About COLLAGENASE CLOSTRIDIUM HISTOLYTICUM
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM belongs to the class of medicine called bacterial enzymes. It is used in the treatment of Dupuytren’s contracture (an abnormal tightening of tissues beneath the skin of the hand) with a palpable cord and Peyronie’s disease (a scar formation under the skin of the penis causing painful erections).
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM contains Collagenase Clostridium histolyticum as an active ingredient, which belongs to the class of bacterial enzymes. It works by hydrolyzing the collagen, thus resulting in the lysis of collagen fragments.
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM may cause certain common side effects such as confusion, penile rupture, penile pain, tendon rupture, tenderness, and pain at the site of injection. Most of these side effects do not require medical attention. However, you are advised to talk to your doctor if you experience these side effects persistently. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM will be administered by a trained healthcare professional.
Inform your doctor if you are allergic to COLLAGENASE CLOSTRIDIUM HISTOLYTICUM. It is contraindicated in patients with a history of Peyronie’s plaques that involve the penile urethra and severe hypersensitivity reactions. Hence, inform your doctor if you have conditions like liver/kidney disease, bleeding disorders, gastrointestinal disease, and bone disease. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is not recommended for children younger than 18 years of age. Let your doctor know if you are pregnant, planning pregnancy, or breastfeeding.
Uses of COLLAGENASE CLOSTRIDIUM HISTOLYTICUM
Dupuytren’s contracture with a palpable cord, Peyronie’s disease
Medicinal Benefits
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is a bacterial enzyme that helps treat penile fibrosis and Dupuytren’s contracture. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM contains Collagenase Clostridium histolyticum, which works by hydrolysing the collagen under physiological conditions and results in the lysis of collagen fragments. This causes enzymatic disruption of the cord or the plaque.
Directions for Use
Storage
Side Effects of COLLAGENASE CLOSTRIDIUM HISTOLYTICUM
Confusion
Penile pain
Penile rupture
Tenderness
Injection site haematuria
Pain at the site of injection
Allergic reactions
Tendon rupture
In-Depth Precautions and Warning
Drug Warnings
Discontinue taking COLLAGENASE CLOSTRIDIUM HISTOLYTICUM and inform your doctor if you have any allergic reactions. This medicine is contraindicated in patients with a history of Peyronie’s plaques that involve the penile urethra and severe hypersensitivity reactions. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM may cause tendon rupture, ligament damage, or skin laceration if injected into tendons, nerves, blood vessels, or other collagen-containing structures of the hand. It also causes corporal rupture or other serious injuries to the penis, severe hypersensitivity reactions and bleeding disorders. Hence, inform your doctor if you have conditions like liver/kidney disease, abnormal bleeding disorders, and bone disease. Let your doctor know if you are pregnant, planning to be pregnant, or breastfeeding. COLLAGENASE CLOSTRIDIUM HISTOLYTICUM is not recommended for children below 18 years of age as the safety and efficacy are not established.
Drug Interactions
Drug-Drug Interactions: COLLAGENASE CLOSTRIDIUM HISTOLYTICUM may interact with anticoagulants (warfarin, heparin, aspirin, clopidogrel) and other medicines
Drug-Food Interactions: No interactions found.
Drug-Disease Interactions: Inform your doctor if you have any history of liver/kidney disease, bone disorder, or abnormal bleeding condition before receiving COLLAGENASE CLOSTRIDIUM HISTOLYTICUM.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is unknown whether COLLAGENASE CLOSTRIDIUM HISTOLYTICUM interacts with alcohol. Please consult your doctor.
Pregnancy
cautionLimited data available on the effect of COLLAGENASE CLOSTRIDIUM HISTOLYTICUM in pregnancy. Hence, if you are pregnant, or planning pregnancy, inform your doctor before receiving COLLAGENASE CLOSTRIDIUM HISTOLYTICUM. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
cautionIf you are breastfeeding, inform your doctor before receiving COLLAGENASE CLOSTRIDIUM HISTOLYTICUM. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Driving
safeUsually COLLAGENASE CLOSTRIDIUM HISTOLYTICUM does not impact on your ability to drive or operate machinery.
Liver
cautionCOLLAGENASE CLOSTRIDIUM HISTOLYTICUM to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.
Kidney
cautionCOLLAGENASE CLOSTRIDIUM HISTOLYTICUM to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.
Children
unsafeCOLLAGENASE CLOSTRIDIUM HISTOLYTICUM is not recommended for children under 18 years of age as the safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
Maintaining a healthy weight, eating a balanced diet, and regular exercise may help you manage erectile dysfunction.
Avoid consumption of alcohol, as it may temporarily impair your ability to get an erection.
Avoid the usage of tobacco.
Share intimate time with your partner.
Patients Concern
Disease/Condition Glossary
Dupuytren’s contracture: Also called palmar fibromatosis, is a condition causing an abnormal thickening or tightening of tissues beneath the skin of the hand. This causes curling (contraction) of one or more fingers. It pulls towards your palm and may form a scar over time. The main cause of this condition is unknown but is more common in people with the same family history. It mostly occurs in men than in women.
Peyronie’s disease: Also called penile fibrosis, is a non-cancerous condition that forms a scar-like tissue called plaque under the skin of the penis. This causes curved and painful erections. It mainly occurs due to repeated penile injury, mostly during sex or physical activity.
