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About Uromixtexan 200 mg Injection
Uromixtexan 200 mg Injection belongs to a class of medication known as 'cytoprotectant' primarily used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). Our bodies degrade the anticancer drug (ifosfamide) to generate a compound (acrolein) that can injure and irritate the bladder. Uromixtexan 200 mg Injection decreases the risk of bladder irritation and bleeding caused by other anti-cancer drugs.
Uromixtexan 200 mg Injection contains 'Mesna', a chemo-protectant medicine that alters the breakdown of anti-cancer agents (Ifosfamide) found in the urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.
Uromixtexan 200 mg Injection will be administered to your vein by a trained healthcare professional; hence, do not self-administer. In some cases, this medicine may cause certain side effects such as nausea, vomiting, headache, flushing (sense of warmth in the face, ears, neck, and trunk), lethargy, rash, diarrhea, light-headedness, abdominal pain, flu-like symptoms, fever, and injection site reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Uromixtexan 200 mg Injection is not recommended if you are allergic to it or any of its ingredients. An effective birth control measure should be taken to avoid pregnancy in women of a mother-bearing you’re your doctor may suggest regular urine and blood test while receiving Uromixtexan 200 mg Injection to monitor your CBC (blood cell count). Uromixtexan 200 mg Injection is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is advised to drink at least 1-2 litres of fluid daily while receiving Uromixtexan 200 mg Injection. This medicine should be avoided in pregnant and breastfeeding populations due to serious side effects; hence inform your doctor before administration.
Uses of Uromixtexan 200 mg Injection
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Directions for Use
Medicinal Benefits
Uromixtexan 200 mg Injection belongs to a class of medication known as 'chemoprotectant' primarily used to prevent bleeding into the urine by a particular anticancer medicine known as ifosfamide (ifosfamide-induced hemorrhagic cystitis). It also reduces the risk of inflammation and bleeding in the bladder by receiving anti-cancer medication. It contains Mesna, which works by reacting chemically with the urotoxic ifosfamide (anti-cancer medicines) metabolites, resulting in their detoxification. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.
How Uromixtexan 200 mg Injection Works
Storage
What if I have taken an overdose of Uromixtexan 200 mg Injection
Drug Warnings
Do not take this injection if you are allergic to Uromixtexan 200 mg Injection or any of its ingredients. An effective birth control method should be used to avoid pregnancy in women of childbearing age. Maintain a three-month gap between your last dose of Uromixtexan 200 mg Injection and your next pregnancy. Regular urine and blood test should be done while receiving Uromixtexan 200 mg Injection to monitor your CBC (blood cell count). It is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. This medicine is known to cause blurry vision and dizziness, so do not drive or operate machinery.
Drug-Drug Interactions
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Drug-Food Interactions
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Diet & Lifestyle Advise
Habit Forming
Therapeutic Class
Alcohol
Caution
Avoid consumption of alcohol while on treatment with Uromixtexan 200 mg Injection as it may lead to serious side effects.
Pregnancy
Unsafe
Uromixtexan 200 mg Injection is not recommended to be used in pregnancy as it may cause serious side effects. Use effective birth control measures before starting the treatment with Ifosamide and for 3 months after completing the treatment. If you get pregnant while you are receiving Uromixtexan 200 mg Injection, inform your doctor.
Breast Feeding
Unsafe
Uromixtexan 200 mg Injection should not be used if you are breastfeeding as it is known to pass through the breast milk and harm your infant. Do not breastfeed for at least one week following your last dosage of mesna or ifosfamide.
Driving
Unsafe
Uromixtexan 200 mg Injection is known to cause blurred vision and drowsiness. So, do not drive or operate machinery, which requires mental alertness.
Liver
Caution
Let your doctor know if you have any history of liver diseases before receiving Uromixtexan 200 mg Injection.
Kidney
Caution
Let your doctor know if you have any history of kidney diseases before receiving Uromixtexan 200 mg Injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.
Children
Caution
The safety and efficacy of Uromixtexan 200 mg Injection in children have not been established. Moreover, Uromixtexan 200 mg Injection contains benzyl alcohol, which is known to cause a gasping syndrome in children. Hence, use is not recommended.
Uromixtexan 200 mg Injection is used to treat Ifosfamide-induced hemorrhagic cystitis.
Our body breaks down anticancer agents like ifosfamide or cyclophosphamide to form a chemical known as acrolein, which can harm and irritate the bladder. Uromixtexan 200 mg Injection works by making this natural chemical less harmful or toxic. However, Uromixtexan 200 mg Injection does not change ifosfamide's anti-cancer effects.
No, Uromixtexan 200 mg Injection should not be taken with an anti-coagulant like warfarin, heparin or coumarin as it might increase the risk of bleeding and lead to serious complications.
An autoimmune disorder is a condition in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage. Some autoimmune disorders are rheumatoid arthritis, systemic lupus erythematosus or nephritis.
Please inform your doctor if you observe any change in the urine colour (like if you have red/pink-coloured urine).
In addition to bladder bleeding in hemorrhagic cystitis, an individual might also experience bladder wall scarring, decreased bladder size (atrophy), severe systemic infection (urosepsis), and urinary obstruction.
Uromixtexan 200 mg Injection is given with ifosfamide or cyclophosphamide to prevent haemorrhagic cystitis which is a serious side effect caused by the toxic metabolite acrolein produced when these drugs are metabolized.
Yes, Uromixtexan 200 mg Injection is compatible with potassium chloride and doxorubicin. Though no interactions were found, it is advised to consult the doctor before taking Uromixtexan 200 mg Injection with potassium chloride and doxorubicin.
No, Uromixtexan 200 mg Injection is not a chemotherapy drug by itself. However, it is used along with chemotherapy drugs like Ifosfamide to prevent haemorrhagic cystitis, a side effect caused by the toxic metabolites of Ifosfamide, such as acrolein.
No, Uromixtexan 200 mg Injection is not cytotoxic. It is used as a chemo protectant, mainly to prevent haemorrhagic cystitis caused by chemotherapy drugs. It protects the bladder from damage by detoxifying toxic metabolites such as acrolein. Uromixtexan 200 mg Injection itself does not have cytotoxic effects, it is administered with cytotoxic drugs.
No, Uromixtexan 200 mg Injection is not a vesicant. Instead, Uromixtexan 200 mg Injection serves as a chemo protectant to safeguard the bladder from toxic metabolites produced by chemotherapy drugs, particularly preventing haemorrhagic cystitis.
The side effects of Uromixtexan 200 mg Injection include headache, nausea, vomiting, fever, diarrhoea, lethargy, flushing (sense of warmth in the face, ears, neck, and trunk), rash, light-headedness, abdominal pain, flu-like symptoms, and injection site reactions. Consult the doctor if any of these symptoms persist or worsen.
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