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  3. TOSIBAN 37.5MG INJECTION 5ML

TOSIBAN 37.5MG INJECTION 5ML, Pack of 1 INJECTION
TOSIBAN 37.5MG INJECTION 5ML, Pack of 1 INJECTION
TOSIBAN 37.5MG INJECTION 5ML, Pack of 1 INJECTION
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Composition :

ATOSIBAN-37.5MG

Manufacturer/Marketer :

Zuventus Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About TOSIBAN 37.5MG INJECTION 5ML

TOSIBAN 37.5MG INJECTION 5ML belongs to a class of medications called ‘tocolytic agents. It is used in adult women from week 24 to week 33 of the pregnancy to delay the premature birth of the baby. Premature labour occurs when the cervix opens after week 20 but before week 37 of pregnancy as a consequence of regular contractions. Preterm labour can result in premature delivery.

TOSIBAN 37.5MG INJECTION 5ML contains Atosiban, which works by weakening the contractions of the uterus. It also reduces the frequency with which contractions occur. It accomplishes this by inhibiting the function of oxytocin, a natural hormone in your body that causes uterine contractions.

A qualified healthcare professional will administer TOSIBAN 37.5MG INJECTION 5ML. The common side effects are injection site reactions, feeling sick (nausea), being sick (vomiting), headache, feeling dizzy, hot flushes, fast heartbeat, low blood pressure, feeling dizzy or light-headed, and high blood sugar. These side effects usually go away without requiring any treatment. However, if these side effects persist or worsen, inform your doctor immediately.

TOSIBAN 37.5MG INJECTION 5ML may not be suitable for everyone, so tell your doctor about any medical conditions you have, especially if you are less than 24 weeks pregnant, more than 33 weeks pregnant, or amniotic fluid loss (premature rupture of your membranes), or if you have completed 30 weeks of your pregnancy or more, if your unborn baby (foetus) has an abnormal heart rate, or if you have bleeding from your vagina. You should stop breastfeeding while you are given TOSIBAN 37.5MG INJECTION 5ML.

Uses of TOSIBAN 37.5MG INJECTION 5ML

TOSIBAN 37.5MG INJECTION 5ML is used in the prevention of premature labour or premature birth. The detailed uses of TOSIBAN 37.5MG INJECTION 5ML are as follows:<br/>• Prevention of preterm birth: TOSIBAN 37.5MG INJECTION 5ML is used in prevention of preterm birth in women between 24 and 33 weeks of pregnancy.<br/>• Management of early uterine contractions: TOSIBAN 37.5MG INJECTION 5ML is used in management of early uterine contractions to allow more time for fetal development.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• TOSIBAN 37.5MG INJECTION 5ML is administered by the doctor or nurse.• Do not self-administer.

Medicinal Benefits

TOSIBAN 37.5MG INJECTION 5ML contains Atosiban, which belongs to a class of medications called ‘tocolytic agents. It works by delaying the contractions of the uterus. It also reduces the frequency with which contractions occur. It accomplishes this by inhibiting the function of oxytocin, a natural hormone in your body that causes uterine contractions. Thereby delaying the delivery, decreasing the risk of miscarriage, and preventing immature birth.

How TOSIBAN 37.5MG INJECTION 5ML Works

TOSIBAN 37.5MG INJECTION 5ML contains Atosiban, which works by weakening the contractions of the uterus. It also reduces the frequency with which contractions occur. It accomplishes this by inhibiting the function of oxytocin, a natural hormone in your body that causes uterine contractions.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tosiban 37.5mg Injection 5ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of TOSIBAN 37.5MG INJECTION 5ML

As TOSIBAN 37.5MG INJECTION 5ML is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. No specific side effects have been reported under these circumstances.

Drug Warnings

TOSIBAN 37.5MG INJECTION 5ML should not be used if your unborn baby has died, you have or could have an infection of the uterus, your placenta is covering the birth canal, your placenta is detaching from the wall of your womb, or you or your unborn baby have any other conditions that make continuing your pregnancy dangerous. If any of the following apply to you or you are unsure, check your doctor before being given TOSIBAN 37.5MG INJECTION 5ML. Also, let your doctor know about all your medical conditions and the medications you are taking.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Follow a healthy diet. Include vegetables, fruits, and whole grains in your meals.
  • Stay hydrated; drink plenty of water.
  • Cut down on sugars, salts, spicy food, coffee, and alcohol.
  • A heating pad can help ease the pain by placing it on the belly or lower back.
  • Exercise can help ease the pain of menstrual cramps.
  • Avoid stress by performing meditation or yoga.
  • Massage your lower back or abdomen to relieve the pain.
  • Take proper rest.

Habit Forming

No

Therapeutic Class

TOCOLYTIC AGENTS / PRETERM LABOUR PREVENTIVE DRUGS

TOSIBAN 37.5MG INJECTION 5ML Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol as it may cause serious side effects.

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Pregnancy

Safe if prescribed

TOSIBAN 37.5MG INJECTION 5ML is used to prevent premature labour during pregnancy.

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Breast Feeding

Unsafe

You should stop breastfeeding while you are given TOSIBAN 37.5MG INJECTION 5ML.

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Driving

Unsafe

TOSIBAN 37.5MG INJECTION 5ML may cause dizziness and blurred vision. Hence, avoid driving or operating machines until you are alert and your vision is clear.

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Liver

Caution

Limited information is available about using TOSIBAN 37.5MG INJECTION 5ML in patients with liver disease. Inform your doctor before receiving the TOSIBAN 37.5MG INJECTION 5ML if you have a pre-existing or a history of liver disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available about using TOSIBAN 37.5MG INJECTION 5ML in patients with kidney disease. Inform your doctor before receiving the TOSIBAN 37.5MG INJECTION 5ML if you have a pre-existing or a history of kidney disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

TOSIBAN 37.5MG INJECTION 5ML is not recommended for use in children as it is used during pregnancy only.

Have a query?

FAQs

TOSIBAN 37.5MG INJECTION 5ML is used to prevent premature labour or premature birth.

TOSIBAN 37.5MG INJECTION 5ML contains Atosiban works by weakening uterine contractions. It also lessens the frequency with which contractions occur. It accomplishes this by suppressing the activity of oxytocin, a natural hormone in your body that causes the contractions. As a result, the delivery is postponed, the danger of miscarriage is reduced, and premature birth is avoided.

No, do not use TOSIBAN 37.5MG INJECTION 5ML in women who are more than 33 weeks pregnant.

No, do not use TOSIBAN 37.5MG INJECTION 5ML in women who are less than 24 weeks pregnant.

TOSIBAN 37.5MG INJECTION 5ML increases blood glucose levels, so it should be used with caution in pregnant women with diabetes mellitus. In addition, TOSIBAN 37.5MG INJECTION 5ML is not recommended for use in pregnant women with uncontrolled diabetes.

You should consult your doctor on a frequent basis throughout your pregnancy. Take your medications as given by your doctor and take care of any health issues you may have, particularly diabetes, high blood pressure, depression, and thyroid issues. Don&amp;#039;t drink alcohol and quit smoking, as both might make your health worse.

TOSIBAN 37.5MG INJECTION 5ML belongs to a class of drugs known as tocolytic agents. It contains the active ingredient Atosiban, which delays premature birth in pregnant women.

TOSIBAN 37.5MG INJECTION 5ML is usually administered by a healthcare provider in a medical setting. The standard procedure involves three stages over 48 hours: an initial intravenous injection, a high-dose infusion over three hours, and a lower-dose infusion for up to 45 hours. If contractions return, the treatment can be repeated up to three more times. Always follow the doctor's instructions and never self-administer it.

The possible side effects associated with TOSIBAN 37.5MG INJECTION 5ML may include injection site reactions, nausea, vomiting, headache, dizziness, hot flushes, fast heartbeat, low blood pressure, light-headedness, and high blood sugar. These side effects are usually temporary and resolve when the treatment is stopped. However, if they persist or worsen, inform your doctor immediately.

Country of origin

India

Manufacturer/Marketer address

Office No. 5119, 5th Floor, 'D' Wing, Oberoi Garden Estates, Chandivili, Andheri (E), Mumbai - 400 072.
Other Info - TOS0024

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.3262.pdf
  2. https://www.ema.europa.eu/en/documents/product-information/atosiban-sun-epar-product-information_en.pdf
  3. https://www.nhs.uk/pregnancy/labour-and-birth/signs-of-labour/premature-labour-and-birth/#:~:text=If%20you're%20in%20premature%20labour%20and%20you're%2024,30%20to%2033%20weeks%20pregnant.
  4. https://go.drugbank.com/drugs/DB09059

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