AMITRIPTYLINE+KETAMINE is a combination medicine indicated for the management of neuralgia (neuropathic pain). Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to damaged sensory nerves. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).
AMITRIPTYLINE+KETAMINE is a combination of two drugs: Amitriptyline (tricyclic antidepressant) and Ketamine (anaesthesia). Amitriptyline works by increasing the serotonin and noradrenaline (natural substances) levels in the brain, thereby preventing the movement of pain signals in the brain. Ketamine is a general anaesthetic that blocks certain receptors (NMDA), thereby decreasing pain sensation. Thus, AMITRIPTYLINE+KETAMINE effectively alleviates neuropathic pain.
Depending on your medical condition, you are advised to use AMITRIPTYLINE+KETAMINE for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side effects such as application site reactions such as skin dryness and itching. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Do not use AMITRIPTYLINE+KETAMINE if you are pregnant or breastfeeding unless prescribed by the doctor. To rule out any side effects/interactions, keep your doctor informed about your health condition and ongoing medications before using AMITRIPTYLINE+KETAMINE. Limited information is available regarding using AMITRIPTYLINE+KETAMINE in children, so do not use AMITRIPTYLINE+KETAMINE unless prescribed by the doctor.
Neuralgia (neuropathic pain)
AMITRIPTYLINE+KETAMINE is a combination of two drugs: amitriptyline (tricyclic antidepressant) and ketamine (anaesthesia). Amitriptyline works by increasing serotonin and noradrenaline (natural substances) levels in the brain, preventing the movement of pain signals. Ketamine is a general anaesthetic that reduces pain by blocking specific receptors (NMDA). Thus, AMITRIPTYLINE+KETAMINE effectively reduces neuropathic pain.
Application site reactions such as skin dryness and itching
Do not use AMITRIPTYLINE+KETAMINE on your own unless prescribed by the doctor. AMITRIPTYLINE+KETAMINE is not recommended to use if you are allergic to any component present in it. AMITRIPTYLINE+KETAMINE should not be used in pregnant or lactating women and the paediatric population unless prescribed by the doctor. Do not use any other medications along with AMITRIPTYLINE+KETAMINE unless instructed by the doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Drug-Drug Interactions: No interactions found/established.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: No interactions found/established.
It is not known whether AMITRIPTYLINE+KETAMINE interacts with alcohol. However, as a precautionary measure, it is advisable to avoid consumption of alcohol.
Limited data is available on the effect of AMITRIPTYLINE+KETAMINE in pregnancy. Hence, please consult your doctor before using AMITRIPTYLINE+KETAMINE.
If you are breastfeeding, please consult your doctor before using AMITRIPTYLINE+KETAMINE.
AMITRIPTYLINE+KETAMINE does not affect your ability to drive.
Limited information is available about using AMITRIPTYLINE+KETAMINE in patients with liver disease. Inform your doctor before using AMITRIPTYLINE+KETAMINE if you have a history of liver disease. Your doctor will prescribe only if the benefits outweigh the risks.
Limited information was available about using AMITRIPTYLINE+KETAMINE in patients with kidney disease. Inform your doctor before using AMITRIPTYLINE+KETAMINE if you have a history of kidney diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.
Limited information is available regarding using AMITRIPTYLINE+KETAMINE in children. Please consult your doctor for more information.
Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury; the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).