apollo
0
  1. Home
  2. Medicine
  3. Zyrifa 120 Injection 1.7 ml

Prescription drug
 Trailing icon
coupon
Get 18% Off with Coupons
coupon
coupon
coupon
Extra 10% Off with Bank Offers
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Zyrifa 120 Injection 1.7 ml is used to treat osteoporosis, bone loss, giant cell tumours of the bone, high calcium levels and reduce the risk of fractures. It contains denosumab, which blocks a receptor that causes bone loss; thereby increasing bone density, and strengthening the bone. It slows the tumour growth by blocking certain receptors in the tumour cells. In some cases, this medicine may cause side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Read more

Composition :

DENOSUMAB-70MG

Manufacturer/Marketer :

Zydus Lifescience Ltd

Consume Type :

Parenteral

Expires on or after :

Return Policy :

Not Returnable

About Zyrifa 120 Injection 1.7 ml

Zyrifa 120 Injection 1.7 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Zyrifa 120 Injection 1.7 ml is also used to treat bone loss due to reduced testosterone level caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. Zyrifa 120 Injection 1.7 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumour of the bone, and to treat high calcium levels caused by cancer.
 
Zyrifa 120 Injection 1.7 ml contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Zyrifa 120 Injection 1.7 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Zyrifa 120 Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Zyrifa 120 Injection 1.7 ml makes the bones stronger and less likely to break.
 
Zyrifa 120 Injection 1.7 ml will be administered by a healthcare professional; do not self-administer. Sometimes, you may experience common side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You should talk to your doctor if the side effects persist or worsen.
 
Zyrifa 120 Injection 1.7 ml might cause jaw osteonecrosis; therefore, maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Zyrifa 120 Injection 1.7 ml. Avoid taking Zyrifa 120 Injection 1.7 ml if you are pregnant. Consult your doctor before taking Zyrifa 120 Injection 1.7 ml if you are breastfeeding. Zyrifa 120 Injection 1.7 ml is not recommended for children below 18 years as safety and effectiveness have not been established. To rule out any interactions, keep your doctor informed about your health condition and medicines.

Uses of Zyrifa 120 Injection 1.7 ml

Zyrifa 120 Injection 1.7 ml used to treat osteoporosis, bone loss, giant cell tumour of the bone, and high calcium levels. The detailed uses of Zyrifa 120 Injection 1.7 ml are as follows:

  • Management of Osteoporosis: Zyrifa 120 Injection 1.7 ml treats osteoporosis in postmenopausal women, increasing bone density and reducing fracture risk.
  • Giant cell tumour of the bone treatment: Zyrifa 120 Injection 1.7 ml is prescribed for the treatment of giant cell tumour of the bone, which helps by reducing tumour size and slowing its growth.
  • Increases bone mass: Zyrifa 120 Injection 1.7 ml increases bone mass in patients at high risk for fracture, including those undergoing androgen deprivation therapy for prostate cancer or adjuvant aromatase inhibitor therapy for breast cancer.
  • Hypercalcemia Treatment: Zyrifa 120 Injection 1.7 ml treats hypercalcemia caused by cancer, helping normalise calcium levels in the blood.
  • Paget’s Disease: Zyrifa 120 Injection 1.7 ml treats Paget’s disease by alleviating bone pain and complications caused by enlarged and deformed bones.

Have a query?

Directions for Use

  • Your doctor will determine the dosage and timing of Zyrifa 120 Injection 1.7 ml based on your health condition. Usually, it is given once every 6 months.
  • Zyrifa 120 Injection 1.7 ml is administered subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area by the doctor or nurse in a hospital setting.
  • Do not self-administer it.

Key Benefits

Zyrifa 120 Injection 1.7 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Zyrifa 120 Injection 1.7 ml is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. Zyrifa 120 Injection 1.7 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused by cancer. Zyrifa 120 Injection 1.7 ml binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. It decreases bone breakdown, increases bone density, and strengthens the bone. Zyrifa 120 Injection 1.7 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Zyrifa 120 Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown, as the breakdown of the bones releases calcium. Zyrifa 120 Injection 1.7 ml makes the bones stronger and less likely to break.

How Zyrifa 120 Injection 1.7 ml Works

Zyrifa 120 Injection 1.7 ml contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Zyrifa 120 Injection 1.7 ml treats giant cell tumours of bone (GCTB) by blocking specific receptors in the tumour cells, thereby slowing the growth of the tumour. Zyrifa 120 Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Zyrifa 120 Injection 1.7 ml makes the bones stronger and less likely to break.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Zyrifa 120 Injection 1.7 ml

It is unlikely to overdose on parenteral medication as a healthcare professional administers it. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take Zyrifa 120 Injection 1.7 ml if you are allergic to any of its components or have hypocalcaemia (low levels of calcium in the blood). Inform your doctor if you have low levels of calcium, kidney dysfunction, liver problems, poor dental health, gum problems, weak immune system, hypoparathyroidism (decreased function of the parathyroid gland), malabsorption, latex allergy, undergone thyroid surgery, planned dental procedure, if you are taking glucocorticoids, or cannot take calcium and vitamin D supplements. Avoid taking Zyrifa 120 Injection 1.7 ml if you are pregnant. Consult your doctor if you are breastfeeding. Zyrifa 120 Injection 1.7 ml is not recommended for children below 18 years as safety and effectiveness have not been established.

Diet & Lifestyle Advise

  • Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
  • Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
  • Snack on calcium-rich nuts like Brazil nuts or almonds.
  • Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
  • Avoid or reduce the intake of caffeine, soft drinks, and alcohol as they may inhibit calcium absorption.
  • Replace the meat with tofu or tempeh for extra calcium in your food.

Habit Forming

No

Therapeutic Class

[MONOCLONAL ANTIBODIES]

bannner image

Alcohol

Caution

It is not known if alcohol interacts with Zyrifa 120 Injection 1.7 ml, so please consult a doctor.

bannner image

Pregnancy

Unsafe

Zyrifa 120 Injection 1.7 ml is not recommended during pregnancy as it might cause foetal harm. If you are a woman of child-bearing potential, use effective contraception during the treatment with Zyrifa 120 Injection 1.7 ml and for 5 months after discontinuation. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

bannner image

Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide if breastfeeding mothers can take Zyrifa 120 Injection 1.7 ml or not.

bannner image

Driving

Safe if prescribed

Zyrifa 120 Injection 1.7 ml generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

bannner image

Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Zyrifa 120 Injection 1.7 ml is not recommended for children below 18 years as safety and effectiveness were not established.

bannner image

Heart

Zyrifa 120 Injection 1.7 ml should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Zyrifa 120 Injection 1.7 ml.

bannner image

Geriatrics

Caution

Zyrifa 120 Injection 1.7 ml should be administered with caution in older adults. Always seek medical advice before receiving it.

FAQs

Zyrifa 120 Injection 1.7 ml is used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. It is also used to treat bone loss and reduce the risk of fractures.

Zyrifa 120 Injection 1.7 ml binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Zyrifa 120 Injection 1.7 ml makes the bones stronger and less likely to break.

Osteonecrosis of the jaw (bone damage in the jaw) might be a side-effect of Zyrifa 120 Injection 1.7 ml. The risk increases in people taking Zyrifa 120 Injection 1.7 ml for longer durations. It might also occur upon discontinuation of the treatment. Maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Zyrifa 120 Injection 1.7 ml. Inform your doctor if you have dental problems, gum disease, planned tooth extractions, cancer, if you smoke, or are taking bisphosphonates or corticosteroids.

Breakdown of bones releases calcium and causes hypercalcemia (high calcium levels in the blood). Zyrifa 120 Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown.

Unusual thigh bone fractures might occur whilst on treatment with Zyrifa 120 Injection 1.7 ml. Consult your doctor if you experience new or unusual pain in the thigh, hip, or groin.

Zyrifa 120 Injection 1.7 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Giant cell tumour of the bone is a non-cancerous tumour that typically grows at the ends of long bones.

Zyrifa 120 Injection 1.7 ml might cause skin infections. Consult your doctor immediately if you notice symptoms such as swollen skin, redness, cellulitis (hot and tender skin), commonly in the lower leg with feverish symptoms.

Zyrifa 120 Injection 1.7 ml has been used safely for up to 8 years, showing substantial increases in bone density during that time. However, the optimal duration of therapy varies depending on individual health conditions and needs. Long-term use should be closely monitored by your healthcare provider to assess benefits, risks, and the need for continued therapy. Always consult the doctor for personalized guidance.

Some people may experience hair loss while using Zyrifa 120 Injection 1.7 ml. However, individual reactions to medications can vary. If you experience hair loss or any unusual symptoms while taking Zyrifa 120 Injection 1.7 ml, consult the doctor to determine the cause and discuss appropriate management options.

No, Zyrifa 120 Injection 1.7 ml is not a chemotherapy medication. It is a monoclonal antibody which is used to treat conditions like osteoporosis, and bone loss associated with certain cancers, and to prevent bone fractures in patients with metastatic bone disease. It targets a protein called RANKL to inhibit bone breakdown, thereby increasing bone strength and density.

Zyrifa 120 Injection 1.7 ml is administered subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area by the doctor or nurse, usually given once every 6 months for osteoporosis. Your doctor will determine the exact schedule based on your condition. Always follow the doctor's instructions regarding dosage and scheduling, as it may vary based on your specific medical condition.

You should inform your doctor before receiving Zyrifa 120 Injection 1.7 ml, as it is not recommended during pregnancy due to the potential risk of harm to the foetus.

Zyrifa 120 Injection 1.7 ml should be stored in a refrigerator at a temperature between 2°C and 8°C. Do not freeze it. Keep the vial in its outer carton to protect it from light.

The side effects of Zyrifa 120 Injection 1.7 ml include abdominal discomfort, bone/joint/muscle pain, arm/leg pain, constipation, and painful/frequent urination. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481
Other Info - ZYR0119

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
icon image

Keep Refrigerated. Do not freeze.

whatsapp Floating Button
Buy Now
Add to Cart