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About CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL

CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL is a combination medicine indicated to treat and prevent migraine. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by the intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.
 
CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain, and also affects the blood flow patterns associated with headache. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
 
You are advised to take CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL contains paracetamol, do not take other medicines containing paracetamol along with CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL unless prescribed. Do not take CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL if you are pregnant or breastfeeding. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL may cause drowsiness and dizziness, so drive with caution. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL

Migraine

Medicinal Benefits

CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headache. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

Directions for Use

Take CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL with or without food. Swallow CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL as a whole with a glass of water; do not chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL

  • Stomach upset
  • Dizziness
  • Dry mouth
  • Constipation
  • Insomnia (trouble sleeping)

In-Depth Precautions and Warning

Drug Warnings

Do not take CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL, when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL contains paracetamol, do not take other medicines containing paracetamol along with CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL unless prescribed. Inform your doctor before taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL if you are pregnant or breastfeeding. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL may cause drowsiness and dizziness, so drive only if you are alert. CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL unless prescribed. 

Drug Interactions

Drug-Drug Interactions: CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL may interact with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole), anti-HIV medicines (indinavir, nelfinavir, ritonavir), decongestant (oxymetazoline), pain killers (acetaminophen, butalbital, fentanyl), anti-depressant (fluoxetine, duloxetine), anti-anxiety (diazepam, lorazepam, alprazolam), antacid (ranitidine), antihistamine (diphenhydramine), anti-convulsant (pregabalin), anti-hypertensive (metoprolol), bronchodilators (albuterol), anti-emetic (ondansetron).

Drug-Food Interactions: Avoid the consumption of alcohol, smoking, and caffeinated products. Do not consume grapefruit while taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL.

Drug-Disease Interactions: Inform your doctor if you have high blood pressure, vasospastic reactions, heart problems, bipolar disorder, psychotic disorders, seizure disorders, gastroesophageal reflux disease, liver or kidney problems.

Drug-Drug Interactions Checker List:

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • TROLEANDOMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • INDINAVIR
  • NELFINAVIR
  • RITONAVIR
  • OXYMETAZOLINE
  • ACETAMINOPHEN
  • FENTANYL
  • BUTALBITAL
  • FLUOXETINE
  • DULOXETINE
  • DIAZEPAM
  • LORAZEPAM
  • ALPRAZOLAM
  • RANITIDINE
  • DIPHENHYDRAMINE
  • PREGABALIN
  • METOPROLOL
  • ALBUTEROL
  • ONDANSETRON

    • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid consumption of alcohol while taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL as it may cause increased drowsiness.

    • Safety Warning

      Pregnancy

      unsafe

      Avoid taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL if you are pregnant or planning for pregnancy. Please consult your doctor if you are pregnant or if you have any concerns regarding this.

    • Safety Warning

      Breast Feeding

      unsafe

      CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL may pass into breastmilk. Avoid taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL if you are breastfeeding.

    • Safety Warning

      Driving

      caution

      CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

    • Safety Warning

      Liver

      caution

      Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

    • Safety Warning

      Kidney

      caution

      Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

    • Safety Warning

      Children

      unsafe

      CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL should not be given to children as the safety and effectiveness were not established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
    • Avoid bright lights, loud noise, and extreme temperatures.
    • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
    • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
    • Massage your scalp to ease the pain.
    • Lie down in a quiet, dark room.
    • Avoid smoking, alcohol, and caffeinated drinks. 
    • Learn what triggers your migraine and try avoiding them.
    • Stay hydrated. Drink plenty of fluids.
    • Learn relaxation skills as they help in reducing stress.

    Patients Concern

    Disease/Condition Glossary

    Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Migraine headache is preceded by warning symptoms one or two days prior to the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, and sensitivity to sound and light.

    FAQs

    How does CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL work?

    CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL contains Ergotamine, caffeine, prochlorperazine, and paracetamol. Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

    How to cope with dry mouth?

    Dry mouth could be a side-effect of CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

    Does CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing)?

    Orthostatic hypotension could be a side-effect of CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.

    Can I stop taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL if I feel well?

    Do not discontinue CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL without consulting your doctor as it could lead to recurring or worsening of symptoms. To treat your condition effectually, continue taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL.

    Can I take antibiotics with CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL?

    Do not take CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL along with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole) and anti-HIV medicines (indinavir, nelfinavir, ritonavir). CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL contains ergotamine and caffeine, which, when taken along with these drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain.

    Does CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL cause constipation?

    CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL may cause constipation. Eat high-fibre foods and drink plenty of fluids if you experience constipation. Talk to your doctor if the condition persists or worsens.

    Available Medicines for

    CAFFEINE+ERGOTAMINE+PROCHLORPERAZINE+PARACETAMOL

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