Do not take ESOMEPRAZOLE+DOMPERIDONE if you are allergic to any of its contents or other proton pump inhibitors (such as pantoprazole, rabeprazole, lansoprazole or omeprazole); if you are taking nelfinavir (used to treat HIV); if you have prolactinoma (tumour of the pituitary gland), blockage in intestines, bleeding in stomach or intestine, moderate to severe liver disease, low level of potassium or magnesium or high levels of magnesium, or heart problems. Inform your doctor before taking ESOMEPRAZOLE+DOMPERIDONE if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems or HIV infection. Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomit food or blood, or if you pass black stools while taking ESOMEPRAZOLE+DOMPERIDONE. On long-term treatment, ESOMEPRAZOLE+DOMPERIDONE may cause low magnesium levels, vitamin B12 levels, and might increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Consult your doctor if you are pregnant or breastfeeding. ESOMEPRAZOLE+DOMPERIDONE may cause dizziness, so drive only if you are alert. ESOMEPRAZOLE+DOMPERIDONE should not be given to children as safety has not been established. Avoid consuming alcohol along with ESOMEPRAZOLE+DOMPERIDONE as it could lead to increased drowsiness and can elevate the production of stomach acid. A prolonged intake of ESOMEPRAZOLE+DOMPERIDONE is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor. 

Drug-Drug Interactions: ESOMEPRAZOLE+DOMPERIDONE may interact with anti-HIV (atazanavir, nelfinavir, saquinavir, ritonavir), blood thinner (clopidogrel, warfarin), anti-fungal (ketoconazole, itraconazole, voriconazole, fluconazole), anti-cancer (erlotinib, toremifene, vandetanib, vincamine), benzodiazepine (diazepam), anti-convulsant (phenytoin), anti-platelet (Cilostazol), antacid (cisapride, dolasetron, prucalopride), immunosuppressant (tacrolimus), anti-TB (rifampicin), antibiotics (Erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine), a drug used to treat hypothyroidism (levothyroxine), anti-rheumatoid (methotrexate), anti-depressant (citalopram, escitalopram), cardiac glycoside (digoxin), anti-malarial (halofantrine), anti-psychotic (haloperidol, pimozide, sertindole), anti-allergy ( mequitazin, mizolastine), anti-arrhythmic (amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol), anti-hypertensives (diltiazem, verapamil), St.John’s wort (herbal supplement used to treat depression).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, prolactinoma (tumour of the pituitary gland), blockage in the intestines, bleeding in the stomach or intestine, moderate to severe liver disease, low level of potassium/magnesium, high levels of magnesium, or heart problems.

• Eat smaller meals more often.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
• Maintain a healthy weight by regular exercising.
• Avoid lying down after eating as it causes acid reflux.
• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
• Practise relaxation techniques and avoid stress by doing yoga or meditation.
• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
• Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

• Inform your doctor before taking ESOMEPRAZOLE+DOMPERIDONE if you are due to have Chromogranin A blood test.
• ESOMEPRAZOLE+DOMPERIDONE may cause changes in blood tests. Inform the person doing the tests that you are taking ESOMEPRAZOLE+DOMPERIDONE.