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compositionComposition:GLIMEPIRIDE-1MG+METFORMIN-500MG+PIOGLITAZONE-15MG
prescription
Prescription Medicine
info
Tri Glynase 1 Tablet 10's
Tri Glynase 1 Tablet 10's
Tri Glynase 1 Tablet 10's
Tri Glynase 1 Tablet 10's
Tri Glynase 1 Tablet 10's

Tri Glynase 1 Tablet is used to treat type 2 diabetes. It works by reducing sugar production in the liver, delaying sugar absorption from the intestines, and removing sugar from the blood. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-1MG+METFORMIN-500MG+PIOGLITAZONE-15MG

Manufacturer/Marketer :

USV Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tri Glynase 1 Tablet

Tri Glynase 1 Tablet belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose.

Tri Glynase 1 Tablet contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Tri Glynase 1 Tablet helps to control blood sugar levels.

In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache, a metallic taste, or low blood sugar. Most of these side effects of Tri Glynase 1 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tri Glynase 1 Tablet or any other medicines, please tell your doctor. Tri Glynase 1 Tablet is not recommended for children. Consult your doctor if you are breastfeeding, pregnant or planning for pregnancy. Avoid alcohol consumption with Tri Glynase 1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Tri Glynase 1 Tablet

Tri Glynase 1 Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Tri Glynase 1 Tablet are as follows:

  • Manages Type 2 Diabetes Mellitus: Tri Glynase 1 Tablet to treat type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
  • Reduces Risk of Diabetes-Related Complications: By effectively controlling blood sugar levels, Tri Glynase 1 Tablet helps reduce the risk of long-term complications such as neuropathy and cardiovascular disease.

Key Benefits

  • Tri Glynase 1 Tablet is effective in controlling blood sugar levels in people with Type 2 Diabetes.
  • It combines three complementary antidiabetic agents to provide comprehensive glycemic control when diet, exercise, or monotherapy is insufficient.
  • Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.
  • Metformin works by reducing the sugar production by cells in the liver and delaying sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.
  • Pioglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enabling them to remove glucose from the blood more effectively.
  • This medicine ensures long-lasting glycaemic control, reducing the frequency of dosage. It also prevents unnecessary sugar spikes.
  • Tri Glynase 1 Tablet manages blood glucose levels, thereby lowering the risk of complications such as nerve problems, kidney problems, eye problems, and cardiovascular disease.
Side effects of Tri Glynase 1 Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Tri Glynase 1 Tablet can be taken with food to avoid stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Tri Glynase 1 Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Tri Glynase 1 Tablet Works

Tri Glynase 1 Tablet contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Tri Glynase 1 Tablet helps to control blood sugar levels.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Tri Glynase 1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Tri Glynase 1 Tablet is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tri Glynase 1 Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Tri Glynase 1 Tablet if you are breastfeeding.

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Driving

Caution

Tri Glynase 1 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Tri Glynase 1 Tablet .

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Liver

Caution

Take Tri Glynase 1 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Tri Glynase 1 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Tri Glynase 1 Tablet is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

Tri Glynase 1 Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Tri Glynase 1 Tablet .

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Geriatrics

Caution

Tri Glynase 1 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Tri Glynase 1 Tablet .

What if I have taken an overdose of Tri Glynase 1 Tablet

Take Tri Glynase 1 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include loss of consciousness, lactic acidosis (buildup of lactic acid in the blood), and pancreatitis (inflammation of the pancreas). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Health Queries

I have been taking Tri glynase 1 for the past four years, but my fasting blood sugar is still above 220 mg/dL, and my post-lunch blood sugar is 270 mg/dL. What alternative medication or dosage adjustment should I take to better control my blood sugar levels?

Vikas Singh

Vikas Singh

M Pharmacy

Your blood sugar levels (fasting 220 mg/dL and post-lunch 270 mg/dL) are elevated, suggesting your current treatment needs to be updated. Your medication Tri glynase 1 is a combination of glimepiride, metformin, and pioglitazone. Over four years, the body?s response to diabetes medications can naturally change. Your doctor may suggest safely increasing the doses of these generic medicines, or adding other classes like DPP-4 inhibitors, SGLT2 inhibitors, or insulin to bring your levels into a target range. Please do not change your dosage on your own. I highly recommend consulting your doctor soon, preferably with a recent HbA1c test, to safely adjust your prescription.

I have been a diabetic patient for the last 6 to 7 years and regularly take Tri glynase 1 mg twice daily. Since my fasting blood sugar level is high at 200 mg/dL, is this medication safe for long-term use, or do I need to change my medicine?

Vikas Singh

Vikas Singh

M Pharmacy

While the active ingredients in your current treatment, Tri glynase 1 (glimepiride, metformin, and pioglitazone), are generally safe for long-term use, your fasting blood sugar of 200 mg/dL indicates that your diabetes is not currently well-controlled. Over time, the body's response to diabetes medications can change. There is no need to panic, but your treatment plan likely needs an adjustment. This could involve modifying your dosage, adding a different class of medication, or focusing more on diet and exercise. Please consult your doctor soon to check your HbA1c levels and safely update your prescription. Do not change your dosage without medical guidance.

Have a query?

How Soon It Starts Working

The time required for Tri Glynase 1 Tablet to start to work: Tri Glynase 1 Tablet ideally shows its action within a few hours after administration.

The time for which the effects of Tri Glynase 1 Tablet last: The duration of action for Tri Glynase 1 Tablet is clinically unknown.

What if you forget to take Tri Glynase 1 Tablet

If you miss a dose of Tri Glynase 1 Tablet , take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Tri Glynase 1 Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are allergic to Tri Glynase 1 Tablet or any other medicines, please tell your doctor.
  • Tri Glynase 1 Tablet is not recommended for children.
  • Avoid breastfeeding while taking Tri Glynase 1 Tablet as it may be excreted in human milk.
  • If you are pregnant or planning for pregnancy, please inform your doctor before taking Tri Glynase 1 Tablet as it may harm the unborn baby.
  • Tri Glynase 1 Tablet should be used with caution in elderly patients.
  • Avoid alcohol consumption with Tri Glynase 1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
  • Drive only if you are alert after taking Tri Glynase 1 Tablet .
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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Drug-Drug Interaction: Tri Glynase 1 Tablet may have interaction with other antidiabetic drugs (insulin, sitagliptin, empagliflozin), water pill (furosemide), antithyroid drugs (levothyroxine), anticonvulsant (pregabalin).

Drug-Food Interaction: No interaction found.

Drug-Disease Interaction: If you have bladder cancer, uncontrolled diabetes, lactic acidosis, diabetic ketoacidosis (accumulation of ketone bodies in the blood), or eye problems caused by diabetes, liver, kidney, or heart problems, inform your doctor before taking Tri Glynase 1 Tablet .

Metformin + Pioglitazone + GlimepirideMetrizamide
Critical
Metformin + Pioglitazone + GlimepirideGatifloxacin
Critical

Drug-Drug Interactions

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Metformin + Pioglitazone + GlimepirideMetrizamide
Critical
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideGatifloxacin
Critical
How does the drug interact with Tri Glynase 1 Tablet:
Taking Glimepiride with Gatifloxacin may cause both low blood glucose and, less frequently, high blood glucose.

How to manage the interaction:
Gatifloxacin is not recommended for patients with diabetes, however, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideIomeprol
Critical
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIodixanol
Critical
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIodamide
Critical
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIopamidol
Critical
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIopromide
Critical
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideLevofloxacin
Severe
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Glimepiride with Levofloxacin can cause both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose).

How to manage the interaction:
Co-administration of Levofloxacin with Glimepiride can result in an interaction, it can be taken if a doctor has advised it. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideTeriflunomide
Severe
How does the drug interact with Tri Glynase 1 Tablet:
Co-administration of Teriflunomide and Pioglitazone may increase the risk of liver damage.

How to manage the interaction:
Although taking Pioglitazone and Teriflunomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Metformin + Pioglitazone + GlimepirideClopidogrel
Severe
How does the drug interact with Tri Glynase 1 Tablet:
Taking Pioglitazone with Clopidogrel can increases the blood levels of Pioglitazone, this may lead to hypoglycemia (low blood sugar).

How to manage the interaction:
Taking Clopidogrel together with Pioglitazone may lead to interaction, but it can be taken if prescribed by a doctor. Consult a doctor immediately if you experience any symptoms like headache, dizziness, drowsiness, nervousness, weakness, shakings, nausea, hunger, sweating, and palpitation. Do not discontinue any medication without consulting the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

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FAQs

Tri Glynase 1 Tablet is used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
Tri Glynase 1 Tablet contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Tri Glynase 1 Tablet helps to control blood sugar levels.
Tri Glynase 1 Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.
You are not recommended to take Tri Glynase 1 Tablet with pregabalin as it may cause weight gain and fluid retention that could lead to heart failure. However, please consult a doctor before using Tri Glynase 1 Tablet with other medicines.
In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are completely destroyed. In type 2 diabetes, though islet cells are working, the body does not respond to insulin as the body becomes resistant to it.
You are not recommended to stop taking Tri Glynase 1 Tablet on your own, as discontinuing Tri Glynase 1 Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Tri Glynase 1 Tablet , please consult your doctor so that alternative medicine may be prescribed.
Yes, Tri Glynase 1 Tablet may cause stomach upset as a side effect. Drink water/fluids in small, frequent amounts and chew the food properly while eating.
You are recommended to avoid consumption of alcohol with Tri Glynase 1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
Inform the doctor if you are taking any other medicines, have any other medical conditions, and if you are pregnant or breastfeeding.
Yes, Tri Glynase 1 Tablet may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin b12 deficiency such as headache, loss of appetite, fatigue, mental impairment, pins and needle sensation, and pale skin.
Store Tri Glynase 1 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Tri Glynase 1 Tablet may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. If the side effects persist or worsen, please consult your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai - 400 088. , India.
Other Info - TRI0479

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