About AMITRIPTYLINE+PANTOPRAZOLE
AMITRIPTYLINE+PANTOPRAZOLE is a combination medication. It is used to treat gastroesophageal reflux disease (GERD) associated with anxiety. GERD is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). An anxiety disorder is a mental health disorder characterised by feelings of excessive fear or worry that affect an individual's daily activities.
AMITRIPTYLINE+PANTOPRAZOLE is a combination of two drugs: Amitriptyline and Pantoprazole. Amitriptyline belongs to a class of medications known as tricyclic antidepressants, and it works by boosting serotonin levels in the brain that help regulate mood. Pantoprazole is a proton pump inhibitor (PPI) that reduces the amount of acid in the stomach; thus, it relieves symptoms of heartburn, acid reflux, and gastro-oesophageal reflux disease (GERD).
Take AMITRIPTYLINE+PANTOPRAZOLE as prescribed by your doctor. Depending on your medical condition, you are advised to take AMITRIPTYLINE+PANTOPRAZOLE for as long as your doctor prescribes it. Sometimes, you may experience common side effects such as headaches, diarrhoea, constipation, light-headedness or dizziness, dry mouth, sleepy or tiredness, and difficulty peeing. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Avoid taking AMITRIPTYLINE+PANTOPRAZOLE if you are allergic to AMITRIPTYLINE+PANTOPRAZOLE or any ingredients in it. This medicine is not recommended for pregnant and breastfeeding women; hence, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. AMITRIPTYLINE+PANTOPRAZOLE may cause light-headedness or dizziness. Hence, do not drive or operate machinery until you are mentally alert. Avoid consuming alcohol with AMITRIPTYLINE+PANTOPRAZOLE as it could lead to increased dizziness and sleepiness. Tell your doctor about your medical and medication history to avoid side effects.
Uses of AMITRIPTYLINE+PANTOPRAZOLE
Gastroesophageal Reflux Disease (GERD) Associated with Anxiety
Medicinal Benefits
AMITRIPTYLINE+PANTOPRAZOLE is a combination of two medications: amitriptyline and pantoprazole. Amitriptyline is a tricyclic antidepressant medicine that works by increasing serotonin levels in the brain, which helps regulate mood. Pantoprazole is a proton pump inhibitor (PPI) that reduces the amount of acid in the stomach, thereby reducing symptoms of heartburn, acid reflux, and gastro-oesophageal reflux disease (GERD).
Directions for Use
Storage
Side Effects of AMITRIPTYLINE+PANTOPRAZOLE
Headaches
Diarrhoea
Constipation
light-headedness or dizziness
Dry mouth
Feeling sleepy or tired
Difficulty peeing
In-Depth Precautions and Warning
Drug Warnings
AMITRIPTYLINE+PANTOPRAZOLE is not suitable for some people. To make sure it's safe for you, discuss with your doctor if you have ever had an allergic reaction to any food or any medicine, have any medical condition, are pregnant, trying to get pregnant or breastfeeding. Do not take any other medications together with AMITRIPTYLINE+PANTOPRAZOLE unless prescribed by the doctor. Amitriptyline may cause blood sugar fluctuations. If you have diabetes and regularly check your blood sugar levels, you may need to do so more frequently during the first few weeks of medication. If your blood sugar levels get too high or too low, consult your diabetic doctor.
Drug Interactions
Drug-Drug interactions: AMITRIPTYLINE+PANTOPRAZOLE may interact with certain antidepressant medicines (e.g. duloxetine, escitalopram, fluoxetine, sertraline), skeletal muscle relaxants (e.g. cyclobenzaprine), and anticonvulsants (e.g. topiramate), and a medication used to prevent nausea and vomiting caused by cancer chemotherapy (ondansetron)
Drug-Food Interactions: Avoid consuming alcohol with AMITRIPTYLINE+PANTOPRAZOLE as it could lead to increased dizziness and sleepiness.
Drug-Disease Interactions: AMITRIPTYLINE+PANTOPRAZOLE may interact with disease conditions, including pseudomembranous colitis, diarrhoea, liver disorders, bone fractures, magnesium imbalance, seizure disorders, depression, cardiovascular disease, glaucoma/intraocular hypertension, urinary retention, gastrointestinal obstruction, hyperthyroidism, cerebrovascular disease, myocardial infarction, hypotension, dehydration, arrhythmias, pheochromocytoma (noncancerous (benign) tumour that develops in an adrenal gland), acute myocardial infarction recovery, alcoholism, and CNS disorder.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consuming alcohol while taking AMITRIPTYLINE+PANTOPRAZOLE as it may increase the risk of side effects.
Pregnancy
cautionAMITRIPTYLINE+PANTOPRAZOLE is generally not recommended for use in pregnancy. Hence, if you are pregnant, consult your doctor before taking AMITRIPTYLINE+PANTOPRAZOLE. Your doctor will only prescribe AMITRIPTYLINE+PANTOPRAZOLE if the benefits outweigh the risks.
Breast Feeding
cautionAMITRIPTYLINE+PANTOPRAZOLE is generally not recommended in breastfeeding as it passes into breastmilk and may harm your infant. If you are a breastfeeding mother, consult your doctor before taking AMITRIPTYLINE+PANTOPRAZOLE. Your doctor will only prescribe this medicine if the benefits outweigh the risks.
Driving
cautionAMITRIPTYLINE+PANTOPRAZOLE may cause side effects like light-headedness or dizziness, affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert after taking AMITRIPTYLINE+PANTOPRAZOLE. Seek medical attention if the symptoms persist longer.
Liver
cautionIf you have liver problems, inform your doctor before taking AMITRIPTYLINE+PANTOPRAZOLE. Your doctor may adjust your dose or prescribe a suitable alternative based on your condition.
Kidney
cautionIf you have kidney problems, inform your doctor before taking AMITRIPTYLINE+PANTOPRAZOLE. Your doctor may adjust your dose or prescribe a suitable alternative based on your condition.
Children
cautionLimited information was available for the use of AMITRIPTYLINE+PANTOPRAZOLE in children. Please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.
Habit Forming
Diet & Lifestyle Advise
Maintain a healthy weight by eating well.
Avoid foods that can aggravate your symptoms, such as rich, spicy, and fatty foods, as well as acidic foods like tomatoes, citrus fruits, salad dressings, and fizzy drinks.
Reduce your intake of caffeinated beverages such as tea, coffee, and cola.
If you have symptoms at night, try not to eat for at least 3 hours before going to bed.
Cut down the consumption of alcohol.
Quitting smoking is the best strategy for avoiding many health complications.
When you go to bed, raise your head and shoulders using a pillow to prevent stomach acid from flowing back.
Avoid prolonged sitting because it can increase stomach acid production. Try to take a 5-minute break every hour by moderate walking or stretching.
Special Advise
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): It is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms of GERD include chest pain, difficulty swallowing, regurgitation (expulsion of food from the pharynx or oesophagus) of food/sour liquid, and a burning sensation in the chest.
Anxiety Disorder: An anxiety disorder is a mental health disorder characterised by feelings of excessive fear or worry that affect an individual's daily activities. Anxiety disorders differ from normal feelings of anxiety and nervousness, involving excessive anxiety, fear or worry. Anxiety disorders can affect an individual’s job performance, school work and personal relationships.
