue infections: Synclar 500mg Infusion is used to treat conditions like cellulitis, infected wounds, and other skin infections caused by susceptible bacteria.
  • Treatment of ear infections: Synclar 500mg Infusion is sometimes used for bacterial middle ear infections in children and adults.
  • Part of combination therapy for Helicobacter pylori: Synclar 500mg Infusion may be used with other medicines to eradicate H. pylori, which is linked to peptic ulcers.

Key Benefits

  • Synclar 500mg Infusion belongs to the macrolide class of antibiotics. It is used to treat a wide range of bacterial infections.
  • It is effective in treating lower respiratory tract infections, such as acute and chronic bronchitis and pneumonia.
  • It also treats upper respiratory tract infections, including sinusitis and pharyngitis.
  • It helps manage skin and soft tissue infections such as folliculitis, erysipelas and cellulitis.
  • Synclar 500mg Infusion works by blocking bacterial protein synthesis, preventing bacteria from growing and multiplying.
  • It is useful in severe infections or when oral antibiotic therapy is ineffective.
  • Synclar 500mg Infusion helps eliminate infection and improve symptoms by killing the bacteria at the infection site.
Side effects of Synclar 500mg Infusion
  • Use a warm compress on the affected area to help reduce discomfort.
  • Elevate the affected limb above heart level.
  • Remove the IV catheter (if applicable) and reinsert at a different site.
  • Consult your healthcare provider if symptoms are severe or persist.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Synclar 500mg Infusion will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Synclar 500mg Infusion Works

Synclar 500mg Infusion contains 'Clarithromycin', which works by killing the bacteria that cause the infection by preventing the synthesis of essential proteins necessary for the survival of the bacteria. Thereby, it effectively treats bacterial infections.
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Alcohol

Caution

It is advisable to avoid or limit alcohol intake.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Consult your doctor

It is not known if Synclar 500mg Infusion passes into breastmilk. Please consult your doctor.

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Driving

Caution

Synclar 500mg Infusion may cause dizziness, confusion, and loss of balance. Therefore avoid driving or operating machinery if you experience any of these symptoms.

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Liver

Caution

Caution is advised. If you have/had liver problems, your doctor may need to monitor your liver function or discontinue treatment.

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Kidney

Caution

Consult your doctor if you have kidney problems, as your doctor may need to adjust the dose.

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Children

Caution

Synclar 500mg Infusion is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Inform your doctor before receiving Synclar 500mg Infusion if you have a pre-existing or a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Synclar 500mg Infusion should be used in the elderly only if advised by a doctor, as dose adjustment may be required.

What if I have taken an overdose of Synclar 500mg Infusion

Synclar 500mg Infusion is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include agitation, confusion, coma (decreased level of consciousness and lack of responsiveness), and Seizures, in a very severe overdose. Dizziness, drowsiness, blurred vision, and delirium are the common symptoms of overdose. Your doctor may take necessary measures if an overdose is suspected.

Diet & Lifestyle Advise

  • Take probiotics after completing the full course of Synclar 500mg Infusion to restore healthy bacteria in the intestine that may have been killed due to the use of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Whole grains like whole-grain bread and brown rice should be included in the diet.
  • Avoid intake of alcoholic beverages with Synclar 500mg Infusion as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Synclar 500mg Infusion in fighting off infections.

Have a query?

How Soon It Starts Working

The time required for Synclar 500mg Infusion to start to work: The onset time of Synclar 500mg Infusion has not been clinically established.

The time for which the effects of Synclar 500mg Infusion last: The duration of Synclar 500mg Infusion’s effect is clinically not established.

What if you forget to take Synclar 500mg Infusion

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Synclar 500mg Infusion if you are allergic or hypersensitive to clarithromycin, any of the ingredients in Synclar 500mg Infusion, any other macrolide antibiotic, or ketolide (macrolide derivatives).
  • Consult your doctor if you are pregnant or breastfeeding.
  • Inform your doctor if you have/had hypokalemia (abnormally low levels of potassium in the blood), hypomagnesemia (abnormally low levels of magnesium in the blood), severe kidney or liver problems, heart rhythm disorders, heart problems, or are prone to fungal infections (e.g. thrush).
  • Let your doctor know if you are taking any other medicines.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Synclar 500mg Infusion interacts with certain medicines used to treat migraine (ergotamine, dihydroergotamine), antihistamines (terfenadine, astemizole), medications used to treat stomach disorders (cisapride or domperidone), antipsychotic drug (pimozide), statins or medicines used to lower levels of cholesterol (lovastatin, simvastatin, lomitapide, atorvastatin), certain sedative medications (midazolam), GOUT medications (colchicine), medicines used to treat heart attack, chest pain or angina (ticagrelor or ranolazine), medicines used to treat anxiety and panic disorder (alprazolam), and medications used to treat asthma or chronic obstructive pulmonary disease (budesonide/formoterol)

Drug-Food Interactions: No relevant interactions found.

Drug-Disease Interactions: Inform your doctor if you have liver problems, renal dysfunction, heart rhythm disorder (arrhythmia) or QT prolongation, electrolyte imbalance (low potassium or magnesium level), and muscle problems (myasthenia gravis).

ClarithromycinPimozide
Critical
ClarithromycinSparfloxacin
Critical

Drug-Drug Interactions

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ClarithromycinPimozide
Critical
How does the drug interact with Synclar 500mg Infusion:
Combining Synclar 500mg Infusion with Pimozide can increase the risk of heart rhythm problems.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Pimozide can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like irregular heartbeat, chest tightness, blurred vision or nausea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinSparfloxacin
Critical
How does the drug interact with Synclar 500mg Infusion:
Co-administration of Synclar 500mg Infusion and Sparfloxacin may result in an increased risk of QT interval prolongation.

How to manage the interaction:
Co-administration of Sertraline and Desvenlafaxine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinLurasidone
Critical
How does the drug interact with Synclar 500mg Infusion:
Using Lurasidone together with Synclar 500mg Infusion may result in significantly higher Lurasidone blood levels. This may increase the possibility of side effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Synclar 500mg Infusion may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ClarithromycinTerfenadine
Critical
How does the drug interact with Synclar 500mg Infusion:
When Terfenadine is taken with Synclar 500mg Infusion, the amount of Terfenadine in the blood can go up.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinBepridil
Critical
How does the drug interact with Synclar 500mg Infusion:
Co-administration of Bepridil with Synclar 500mg Infusion may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Synclar 500mg Infusion with Bepridil is not recommended as it can result in an interaction, it should be taken only if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinNaloxegol
Critical
How does the drug interact with Synclar 500mg Infusion:
When Naloxegol is taken with Synclar 500mg Infusion, the amount of Naloxegol in the blood can go up.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Naloxegol can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinLovastatin
Critical
How does the drug interact with Synclar 500mg Infusion:
Taking Synclar 500mg Infusion with Lovastatin can increase the risk of muscle problems.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Lovastatin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinAlfuzosin
Critical
How does the drug interact with Synclar 500mg Infusion:
When Alfuzosin and Synclar 500mg Infusion can increase the risk or severity of side effects like low blood pressure or irregular heart rates.

How to manage the interaction:
Taking Synclar 500mg Infusion with alfuzosin is not recommended as it can result in an interaction; it should be taken only if your doctor has advised it. However, if you experience dizziness, headache, palpitations, or chest discomfort, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinSimvastatin
Critical
How does the drug interact with Synclar 500mg Infusion:
Co-administration of Synclar 500mg Infusion and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Synclar 500mg Infusion and Simvastatin together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
ClarithromycinDronedarone
Critical
How does the drug interact with Synclar 500mg Infusion:
When Dronedarone is taken with Synclar 500mg Infusion, can increase the blood levels of dronedarone and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Synclar 500mg Infusion with Dronedarone can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

Synclar 500mg Infusion belongs to the group of medicines known as macrolide antibiotics, used to treat infections caused by bacteria such as bronchitis, pneumonia, throat, sinus, skin and soft tissue infections.

Synclar 500mg Infusion kills the harmful bacteria by preventing the production of proteins required by the bacteria for their survival.

Using Synclar 500mg Infusion together with statins (medicines used to lower cholesterol levels) is not advisable. Please notify your doctor if you must take these medications. Your doctor may advise you to maintain a time gap between these two medications.

Synclar 500mg Infusion can cause Clostridium difficile-associated diarrhoea (CDAD). If you have diarrhoea that is watery or bloody, inform your doctor. Do not use anti-diarrhoea medicine unless your doctor tells you to.

You should inform your doctor before taking Synclar 500mg Infusion if you have liver or kidney dysfunction, heart rhythm disorder (arrhythmia) or QT prolongation, electrolyte imbalance (low potassium or magnesium level), or muscle problems (myasthenia gravis).

Synclar 500mg Infusion should not be taken with any ergot derivatives such as ergotamine or dihydroergotamine, used to treat migraine. Consult your doctor if you have any concerns.

Prolonged use of Synclar 500mg Infusion can result in a yeast infection or oral thrush. Look out for symptoms like white patches in the mouth or changes in vaginal discharge.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

  • Bayyarapu Mahesh Kumar

    M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

  • Veda Maddala

    M Pharmacy

Last Updated

Doctor imageWe provide you with authentic, trustworthy and relevant information

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - SYN0267
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