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compositionComposition:THIOTEPA-15MG
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Tepapro 15 mg Injection is used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection; breast cancer, ovarian cancer, bladder cancer, serosal cavity neoplastic disease, and malignant effusions caused by cancerous tumours. It contains Thiotepa, which works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

THIOTEPA-15MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tepapro 15 mg Injection

Tepapro 15 mg Injection is an injectable prescription medicine used to treat certain types of cancer, including breast and ovarian cancers. It is also used to prepare patients for bone marrow or stem cell transplants by clearing out existing bone marrow cells to make room for healthy new donor cells.

Because Tepapro 15 mg Injection is given as an injection or infusion, your healthcare team will schedule and administer your doses at specific intervals. While you do not need to worry about taking it with food, staying well-hydrated before and after each session is very important. Making simple lifestyle adjustments, such as getting plenty of rest and eating small, frequent meals, can help your body cope with the treatment.

While receiving this medicine, you may experience common side effects like nausea, vomiting, or temporary hair loss. However, you must contact your doctor immediately if you face serious side effects, such as a fever, chills, or unusual bleeding and bruising.

Before starting treatment, talk to your doctor if you have kidney disease, liver damage, or a history of heart problems. Do not take this medicine if you have had a severe allergic reaction to it in the past, have severely reduced bone marrow function, or have previously developed aplastic anemia (a rare but serious failure of the bone marrow to produce blood cells) after receiving Tepapro 15 mg Injection or a similar medicine. Tell your doctor if you are receiving other treatments that suppress the bone marrow, such as certain chemotherapy medicines.

Tepapro 15 mg Injection can interact with live vaccines and other treatments that weaken your immune system, which can increase your risk of severe infections. You should also consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine can harm an unborn baby.

Uses of Tepapro 15 mg Injection

This medicine is used to treat certain cancers and to prepare the body for stem cell or bone marrow transplantation. The detailed uses of this medicine are as follows:

  • Breast Cancer: Tepapro 15 mg Injection helps by stopping the growth and spread of rapidly dividing cancer cells in the breast tissue.
  • Ovarian Cancer: It works to control and reduce advanced ovarian tumors when other standard treatments have not worked.
  • Stem Cell and Bone Marrow Transplant Preparation: It prepares the body for a transplant by destroying diseased bone marrow cells, allowing new, healthy cells to grow.
  • Bladder Cancer: When placed directly into the bladder, it helps prevent superficial bladder tumors from returning after surgery.

Key Benefits

Tepapro 15 mg Injection helps treat certain cancers and supports successful stem cell or bone marrow transplantation. Its benefits include:

  • Helps destroy rapidly dividing cancer cells, slowing the growth and spread of cancer.
  • Helps reduce tumor burden, which may relieve cancer-related symptoms and improve quality of life.
  • May help achieve longer periods of remission in suitable patients as part of a comprehensive treatment plan.
  • Prepares the body for stem cell or bone marrow transplantation by destroying diseased bone marrow cells.
  • Creates space for healthy transplanted cells to grow and rebuild a functioning immune system after transplantation.
Side effects of Tepapro 15 mg Injection
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Tepapro 15 mg Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Tepapro 15 mg Injection Works

Tepapro 15 mg Injection belongs to a group of medicines known as alkylating agents. It works by attaching itself to the DNA of rapidly dividing cells, including cancer cells. By damaging the genetic material, it prevents these harmful cells from dividing and multiplying. Because cancer cells grow much faster than most healthy cells in the body, they are highly sensitive to this blocking action, which ultimately leads to their destruction.
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Alcohol

Consult your doctor

It is not known if alcohol affects Tepapro 15 mg Injection. Please consult your doctor.

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Pregnancy

Unsafe

Tepapro 15 mg Injection should not be used during pregnancy as it can cause foetal harm. If you are pregnant, think you may be pregnant or are planning for pregnancy, you must inform the doctor before receiving Tepapro 15 mg Injection.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Tepapro 15 mg Injection.

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Driving

Caution

Tepapro 15 mg Injection may cause dizziness, headache, and blurred vision. Therefore, drive or operate heavy machinery only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Tepapro 15 mg Injection. Monitoring of patients with moderate to severe liver impairment for toxicity is advised.

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Kidney

Caution

If you have a history of kidney diseases, inform your doctor before receiving Tepapro 15 mg Injection. Monitoring of patients with moderate to severe kidney impairment for toxicity is advised.

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Children

Caution

Tepapro 15 mg Injection is safe for use in children for the prevention of graft rejection and bone marrow transplantation. Safety and effectiveness for the treatment of breast cancer, ovarian cancer, malignant effusions and bladder cancer have not been established in children.

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Heart

Caution

Tepapro 15 mg Injection may require caution in patients with heart problems. Therefore, please inform your doctor if you have any heart-related conditions before receiving Tepapro 15 mg Injection.

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Geriatrics

Caution

Tepapro 15 mg Injection may require caution and dose adjustment in geriatric patients. Therefore, please consult your doctor before receiving Tepapro 15 mg Injection.

What if I have taken an overdose of Tepapro 15 mg Injection

An overdose is highly unlikely because your medical team calculates and monitors your dose carefully. However, if you suspect you have received too much or experience severe symptoms after an infusion, seek immediate medical attention or notify the hospital staff right away.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink plenty of water and clear fluids before and after your treatment to help your kidneys flush the medicine from your body.
  • Practice Strict Hygiene: Wash your hands frequently, avoid large crowds, and stay away from people who are actively sick to protect yourself from infections while your immune system is weak.
  • Eat Safe, Cooked Foods: Stick to fully cooked meats and thoroughly washed fruits and vegetables to lower your risk of foodborne illnesses while your blood counts are low.
  • Protect Your Skin: Use gentle, fragrance-free soaps and moisturizers, as your skin may become extra sensitive during treatment.
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Have a query?

How Soon It Starts Working

The time required for Tepapro 15 mg Injection to start to work: Tepapro 15 mg Injection ideally shows its action within 5 minutes after administration. The time for which the effects of Tepapro 15 mg Injection last: The duration of action for Tepapro 15 mg Injection is unknown.

What if you forget to take Tepapro 15 mg Injection

Because you will receive this medication from a healthcare professional in a clinic, it is unlikely that you will miss a dose. If you miss a scheduled appointment for your infusion, contact your clinic immediately to reschedule.

Storage

•The dry powder vials are kept in a refrigerator between 2°C and 8°C (36°F to 46°F) and are protected from light.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the Solution: Ensure your nurse inspects the liquid before injection; it should be clear and free of visible floating particles.
  • Monitor the Injection Site: Tell your healthcare team immediately if you feel any burning, pain, or swelling where the needle is inserted, as the medicine must not leak into surrounding tissues.
  • Avoid Live Vaccines: Do not receive any live vaccines (such as MMR or chickenpox vaccines) during your treatment, as your weakened immune system may not be able to handle them.
  • Use Reliable Birth Control: Both men and women must use highly effective birth control during treatment and for at least 6 months after the final dose, or for as long as advised by their treating doctor, to prevent pregnancy.
  • Keep Up with Monitoring: Attend all scheduled blood tests so your doctor can monitor your blood cell counts, liver function, and kidney function. In certain patients, your doctor may also check blood (serum) Tepapro 15 mg Injection levels to ensure safe and effective dosing.

Drug-Drug Interactions

verifiedApollotooltip
  • Other chemotherapy medicines: Combining Tepapro 15 mg Injection with other cancer treatments can increase the risk of severe bone marrow suppression and dangerously low blood counts.
  • Live vaccines: May cause severe infections because Tepapro 15 mg Injection lowers your body's ability to fight off viruses or bacteria.
  • Medicines that affect liver enzymes: Some medications can change how your body processes Tepapro 15 mg Injection, which may increase the level of the medicine in your blood and lead to more side effects.
ThiotepaBusulfan
Severe
ThiotepaCladribine
Severe

Drug-Drug Interactions

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ThiotepaBusulfan
Severe
How does the drug interact with Tepapro 15 mg Injection:
Combining Busulfan with Tepapro 15 mg Injection can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Tepapro 15 mg Injection and Busulfan, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
ThiotepaCladribine
Severe
How does the drug interact with Tepapro 15 mg Injection:
Combining Cladribine with Tepapro 15 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Tepapro 15 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ThiotepaTofacitinib
Severe
How does the drug interact with Tepapro 15 mg Injection:
Taking Tofacitinib with Tepapro 15 mg Injection may increase the risk of infection.

How to manage the interaction:
Co-administration of Tepapro 15 mg Injection with Tofacitinib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
ThiotepaCyclophosphamide
Severe
How does the drug interact with Tepapro 15 mg Injection:
When Tepapro 15 mg Injection is taken with Cyclophosphamide, can increase the blood levels or add to the medication side effects of cyclophosphamide.

How to manage the interaction:
Although taking Tepapro 15 mg Injection and Cyclophosphamide together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
ThiotepaClozapine
Severe
How does the drug interact with Tepapro 15 mg Injection:
Combining Tepapro 15 mg Injection with Clozapine can increase the risk of infection.

How to manage the interaction:
Although taking Tepapro 15 mg Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
ThiotepaCarboplatin
Severe
How does the drug interact with Tepapro 15 mg Injection:
Using Carboplatin with Tepapro 15 mg Injection can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Tepapro 15 mg Injection and Carboplatin, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without talking to a doctor.
ThiotepaInfliximab
Severe
How does the drug interact with Tepapro 15 mg Injection:
When Tepapro 15 mg Injection is taken with Infliximab, it can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Tepapro 15 mg Injection with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ThiotepaMelphalan
Severe
How does the drug interact with Tepapro 15 mg Injection:
Co-administration of Melphalan with Tepapro 15 mg Injection can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Melphalan and Tepapro 15 mg Injection, you can take these medicines together if prescribed by a doctor. If you notice any unusual symptoms or side effects, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
ThiotepaBaricitinib
Severe
How does the drug interact with Tepapro 15 mg Injection:
Coadministration of Tepapro 15 mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Tepapro 15 mg Injection and Baricitinib, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ThiotepaEtanercept
Severe
How does the drug interact with Tepapro 15 mg Injection:
When Etanercept is used with Tepapro 15 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Etanercept with Tepapro 15 mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

  • No clinically significant food interactions are known with Tepapro 15 mg Injection when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Tepapro 15 mg Injection is used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection; breast cancer, ovarian cancer, bladder cancer, serosal cavity neoplastic disease, and malignant effusions caused by cancerous tumours.
Tepapro 15 mg Injection works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.
Tepapro 15 mg Injection may impair male and female fertility. It may stop sperm production in men and interfere with normal menstrual/period cycle in women. Consult the doctor if you have any concerns.
Tepapro 15 mg Injection may increase the risk of infections or bleeding. Consult the doctor immediately if you notice unusual bleeding or bruising or any signs of infections such as fever, chills, pale skin, shortness of breath, tiredness, or mouth sores.
No, you should not receive Tepapro 15 mg Injection if you are pregnant, as it can cause serious harm to an unborn baby. Talk to your doctor about highly effective birth control options before starting treatment. Both men and women should continue using effective contraception for at least 6 months after completing treatment, or for the duration recommended by their doctor.
Yes, temporary hair loss is a common side effect of Tepapro 15 mg Injection. In most cases, your hair will begin to grow back after you complete your treatment. Talk to your doctor if you have concerns about hair loss.
This medicine is given as an injection or infusion into a vein by a trained healthcare professional. In some cases, it may be put directly into other areas of the body, like the bladder. Talk to your doctor about your specific treatment plan.
It is highly recommended to avoid alcohol during your treatment, as it can worsen side effects like nausea and increase stress on your liver. Talk to your doctor or pharmacist for personalized advice.
This medicine can lower the number of healthy cells in your blood, which increases your risk of infections and bleeding. Regular blood tests help your doctor monitor these levels and ensure it is safe to proceed with your next dose. Talk to your doctor if you experience unusual fatigue or bruising.
You should consult your doctor before receiving any vaccine while being treated with Tepapro 15 mg Injection. Live vaccines, including live bacterial or viral vaccines and yellow fever vaccine, are generally avoided because Tepapro 15 mg Injection can weaken the immune system and increase the risk of serious infections. Your doctor can advise which vaccines are appropriate and when they should be given.
A fever or chills can be a sign of a serious infection due to lowered white blood cells. Contact your healthcare team or go to the nearest emergency room immediately. Talk to your doctor if you experience any sudden changes in your health.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - TEP0024
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