ARTESUNATE+PYRIMETHAMINE+SULFADOXINE belongs to a group of anti-malarial drugs used to treat uncomplicated falciparum malaria. Malaria is a mosquito-borne disease caused by the female anopheles mosquito. Malaria is transmitted through the bite of infected mosquitoes, which carry the Plasmodium parasite. The symptoms usually develop within 10days to 4weeks after the infection.
ARTESUNATE+PYRIMETHAMINE+SULFADOXINE is a combination of three drugs, namely: Artesunate, Pyrimethamine, and Sulfadoxine. Artesunate generates free radicals, thereby inhibits nucleic acid and protein synthesis of the Plasmodium parasites during erythrocytic stages. Pyrimethamine binds to haem and forms a complex which is toxic to the malarial parasite. Sulfadoxine prevents the parasite from producing folinic acid, which is necessary for their multiplication. Together, ARTESUNATE+PYRIMETHAMINE+SULFADOXINE helps in treating malaria.
You are advised to take ARTESUNATE+PYRIMETHAMINE+SULFADOXINE for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as nausea, vomiting, dizziness, abdominal pain, headache, diarrhoea, and fatigue. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Consult your doctor before taking ARTESUNATE+PYRIMETHAMINE+SULFADOXINE if you are pregnant. Avoid breastfeeding while taking ARTESUNATE+PYRIMETHAMINE+SULFADOXINE. ARTESUNATE+PYRIMETHAMINE+SULFADOXINE may cause dizziness, so drive only if you are alert. ARTESUNATE+PYRIMETHAMINE+SULFADOXINE should be given to children only if prescribed by the doctor. Avoid consuming alcohol along with ARTESUNATE+PYRIMETHAMINE+SULFADOXINE as it could lead to increased dizziness. Keep your doctor informed about your health condition and medications to rule out any side effects.
Malaria
ARTESUNATE+PYRIMETHAMINE+SULFADOXINE is a combination of three drugs, namely: Artesunate, Pyrimethamine, and Sulfadoxine. ARTESUNATE+PYRIMETHAMINE+SULFADOXINE belongs to a group of medicines called anti-malarial drugs used to treat uncomplicated Plasmodium falciparum malaria. Artesunate is an anti-parasitic agent which generates free radicals, this results in the inhibition of nucleic acid and protein synthesis of the Plasmodium parasites during erythrocytic stages. Pyrimethamine is an anti-parasitic agent that binds to haem and forms a complex toxic to the malarial parasite. Sulfadoxine is an antibiotic that prevents the parasite from producing folinic acid, which is necessary for their multiplication. Together, ARTESUNATE+PYRIMETHAMINE+SULFADOXINE helps in treating malaria.
Do not take ARTESUNATE+PYRIMETHAMINE+SULFADOXINE if you are allergic to any of its components. Inform your doctor if you have epilepsy, asthma, blood problems, depression, schizophrenia, bipolar disorder, severe anxiety, glucose-6-phosphate dehydrogenase deficiency, stomach or intestinal infection, heart, kidney, or liver problems. Consult your doctor if you are pregnant. Avoid breastfeeding while taking ARTESUNATE+PYRIMETHAMINE+SULFADOXINE. ARTESUNATE+PYRIMETHAMINE+SULFADOXINE may cause dizziness, so drive only if you are alert. ARTESUNATE+PYRIMETHAMINE+SULFADOXINE should be given to children only if prescribed by the doctor. Avoid consuming alcohol with ARTESUNATE+PYRIMETHAMINE+SULFADOXINE as it could lead to increased dizziness. Consult your doctor immediately if you notice signs of infection, unusual tiredness, skin rash, unusual bleeding or bruising, red, swollen, or blistered skin.
Drug-Drug Interactions: ARTESUNATE+PYRIMETHAMINE+SULFADOXINE may interact with anticonvulsant (carbamazepine, phenytoin), antiretroviral (ritonavir, nevirapine), antibiotics (rifampin), anti-malarial (chloroquine), antimetabolite (methotrexate).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have depression, schizophrenia, bipolar disorder, seizure, colitis, or porphyria.
Avoid consumption of alcohol while taking ARTESUNATE+PYRIMETHAMINE+SULFADOXINE as it may lead to increased dizziness.
Consult your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
ARTESUNATE+PYRIMETHAMINE+SULFADOXINE passes into breastmilk. Avoid breastfeeding while taking ARTESUNATE+PYRIMETHAMINE+SULFADOXINE.
ARTESUNATE+PYRIMETHAMINE+SULFADOXINE may cause dizziness. Do not drive or operate machinery unless you are alert.
ARTESUNATE+PYRIMETHAMINE+SULFADOXINE should be used with caution in patients with liver problems. Consult your doctor if you have a liver impairment or any concerns regarding this.
Consult your doctor if you have kidney impairment or any concerns regarding this.
ARTESUNATE+PYRIMETHAMINE+SULFADOXINE should be given to children aged 6months and older only if advised by the doctor.
Malaria: Malaria is a mosquito-borne blood disease caused by the female anopheles mosquito. Malaria is transmitted through the bite of infected mosquitoes, which carry the Plasmodium parasite. When the infected mosquito bites a person, the parasite is released into the bloodstream. The parasite matures in the liver and infects the red blood cells. Then, it multiplies in the red blood cells leading to malarial infection. Symptoms of malaria include fever, headache, fatigue, muscle pain, back pain, chills, sweating, nausea, vomiting, and dry cough. The symptoms usually develop within 10 days to 4 weeks after the infection.