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  1. Home
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  3. Uriset 40mg Tablet

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Uriset 40mg Tablet, Pack of 1 Tablet
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Composition :

FEBUXOSTAT-40MG

Manufacturer/Marketer :

Cam Neuro Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Uriset 40mg Tablet

Uriset 40mg Tablet is used to prevent severe gout attacks or flares. Gout is a chronic condition caused by the deposition of uric acid crystals in the joints. It is characterised by intense pain and swelling at the affected joints.

Uriset 40mg Tablet contains febuxostat, which works by inhibiting the enzyme xanthine oxidase (an enzyme that helps your body produce uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints.

The common side effects of Uriset 40mg Tablet include nausea, rash, dizziness, diarrhoea, pain, and localised swelling due to fluid retention in tissues (oedema). Most of these side effects of Uriset 40mg Tablet do not require medical attention and typically resolve on their own over time. However, if the side effects persist, contact your doctor.

Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment. To help you remember, take it at the same time each day. Tell your doctor if your condition does not improve or worsens (if your blood sugar is too high or too low).

Inform your doctor if you are allergic to Uriset 40mg Tablet, have a heart problem (Uriset 40mg Tablet may cause heart problems that can lead to a heart attack), or have kidney/liver disease. The safety and effectiveness of children under 18 years of age have not been established, so Uriset 40mg Tablet should not be given to them. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Uriset 40mg Tablet.

Uses of Uriset 40mg Tablet

Uriset 40mg Tablet is used to treat severe gout and prevent gout attacks. The detailed uses of Uriset 40mg Tablet are as follows:

  • Gout Management: Uriset 40mg Tablet helps to manage gout by lowering uric acid levels, reducing pain, redness, and swelling in the joints.
  • Chronic Kidney Disease Support: Uriset 40mg Tablet also supports patients with chronic kidney disease by managing uric acid levels, which can help in protecting kidney function.
  • Prevention of Gout Attacks: Uriset 40mg Tablet is also involved in preventing gout attacks by maintaining normal uric acid levels, thereby reducing the frequency of painful episodes.
  • Uric Acid Nephrolithiasis Prevention: Uriset 40mg Tablet can prevent uric acid kidney stones by reducing uric acid levels, lowering the risk of related complications.
  • Treatment of Tumour Lysis Syndrome: Uriset 40mg Tablet manages tumour lysis syndrome in chemotherapy patients by preventing high uric acid levels caused by rapid cell breakdown.

Have a query?

Directions for Use

  • Uriset 40mg Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Uriset 40mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Uriset 40mg Tablet belongs to a class of medications called xanthine oxidase inhibitors (enzymes that help your body make uric acid) used to prevent gout attacks or flares.
  • It works by inhibiting the enzyme xanthine oxidase, thereby reducing the level of uric acid produced in the body.
  • Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation.

How Uriset 40mg Tablet Works

Uriset 40mg Tablet contains febuxostat. It works by inhibiting the enzyme xanthine oxidase (an enzyme that helps your body make uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Uriset 40mg Tablet
  • Drink plenty of water to eliminate uric acid.
  • Avoid purine-rich foods such as red meat, organ meats, certain seafood (sardines, anchovies) and too much alcohol.
  • Regularly do low impact exercises like swimming or walking.
  • To reduce pain and swelling, apply ice packs to the affected area.
  • Take rest and avoid activities that strain the affected joint.
  • Elevate the affected joint to encourage fluid drainage.
  • Aim for weight loss and maintain a healthy body weight to reduce the risk of gout.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Uriset 40mg Tablet

Do not take more than the prescribed dose of Uriset 40mg Tablet as it may cause severe side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • You should avoid taking Uriset 40mg Tablet if you are allergic to any of its components or have heart-related problems, as it increases the risk of a heart attack.
  • Inform your doctor if you are allergic to any other medicines. It should be used cautiously in patients with kidney problems and blood disorders.
  • Stopping Uriset 40mg Tablet may worsen your condition and increase the risk of increased uric acid levels and future gout attacks. So, do not stop Uriset 40mg Tablet on your own.
  • Some people experience more gout flare-ups when they start taking Uriset 40mg Tablet. You should continue taking this medicine even if gout flare-ups occur. Your doctor may prescribe a combination therapy to prevent flare-ups when you start Uriset 40mg Tablet.

Drug-Drug Interactions

verifiedApollotooltip
FebuxostatMercaptopurine
Critical
FebuxostatAzathioprine
Critical

Drug-Drug Interactions

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FebuxostatMercaptopurine
Critical
How does the drug interact with Uriset 40mg Tablet:
Coadministration of Mercaptopurine with Uriset 40mg Tablet can increase the blood levels of mercaptopurine.

How to manage the interaction:
Taking Mercaptopurine with Uriset 40mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
FebuxostatAzathioprine
Critical
How does the drug interact with Uriset 40mg Tablet:
Taking azathioprine and Uriset 40mg Tablet together can increase the blood levels of azathioprine

How to manage the interaction:
Taking Azathioprine with Uriset 40mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FebuxostatTeriflunomide
Severe
How does the drug interact with Uriset 40mg Tablet:
Coadministration of Teriflunomide with Uriset 40mg Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Uriset 40mg Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.
FebuxostatKetoconazole
Severe
How does the drug interact with Uriset 40mg Tablet:
Coadministration of Uriset 40mg Tablet with ketoconazole can increase the risk of liver problems.

How to manage the interaction:
Although taking Uriset 40mg Tablet with Ketoconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
FebuxostatLeflunomide
Severe
How does the drug interact with Uriset 40mg Tablet:
Coadministration of Uriset 40mg Tablet with leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although taking Uriset 40mg Tablet with Leflunomide can result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.
FebuxostatMipomersen
Severe
How does the drug interact with Uriset 40mg Tablet:
Coadministration of Uriset 40mg Tablet with Mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Uriset 40mg Tablet with Mipomersen can result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.
FebuxostatLomitapide
Severe
How does the drug interact with Uriset 40mg Tablet:
Coadministration of Uriset 40mg Tablet with lomitapide can increase the risk of liver problems.

How to manage the interaction:
Although taking Uriset 40mg Tablet with Lomitapide can result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Turmeric and fish can also help reduce inflammation in the tissue.
  • Please avoid heavy exercise, as it may exacerbate your joint pain and arthritis. Instead, you can engage in low-impact aerobic movements, such as walking on a treadmill or swimming. You can also strengthen your muscles by lifting light weights.
  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long-term immobility is harmful in conditions like arthritis. Use a back support, such as a rolled-up towel, to minimise pain at the curve of your spine. Keep your knees and hips at a right angle. You can also use a footrest if required.
  • Avoid a high purine-rich diet, including organ meats (kidneys, liver, and sweetbreads) and oily fish (sardines, anchovies, and herring).
  • Limit meat in favour of plant-based proteins, such as beans and legumes.
  • Eat complex carbohydrates, such as whole-grain bread, fruits, and vegetables, rather than sugary sweets and refined carbohydrates like white bread.
  • Avoid drinking beer and alcoholic beverages, and drink plenty of water or other nonalcoholic beverages.

Habit Forming

No

Therapeutic Class

ANTI- GOUT MEDICATIONS

Uriset 40mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You should avoid taking alcohol while taking Uriset 40mg Tablet because alcohol may affect Uriset 40mg Tablet effectiveness.

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Pregnancy

Caution

Uriset 40mg Tablet should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Breast Feeding

Consult your doctor

There is limited data on how Uriset 40mg Tablet affects breastfeeding. Please consult your doctor before starting Uriset 40mg Tablet.

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Driving

Caution

Do not drive or operate machinery if you experience sleepiness, blurred vision and numbness or tingling sensations while using Uriset 40mg Tablet. Seek medical attention if the symptoms persist longer.

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Liver

Consult your doctor

Let your doctor know if you have any history of liver disease. Your doctor will weigh the benefits and any potential risks before prescribing Uriset 40mg Tablet.

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Kidney

Caution

Uriset 40mg Tablet should be used with caution in patients with renal impairment. The doctor may adjust the dose depending on your condition.

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Children

Unsafe

Uriset 40mg Tablet is not recommended for children below the age of 18 years. The safety and efficacy of Uriset 40mg Tablet have not been established in children due to limited testing of this drug on children.

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Heart

Caution

Uriset 40mg Tablet is not contraindicated for all heart patients; however, it is not recommended for those with a history of significant cardiovascular illness unless no other therapeutic choices are available.

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Geriatrics

Consult your doctor

Limited information is available. Please consult your doctor.

FAQs

Uriset 40mg Tablet is used to prevent severe gout attacks or flares. It prevents the sudden attacks of pain caused by severe gout and decreases pain, swelling, and inflammation.

Uriset 40mg Tablet is a class of antigout drugs called xanthine oxidase inhibitors. It works by decreasing a high amount of uric acid to the normal level that is made in the body. Uriset 40mg Tablet is used to prevent gout attacks but not to treat them once they occur.

No, do not discontinue Uriset 40mg Tablet without consulting your doctor. To treat your condition effectively, continue taking Uriset 40mg Tablet for as long as prescribed. If you stop taking Uriset 40mg Tablet, your uric acid levels will likely remain high and continue to cause gout symptoms.

Uriset 40mg Tablet is not recommended if you have heart disease; taking Uriset 40mg Tablet may cause serious heart problems, which can be life-threatening in some cases. So, please consult your doctor before taking Uriset 40mg Tablet.

Do not drive or operate machinery if you experience dizziness or drowsiness while using Uriset 40mg Tablet.

The dose and duration of Uriset 40mg Tablet depend upon your medical condition. It may take several months before Uriset 40mg Tablet begins to prevent gout attacks. Do not stop taking Uriset 40mg Tablet without the advice of your doctor even if you feel better.

It is best taken in the morning. You can take Uriset 40mg Tablet with or without food. Keep taking Uriset 40mg Tablet every day, to prevent gout attacks.

Chronic hyperuricemia is a condition in which serum uric acid levels are higher than normal.

Hyperuricemia occurs when the body produces too much uric acid or when the kidneys are unable to excrete it properly.

Side effects of Uriset 40mg Tablet include nausea, rash, dizziness, diarrhoea, pain, inaccurate liver function test results, gout flare-ups (intense joint pain that comes on suddenly, often in the middle of the night), and localised swelling due to retention of fluids in tissues (oedema). Most of these side effects may not require medical attention and will gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Uriset 40mg Tablet may cause frequent urination, kidney stones, blood in urine, reduced ability to function properly, and abnormal urine tests. Talk to the doctor if you have any concerns.

You should know that Uriset 40mg Tablet may cause gout flares, cardiovascular events, and liver problems. Inform the doctor if you have kidney or liver problems, a history of heart disease or stroke, or if you are pregnant/breastfeeding.

Uriset 40mg Tablet may cause liver failure and liver function abnormalities. Consult the doctor if you notice signs of liver injury such as fatigue, right upper abdominal discomfort, jaundice, dark urine, or anorexia.

Manufacturer/Marketer address

Indoco Remedies Limited, Indoco House, 166 Cst Road, Santacruz (E), Mumbai 400 098, India
Other Info - UR28827

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Sep 25, 2025 | 10:58 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/1925/smpc
  2. https://medlineplus.gov/druginfo/meds/a609020.html
  3. https://www.drugs.com/mtm/febuxostat.html
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