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compositionComposition:TOCILIZUMAB-400MG
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Prescription Medicine
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Tocira-400 Infusion is used to treat rheumatoid arthritis, ankylosing spondylitis, and giant cell arteritis (inflammation of the lining of your arteries) in adults. It contains Tocilizumab which works by blocking the substances that cause inflammation. In some cases, this medicine may cause side effects such as runny nose, pain and swelling at the injection site, and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOCILIZUMAB-400MG

Manufacturer/Marketer :

Hetero Healthcare Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tocira-400 Infusion

Tocira-400 Infusion is a prescription injection used to treat inflammatory conditions like moderate to severe rheumatoid arthritis, giant cell arteritis, and certain types of juvenile arthritis. It helps reduce swelling, joint pain, and stiffness by targeting a specific protein in the body that causes inflammation.

This medicine is typically injected either under the skin at home or given through a vein by a healthcare professional in a clinic. Because it is given as an injection, you can take it regardless of meal times. Making gentle lifestyle adjustments, like eating an anti-inflammatory diet and doing low-impact exercises, can also support your joint health.

While taking Tocira-400 Infusion, you may experience common side effects like a runny nose, headache, or skin reactions at the injection site. However, because it affects your immune system, it can make it easier for you to get serious infections; you must consult your doctor immediately if you develop a fever, persistent cough, or severe fatigue.

Do not take this if you have a severe active infection, or if you are allergic to any of its ingredients. Before starting, tell your doctor if you have a history of tuberculosis, hepatitis B, liver damage, or stomach ulcers, as this medicine may worsen these conditions.

This medicine can interact with other drugs that suppress your immune system, as well as certain vaccines, so always discuss your full medication list with your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider to weigh the risks and benefits before starting treatment.

Uses of Tocira-400 Infusion

Tocira-400 Infusion is prescribed for specific inflammatory conditions where controlling immune activity can help reduce symptoms and prevent complications. The uses of this medicine include:

  • Rheumatoid Arthritis: Tocira-400 Infusion helps reduce pain, swelling, and joint damage in adults with moderate to severe active rheumatoid arthritis who have not responded well to other treatments.
  • Giant Cell Arteritis: It is used to treat this painful inflammation of the blood vessels, helping to reduce blood vessel swelling and prevent serious complications like vision loss.
  • Systemic Juvenile Idiopathic Arthritis (sJIA): Tocira-400 Infusion helps manage severe joint inflammation, fevers, and rashes in children aged two and older.
  • Polyarticular Juvenile Idiopathic Arthritis (pJIA): It helps reduce active joint inflammation and pain in children aged two and older who have multiple affected joints.
  • Cytokine Release Syndrome (CRS): It treats severe or life-threatening inflammatory reactions caused by certain specialized cancer immunotherapies.

Key Benefits

Tocira-400 Infusion offers significant relief from the chronic pain and physical limitations caused by severe inflammatory diseases. By targeting the root cause of swelling, this medication helps restore physical function and improves your overall quality of life. Key benefits include:

  • Reduced Joint Pain and Stiffness: Many patients experience a noticeable decrease in morning stiffness and joint swelling, allowing for easier, more comfortable movement.
  • Prevention of Permanent Joint Damage: By controlling ongoing inflammation, Tocira-400 Infusion helps protect your bones and cartilage from long-term wear and destruction.
  • Improved Daily Functioning: With less pain and fatigue, you can more easily manage everyday activities like walking, dressing, and working.
  • Fewer Flare-ups: Regular use of this medicine helps keep the immune system stable, reducing the frequency and severity of painful symptom flare-ups.
Side effects of Tocira-400 Infusion 20 ml
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
Here's a comprehensive approach to managing medication-triggered high blood pressure (hypertension):
  • Inform your doctor if you experience high blood pressure symptoms after starting a new medication or changing your medication regimen.
  • To reduce high blood pressure symptoms, your doctor may change your medication regimen or dose.
  • Monitor your blood pressure regularly to track changes and potential side effects.
  • Make lifestyle changes, such as following a healthy diet, exercising regularly, and reducing sodium intake.
  • Consider incorporating stress-reducing activities, like meditation or deep breathing exercises, into your daily routine.
  • Create a personalized plan with your doctor to manage high blood pressure, which may include additional medications, therapies, or lifestyle modifications.
  • Follow up with your doctor on a frequent basis to assess progress, change treatment plans, and address any concerns or issues.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Tocira-400 Infusion will be administered by the doctor. In some cases, your doctor may advise self-administration subcutaneously in the thighs, abdomen or upper arms. In that case, your doctor will provide training on the right way to prepare and inject Tocira-400 Infusion.
  • Check the label for directions and use it as advised by the doctor.
  • Rotate the injection site each time.
  • Do not inject into moles, scars, bruises, or areas where the skin is tender, red, hard or not intact.

How Tocira-400 Infusion Works

Tocira-400 Infusion contains tocilizumab, a monoclonal antibody that helps regulate an overactive immune response responsible for inflammation. In diseases like rheumatoid arthritis, the body may produce excessive amounts of a protein called Interleukin-6 (IL-6). This protein acts as an inflammatory messenger that activates immune responses and contributes to joint swelling, pain, and tissue damage. Tocira-400 Infusion works by blocking IL-6 receptors, reducing these inflammatory signals and helping control disease symptoms. Tocira-400 Infusion is designed to act as a blocker. It specifically binds to IL-6 receptors on your cells, preventing the IL-6 protein from attaching and sending its inflammatory signals. By shutting down this pathway, the medicine helps calm your overactive immune response, lowering inflammation throughout your body and protecting your joints from further harm.
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Alcohol

Caution

You are recommended to avoid alcohol consumption if you are being treated with Tocira-400 Infusion. Alcohol intake, along with Tocira-400 Infusion, may cause increased dizziness and risk of stomach bleeding/ulcers.

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Pregnancy

Caution

Tocira-400 Infusion is a pregnancy category C drug and is not recommended during pregnancy since animal studies showed harmful effects on the developing baby. Your doctor will prescribe Tocira-400 Infusion only if the benefit outweighs the risk.

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Breast Feeding

Caution

It is not known if Tocira-400 Infusion passes into the breastmilk when used by breastfeeding mother. Your doctor will prescribe Tocira-400 Infusion only if the benefit outweighs the risk.

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Driving

Unsafe

Tocira-400 Infusion may make you feel dizzy and sleepy. Do not drive or operate machinery if you experience dizziness or drowsiness.

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Liver

Caution

Please consult your doctor since Tocira-400 Infusion should be used with caution in patients with liver impairment/liver disease. Dose adjustment may be needed in patients with liver impairment. However, Tocira-400 Infusion is not recommended in patients with active liver diseases.

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Kidney

Caution

Please consult your doctor since Tocira-400 Infusion should be used with caution in patients with kidney impairment/kidney disease. Dose adjustment may be required.

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Children

Caution

Tocira-400 Infusion is not recommended in children younger than two years of age.

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Heart

Caution

Tocira-400 Infusion should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Tocira-400 Infusion.

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Geriatrics

Caution

Tocira-400 Infusion should be administered with caution in older adults. Always seek medical advice before receiving it.

What if I have taken an overdose of Tocira-400 Infusion

If you accidentally inject too much of this medicine, seek immediate medical attention or call emergency services, even if you do not feel any symptoms.

Diet & Lifestyle Advise

  • Eat an Anti-Inflammatory Diet: Incorporate foods rich in omega-3 fatty acids (like salmon, walnuts, and flaxseeds) and colorful vegetables, which naturally help lower systemic inflammation.
  • Engage in Low-Impact Exercise: Activities like swimming, cycling, or walking keep your joints flexible and strengthen supporting muscles without putting excessive stress on them.
  • Protect Your Joints: Use assistive devices or joint-saving techniques, like carrying grocery bags with your forearms instead of your hands, to minimize mechanical strain.
  • Prioritize Rest: Chronic inflammation can cause fatigue. Ensure you get 7 to 9 hours of quality sleep nightly, and pace your activities to avoid overexertion.
  • Avoid Raw Foods: Because Tocira-400 Infusion affects your immune system, you are more vulnerable to foodborne illnesses. Avoid raw or undercooked meats, seafood, and unpasteurized dairy products.
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Have a query?

How Soon It Starts Working

The time required for Tocira-400 Infusion to start to work: The time required for Tocira-400 Infusion to show its action is unknown. The time for which the effects of Tocira-400 Infusion last: The effect of Tocira-400 Infusion lasts for 15 hours.

What if you forget to take Tocira-400 Infusion

If you self-inject Tocira-400 Infusion at home and miss a scheduled dose, do not double the dose to make up for it. Talk to your doctor or pharmacist to get a personalized schedule on when to take your next dose safely.

Storage

•Store this medicine in the refrigerator between 2°C to 8°C (36°F to 46°F). •Do not freeze this medicine. If a syringe or autoinjector becomes frozen, do not use it.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Inspect Before Using: Always look closely at the solution before injecting. It must be clear and colorless to pale yellow; do not use it if you notice cloudiness, floating particles, or discoloration.
  • Rotate Injection Sites: Choose a different spot for each injection (at least 1 inch away from your last site) to prevent skin irritation and tissue hardening. Avoid injecting into areas that are sore, bruised, red, or scarred.
  • Never Reuse Needles: Always use a brand-new, sterile syringe or autoinjector for every single dose to prevent dangerous bacterial infections.
  • Stay Up to Date on Vaccines: Avoid getting live vaccines (such as the nasal spray flu vaccine or MMR vaccine) while using Tocira-400 Infusion, as your lowered immune response may make the vaccine unsafe or ineffective. Talk to your doctor before scheduling any immunizations.
  • Monitor for Infections: Pay close attention to your body. Since this medicine suppresses your immune system, even a minor cut that becomes red, warm, or swollen needs prompt medical evaluation.
  • Get Regular Blood Tests: Your doctor will need to perform periodic blood tests to check your liver enzymes, cholesterol, and white blood cell levels while you are on this therapy.

Drug-Drug Interactions

verifiedApollotooltip
  • Biologic medicines and immunosuppressants: Combining Tocira-400 Infusion with other biologic medications (such as TNF blockers) or strong immune-suppressing drugs may significantly increase the risk of serious infections.
  • Blood thinners and cholesterol-lowering medicines: Tocira-400 Infusion can affect how your liver processes medicines such as warfarin and statins, which may reduce their effectiveness or require dose adjustments.

Drug-Drug Interactions

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How does the drug interact with Tocira-400 Infusion 20 ml:
Coadministration of Tocira-400 Infusion 20 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Tocira-400 Infusion 20 ml with Baricitinib can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tocira-400 Infusion 20 ml:
Combining Tocira-400 Infusion 20 ml with Clozapine can increase the risk of infection.

How to manage the interaction:
Although taking Tocira-400 Infusion 20 ml and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. Your doctor can recommend other options that won't cause problems when taken together. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Tocira-400 Infusion when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Tocira-400 Infusion contains Tocilizumab, an immunosuppressant. It blocks the action of Interleukin-6 (IL-6), a substance released by the body that causes inflammation. Thus, it helps in decreasing pain and inflammation in various diseases like rheumatoid arthritis, ankylosing spondylitis, and giant cell arteritis.
When a person is infected with the coronavirus, his/her immune system responds in such a way that it sends useful immune chemicals to the affected areas of the lungs to fight the infection. However, in some people, this release of immune chemicals is overactive, resulting in a cytokine storm, an excessive immune response in the lungs. This can further lead to severe breathing complications in an infected person. Tocira-400 Infusion reduces this cytokine storm and further prevents the inflammation and damage in the lungs of a COVID-19 infected person.
Though Tocilizumab in Tocira-400 Infusion is under the clinical trial stage of development by FDA for being used in COVID-19 infection, it is currently used to treat breathing complications for COVID-19 patients. It is known to show improvement in pneumonia during coronavirus infection.
Tocira-400 Infusion is to be carefully administered with caution in patients under doctor's supervision only since it can cause potential side effects like elevated liver enzymes, neutropenia (low levels of neutrophils), and thrombocytopenia (low levels of platelets). It can also cause serious viral infections like hepatitis B, bacterial infections including active tuberculosis, and fungal infections including candidiasis, aspergillosis, and pneumocystis.
Tocira-400 Infusion affects your immune system and makes you more susceptible to infections. Hence, it is not recommended in people with active infections like tuberculosis, hepatitis B, abnormal liver enzymes, and platelet counts less than 50,000. Tocira-400 Infusion can also increase the risk of developing cancers; hence it is essential to mention your doctor if you had a history of any cancer.
Even if there is no improvement after administering Tocira-400 Infusion, your doctor may suggest an alternate course. Please note that Tocira-400 Infusion does not reverse the damage caused due to coronavirus infection, but it will further prevent the inflammation of the lungs. It is also advised to medically examine for other lung and heart related dysfunctions even the patient suffers breathlessness after Tocira-400 Infusion administration.
It is not recommended to get live vaccines like measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine while being treated with Tocira-400 Infusion. This could lead to a severe infection. Please consult a doctor before you start Tocira-400 Infusion if you are undergoing any vaccinations.
The common side effects of the Tocira-400 Infusion are headache, runny nose or sneezing, redness, itching, pain, or swelling in the place where injected, constipation, diarrhea, and Increased blood pressure. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
If you have stomach or intestinal ulcers (diverticulitis), inform your doctor before receiving Tocira-400 Infusion. Your doctor will assess your condition and determine whether Tocira-400 Infusion is safe for you, adjusting the dosage if necessary to minimize risks and ensure effective treatment.
Tocira-400 Infusion is a versatile medication that can help manage various conditions. It's used to treat adults with rheumatoid arthritis, ankylosing spondylitis, and giant cell arteritis. Children with systemic juvenile idiopathic arthritis (SJIA) and polyarticular juvenile idiopathic arthritis (PJIA) can also benefit from Tocira-400 Infusion. Additionally, hospitalized adults with COVID-19 may be treated with Tocira-400 Infusion to manage breathing complications and reduce the risk of respiratory failure. However, it's crucial to note that Tocira-400 Infusion should only be used under the guidance and supervision of a qualified healthcare professional, who will determine the appropriate treatment course based on individual patient needs and circumstances.
Tocira-400 Infusion is not recommended for all COVID-19 patients. It is typically reserved for hospitalized patients with severe COVID-19 who are receiving corticosteroids and require supplemental oxygen or mechanical ventilation. This is because the medication can have significant side effects and should be administered under close medical supervision in a monitored clinical setting.
There is limited data on using this medicine during pregnancy. Talk to your doctor to weigh the potential benefits of controlling your inflammatory condition against any potential risks to the developing baby.
You should limit or avoid alcohol while using this medicine, as both alcohol and this drug can place extra stress on your liver, increasing the risk of liver damage. Talk to your doctor or pharmacist about what is safe for you.
Yes, this medicine must be kept cold. When traveling, use a cooler bag with ice packs to maintain a temperature of 2°C to 8°C (36°F to 46°F), making sure the medicine does not touch the ice directly to prevent freezing. Talk to your pharmacist for travel tips.
A fever is a common sign of an infection, which can become serious very quickly while using this medicine. Contact your doctor immediately and do not take your next dose until you have been evaluated.
Regular blood tests allow your doctor to monitor your liver enzymes, cholesterol levels, and white blood cell counts, ensuring the medicine is not causing hidden side effects in your body.
No, you must rotate your injection sites with each dose to prevent skin irritation, bruising, or the buildup of hard tissue. Talk to your doctor or pharmacist if you need guidance on selecting safe injection areas.

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Country of origin

INDIA

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - TOC0078
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