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About AMLODIPINE+INDAPAMIDE

AMLODIPINE+INDAPAMIDE belongs to the class of combination medication called 'anti-hypertensive drugs', primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition, in which the blood exerts high pressure (force exerted by circulating blood) against the blood vessel's walls. This condition makes the heart to work harder in pumping the blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.

AMLODIPINE+INDAPAMIDE is composed of two medicines, namely: Amlodipine and Indapamide.  Amlodipine belongs to the class of calcium channel blockers and is used to treat high blood pressure. It relaxes blood vessels, so that blood passes through them easily, thereby lowers the blood pressure. Thus, AMLODIPINE+INDAPAMIDE lowers the risk of stroke and heart attack in people with diabetes and coronary heart disease with raised cholesterol levels.  Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure. Indapamide is also used to treat fluid retention in patients with congestive heart failure.

AMLODIPINE+INDAPAMIDE is an orally administered drug in the form of a tablet. Your doctor will advise you how often you take AMLODIPINE+INDAPAMIDE based on your medical condition. The common side effects of AMLODIPINE+INDAPAMIDE include nausea, stomach pain, headache, sleepiness, ankle swelling, flushing (warm sensation in the face, ears, neck, and trunk), palpitations (pounding heartbeat), constipation, muscle pain, and tiredness. These side effects do not occur in everyone using AMLODIPINE+INDAPAMIDE and may vary individually. If these side effects occur, they resolve gradually over time and do not usually require medical attention. However, if you notice any side effects that are not manageable, it is advised to consult your doctor.

Try not to stop taking this medicine of your own. Stopping AMLODIPINE+INDAPAMIDE may worsen your condition and increase the risk of a future heart attack. Let your doctor know if are sensitive to AMLODIPINE+INDAPAMIDE and have any kidney/liver diseases and heart problems like aortic/mitral stenosis (reduced blood flow from the left atrium to the left ventricle due to narrowing of the mitral valve). AMLODIPINE+INDAPAMIDE is not recommended for use in pregnancy and breastfeeding. AMLODIPINE+INDAPAMIDE may cause dizziness, hence it is advised to drive only when you are mentally alert.

Uses of AMLODIPINE+INDAPAMIDE

High blood pressure (hypertension)

Medicinal Benefits

AMLODIPINE+INDAPAMIDE is composed of two medicines, namely: Amlodipine and Indapamide.  Amlodipine belongs to the class of calcium channel blockers and is used to treat high blood pressure. It relaxes blood vessels, so that blood passes through them easily, thereby lowers the blood pressure. Thus, AMLODIPINE+INDAPAMIDE lowers the risk of stroke and heart attack in people with diabetes and coronary heart disease with raised cholesterol levels.  Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure. Indapamide is also used to treat fluid retention in patients with congestive heart failure.

Directions for Use

Take the tablet of AMLODIPINE+INDAPAMIDE with or without food or as directed by your physician. Swallow the whole tablet with a glass of water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of AMLODIPINE+INDAPAMIDE

  • Blurred Vision 
  • Sweating
  • Tiredness 
  • Dehydration 
  • Constipation 
  • Dizziness 
  • Headache 
  • Nausea 
  • Cold hands or feet 
  • Muscle cramps
  • Difficulty breathing
  • Tightness in the chest

In-Depth Precautions and Warning

Drug Warnings

Do not use AMLODIPINE+INDAPAMIDE if you are allergic to AMLODIPINE+INDAPAMIDE or any of its components. Let your doctor know if you have any history of severe kidney or liver diseases, low potassium levels (hypokalaemia), chest pain (angina), poor blood circulation or controlled heart failure, first-degree heart block, diabetes, thyrotoxicosis (a condition caused by an overactive thyroid gland), liver problems and adrenal gland diseases. Let your doctor know if you have anuria (kidneys aren't producing urine), fluid or electrolyte imbalance, lupus erythematosus (an autoimmune inflammatory disease-causing scaly red patches on the skin), gout, abnormal heart rhythms, thyroid disorders and asthma before starting AMLODIPINE+INDAPAMIDE. It is essential to let your doctor know if you are a breastfeeding mother before using AMLODIPINE+INDAPAMIDE since Indapamide may pass into the breast milk. Indapamide is not recommended during pregnancy. Please ask your doctor if you plan to conceive or are pregnant before using AMLODIPINE+INDAPAMIDE. AMLODIPINE+INDAPAMIDE can increase the chances of light-headedness so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness. AMLODIPINE+INDAPAMIDE is not recommended in people less than 18 years of age.

Drug Interactions

Drug-Drug Interaction: AMLODIPINE+INDAPAMIDE may interact with other diuretic medications (hydrochlorothiazide, furosemide, torsemide), anti-hypertensive drugs (chlorthalidone, ramipril, metoprolol, lisinopril,  candesartan, baclofen, levodopa, clonidine), drugs treating mental illness (alprazolam, risperidone, amisulpride, pimozide), painkillers (ibuprofen, naproxen), anti-depressants (lithium, duloxetine), Vitamins (vitamin D, cholecalciferol (vitamin D3)), heart-related drugs (amiodarone, digoxin, sotalol), diabetic drugs (Insulin glargine, metformin), drugs treating stomach acid (esomeprazole), fits medicine (clonazepam), pain medicine (oxycodone), corticosteroids (prednisone), drugs treating impotence (sildenafil), and multivitamin with minerals.

Drug-Food Interaction: AMLODIPINE+INDAPAMIDE may interact or may have decreased effect when used with alcohol and large amounts of orange juice.

Drug-Disease Interaction: Before using AMLODIPINE+INDAPAMIDE, let your doctor know if have any severe kidney or liver diseases, low potassium levels (hypokalaemia), chest pain (angina), poor blood circulation or controlled heart failure, first-degree heart block, diabetes, thyrotoxicosis (a condition caused by an overactive thyroid gland), liver problems, adrenal gland diseases, anuria (kidneys aren't producing urine), fluid or electrolyte imbalance, lupus erythematosus (an autoimmune inflammatory disease-causing scaly red patches on the skin), gout, abnormal heart rhythms, thyroid disorders and asthma.

Safety Advice

  • Safety Warning

    Alcohol

    Alcohol may lower your blood pressure. It would help if you avoided or limit consuming alcohol whilst taking this medicine

  • Safety Warning

    Pregnancy

    Indapamide in AMLODIPINE+INDAPAMIDE is not recommended during pregnancy. However, it is advised to seek medical advice before using AMLODIPINE+INDAPAMIDE if you plan to conceive or pregnant.

  • Safety Warning

    Breast Feeding

    There are limited studies on how AMLODIPINE+INDAPAMIDE affects the breastfed infants. However, Indapamide in AMLODIPINE+INDAPAMIDE may pass into the breast milk during breastfeeding. Please consult your doctor before using AMLODIPINE+INDAPAMIDE if you are a lactating mother.

  • Safety Warning

    Driving

    AMLODIPINE+INDAPAMIDE may cause side effects due to lowering of the blood pressure such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.

  • Safety Warning

    Liver

    Let your doctor know if you have any history of liver diseases before using AMLODIPINE+INDAPAMIDE.

  • Safety Warning

    Kidney

    Let your doctor know if you have any history of kidney diseases before using AMLODIPINE+INDAPAMIDE.

Habit Forming

No

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, use only one serving for women and two servings for men.
  • Quit smoking to lower the risk of heart diseases. 
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
  • Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil that help in lowering your elevated blood pressure.

Special Advise

  • Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
  • Let your doctor know if you are advised for any blood examinations as, diuretics like Indapamide can cause changes in the laboratory parameters like low potassium levels in the blood, low sodium in the blood, low blood pressure, increase in uric acid, increase in blood glucose levels in diabetic patients, increase in calcium levels in the blood, and increase in the liver enzyme levels. 
  • Let your anesthetist or medical staff know that you are taking AMLODIPINE+INDAPAMIDE since AMLODIPINE+INDAPAMIDE can lower blood pressure levels when certain anesthetic medications are given during any operation or surgery.
  • Athletes should be aware that Indapamide in AMLODIPINE+INDAPAMIDE gives a positive reaction in doping tests.

Patients Concern

Disease/Condition Glossary

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke) and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nose bleed, vomiting, and chest pain.

Oedema: It is a condition caused by a build-up of fluid and swelling in the body parts, especially ankles, feet, and legs.

FAQs

AMLODIPINE+INDAPAMIDE is recommended to use in dose and duration as advised by the doctor. Do not stop taking AMLODIPINE+INDAPAMIDE on your own as it may lead to a sudden rise in blood pressure increases the risk of heart attack and stroke.

AMLODIPINE+INDAPAMIDE can cause dehydration and dry mouth. Drink plenty of fluids to manage and let your doctor know if you develop extreme thirst, muscle weakness or very dry mouth.

AMLODIPINE+INDAPAMIDE can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.

It is advised to consult your doctor before taking AMLODIPINE+INDAPAMIDE if you have a history of severe kidney or liver diseases, low potassium levels (hypokalaemia), diabetes, gout, abnormal heart rhythms, thyroid disorders and asthma.

It is recommended to please consult your doctor since diuretics (water pills) may increase blood sugar levels. Besides this, beta-blockers (blood pressure-lowering agents) can mask hypoglycemia symptoms (low blood sugar).

Even though your blood pressure becomes normal after using AMLODIPINE+INDAPAMIDE, it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range