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  3. Xtrant Capsule 100's

Xtrant Capsule 100's, Pack of 1 CAPSULE
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Composition :

ESTRAMUSTINE-140MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Xtrant Capsule

Xtrant Capsule is an antineoplastic medicine used in the treatment of prostate cancer. It is used to treat metastatic or progressive prostate cancer (a condition where cancer does not get cured) in men. Prostate cancer is a condition that occurs when the number of prostate gland cells increases abnormally. Symptoms may include difficulty in urinating, pain, numbness, etc.

Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

Xtrant Capsule may cause certain side effects such as nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, hot flushes, nausea, vomiting, thirst, flatulence, edema, and GI bleeding. These side effects usually disappear without any medical attention. However, if these side effects persist or worsen, consult your doctor. Take this medicine as advised by your doctor. It should be taken on an empty stomach at least 2 hours before or post meals. Your doctor will decide the dose of the medicine based on the severity of your disease.

Xtrant Capsule should be avoided if you are allergic to estradiol, nitrogen mustard or any component present in this medicine. Inform your doctor about medications you use to avoid interactions. Inform your doctor if you have any pre-existing or a history of liver/kidney disease, hypocalcemia, thrombophlebitis, fluid retention, coronary artery disease, diabetes, gynecomastia, or impotence before taking Xtrant Capsule . Xtrant Capsule is not recommended for use in women and children as this medicine is recommended for men. Xtrant Capsule is known to cause thrombosis, fatal and nonfatal myocardial infarction, glucose intolerance and elevated blood pressure in some patients. Hence, close monitoring should be done during the treatment.

Directions for Use

• Xtrant Capsule should be taken on an empty stomach, at least two hours before or after a meal.• Xtrant Capsule is usually taken 3-4 times in a day; however, follow your doctor's advice regarding the dosage and duration.• Swallow the whole medicine with a glass of water.• Do not split, chew or crush it.

Medicinal Benefits

Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

How Xtrant Capsule Works

Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Xtrant Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Xtrant Capsule or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

Xtrant Capsule should be avoided if you are allergic to it or either estradiol or nitrogen mustard. Keep a note of all your ongoing medications to avoid interactions. Inform your doctor if you have any pre-existing or a history of liver/kidney disease, hypocalcemia, thrombophlebitis, fluid retention, coronary artery disease, diabetes, Gynecomastia, or impotence before taking Xtrant Capsule . Xtrant Capsule is not recommended for use in women and children as the safety and efficacy of this medicine are not established. Xtrant Capsule is known to cause thrombosis, fatal and nonfatal myocardial infarction, glucose intolerance and elevated blood pressure in some patients. Hence, close monitoring should be done during the entire treatment course. Do not take Xtrant Capsule with milk or any other dairy products.

Drug-Drug Interactions

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EstramustineExemestane
Severe
EstramustineTranexamic acid
Severe

Drug-Drug Interactions

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EstramustineExemestane
Severe
How does the drug interact with Xtrant Capsule:
Co-administration of Exemestane with Xtrant Capsule may interfere with exemestane's activity and make it less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Exemestane and Xtrant Capsule, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
EstramustineTranexamic acid
Severe
How does the drug interact with Xtrant Capsule:
Co-administration of Xtrant Capsule with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Xtrant Capsule with Tranexamic acid possibly lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EstramustineLetrozole
Severe
How does the drug interact with Xtrant Capsule:
when taken together letrozole's function could be blocked by Xtrant Capsule, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Letrozole and Xtrant Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to take vegetables like cauliflower, cabbage, broccoli, spinach and kale. This food slows the growth of prostate cancer and even reduces the risk of prostate cancer.
  • It is advised to consume fewer dairy products as these foods may increase the risk of prostate cancer.
  • Physical activity helps strengthen muscles, reduces fatigue, helps with weight loss, and gives strength.
  • Maintain a healthy weight by doing regular simple exercises and yoga.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • Avoid including red meat high amounts of meat in your diet. When meat is cooked, it may increase the risk of developing prostate cancer.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Xtrant Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

Interaction of Xtrant Capsule with alcohol is unknown. It is advisable to consult your doctor if you have concerns.

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Pregnancy

Not applicable

Not intended for women. Xtrant Capsule has the potential to harm a fetus. If there is a chance that your partner will become pregnant while you are on estramustine, you should utilize effective birth control.

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Breast Feeding

Not applicable

Not intended for women.

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Driving

Unsafe

Xtrant Capsule may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery after taking Xtrant Capsule until your vision improves.

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Liver

Caution

Xtrant Capsule should be used with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Xtrant Capsule should be used with caution, especially if you have a history of kidney diseases/conditions. This medicine causes fluid retention and edema which can be worsened by kidney impairment. Your doctor may adjust the dose based on your condition.

bannner image

Children

Not applicable

Intended for use in adult men.

Have a query?

FAQs

Xtrant Capsule is used to treat metastatic prostate cancer.

Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

No, do not stop taking Xtrant Capsule without consulting your doctor. It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve.

Xtrant Capsule is an antineoplastic medicine that contains the active ingredient Estramustine, which is used in the treatment of prostate cancer in men.

The common side effects of Xtrant Capsule include nausea, dizziness, heartburn, headache, diarrhea, muscle weakness, joint pain, hot flushes, vomiting, thirst, flatulence, edema, and stomach bleeding. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - XTR0012

Disclaimer

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 17, 2025 | 10:56 AM IST

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Reference

  1. https://go.drugbank.com/drugs/DB01196
  2. https://www.mayoclinic.org/drugs-supplements/estramustine-oral-route/description/drg-20063721
  3. https://medlineplus.gov/druginfo/meds/a608046.html
  4. https://pubmed.ncbi.nlm.nih.gov/7579781/
  5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/018045s023lbl.pdf

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