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compositionComposition:INSULIN DEGLUDEC-100IU
prescription
Prescription Medicine
info
Tresiba 100U/ml Penfil Injection 3 ml
Tresiba 100U/ml Penfil Injection 3 ml
Tresiba 100U/ml Penfil Injection 3 ml
Tresiba 100U/ml Penfil Injection 3 ml

Tresiba 100U/ml Penfil Injection 3 ml is used for the treatment of type 1 and type 2 diabetes mellitus in both children (above 1 year of age) and adults. It contain Insulin degludec, which is a fast-acting insulin that works rapidly to normalize blood sugar levels by helping the sugar move from the blood into other tissues of the body. It prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver. It may cause common side effects such as hypokalaemia (low potassium), hypoglycemia (low blood sugar level), local injection site reactions, lipodystrophy (fat deposition under the skin), rash, and pruritus (itch skin) which may occur at the injection site.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

INSULIN DEGLUDEC-100IU

Manufacturer/Marketer :

Novo Nordisk India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tresiba 100U/ml Penfil Injection 3 ml

Tresiba 100U/ml Penfil Injection 3 ml is a long-acting injection used to control high blood sugar in adults and children with diabetes mellitus. By maintaining stable insulin levels, it helps prevent serious long-term complications associated with high blood sugar. It is an essential part of daily diabetes management for individuals who require ongoing blood sugar control.

You will typically inject Tresiba 100U/ml Penfil Injection 3 ml once daily, and it is highly recommended to keep your injection times as consistent as possible. This medicine can be injected with or without food. Alongside this treatment, incorporating a balanced diet plan and regular physical activity will significantly improve your overall blood sugar control.

While using Tresiba 100U/ml Penfil Injection 3 ml , you may experience common side effects such as mild low blood sugar or redness and swelling at the injection site. If you experience severe symptoms like extreme confusion, sweating, or signs of a serious allergic reaction, you must consult your doctor immediately.

Talk to your doctor before starting this medicine if you have a history of kidney disease, liver damage, or heart problems. Do not take this if you are currently experiencing an episode of low blood sugar or if you are allergic to any of the ingredients in this injection.

Certain medications, alcohol, and smoking can affect how Tresiba 100U/ml Penfil Injection 3 ml works, potentially causing your blood sugar to drop too low or rise too high. If you are pregnant, breastfeeding, or an elderly individual, consult your doctor or pharmacist to discuss your specific care plan.

Uses of Tresiba 100U/ml Penfil Injection 3 ml

Tresiba 100U/ml Penfil Injection 3 ml is used to help control blood sugar levels in people with diabetes. It is commonly prescribed for:

  • Type 1 Diabetes Mellitus: Tresiba 100U/ml Penfil Injection 3 ml helps by replacing the natural insulin that your body is unable to produce, helping move sugar from your blood into your body's cells to be used for energy.
  • Type 2 Diabetes Mellitus: Tresiba 100U/ml Penfil Injection 3 ml helps lower and stabilise high blood sugar levels when oral diabetes medications or other types of insulin are not sufficient to manage your condition.
     

Key Benefits

Tresiba 100U/ml Penfil Injection 3 ml is a long-acting insulin that provides steady blood sugar control throughout the day and night. It helps reduce blood sugar fluctuations and supports the long-term management of diabetes.

  • Provides Long-Lasting Blood Sugar Control: Delivers a steady supply of insulin to help maintain stable blood glucose levels for up to 24 hours or longer.
  • Reduces Blood Sugar Fluctuations: Helps minimise sudden spikes and drops in blood sugar, supporting more consistent glucose control.
  • Lowers the Risk of Diabetes Complications: Maintaining good blood sugar control helps reduce the risk of complications affecting the eyes, kidneys, nerves, heart, and blood vessels.
  • Supports Daily Well-Being: Stable blood sugar levels may help improve energy levels and overall quality of life.
  • Offers Flexible Diabetes Management: Its long duration of action allows convenient once-daily dosing in most patients, as prescribed by the doctor.
     
Side effects of Tresiba 100U/ml Penfil Injection 3 ml
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Administer Tresiba 100U/ml Penfil Injection 3 ml subcutaneously as instructed by the doctor. Your doctor will train you on how to use Tresiba 100U/ml Penfil Injection 3 ml at home.
  • Check the label for directions and use it as advised by the doctor. Tresiba 100U/ml Penfil Injection 3 ml should be administered subcutaneously (under the skin) in the thighs, abdomen, buttocks, or upper arm.
  • Rotate the injection site each time.
  • Do not inject into the areas where the skin is tender, red, bruised, hard, scarred, or has stretch marks.

How Tresiba 100U/ml Penfil Injection 3 ml Works

The main active component of Tresiba 100U/ml Penfil Injection 3 ml , insulin degludec, works as a long-acting insulin that mimics the natural baseline insulin your pancreas normally releases. Once injected under the skin, it forms a slow-release repository in your fat tissue. From there, the medicine is gradually and continuously absorbed into your bloodstream at a very steady rate. This continuous release ensures there is no sharp peak or sudden drop in your insulin levels for over 24 hours. Once in the bloodstream, Tresiba 100U/ml Penfil Injection 3 ml helps your body’s cells absorb glucose from your blood to use for energy, while also signalling your liver to stop producing excess sugar.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Tresiba 100U/ml Penfil Injection 3 ml to avoid unpleasant side-effects. Alcohol may either decrease or increase the blood sugar level which can be fatal.

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Pregnancy

Safe if prescribed

Tresiba 100U/ml Penfil Injection 3 ml can be used during pregnancy. Your insulin dose may need to be changed during pregnancy and after delivery.

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Breast Feeding

Safe if prescribed

Tresiba 100U/ml Penfil Injection 3 ml can be given safely to nursing mothers but only under the supervision of a physician.

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Driving

Unsafe

Drive with caution, Tresiba 100U/ml Penfil Injection 3 ml usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycaemia (low blood sugar).

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Liver

Caution

Tresiba 100U/ml Penfil Injection 3 ml to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Tresiba 100U/ml Penfil Injection 3 ml to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Tresiba 100U/ml Penfil Injection 3 ml can be given safely to children more than 1-year-old; dose has to be prescribed by a child specialist.

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Heart

Caution

Tresiba 100U/ml Penfil Injection 3 ml should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Tresiba 100U/ml Penfil Injection 3 ml .

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Geriatrics

Caution

Tresiba 100U/ml Penfil Injection 3 ml should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Tresiba 100U/ml Penfil Injection 3 ml

An overdose can cause severe, life-threatening low blood sugar (hypoglycemia). If you experience confusion, sweating, tremors, or weakness, consume fast-acting sugar immediately (like fruit juice, non-diet soda, or glucose tablets). If someone using this medicine faints or becomes unresponsive, seek emergency medical attention or call your local poison control centre right away.

Diet & Lifestyle Advise

  • Monitor your blood sugar regularly: Keep a daily log of your readings as directed by your doctor to track how well your treatment is working.
  • Eat balanced, regular meals: Avoid skipping meals or changing your eating schedules dramatically, as this can cause your blood sugar to drop dangerously low.
  • Carry fast-acting sugar at all times: Always keep glucose tablets, fruit juice, or hard candies with you to quickly treat sudden episodes of low blood sugar.
  • Stay active, but plan ahead: Regular exercise helps manage your condition, but you should check your blood sugar before and after physical activity, as exercise can lower your sugar levels.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys flush out excess sugar.
     

Have a query?

How Soon It Starts Working

The time required for Tresiba 100U/ml Penfil Injection 3 ml to start to work: The time required for Tresiba 100U/ml Penfil Injection 3 ml to start to work is 60 minutes after administration. The time for which the effects of Tresiba 100U/ml Penfil Injection 3 ml last: The duration of action for Tresiba 100U/ml Penfil Injection 3 ml is not clinically established.

What if you forget to take Tresiba 100U/ml Penfil Injection 3 ml

If you miss a dose of Tresiba 100U/ml Penfil Injection 3 ml , inject it as soon as you remember. However, you must ensure there are at least 8 hours between your doses. If your next scheduled dose is less than 8 hours away, skip the missed dose and resume your regular once-daily schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store the medicine in your refrigerator between 2°C and 8°C. •Do not freeze this medicine, and keep it away from the refrigerator's cooling elements.
icon image

Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect Before Use: Do not use the insulin if it appears cloudy, coloured, thickened, or contains particles. It should be clear and colourless.
  • Never Share Injection Devices: Do not share insulin pens, cartridges, needles, or syringes with anyone to prevent the spread of infections.
  • Rotate Injection Sites: Alternate injection sites between the abdomen, thigh, and upper arm to reduce the risk of skin thickening or fat tissue changes.
  • Use a New Needle Each Time: Always attach a new sterile needle before each injection and remove it immediately after use.
  • Avoid Alcohol: Alcohol may cause unpredictable changes in blood sugar levels and increase the risk of hypoglycaemia.
  • Plan Ahead for Travel: If travelling across time zones, consult your doctor about adjusting your insulin schedule.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Tresiba 100U/ml Penfil Injection 3 ml :

  • Other Diabetes Medicines: Using insulin with other antidiabetic medicines may increase the risk of low blood sugar.
  • Beta-Blockers: Medicines such as atenolol or metoprolol may mask warning signs of low blood sugar, such as a rapid heartbeat.
  • Corticosteroids and Thyroid Medicines: These medicines may increase blood sugar levels and require adjustment of your insulin dose.

Drug-Food Interactions

Certain foods and drinks may affect how Tresiba 100U/ml Penfil Injection 3 ml works or increase the risk of side effects.

  • Alcohol: Avoid or limit alcohol consumption, as it can cause unpredictable changes in blood sugar levels and increase the risk of severe hypoglycaemia. 

Drug-Disease Interactions

Certain medical conditions may affect how Tresiba 100U/ml Penfil Injection 3 ml works or increase the risk of side effects. Inform your doctor if you have any of the following conditions before starting treatment.

  • Kidney disease or liver damage: These conditions can slow down how your body clears insulin, meaning you may need a gradually decreasing dose to prevent low blood sugar.
  • Heart failure: Taking this medicine with certain oral diabetes drugs (such as thiazolidinediones) can cause or worsen fluid retention and heart failure.
     
Insulin degludecGemifloxacin
Severe
Insulin degludecLevofloxacin
Severe

Drug-Drug Interactions

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Insulin degludecGemifloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Gemifloxacin affects blood glucose levels, which may cause hyperglycaemia (high blood glucose) and hypoglycaemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and Gemifloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycaemia or hyperglycaemia. Symptoms of hypoglycaemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycaemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecLevofloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Coadministration of levofloxacin and Tresiba 100U/ml Penfil Injection 3 ml can sometimes affect blood glucose levels - Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose).

How to manage the interaction:
Although using levofloxacin and Tresiba 100U/ml Penfil Injection 3 ml at the same time may cause an interaction, they can be taken together if a doctor has prescribed it. Inform doctor if you develop hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose), or if you have trouble controlling your blood glucose. Hypoglycemia symptoms include headache, dizziness, tiredness, anxiety, disorientation, a shaking sensation, nausea, hunger, weakness, sweating, palpitation, and a rapid pulse. Hyperglycemia symptoms include Increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecEnoxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Enoxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia(low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and cinoxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecNalidixic acid
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with nalidixic acid affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and nalidixic but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecSparfloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with sparfloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and sparfloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecCinoxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with cinoxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and Cinoxacin, it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecGatifloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Gatifloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia less frequently.

How to manage the interaction:
There could be a possible interaction between insulin aspart and Gatifloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecMoxifloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Moxifloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and Moxifloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience headache, dizziness, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecOfloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with ofloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and ofloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecCiprofloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with ciprofloxacin can effect blood sugar levels, both hyperglycemia (high blood sugar) and, less frequently, hypoglycemia (low blood sugar).

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and Ciprofloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, excessive sweating, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Tresiba 100U/ml Penfil Injection 3 ml is used for the treatment of type 1 and type 2 diabetes mellitus in both children (above 1 year of age) and adults.
Tresiba 100U/ml Penfil Injection 3 ml is only a part of a complete diabetes control program that includes regular blood sugar testing, diet, exercise, weight control, and special medical care. So follow all the instructions given by the doctor.
It is advised to tell all the medicines that you are using like pioglitazone or rosiglitazone as taking other diabetes medicines may increase the risk of serious heart problems.
Tresiba 100U/ml Penfil Injection 3 ml typically begins working after 60 minutes and will last for more than 24 hours.
Tresiba 100U/ml Penfil Injection 3 ml can be given to treat both the condition of type 1 and type 2 diabetes mellitus. However, your doctor will decide whether Tresiba 100U/ml Penfil Injection 3 ml can be given to you or not depending on your present condition. Tresiba 100U/ml Penfil Injection 3 ml should be avoided in patients who are allergic to Tresiba 100U/ml Penfil Injection 3 ml or other forms of insulin, patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycemia), and low potassium level (hypokalaemia).
Try to avoid intake of alcoholic beverages with Tresiba 100U/ml Penfil Injection 3 ml as it may increase or decrease your blood sugar level.
If you experience low blood sugar, eat glucose tablets, or another high sugar snack (e.g. sweets, biscuits, fruit juice). Measure your blood sugar if possible and rest. Always carry glucose tablets or high sugar snacks with you. You should give a call to any of your family members if you are feeling dizziness or drowsiness.
Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.
Tresiba 100U/ml Penfil Injection 3 ml should not be discontinued without a doctor's consultation as stopping Tresiba 100U/ml Penfil Injection 3 ml may cause severe hypoglycaemia (low blood sugar) and ketoacidosis (buildup of acid in the blood). Consult the doctor if you feel uncomfortable after taking Tresiba 100U/ml Penfil Injection 3 ml .
Maintain a healthy diet and exercise regularly. Limit sugar intake and avoid smoking & alcohol consumption. Manage stress by doing meditation or yoga.
Hypoglycaemia (low blood sugar) may occur because you inject too much insulin, miss or delay meals, do not eat enough, eat food containing less carbohydrate than normal, drink alcohol, lose carbohydrates due to vomiting or diarrhoea, do more exercise than usual or a different type of physical activity, are recovering from an injury, illness, operation or stress, or are taking/have stopped taking other medicines.
Tresiba 100U/ml Penfil Injection 3 ml is a long-acting human insulin analogue produced by rDNA process in Saccharomyces cerevisiae followed by chemical modification.
No, insulin glargine and Tresiba 100U/ml Penfil Injection 3 ml are not the same. Tresiba 100U/ml Penfil Injection 3 ml contains insulin degludec which has a longer half-life compared to insulin glargine. Insulin degludec and insulin glargine provide similar glycemic control, but insulin degludec also lowers the risk of low blood sugar.
Tresiba 100U/ml Penfil Injection 3 ml contains insulin degludec. Insulin degludec and insulin detemir were found to be equally effective in managing blood sugar levels.
Avoid sharing Tresiba 100U/ml Penfil Injection 3 ml , insulin syringe or needle with other patients. Do not miss meals and regularly monitor blood sugar levels. Avoid driving or operating machinery until you know how this medicine affects you. Do not consume alcohol or use prescription or over-the-counter medicines that contain alcohol.
Yes, Tresiba 100U/ml Penfil Injection 3 ml can be used alone to treat diabetes. However, Tresiba 100U/ml Penfil Injection 3 ml can be used with other diabetic medicines if prescribed by the doctor.
Yes, Tresiba 100U/ml Penfil Injection 3 ml is a long-acting basal human insulin analogue that is used to improve glycaemic control in patients with diabetes mellitus.
Yes, Tresiba 100U/ml Penfil Injection 3 ml can cause weight gain due to the anabolic effects of insulin. Eating healthy food and exercising regularly may help manage weight gain.
Tresiba 100U/ml Penfil Injection 3 ml does not raise blood sugar. However, hyperglycaemia has been reported with repeated insulin injections into areas of localised cutaneous amyloidosis (clumps of abnormal proteins called amyloids build up in the skin). Also, changes in insulin regimen may cause high/low blood sugar levels.
Side effects of Tresiba 100U/ml Penfil Injection 3 ml include hypoglycaemia (low blood sugar level), local injection site reactions, lipodystrophy (fat deposition under the skin), rash, and pruritus (itching skin) which may occur at the injection site. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
You should inject Tresiba 100U/ml Penfil Injection 3 ml once daily, preferably at the same time each day, to maintain steady blood sugar levels. Talk to your doctor or pharmacist to establish the best daily schedule for your routine.
No, you should never mix Tresiba 100U/ml Penfil Injection 3 ml with any other insulin or liquids in the same syringe or pen. Doing so can change how the medicine works and lead to unpredictable blood sugar levels. Talk to your doctor or pharmacist if you require multiple types of insulin.
If you notice signs of low blood sugar (such as shakiness, sweating, or dizziness), consume 15 to 20 grams of fast-acting sugar, such as fruit juice, regular soda, or glucose tablets. Check your blood sugar again after 15 minutes. If it is still low, repeat the process, and talk to your doctor if this happens frequently.
Once opened, you can keep Tresiba 100U/ml Penfil Injection 3 ml at room temperature (below 30°C) or in the refrigerator for up to 8 weeks. Always keep the pen cap on to protect it from light, and throw away any remaining liquid after 8 weeks. Talk to your pharmacist if you have questions about storage.
Managing blood sugar is incredibly important during pregnancy and breastfeeding, but your insulin requirements may change during these times. Talk to your doctor to see if Tresiba 100U/ml Penfil Injection 3 ml is the right choice for you and how to adjust your dose safely.
Inject Tresiba 100U/ml Penfil Injection 3 ml under the skin of your upper arm, thigh, or abdomen as instructed by your doctor. Never inject it into a vein or muscle. Rotate injection sites with each dose to help prevent fatty lumps, thickened skin, or pits that may affect insulin absorption.
If no insulin comes out when you press the button, change the needle immediately. Always use a new, sterile needle for every injection to prevent blockages, contamination, and pain. Talk to your pharmacist if you continue to have trouble with your injection device.
You can remain active, but physical activity can cause your blood sugar to drop, especially if you exercise the muscle group near your injection site. Monitor your blood sugar levels closely before, during, and after exercise, and talk to your doctor about how to balance your activity with your doses.
Common symptoms of low blood sugar include sweating, pale skin, shakiness, headache, rapid heartbeat, hunger, dizziness, drowsiness, anxiety, confusion, difficulty concentrating, and temporary vision changes. If you experience these symptoms, consume 15–20 g of fast-acting sugar (such as glucose tablets, fruit juice, or regular soda), recheck your blood sugar after 15 minutes, and repeat treatment if needed. Contact your doctor if episodes occur frequently or do not improve.

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Reference

  1. U.S. Food and Drug Administration (FDA). 203314Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Insulin Degludec Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. Insulin degludec injection [Prescribing Information]. 2016. [Accessed on 17 Oct. 2017] Check here
  4. Zinman B, Philis-Tsimikas A, Cariou B, et al. Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: A 1-year, randomized, treat-to-target trial (BEGIN Once Long). Diabetes Care. 2012;35(12):2464-71 Check here
  5. Novo Nordisk A/S. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Assessed on 18th January 2024 ] Check here
  6. Tresiba [Summary of Product Characteristics]. 2017. [Accessed on 08 Oct. 2021]Check here

Country of origin

India

Manufacturer/Marketer address

Plot No.32, 47-50, EPIP Area, Whitefield, Bangalore - 560 066
Other Info - TRE0214

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