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Topnac-SP Tablet 10's

Topnac-SP Tablet 10's is used to reduce pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. It works by blocking the action of the enzyme cyclo-oxygenase (COX), which causes pain and swelling in injured or damaged tissue. Also, it helps in the breakdown of a protein (fibrin), which is formed as a by-product of the blood clot at the site of injury. Thus, it causes thinning of the fluids around the injury site, thereby facilitating smoother fluid drainage in the swollen tissue. It may cause common side effects such as nausea, vomiting, indigestion, stomach pain, etc. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACECLOFENAC-100MG+PARACETAMOL-325MG+SERRATIOPEPTIDASE-15MG

Manufacturer/Marketer :

Systopic Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Topnac-SP Tablet 10's

Topnac-SP Tablet 10's is a prescription-strength oral medication designed to relieve severe pain, swelling, and localised inflammation. It is commonly prescribed to treat painful conditions affecting the joints and muscles, such as arthritis, spinal inflammation, and acute muscle spasms. Additionally, it helps manage post-surgical tissue swelling and dental pain.

To achieve the best results, you should take Topnac-SP Tablet 10's consistently and at the exact intervals prescribed by your physician. It is essential to take this tablet with food or a glass of milk to protect your digestive tract from irritation. Incorporating light, low-impact exercises and maintaining a well-balanced diet can also support your body’s natural healing process.

While using Topnac-SP Tablet 10's, some individuals may experience mild side effects like nausea or indigestion. However, if you develop rare but serious symptoms, such as severe stomach pain, dark stools, or yellowing of the skin, you must contact your healthcare provider immediately.

Talk to your doctor before starting Topnac-SP Tablet 10's if you have a history of asthma, kidney problems, or high blood pressure. Do not take this if you have active stomach ulcers, severe heart failure, or a history of allergic reactions to other pain relievers.

Avoid drinking alcohol while taking Topnac-SP Tablet 10's, as the combination can lead to severe liver damage and stomach bleeding. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist before using this medicine, as specific safety precautions must be followed.

Uses of Topnac-SP Tablet 10's

Topnac-SP Tablet 10's is used to treat muscle pain. The detailed uses of Topnac-SP Tablet 10's are as follows:

  • Osteoarthritis and Rheumatoid Arthritis: Topnac-SP Tablet 10's helps reduce the swelling, stiffness, and chronic joint pain associated with these conditions, allowing for better joint mobility.
  • Ankylosing Spondylitis: This medicine may help relieve pain and inflammation caused by ankylosing spondylitis, a type of inflammatory arthritis that mainly affects the spine and can cause stiffness and reduced movement
  • Post-Surgical Pain and Swelling: It aids in recovery by reducing surgical site pain and speeding up the clearance of fluid and swelling around the wound.
  • Dental and Muscle Pain: It targets localised inflammation and tissue swelling, providing rapid relief from acute toothaches and muscle strains.
     

Key Benefits

Topnac-SP Tablet 10's provides reliable, daily support to help you manage your health. This medicine brings several key health benefits:

  • Dual pain relief: Combines aceclofenac and paracetamol to reduce pain through different mechanisms.
  • Reduces inflammation and swelling: Aceclofenac helps decrease inflammatory chemicals, while serratiopeptidase may help reduce swelling and support recovery as part of combination therapy, although the clinical benefits of serratiopeptidase remain under evaluation.
  • Improves mobility: Relief from pain and stiffness may help improve movement in joint and muscle conditions.
  • Supports recovery after injury or procedures: May help manage pain and swelling during recovery when prescribed.
  • Serratiopeptidase is used in some combination medicines for swelling and inflammation; however, its effectiveness is not equally recognised across all clinical guidelines, and further research continues to evaluate its role. 
     

Directions for Use

To get the safest and most effective results from Topnac-SP Tablet 10's, follow these step-by-step instructions carefully:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can interfere with how the medication is absorbed in your body.
  • Always take Topnac-SP Tablet 10's with food or immediately after a meal to minimise the risk of stomach irritation.
  • Take the medicine at the same time each day to maintain a consistent level in your bloodstream.
  • Always follow your doctor's exact instructions regarding how long to take this medication. Do not exceed the prescribed duration.
     

How Topnac-SP Tablet 10's Works

Topnac-SP Tablet 10's combines three active ingredients that work together to tackle pain and swelling from different angles. The first active ingredient is aceclofenac is an non-steroidal anti-inflammatory drug (NSAID). It blocks cyclooxygenase (COX) enzymes, which are involved in making prostaglandins (body chemicals that cause pain and swelling). By reducing these chemicals, aceclofenac helps decrease pain, inflammation, and swelling The second ingredient is paracetamol, a well-known pain reliever and fever reducer. Paracetamol is believed to act mainly within the central nervous system to reduce pain perception and lower fever. Its exact mechanism is not completely understood and may involve effects on central prostaglandin pathways (natural chemicals that contribute to pain, swelling, and inflammation) and other pain-modulating systems. The third ingredient is serratiopeptidase, a proteolytic enzyme (an enzyme that breaks down certain proteins). Serratiopeptidase is a proteolytic enzyme that has been proposed to help break down certain proteins involved in inflammation. Although it may contribute to reducing swelling in some conditions, the clinical evidence supporting its effectiveness in humans is still evolving and varies between studies.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Topnac-SP Tablet 10's to avoid unpleasant side-effects.

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Pregnancy

Caution

Topnac-SP Tablet 10's is generally not recommended during pregnancy. You should consult a healthcare provider for safe pain management options.

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Breast Feeding

Consult your doctor

Only consume Topnac-SP Tablet 10's if it has been prescribed by a doctor as the safety data in nursing mothers is lacking. Inform your doctor if you are breastfeeding.

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Driving

Unsafe

Topnac-SP Tablet 10's may affect driving as it causes dizziness.

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Liver

Caution

Topnac-SP Tablet 10's to be taken with caution, especially if you have a history of liver disease. Doses may have to be adjusted by your doctor.

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Kidney

Caution

Topnac-SP Tablet 10's to be taken with caution, especially if you have a history of kidney disease. Doses may have to be adjusted by your doctor.

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Children

Caution

Topnac-SP Tablet 10's is not recommended for use in children as the safety and efficacy are not established.

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Heart

Unsafe

Topnac-SP Tablet 10's should be avoided in cardiac patients as it can lead to serious cardiavascular risks

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Geriatrics

Caution

Topnac-SP Tablet 10's should be used under caution in geriatric patients as it can lead to serious side effects/

What if I have taken an overdose of Topnac-SP Tablet 10's

Do not take more than the prescribed dose of Topnac-SP Tablet 10's as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Drink plenty of water throughout the day to help your kidneys process the medication safely and to maintain joint lubrication.
  • Eat a diet rich in anti-inflammatory foods, such as leafy greens, berries, nuts, and fatty fish, to naturally support your joint health and recovery.
  • Avoid spicy, highly acidic, or fried foods while taking this medication, as they can worsen stomach irritation or acid reflux.
  • Engage in low-impact physical activities like walking or swimming only as advised by your doctor to keep your joints flexible without straining them.
     

Have a query?

How Soon It Starts Working

  • The time required for Topnac-SP Tablet 10's to start to work: Topnac-SP Tablet 10's ideally shows its action within 1 hour after administration.
  • The time for which the effects of Topnac-SP Tablet 10's last: The duration of action for Topnac-SP Tablet 10's is unknown.

What if you forget to take Topnac-SP Tablet 10's

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

Store Topnac-SP Tablet 10's tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medication in its original blister packaging to protect it from moisture and direct sunlight.

Drug Warnings

  • Check the tablet package carefully before use; do not take if the foil packaging is torn or damaged.
  • Avoid taking other medications containing paracetamol or other non-steroidal anti-inflammatory drug (NSAID) (like ibuprofen or diclofenac) at the same time, as this can lead to an accidental overdose and severe liver damage.
  • Be cautious when driving or operating machinery, as this medication can occasionally cause mild dizziness or drowsiness.
  • If you are scheduled for any surgery or dental procedure, inform your surgeon or dentist that you are taking Topnac-SP Tablet 10's, as it may affect blood clotting.
  • Regularly monitor your kidney and liver function through blood tests if your doctor has prescribed this medication for long-term use.
     

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Blood thinners (like warfarin): May increase the risk of severe stomach bleeding.
  • Other pain relievers (NSAIDs or paracetamol products): May increase the risk of liver damage and stomach ulcers.
  • Blood pressure medications (like ACE inhibitors or diuretics): Topnac-SP Tablet 10's may reduce their effectiveness and increase the risk of kidney strain.
  • Corticosteroids (like prednisone): May increase the risk of stomach ulcers and bleeding.
  • Certain antibiotics (like quinolones): Certain antibiotics such as quinolones, may rarely increase the risk of nervous system side effects, including seizures, when combined with non-steroidal anti-inflammatory drug (NSAID). Inform your doctor if you are taking these medicines, especially if you have a history of seizures.

Drug-Food Interactions

  • Alcohol: Significantly increases the risk of severe liver damage and stomach bleeding.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Topnac-SP Tablet 10's, as it may worsen your condition or cause complications.

  • Active stomach ulcers or bleeding disorders: Can worsen bleeding and damage the digestive tract lining.
  • Asthma: May trigger breathing difficulties or asthma attacks in individuals sensitive to pain relievers.
  • Liver or kidney disease: May worsen organ function, requiring careful monitoring or avoiding use.
  • Severe heart failure: May cause fluid retention and worsen heart function.
     

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Habit Forming

No

Therapeutic Class

[ANALGESIC AND ANTIPYRETIC AGENT]

FAQs

Topnac-SP Tablet 10's is used to relieve pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. It is used to treat pain after any injury, such as low back pain, Cervical pain, Spondyloarthritis, Osteoarthritis, Rheumatoid arthritis, etc.
Yes, in most of the patients it is safe to take Topnac-SP Tablet 10's, but if it causes any unwanted side effects like diarrhoea, vomiting, or nausea, please consult your doctor immediately.
A chronic inflammatory disorder affecting many joints, including those in the hands and feet. In rheumatoid arthritis, the body's immune system attacks its own tissue, including joints. In severe cases, it attacks internal organs. Rheumatoid arthritis affects joint linings, causing painful swelling.
Ankylosing spondylitis (AS) is a rare type of arthritis that causes pain and stiffness in your spine. This lifelong condition, also known as Bechterew disease, usually starts in your lower back. It can spread up to your neck or damage joints in other parts of your body.
No. Topnac-SP Tablet 10's is not indicated for stomach pain. If you have stomach pain, refer to a doctor as it may be a sign of a stomach ulcer or gastric bleeding.
Long-term usage of Topnac-SP Tablet 10's may result in adverse effects; thus, your health should be monitored frequently. It is best to consult your doctor if you are having problems or if your body is not responding to the Topnac-SP Tablet 10's. Depending on your health, your doctor may advise tests. They can provide you with specific guidance and help you manage any potential side effects successfully.
Topnac-SP Tablet 10's is not an antibiotic medication. It is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. Topnac-SP Tablet 10's does not have antibacterial properties like antibiotics do.
Topnac-SP Tablet 10's can be used to relieve pain and inflammation; therefore, it may help temporarily relieve period pain. It is important to talk to your gynaecologist before using the Topnac-SP Tablet 10's to treat menstrual cramps. Your gynaecologist can determine whether this Topnac-SP Tablet 10's is suitable for you and recommend the appropriate dosage based on your medical conditions.
Topnac-SP Tablet 10's can be used to relieve pain and inflammation; therefore, it may help with a toothache. Talking to your dentist before using the Topnac-SP Tablet 10's to treat your toothache is important. Your doctor can determine the actual reason for your toothache if this Topnac-SP Tablet 10's is acceptable to you, and the dentist may recommend the proper dosage and usage.
Yes, Topnac-SP Tablet 10's is a painkiller. It belongs to the class of drugs known as ''nonsteroidal anti-inflammatory drugs'' (NSAIDs) that help to reduce pain and inflammation.
Combiflam and Topnac-SP Tablet 10's are pain relievers, but their ingredients and uses differ. Combiflam is better for general pain and fever, while Topnac-SP Tablet 10's is more effective for musculoskeletal pain, inflammation, and swelling. If you have severe pain or inflammation, Topnac-SP Tablet 10's might be a better choice. However, if you have stomach issues or bleeding, Combiflam might be a safer option. Consult your doctor to determine which medication is best for your specific condition and needs. They will assess your individual situation and provide personalised guidance.
Topnac-SP Tablet 10's and Enzoflam are two different pain relievers with some similarities, but also a key difference. Both medications have paracetamol and serratiopeptidase, which help relieve pain and reduce inflammation. However, Topnac-SP Tablet 10's contains aceclofenac, while Enzoflam contains diclofenac. This difference in ingredients means that your doctor will choose the best one for you based on your specific needs and medical history.
If you are experiencing lower back pain, Topnac-SP Tablet 10's might be worth considering. This medication combines three active ingredients to help relieve muscle and joint pain. However, consulting with your healthcare provider before starting any new medication is crucial. They will evaluate your specific condition, medical history, and other factors to determine the best course of treatment and ensure your safety.
If you have diabetes, consult your doctor before taking Topnac-SP Tablet 10's. This medication may impact blood sugar control, kidney function, and gastrointestinal health. Your doctor will help you weigh the benefits and risks and monitor you closely to ensure your safety.
Topnac-SP Tablet 10's is not usually used to treat piles. Instead, it's primarily designed to relieve pain from conditions such as muscle aches, joint pain, and post-surgery pain. If you are experiencing piles, it's best to consult your doctor for a medication specifically targeting this condition. They can recommend a more appropriate treatment option for you.
Take Topnac-SP Tablet 10's only as directed by your doctor or the product label. Usually, this means taking it every 8-12 hours as needed, but follow the specific instructions given to you.
Topnac-SP Tablet 10's and Zerodol are similar medications but differ in one key ingredient: Serratiopeptidase. Topnac-SP Tablet 10's contains Serratiopeptidase, while Zerodol does not. This difference in formulation may affect how the medications work for you, so it is essential to consult your doctor to determine which one is best for your needs.
Topnac-SP Tablet 10's is primarily used to relieve pain and inflammation, but it can also be used to reduce fever. However, it is not typically the first choice for treating fever alone. If you have a fever, your doctor may recommend a different medication, such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin), depending on the cause and severity of the fever. Always consult your doctor for proper diagnosis and treatment.
Take Topnac-SP Tablet 10's as directed: one tablet every 8-12 hours as needed. Don't take two at once, as this can cause serious side effects. If you need more pain relief, ask your doctor about alternative options. Follow the instructions on the label or your doctor's advice to use Topnac-SP Tablet 10's safely.
Topnac-SP Tablet 10's is not recommended for heart patients because it contains an NSAID, which can increase the risk of heart-related side effects, such as heart attack or stroke, especially with long-term use. If you have a heart condition, consult your doctor before taking Topnac-SP Tablet 10's. They will assess your individual situation and provide personalized guidance on safe treatment options.
Topnac-SP Tablet 10's may not help you with throat pain as its composition consists of anti-inflammatory and pain relievers for muscle, joint, or surgical pain. It's best to consult your doctor for a medication that is specifically designed to address this throat pain issue.
Topnac-SP Tablet 10's is a pain reliever, but it's not for chest pain. If you have chest pain, get medical help right away. It could be a sign of a severe condition like a heart attack. Topnac-SP Tablet 10's might help with mild to moderate pain, but it's not enough for chest pain. If you have chest pain, call emergency services or go to the emergency room. Don't wait!
Topnac-SP Tablet 10's belongs to the class of drugs known as ''nonsteroidal anti-inflammatory drugs'' (NSAID). It is a fixed-dose combination composed of aceclofenac, paracetamol, and serratiopeptidase.
No, don't stop Topnac-SP Tablet 10's-taking suddenly; there can be sudden negative consequences. If you are relieved by your pain, consult with your doctor first. Your doctor will provide you with guidance by examining your health status in detail to decide whether it is safe to stop or continue for some period for complete relief of your issue.
Nausea and vomiting are the most common side effects people may experience while using this Topnac-SP Tablet 10's. These symptoms will go away with time. If they worsen or persist, consult your doctor.
Dizziness is one of the most common side effects of Topnac-SP Tablet 10's. So, caution should be taken while driving a car or bike.
Taking Topnac-SP Tablet 10's is not recommended if you have allergies to any ingredient, severe liver or kidney disease, stomach bleeding, heart failure, or coronary artery disease. Additionally, pregnant or breastfeeding women should avoid it. If you have mild to moderate liver or kidney issues, a history of stomach ulcers, high blood pressure, heart disease, asthma, or bleeding disorders, use caution and consult your doctor. Also, avoid combining it with other pain relievers, blood thinners, blood pressure medications, or water pills. Always follow your doctor's advice, especially if you have underlying medical conditions or take other medications.
You can use Topnac-SP Tablet 10's with the B complex because it does not interact with it. However, make sure to consult your doctor before taking it.
Yes, prolonged usage of the Topnac-SP Tablet 10's may lead to kidney damage, especially for people who are already experiencing kidney problems. It is more important to take the Topnac-SP Tablet 10's under medical supervision only. Your doctor may monitor your daily kidney function if you are prescribed to take the Topnac-SP Tablet 10's for a long period based on your medical condition.
No, you shouldn'tshouldn't take more Topnac-SP Tablet 10's than your doctor has prescribed. It causes major negative effects, including liver damage, renal damage, gastrointestinal bleeding, and cardiovascular problems, which might worsen with higher dosages. If you believe the recommended dosage is not having a significant impact on you, speak with your doctor right away to better understand your condition and receive better care.
Storage: Store the Topnac-SP Tablet 10's in its original container to protect it from the external environment. Keep the medication out of reach of children. Store in a cool and dry place away from sunlight. Disposal: Do not consume it after the expiration date. Check the expiration date, remove the label, keep it in a plastic bag, and throw it in household trash. Do not flush the medication down the toilet or sink.
Some common side effects may include diarrhoea, indigestion, loss of appetite, nausea, stomach pain, stomach upset, and indigestion. Most of these side effects of Topnac-SP Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Topnac-SP Tablet 10's should not be given to children without the prescription of a child specialist. Your doctor will determine the dose of the medicine depending on your child's weight and the severity of the condition.
There is insufficient information on Topnac-SP Tablet 10's's safety for nursing moms, so only take it as directed by a physician.
It is highly recommended to take Topnac-SP Tablet 10's with food or a glass of milk rather than on an empty stomach. Taking it with food helps protect your stomach lining and reduces the risk of side effects like indigestion or stomach upset. Talk to your doctor if you experience persistent stomach discomfort.
No, taking Topnac-SP Tablet 10's is generally not recommended during pregnancy, especially in the third trimester, as it may harm the unborn baby or cause complications during delivery. If you are pregnant or planning to conceive, talk to your doctor to discuss safer alternatives.
You should strictly avoid drinking alcohol while taking Topnac-SP Tablet 10's. Alcohol combined with this medication increases the risk of severe stomach bleeding and can lead to serious liver damage. Talk to your doctor if you have concerns about alcohol use.
Paracetamol may begin providing pain relief within about 30–60 minutes after taking the medicine. Aceclofenac may take longer, often around 1–2 hours, to produce noticeable anti-inflammatory and pain-relieving effects. The swelling-reducing effects of serratiopeptidase, if beneficial, may vary depending on the condition and individual response.
No, you should not take other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, or aspirin alongside Topnac-SP Tablet 10's. Doing so significantly increases the risk of stomach ulcers, bleeding, and kidney damage. Always talk to your doctor or pharmacist before combining any pain medications.
Some people may experience drowsiness, dizziness, or visual disturbances while taking Topnac-SP Tablet 10's. If you feel dizzy or sleepy, avoid driving, riding a bicycle, or operating tools and machinery. Talk to your doctor if these symptoms persist or affect your daily activities.
Do not take extra medicine to make up for a missed dose. Contact your doctor or pharmacist if you are unsure what to do.
Yes, because it contains paracetamol, taking more than the recommended dose of Topnac-SP Tablet 10's or combining it with alcohol can cause severe liver damage. Always stick to the dose prescribed by your healthcare provider and avoid other paracetamol-containing products. Talk to your doctor if you notice yellowing of your skin or eyes.

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Reference

  1. CiplaMed Clinical Compendium. Voltanec Sps Product Specification Guide. Mumbai, India: Cipla; 2024. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Pil.4240 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. VOLTANEC SP [Internet]. CiplaMed. 2021 [Accessed on 7 April 2022] Check here
  4. Acetaminophen (paracetamol)- NCBI [Internet]. Ncbi.nlm.nih.gov. 2021 [Accessed on 7 April 2022] Check here
  5. Manju Tiwari. The role of serratiopeptidase in the resolution of inflammation. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in May 2017] [Accessed on 25th September 2025] Check here
  6. Ciplamed. MOVEXX SP Tablets [Revised in September 2023] [Accessed on 25th September 2025] Check here
  7. Aceclofenac, Paracetamol & Serratiopeptidase [Prescribing Information]. 2021. [Accessed on 24 Mar. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

101, Pragati Chambers, Commercial Complex, Ranjit Nagar, New Delhi-110008.
Other Info - TOP0676
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