• It is recommended not to take ACECLOFENAC+TRAMADOL if you are allergic to any of the ingredients of ACECLOFENAC+TRAMADOL. 

• Patients with stomach ulcers, gastric bleeding, severe heart failure, high blood pressure, and liver or kidney disease should not take ACECLOFENAC+TRAMADOL. 

• This medicine is not recommended for use during pregnancy as it may cause fetal deformities. While ACECLOFENAC+TRAMADOL may pass in the lactating mother's breast milk, there is not enough evidence to establish the safety of ACECLOFENAC+TRAMADOL in nursing mothers. So, it is advisable to take it only if prescribed by your doctor. 

• If you have a severe allergy to painkillers and have conditions like asthma, rhinitis, angioedema (swelling under the skin), or skin rashes, immediately stop taking ACECLOFENAC+TRAMADOL. 

• Consumption of alcohol should be avoided during the treatment as it may lead to an increased risk of liver damage. 

• Do not give your medicine to others, especially children, as ACECLOFENAC+TRAMADOL contains Tramadol, which may cause undesirable effects and sometimes death. 

• ACECLOFENAC+TRAMADOL tends to cause stomach upset. Thus, consuming ACECLOFENAC+TRAMADOL with meals is recommended to minimize gastric side effects. If you have a peptic ulcer diagnosis, ACECLOFENAC+TRAMADOL is best avoided unless prescribed by your doctor. 

• It can cause liver injury when taken in large doses. Concomitant use of alcohol is best avoided as it aggravates liver toxicity. Avoid using this medicine if you have kidney impairment, as it may worsen your condition. 

• It contains Tramadol, which is a habit-forming drug. So, it should be taken for a short duration to avoid unpleasant withdrawal symptoms like breathing difficulties.

Drug-Drug Interactions: ACECLOFENAC+TRAMADOL is known to interact with antidepressants (e.g. duloxetine, zolpidem, cyclobenzaprine), antiemetic medications (e.g. ondansetron), and pain killers (e.g. aspirin, naproxen, etoricoxib).

Drug-Food Interactions: Avoid consumption of alcohol and St. John's Wort plant (a natural remedy to treat depression).

Drug-Disease Interactions: Inform your doctor if you have stomach ulcers, blood disorders, disorders of the stomach, gastric bleeding, diarrhoea, blood circulation problems to the brain, asthma, porphyria, diabetes, high blood pressure, auto-immune diseases, connective tissue diseases, heart, kidney and liver problems.

• Adopting a balanced diet is an important lifestyle component in pain therapy or management.

• Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.

• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.

• In a chronic condition of arthritis or joint pain, including fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize cytokine levels, which ramp up inflammation.

• Your sitting posture is important, especially when you have pain and inflammation conditions. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

• Although ACECLOFENAC+TRAMADOL provides symptomatic relief in conditions like arthritis and may reduce the inflammation caused by these conditions, to achieve the best results, it is strongly recommended to remain physically active as much as your condition allows to achieve the best results. Adopting a healthy lifestyle and a healthy diet containing high proteins is the mainstay for managing arthritic conditions.