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About BUSERELIN

BUSERELIN belongs to a group of medicines called gonadotropin-releasing hormone analogues indicated in women for the treatment of infertility and endometriosis. This medicine is also indicated in the treatment of prostate cancer (cancer of the prostate gland) in men who have not had testicles removed by surgery.

BUSERELIN contains Buserelin, a synthetic version of the hormone that naturally occurs in the body. It works by stopping the production of natural hormones that control ovulation. It helps relieve symptoms of endometriosis by reducing the production of female sex hormones by acting on the pituitary gland. This medicine helps treat prostate cancer by reducing the production of testosterone and helps to stop the growth of cancer cells.

In some cases, BUSERELIN may cause side effects like diarrhoea, constipation, nausea, vomiting, abdominal pain, and headache. Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.

Avoid using BUSERELIN if you are pregnant, think you are pregnant, breastfeeding, or have abnormal menstrual bleeding. Consult your doctor immediately if you become pregnant while on treatment with BUSERELIN. Do not father a child during treatment with BUSERELIN and for a few months afterwards, as it might harm the developing baby in the womb. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of BUSERELIN

Infertility, Endometriosis, Prostate cancer

Medicinal Benefits

BUSERELIN belongs to a group of medicines called gonadotropin-releasing hormone analogues indicated in the treatment of infertility and endometriosis in women. It is also indicated in the treatment of prostate cancer in men who have not had testicles removed by surgery. BUSERELIN contains Buserelin, a synthetic version of the hormone that naturally occurs in the body. It acts on the pituitary gland in the brain to stop the production of natural hormones that control the release of eggs from the ovaries. Other hormonal treatments are then used to stimulate ovulation artificially. Female hormones such as oestrogen may worsen problems like endometriosis. It helps relieve symptoms of endometriosis by reducing the production of female sex hormones by acting on the pituitary gland. In men, it prevents the pituitary gland from releasing luteinising hormone. This prevents the testicles from producing testosterone, which is required by the prostate gland to grow. By reducing testosterone, it shrinks and prevents the growth of prostate cancer.

Directions for Use

A healthcare professional will administer BUSERELIN. After receiving proper training, you may be advised to inject the medicine yourself.

Storage

Store in a cool and dry place away from sunlight

Side Effects of BUSERELIN

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhoea
  • Constipation
  • Headache

In-Depth Precautions and Warning

Drug Warnings

Do not use BUSERELIN if you are allergic to any of its components, if you have abnormal menstrual bleeding, if you are pregnant or breastfeeding or if you have had an operation to remove testicles. Stop using BUSERELIN and consult the doctor immediately if you become pregnant while on treatment with BUSERELIN. Inform the doctor if you have depression, high blood pressure, diabetes, polycystic ovarian disease, heart/blood vessel conditions, heart rhythm problems, metabolic bone disease or risk factors for osteoporosis like smoking, chronic alcohol abuse, a family history of osteoporosis, or if you are on long-term treatment with corticosteroids or anticonvulsants. Stop using BUSERELIN and consult a doctor immediately if you experience symptoms of serious side effect called ovarian hyperstimulation syndrome, such as diarrhoea, weight gain, difficulty breathing, shortness of breath, passing less urine, feeling sick or being sick, pain, swelling or a feeling of tension in your stomach. Ovarian hyperstimulation syndrome is more likely to occur if you are taking other hormones along with BUSERELIN as a part of infertility treatment. Consult the doctor straight away if you notice bruising more easily than usual, signs of infections (fever, sore throat or mouth ulcers), severe headache, eyesight problems, or high blood pressure (crushing chest pain, problems with eyesight, confusion, tiredness and an uneven heartbeat).

Drug Interactions

Drug-Drug Interactions: Inform the doctor if you are taking medicines for heart rhythm problems (quinidine, procainamide, amiodarone, sotalol), pain killers (methadone), antibiotics (moxifloxacin), anti-diabetics, and antipsychotics.

Drug-Food Interactions: No interactions found. 

Drug-Disease Interactions: Inform the doctor if you have depression, high blood pressure, diabetes, polycystic ovarian disease (PCOD), heart rhythm problems, or metabolic bone disease.

Drug-Drug Interactions Checker List:

  • QUINIDINE
  • PROCAINAMIDE
  • AMIODARONE
  • SOTALOL
  • METHADONE
  • MOXIFLOXACIN
  • Safety Advice

    • Safety Warning

      Alcohol

      consult your doctor

      It is unknown if BUSERELIN interacts with alcohol. Please consult your doctor.

    • Safety Warning

      Pregnancy

      unsafe

      BUSERELIN is not recommended during pregnancy as it may be harmful to the developing baby. Please consult the doctor if you are pregnant, think you may be pregnant or become pregnant while on treatment with BUSERELIN.

    • Safety Warning

      Breast Feeding

      unsafe

      Breastfeeding is not recommended during treatment with BUSERELIN as it might pass into the mother’s milk.

    • Safety Warning

      Driving

      caution

      BUSERELIN may cause dizziness, drowsiness, or blurred eyesight. Do not drive or operate machinery if you experience these symptoms.

    • Safety Warning

      Liver

      consult your doctor

      Limited information is available. Please consult the doctor if you have a liver impairment or any concerns regarding this.

    • Safety Warning

      Kidney

      consult your doctor

      Limited information is available. Please consult the doctor if you have a kidney impairment or any concerns regarding this.

    • Safety Warning

      Children

      consult your doctor

      Limited information is available. Please consult the doctor if you have any concerns.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Include fibrous foods, iron-rich foods, foods rich in essential fatty acids, and anti-oxidant-rich foods in the diet.
    • Practice meditation and yoga. 
    • Avoid or limit caffeine intake.
    • Include healthy fruits and vegetables in your diet.
    • Avoid smoking and alcohol consumption.
    • Try relaxation therapy. Read a book or listen to soothing music.
    • Exercise moderately.
    • Do yoga or meditation, as it helps relieve stress.

    Special Advise

    • The use of this medicine may lead to positive results in doping tests. Additionally, misuse as a doping agent may harm your health.
    • BUSERELIN might affect certain blood test results; particularly, it may affect the levels of liver enzymes and fats in the blood shown in blood tests. Therefore, if you are undergoing any tests, inform the doctor that you are on treatment with BUSERELIN.
    • Regular monitoring of blood pressure and blood glucose levels is advised.
    • Women are recommended to have a pregnancy test to make sure they are not pregnant before using BUSERELIN.
    • Do not father a child during treatment with BUSERELIN and for a few months afterwards, as it might harm the developing baby in the womb. Discuss with your doctor regarding effective contraception.
    • The doctor may advise regular blood tests before and during the treatment to check the levels of testosterone, blood levels, and liver/kidney functioning.

    Patients Concern

    Disease/Condition Glossary

    Endometriosis: Endometriosis is a painful disorder in which the tissue that generally lines the endometrium (inside the uterus) grows outside the uterus. Endometriosis usually occurs when the endometrial tissue grows on the ovaries, pelvis lining, and fallopian tubes. Symptoms include pelvic pain, painful periods, pain in the abdomen during and before menstruation, heavy menstrual bleeding, discomfort during bowel movements, lower back pain during menstruation, pain during sexual intercourse, and cramps 1-2 weeks around menstruation.

    Infertility: It is a condition in which a woman cannot become pregnant even after having carefully timed, unprotected sex for a year. Age, hormonal problems, physical problems, lifestyle or environmental factors could be the causes of infertility.

    Prostate cancer: Prostate cancer, also called prostatic carcinoma, is cancer in the prostate gland (a gland that produces seminal fluid). Symptoms include difficulty with urination, weak or interrupted flow of urine, trouble emptying the bladder completely, and pain or burning sensation during urination.

    FAQs

    How does BUSERELIN work?

    BUSERELIN works by stopping the production of natural hormones that control ovulation and relieves symptoms of endometriosis by reducing the production of female sex hormones. It reduces the production of testosterone, thereby preventing the growth of prostate cancer.

    Does BUSERELIN cause menopausal symptoms?

    BUSERELIN might cause menopausal symptoms such as hot flushes, dry vagina, increased sweating, loss of sex drive, or painful sexual intercourse in women. If these symptoms become serious or last longer than a few days, consult a doctor.

    Does BUSERELIN cause osteoporosis?

    BUSERELIN might increase the risk of osteoporosis if used for a longer duration due to a lowering in the amount of bone mineral. However, this effect is reversible when the treatment is stopped. Consult a doctor if you experience bone or muscle discomfort, such as shoulder stiffness or pain that lasts longer than a few days.

    I have heart rhythm problems. Is it safe to use BUSERELIN?

    BUSERELIN may increase the risk of heart rhythm problems. Inform the doctor if you have heart or blood vessel problems, including arrhythmia (heart rhythm problems), or if you are being treated with medicines for these conditions.

    Does BUSERELIN cause muscle pain?

    BUSERELIN may cause muscle or bone pain, including pain in the back or jaw. Consult the doctor if you experience muscle or bone pain; the doctor may prescribe painkillers.

    Does BUSERELIN affect blood sugar levels?

    BUSERELIN might affect blood sugar levels. You may need to check your blood glucose levels more regularly if you have diabetes.

    Available Medicines for

    BUSERELIN