Saxagliptin+dapagliflozin
About Saxagliptin+dapagliflozin
Dapagliflozin+saxagliptin is used to treat type 2 diabetes mellitus as an adjunct to diet and exercise. Type 2 diabetes mellitus is also known as non-insulin-dependent diabetes or adult-onset diabetes. Dapagliflozin+saxagliptin is not indicated to treat diabetic ketoacidosis or type-1 diabetes mellitus.
Dapagliflozin+saxagliptin is a combination of Saxagliptin and Dapagliflozin. Saxagliptin enhances glucose-mediated insulin secretion. Thus, it reduces fasting and post-prandial blood sugar concentrations. Dapagliflozin removes excess sugar from the body via urine.
In some cases, you may experience certain common side effects, such as urinary tract infection, hypoglycaemia, upper respiratory tract infection, and dyslipidaemia. You are advised to consult your doctor if the side effects persist or worsen.
Avoid taking Dapagliflozin+saxagliptin if you are pregnant or breastfeeding. Dapagliflozin+saxagliptin is not recommended for children below 18 years as safety and effectiveness have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.
Uses of Saxagliptin+dapagliflozin
Medicinal Benefits
- Dapagliflozin+saxagliptin is a combination of two drugs: Saxagliptin and Dapagliflozin.
- Dapagliflozin+saxagliptin belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus, adjunct to diet and exercise.
- Saxagliptin is a dipeptidyl peptidase-4 inhibitor that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations.
- Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor that removes excess sugar from the body via urine. Together, Dapagliflozin+saxagliptin helps treat type 2 diabetes mellitus.
Directions for Use
- Dapagliflozin+saxagliptin can be taken with or without food. However, inform your doctor before taking this medication if you are on a low-sodium diet, as it may increase the risk of dehydration.
- It is recommended to take Dapagliflozin+saxagliptin once daily in the morning, or as advised by your doctor.
- Swallow Dapagliflozin+saxagliptin as a whole with a glass of water.
- Do not break, chew, or crush it.
Storage
Side Effects of Saxagliptin+dapagliflozin
- Urinary tract infection
- Hypoglycaemia (low blood glucose levels)
- Upper respiratory tract infection
- Dyslipidaemia (high levels of lipids)
Drug Warnings
- Do not take Dapagliflozin+saxagliptin if you are allergic to any of its components.
- Inform your doctor if you have type-1 diabetes mellitus, pancreas disorder, AIDS, reduced kidney function, diabetic ketoacidosis, heart disease, liver problems, high/low blood pressure, infections, if you are older than 75years, if you are taking insulin, sulphonylurea or pioglitazone.
- Avoid taking Dapagliflozin+saxagliptin if you are pregnant or breastfeeding.
- Dapagliflozin+saxagliptin is not recommended for children below 18 years as safety and effectiveness have not been established.
- Avoid alcohol consumption while taking Dapagliflozin+saxagliptin as it might cause unpleasant side-effects.
- Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.
Drug Interactions
Drug-Drug Interactions: Dapagliflozin+saxagliptin may interact with diuretics, anticonvulsants (carbamazepine, phenobarbital, phenytoin), corticosteroids (dexamethasone), antibiotics (rifampicin), antifungals (ketoconazole), and calcium channel blockers (diltiazem).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have diabetic ketoacidosis, type-1 diabetes mellitus, infections, pancreatitis, low blood sugar levels, or heart, kidney, or liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid alcohol consumption while taking Dapagliflozin+saxagliptin to prevent unpleasant side effects.
Pregnancy
unsafeDapagliflozin+saxagliptin is not recommended for use during pregnancy. Please consult your doctor if you have any concerns.
Breast Feeding
unsafeIt is not known if Dapagliflozin+saxagliptin passes into breast milk. Therefore, avoid taking Dapagliflozin+saxagliptin if you are breastfeeding. Please consult your doctor if you have any concerns.
Driving
cautionGenerally, Dapagliflozin+saxagliptin does not affect your ability to drive. However, in some cases, Dapagliflozin+saxagliptin can cause dizziness or low blood sugar, leading to sweating, shakiness, and changes in vision. Therefore, drive or operate machinery only if you are alert.
Liver
consult your doctorDose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
consult your doctorDose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeDapagliflozin+saxagliptin is not recommended for children below 18 years as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Include foods rich in healthy carbohydrates and fibre, fruits, whole grains, and vegetables in your diet.
- Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
- Follow a healthy diet and walk for at least 45 minutes to complement treatment with Dapagliflozin+saxagliptin.
- Maintain a healthy weight by exercising regularly.
- Rest properly and avoid stress by practising meditation or yoga.
Special Advise
- Regularly monitor blood glucose levels while taking Dapagliflozin+saxagliptin.
- Try not to skip any doses and take Dapagliflozin+saxagliptin for as long as your doctor has prescribed it for you.
- Your urine will test positive for sugar whilst on treatment with Dapagliflozin+saxagliptin. Inform the person doing the test that you are taking Dapagliflozin+saxagliptin.
- Dapagliflozin+saxagliptin might alter laboratory tests such as creatinine, renal clearance, and haematocrit. Inform the person doing the test that you are taking Dapagliflozin+saxagliptin.
- Kidney function should be checked before starting and whilst on treatment with Dapagliflozin+saxagliptin.
Patients Concern
Disease/Condition Glossary
Type-2 diabetes mellitus: It is also known as non-insulin-dependent diabetes. It is a chronic or lifelong disease that keeps the body from utilising insulin properly. Diabetes is a medical condition in which blood glucose levels are above normal. People with type 2 diabetes either do not produce enough insulin, or the insulin produced cannot perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes; hence, it is also known as adult-onset diabetes. Type 2 diabetes symptoms include lack of energy, tiredness, frequent urination, excess thirst, dry mouth, blurry vision, constant hunger, weight loss, and itchy skin.
FAQs
Dapagliflozin+saxagliptin is an anti-diabetic medicine used to treat type-2 diabetes mellitus, as an adjunct to diet and exercise.
Dapagliflozin+saxagliptin contains Saxagliptin and Dapagliflozin. Saxagliptin enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin removes excess sugar from the body via urine. Together, Dapagliflozin+saxagliptin helps treat type 2 diabetes mellitus.
Do not stop taking Dapagliflozin+saxagliptin without consulting your doctor, as it may cause an increase in blood glucose levels. Continue taking Dapagliflozin+saxagliptin for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Dapagliflozin+saxagliptin.
Dehydration could be a side effect of Dapagliflozin+saxagliptin. Drink plenty of fluids if you experience any symptoms of dehydration, such as dry mouth, feeling thirsty, tiredness, sleepiness, passing less urine, and a fast heartbeat.
Dapagliflozin+saxagliptin may sometimes lower the blood glucose levels more than normal, leading to hypoglycemia. Regularly monitor your blood sugar levels while taking Dapagliflozin+saxagliptin. Hypoglycemia symptoms include headache, dizziness, drowsiness, shakiness, faintness, confusion, and visual disturbances.
Maintain a healthy diet by regularly consuming carbohydrates. Eat your meals regularly, and do not exercise strenuously for extended periods on an empty stomach.
Inform your doctor if you are allergic to Dapagliflozin+saxagliptin, if you have type-1 diabetes mellitus, pancreas disorder, AIDS, reduced kidney function, diabetic ketoacidosis, heart disease, liver problems, high/low blood pressure, infections, if you are older than 75years, if you are taking insulin, sulphonylurea or pioglitazone. Also, inform your doctor about all the other medicines you are taking and your health condition. If you are breastfeeding, pregnant or planning pregnancy, inform your doctor.
Dapagliflozin+saxagliptin is not recommended in patients with a history of a serious hypersensitivity reaction to Dapagliflozin+saxagliptin, moderate to severe renal (kidney) impairment, end-stage renal (kidney) disease (ESRD), or patients on dialysis. Dapagliflozin+saxagliptin is not recommended for use by children below 18 years of age. Also, inform your doctor if you are breastfeeding, pregnant or planning pregnancy before taking Dapagliflozin+saxagliptin. However, consult your doctor if you have any concerns.
Dapagliflozin+saxagliptin does not cause weight gain. In fact, it may lead to weight loss in some individuals. However, if you notice any changes in your body weight, maintain a healthy diet and engage in physical activity.
Dapagliflozin+saxagliptin is generally safe for people with normal kidney function. However, it should be used with caution in individuals with moderate to severe kidney impairment or those on dialysis. Dapagliflozin in Dapagliflozin+saxagliptin works by helping the kidneys remove glucose from the bloodstream, which can be problematic for those with existing kidney issues. Therefore, it's important to inform your doctor of any history of kidney problems before starting Dapagliflozin+saxagliptin.
Yes, it is important to manage your diet and exercise while taking Dapagliflozin+saxagliptin. Managing blood sugar levels properly requires not only medication but also a good diet and regular exercise. Therefore, a well-balanced diet is part of a healthy lifestyle for people with type 2 diabetes.
If you accidentally take more than the prescribed dose of Dapagliflozin+saxagliptin, it can lead to serious side effects, including life-threatening hypoglycaemia (low blood sugar). Symptoms of severe hypoglycaemia include, extreme weakness, tremors, confusion, sweating, trouble speaking, fast heart rate, nausea, vomiting, rapid breathing, seizures, and fainting. If you experience any these symptoms or suspect you have taken an overdose, please consult your doctor immediately.
Yes, Dapagliflozin+saxagliptin can cause urinary tract infections (UTIs) as a common side effect. To prevent this, it's important to stay hydrated by drinking plenty of water to help flush out bacteria. Maintain good hygiene to reduce the risk of infection. Monitor signs of a urinary tract infection (UTI), such as pain or burning sensation during urination, frequent urination, or cloudy urine. If you experience any of these symptoms, please consult your doctor.
The duration for which you need to take Dapagliflozin+saxagliptin depends on your individual health condition and how well you respond to the treatment. Typically, it is used as a long-term medication to help manage type 2 diabetes. Therefore, do not stop using Dapagliflozin+saxagliptin without consulting your doctor and continue using Dapagliflozin+saxagliptin as long as your has prescribed you.
If you miss a dose of Dapagliflozin+saxagliptin, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and take your regularly scheduled dose. Do not take double dose to make up for the missed one.
Dapagliflozin+saxagliptin is generally considered as safe for long-term use only when prescribed by your doctor. However, it's important to have regular check-ups with your doctor to monitor your kidney function and overall health while taking Dapagliflozin+saxagliptin.
The common side effects of Dapagliflozin+saxagliptin are urinary tract infection, hypoglycaemia (low blood sugar), upper respiratory tract infection, and dyslipidaemia (high levels of lipids). Consult your doctor if any of these side effects persist or worsen.
