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compositionComposition:GOSERELIN-10.8MG
prescriptionPrescription Medicine

Zoladex Depot 10.8 mg Injection 1's is indicated in the treatment of breast cancer, endometriosis, uterine fibroids and infertility in women. It is also used to treat prostate cancer in men. It contains Goserelin, which acts on the brain's pituitary gland and decreases the production of certain sex hormones (testosterone in men and oestrogen in women) in the body. In some cases, Zoladex Depot 10.8 mg Injection 1's may cause hot flushes, sweating, decreased sex drive, and injection site reactions such as pain, redness, swelling, bleeding or bruising.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GOSERELIN-10.8MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

Parenteral

Return Policy :

Not Returnable

Zoladex Depot 10.8 mg Injection 1's belongs to the group of medicines called LHRH analogues indicated in the treatment of breast cancer, endometriosis, uterine fibroids and infertility in women. It is also used to treat prostate cancer in men.

Zoladex Depot 10.8 mg Injection 1's contains Goserelin, which works by acting on the pituitary gland in the brain and decreases the production of certain sex hormones (testosterone in men and oestrogen in women) in the body.

In some cases, Zoladex Depot 10.8 mg Injection 1's may cause hot flushes, sweating, decreased sex drive, and injection site reactions such as pain, redness, swelling, bleeding or bruising. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Zoladex Depot 10.8 mg Injection 1's if you are pregnant (except for breast cancer and infertility treatment) or breastfeeding. Zoladex Depot 10.8 mg Injection 1's is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Zoladex Depot 10.8 mg Injection 1's

Zoladex Depot 10.8 mg Injection 1's is used in the treatment of Breast cancer, endometriosis, uterine fibroids and infertility in women. It is also used in the treatment of Prostate cancer in men. The detailed uses of Zoladex Depot 10.8 mg Injection 1's are as follows:

  • Treat prostate cancer in men: Zoladex Depot 10.8 mg Injection 1's lowers testosterone levels, which helps shrink prostate tumors and relieve symptoms. It may be used alone or in combination with other therapies such as radiation or antiandrogens.
  • Manage breast cancer in premenopausal women: Zoladex Depot 10.8 mg Injection 1's suppresses estrogen production, slowing the growth of hormone-dependent breast tumors and improving treatment outcomes.
  • Control endometriosis and uterine fibroids: Zoladex Depot 10.8 mg Injection 1's reduces estrogen levels, which helps alleviate pain and shrink endometrial tissue or fibroids, often as part of pre-surgical preparation.
  • Support infertility treatment in women: Zoladex Depot 10.8 mg Injection 1's may be used to regulate hormone levels during assisted reproductive procedures, improving the chances of successful ovulation and implantation.

Key Benefits

Zoladex Depot 10.8 mg Injection 1's belongs to the group of medicines called LHRH analogues indicated in the treatment of breast cancer, endometriosis, uterine fibroids and infertility in women. It is also used to treat prostate cancer in men. Zoladex Depot 10.8 mg Injection 1's contains Goserelin, which acts on the brain's pituitary gland and decreases the production of certain sex hormones (testosterone in men and oestrogen in women) in the body.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Zoladex Depot 10.8 mg Injection 1's will be administered by a healthcare professional.
  • Do not self-administer it.
Zoladex Depot 10.8 mg Injection 1's contains Goserelin, which works by acting on the pituitary gland in the brain and decreases the production of certain sex hormones (testosterone in men and oestrogen in women) in the body.
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Alcohol

Consult your doctor

It is not known if alcohol affects Zoladex Depot 10.8 mg Injection 1's. Please consult your doctor.

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Pregnancy

Caution

Zoladex Depot 10.8 mg Injection 1's should not be used during pregnancy unless for palliative treatment of advanced breast cancer or infertility. Avoid becoming pregnant during treatment and for 12 weeks after your treatment as it may cause foetal harm.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Zoladex Depot 10.8 mg Injection 1's.

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Driving

Safe if prescribed

Zoladex Depot 10.8 mg Injection 1's is unlikely to affect your ability to drive. However, drive or operate heavy machinery only if you are alert.

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Liver

Consult your doctor

If you have a history of liver disease, inform the doctor before receiving Zoladex Depot 10.8 mg Injection 1's.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform the doctor before receiving Zoladex Depot 10.8 mg Injection 1's.

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Children

Unsafe

Zoladex Depot 10.8 mg Injection 1's is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Zoladex Depot 10.8 mg Injection 1's should be used with caution in heart patients, especially those with a history of arrhythmias, QT prolongation, or cardiovascular disease. It may increase the risk of heart rhythm problems and stroke, so close cardiac monitoring is essential during treatment.

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Geriatrics

Caution

Geriatric patients can receive Zoladex Depot 10.8 mg Injection 1's, as studies have not shown age-specific limitations in elderly men. However, careful monitoring is advised due to potential side effects like bone loss, cardiovascular strain, or hormonal shifts.

As Zoladex Depot 10.8 mg Injection 1's is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Have a query?

Drug Warnings

Do not use Zoladex Depot 10.8 mg Injection 1's if you are allergic to any of its components, if you are pregnant (except for breast cancer and infertility treatment) or if you are breastfeeding. Consult the doctor immediately if you become pregnant during treatment. Inform the doctor if you have high blood pressure, heart or blood vessel conditions, heart rhythm problems, bone problems, problems passing urine, diabetes, unusual vaginal bleeding, electrolyte imbalance, heart failure, liver or kidney disease, a family history of osteoporosis, if you smoke or have a poor diet, take medicines like corticosteroids or anticonvulsants or if you develop depressed mood. Let the doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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GoserelinAnagrelide
Critical
GoserelinHalofantrine
Critical

Drug-Drug Interactions

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GoserelinAnagrelide
Critical
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Anagrelide with Zoladex Depot 10.8mg Inj can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Anagrelide with Zoladex Depot 10.8mg Inj is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GoserelinHalofantrine
Critical
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Zoladex Depot 10.8mg Inj and Halofantrine can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj and halofantrine together is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GoserelinBepridil
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Zoladex Depot 10.8mg Inj with Bepridil can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj and bepridil together can possibly result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GoserelinCabozantinib
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Zoladex Depot 10.8mg Inj and Cabozantinib can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj and Cabozantinib together can possibly result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GoserelinAmisulpride
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Zoladex Depot 10.8mg Inj and Amisulpride can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj and amisulpride together can result in an interaction; it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Arsenic trioxide with Zoladex Depot 10.8mg Inj can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking arsenic trioxide and Zoladex Depot 10.8mg Inj together is generally avoided as it can result in an interaction. It can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GoserelinMethadone
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Zoladex Depot 10.8mg Inj and Methadone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj and methadone together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GoserelinDofetilide
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Zoladex Depot 10.8mg Inj and Dofetilide can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj and dofetilide together can possibly result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GoserelinZiprasidone
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Taking Zoladex Depot 10.8mg Inj with Ziprasidone can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj with Ziprasidone together can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
GoserelinNilotinib
Severe
How does the drug interact with Zoladex Depot 10.8mg Inj:
Coadministration of Zoladex Depot 10.8mg Inj with Nilotinib can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zoladex Depot 10.8mg Inj and Nilotinib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Zoladex Depot 10.8 mg Injection 1's is used in the treatment of breast cancer, endometriosis, uterine fibroids and infertility in women. It is also used to treat prostate cancer in men.

Zoladex Depot 10.8 mg Injection 1's works by acting on the pituitary gland in the brain and decreases the production of certain sex hormones in the body.

Zoladex Depot 10.8 mg Injection 1's may decrease bone density, which may increase the chances of fractures or broken bones. Talk to the doctor about the risks and how to prevent them.

Zoladex Depot 10.8 mg Injection 1's might affect blood glucose levels. Therefore, if you have diabetes, inform the doctor. Monitor blood sugar levels more frequently while on treatment with Zoladex Depot 10.8 mg Injection 1's.

Avoid using oral contraceptives such as ‘the pill’ whilst on treatment with Zoladex Depot 10.8 mg Injection 1's. Instead, use barrier methods of contraception such as condoms or diaphragm.

There have been reports of depression in patients receiving Zoladex Depot 10.8 mg Injection 1's. Consult the doctor if you develop a depressed mood.

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