Thalitero-50 Capsule | Uses, Side Effects, Price

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Prescription Medicine

Thalitero-50 Capsule is used to treat multiple myeloma (a type of cancer) and erythema nodosum leprosum (an inflammatory complication). It helps slow the growth of cancer cells and supports the body’s immune response. It also helps reduce inflammation and related symptoms.

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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More about the Product

Composition :

THALIDOMIDE-50MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Thalitero-50 Capsule

Thalitero-50 Capsule is used to treat multiple myeloma (a type of cancer). It is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence. ENL is an immune-mediated inflammatory complication of leprosy.

Thalitero-50 Capsule contains thalidomide, which helps control the growth of cancer cells. It supports the body’s immune response and slows the spread of cancer. It also helps reduce the blood supply that tumours need to grow. This helps manage multiple myeloma.

Take Thalitero-50 Capsule as prescribed by your doctor. You may experience common side effects such as constipation, dizziness, sleepiness, tiredness, tremors (shaking movements), dysaesthesia (abnormal sensation), low blood cell count, nausea, vomiting, and swelling of hands and feet. Talk to your doctor if you experience any of these side effects persistently.

Do not take Thalitero-50 Capsule if you are pregnant, as it might cause severe birth defects or the death of an unborn baby. Avoid taking Thalitero-50 Capsule if you are breastfeeding. Thalitero-50 Capsule may cause dizziness, sleepiness, and blurred vision, so drive only if you are alert. Thalitero-50 Capsule is not recommended for children under 18 years old.

Uses of Thalitero-50 Capsule

Thalitero-50 Capsule is used to treat specific cancers and inflammatory complications of leprosy. The detailed uses of Thalitero-50 Capsule include:

Treatment of multiple myeloma: Thalitero-50 Capsule is used in combination with other medicines to treat multiple myeloma, a type of blood cancer affecting plasma cells in the bone marrow.
Management of erythema nodosum leprosum (ENL): Thalitero-50 Capsule is effective in managing ENL, a painful inflammatory complication of leprosy, by reducing swelling, redness, and discomfort.

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Directions for Use

Thalitero-50 Capsule should be taken at least one hour after meals.
It is usually taken once daily, preferably at bedtime, or as prescribed by your doctor.
Swallow Thalitero-50 Capsule as a whole with a glass of water.
Do not crush, chew, or open it.

Key Benefits

Thalitero-50 Capsule , when used as prescribed, may provide the following benefits:

For Multiple Myeloma:

Helps control the growth of cancer cells in the bone marrow.
Supports treatment when used along with other cancer medicines.
Helps improve disease control and overall treatment response.

For Erythema Nodosum Leprosum (ENL):

Helps reduce swelling, redness, and pain associated with this inflammatory condition.
Calms immune-related inflammation.
Improves comfort and quality of life during flare-ups.

How Thalitero-50 Capsule Works

Thalitero-50 Capsule contains Thalidomide. It works in multiple myeloma by slowing cancer cell growth and supporting the body’s immune response. In erythema nodosum leprosum (ENL), it helps reduce skin inflammation and control moderate to severe flare-ups.

Storage

Store in a cool and dry place away from sunlight

Side effects of Thalitero-50 Capsule

Low Calcium Levels In Blood

Managing Medication-Triggered Hypocalcemia (Calcium deficiency or Low Calcium Levels In Blood): A Step-by-Step Guide:

Consult Your Doctor: If you experience symptoms such as muscle cramps, tingling, numbness, weakness, or spasms, which may indicate low calcium levels (hypocalcemia), consult your doctor to determine if your medication is the cause.
Your doctor will assess your medication regimen and adjust it if necessary to minimize the risk of hypocalcemia.
Your doctor may order blood tests to check your calcium levels and monitor for any changes.
To manage hypocalcemia, your doctor recommends dietary and lifestyle modifications. This may include increasing your intake of calcium-rich foods to support bone health and calcium levels. If necessary, your doctor may also prescribe calcium and vitamin D supplements to help stabilize your calcium levels.
If your condition does not improve or worsens, consult your doctor immediately for further evaluation and treatment.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Increased Risk Of Infection Due To Low Neutrophil Count

Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
Avoid contact with people who are sick.
Wash your hands regularly with soap and water.
Avoid unpasteurized dairy products.

Shortness Of Breath

Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):

Tell your doctor immediately if you experience shortness of breath after taking medication.
Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Muscle Weakness

Muscle weakness can be due to tiredness, which can be managed by eating often.
Observe your movements and understand why the muscle is weakening.
Regularly do strengthening exercises to improve blood flow throughout the body and reduce weakness.
Sleep well and give enough rest to your body.
Take a balanced diet, quit smoking and intake of alcohol.
Practice yoga and meditation to improve inner strength and stay healthy.

Peeling/flaking of the skin

What if I have taken an overdose of Thalitero-50 Capsule

Take Thalitero-50 Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Thalitero-50 Capsule if you are allergic to any of its components.
Inform your doctor if you have/had blood clots, a heart attack, neuropathy, a slow heart rate, high blood pressure, low blood pressure, infections, a viral infection, HIV, hepatitis B, epilepsy, liver or kidney problems.
Do not take Thalitero-50 Capsule if you are pregnant, as it might cause severe birth defects or the death of the unborn baby.
Avoid taking Thalitero-50 Capsule if you are breastfeeding, as it is not known if it passes into breastmilk.
Thalitero-50 Capsule may cause dizziness, sleepiness, and blurred vision; therefore, drive only if you are alert.
Thalitero-50 Capsule is not recommended for children under 18 years, as safety and efficacy have not been established.
Avoid consuming alcohol with Thalitero-50 Capsule as it could lead to increased dizziness and sleepiness.
Thalitero-50 Capsule , when taken with dexamethasone, increases the risk of deep vein thrombosis and pulmonary embolism.
Stop taking Thalitero-50 Capsule and consult a doctor immediately if you think you are pregnant, if you have irregular periods, missed a period, have any change in menstrual bleeding, or if you have had sex without using two forms of birth control.

Drug-Drug Interactions

ThalidomideIfosfamide

Severe

ThalidomidePemetrexed

Severe

Drug-Drug Interactions

ThalidomideIfosfamide

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Thalitero-50 Capsule together with ifosfamide may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalitero-50 Capsule and ifosfamide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

ThalidomidePemetrexed

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Thalitero-50 Capsule together with pemetrexed may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalitero-50 Capsule and pemetrexed together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

ThalidomideLeflunomide

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Leflunomide with Thalitero-50 Capsule may increase the risk of infections.

How to manage the interaction:
Although taking Thalitero-50 Capsule and leflunomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

ThalidomideVinblastine

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Thalitero-50 Capsule together with vinblastine may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalitero-50 Capsule and vinblastine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

ThalidomidePeginesatide

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Thalitero-50 Capsule together with peginesatide may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalitero-50 Capsule and peginesatide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

ThalidomideDiethylstilbestrol

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Thalitero-50 Capsule together with diethylstilbestrol may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalitero-50 Capsule and diethylstilbestrol together can possibly result in an interaction, but it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

ThalidomideDexamethasone

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Dexamethasone with Thalitero-50 Capsule may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Thalitero-50 Capsule if prescribed by the doctor. Consult the doctor immediately if you experience signs and symptoms of blood clots such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue the medication without consulting a doctor.

ThalidomideExemestane

Severe

How does the drug interact with Thalitero-50 Capsule:
Taking Thalitero-50 Capsule together with exemestane may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalitero-50 Capsule and exemestane together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

ThalidomideLetrozole

Severe

How does the drug interact with Thalitero-50 Capsule:
Coadministration of Thalitero-50 Capsule and letrozole may increase the risk of blood clots.

How to manage the interaction:
Although taking Letrozole and Thalitero-50 Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, consult a doctor. Do not discontinue any medications without a doctor's advice.

ThalidomideMercaptopurine

Severe

How does the drug interact with Thalitero-50 Capsule:
Co-administration of Thalitero-50 Capsule together with Mercaptopurine may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalitero-50 Capsule and mercaptopurine together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Diet & Lifestyle Advise

Diet:

Maintain a healthy, balanced diet to achieve an appropriate weight.
Include iron-rich foods like lean meat, raisins, and green vegetables.
Include fibre-rich foods, such as whole grains, fruits, and beans, to prevent constipation.
Drink plenty of water to support digestion and reduce the risk of constipation.

Physical Activity:

Do light to moderate exercise regularly to maintain strength and circulation.
Avoid activities that increase the risk of injury if feeling weak or dizzy.

Habits & Safety:

Avoid smoking and alcohol consumption.
Use effective birth control as advised, as Thalitero-50 Capsule can cause serious birth defects.
Do not donate blood during treatment.
Take the medicine at night if it causes drowsiness and avoid driving if feeling sleepy.

Habit Forming

Therapeutic Class

[ANTILEPROTICS]

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Thalitero-50 Capsule as it might cause increased sleepiness.

Pregnancy

Unsafe

Thalitero-50 Capsule belongs to pregnancy category X. Thalitero-50 Capsule should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of child-bearing age. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

Breast Feeding

Unsafe

Avoid breastfeeding while taking Thalitero-50 Capsule as it is unknown if Thalitero-50 Capsule passes into breastmilk.

Driving

Unsafe

Thalitero-50 Capsule may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

Children

Unsafe

Thalitero-50 Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

Heart

Caution

Thalitero-50 Capsule should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Thalitero-50 Capsule .

Geriatrics

Caution

Thalitero-50 Capsule should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Thalitero-50 Capsule .

FAQs

What is the use of Thalitero-50 Capsule ?

Thalitero-50 Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Thalitero-50 Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence.

How does Thalitero-50 Capsule work?

Thalitero-50 Capsule stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Thalitero-50 Capsule helps treat multiple myeloma.

Can I stop taking Thalitero-50 Capsule on my own?

Do not stop taking Thalitero-50 Capsule on your own. You are advised to take Thalitero-50 Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. Do not hesitate to speak with your doctor if you experience any difficulties while taking Thalitero-50 Capsule .

Does Thalitero-50 Capsule cause orthostatic hypotension?

Orthostatic hypotension could be a side-effect of Thalitero-50 Capsule . Orthostatic hypotension is a sudden lowering of blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.

Is it safe to father a child while taking Thalitero-50 Capsule ?

No, it is not safe to father a child while taking Thalitero-50 Capsule . Thalidomide is present in the semen of male patients taking Thalitero-50 Capsule ; it could cause severe birth defects or death of the unborn baby. During sexual activity with females of reproductive potential, always use effective contraception such as latex or synthetic condom while taking Thalitero-50 Capsule and for at least 4weeks after discontinuing Thalitero-50 Capsule , even if you have undergone a successful vasectomy. Male patients taking Thalitero-50 Capsule must not donate semen.

Is it safe to donate blood while on treatment with Thalitero-50 Capsule ?

Patients taking Thalitero-50 Capsule must not donate blood during the treatment with Thalitero-50 Capsule and for 4weeks after discontinuation of Thalitero-50 Capsule as the donated blood might be given to pregnant women whose foetus should not be exposed to thalidomide since it causes severe birth defects or death of the unborn baby.

Does Thalitero-50 Capsule cause blood clots?

People with multiple myeloma taking Thalitero-50 Capsule may have an increased risk for blood clots in veins, arteries, and lungs. The risk is higher if you take dexamethasone with Thalitero-50 Capsule for treating multiple myeloma. Consult your doctor immediately if you notice symptoms such as shortness of breath, chest pain, and swelling in the legs or arm.

What are the side effects of Thalitero-50 Capsule ?

Thalitero-50 Capsule may cause side effects such as nausea, vomiting, indigestion, dizziness, heartburn, constipation, tiredness, tremor or swelling of hands and feet. If these side effects persist or worsen, please consult your doctor.

What if I forget to take a dose of Thalitero-50 Capsule ?

If you forget to take a dose of Thalitero-50 Capsule , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one, as this may increase the risk of side effects.

Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018

Other Info - THA0078

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Feb 13, 2026 | 11:07 AM IST

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