DOMPERIDONE+LAFUTIDINE belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.
DOMPERIDONE+LAFUTIDINE is a combination of two drugs: Lafutidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Lafutidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles.
You are advised to take DOMPERIDONE+LAFUTIDINE for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects, such as nausea, diarrhoea, dryness in the mouth, headache, drowsiness, dizziness, increased liver enzymes, and increased uric acid level in the blood. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Inform your doctor before taking DOMPERIDONE+LAFUTIDINE if you have a history of gastrointestinal bleeding, intestinal obstruction, liver disease, kidney disease. Do not take DOMPERIDONE+LAFUTIDINE if you are pregnant or breastfeeding unless prescribed by the doctor. DOMPERIDONE+LAFUTIDINE may cause sleepiness and dizziness, so drive only if you are alert. DOMPERIDONE+LAFUTIDINE should not be given to children as safety has not been established. Avoid consuming alcohol along with DOMPERIDONE+LAFUTIDINE as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.
Gastro-oesophageal reflux disease, peptic ulcers.
DOMPERIDONE+LAFUTIDINE belongs to a group of gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. DOMPERIDONE+LAFUTIDINE is a combination of two drugs: Lafutidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Lafutidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles.
Do not take DOMPERIDONE+LAFUTIDINE if you are allergic to any of its contents. Inform your doctor before taking DOMPERIDONE+LAFUTIDINE if you have a history of gastrointestinal bleeding or intestinal obstruction. Do not take DOMPERIDONE+LAFUTIDINE if you are pregnant or breastfeeding unless prescribed by the doctor. DOMPERIDONE+LAFUTIDINE may cause drowsiness and dizziness, so drive only if you are alert. DOMPERIDONE+LAFUTIDINE should not be given to children as safety has not been established. Avoid consuming alcohol along with DOMPERIDONE+LAFUTIDINE as it could lead to increased drowsiness and can elevate the production of stomach acid. The DOMPERIDONE+LAFUTIDINE contains lafutidine which may mask gastric cancer symptoms, so DOMPERIDONE+LAFUTIDINE should be taken only after confirming the tumour is not malignant.
Drug-Drug Interactions: DOMPERIDONE+LAFUTIDINE may have interaction with antifungals (ketoconazole, fluconazole, posaconazole), medication for HIV/AIDS (saquinavir, darunavir), medication for heart diseases (bepridil), allergy medication (terfenadine), antimalarial medication (piperaquine) and antibiotic (sparfloxacin)
Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Drug-Disease Interactions: DOMPERIDONE+LAFUTIDINE may have interactions with gastrointestinal bleeding, pituitary (brain) tumour, hemodialysis, liver, and kidney dysfunction.
Avoid consumption of alcohol while taking DOMPERIDONE+LAFUTIDINE. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Consult your doctor before taking DOMPERIDONE+LAFUTIDINE if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Consult your doctor before taking DOMPERIDONE+LAFUTIDINE; your doctor will decide whether DOMPERIDONE+LAFUTIDINE can be taken by breastfeeding mothers or not.
DOMPERIDONE+LAFUTIDINE may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.
Dose adjustment may be needed. Consult your doctor before taking DOMPERIDONE+LAFUTIDINE if you have a liver impairment or any concerns regarding this.
Dose adjustment may be needed. Consult your doctor before taking DOMPERIDONE+LAFUTIDINE if you have kidney impairment or any concerns regarding this.
DOMPERIDONE+LAFUTIDINE should not be given to children as the safety and effectiveness were not established.
The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of stomach protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.