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About RIFAMPICIN+ETHAMBUTOL+ISONIAZID+PYRIDOXINE+PYRAZINAMIDE

ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat tuberculosis (TB). Tuberculosis is an infectious disease that mainly affects the lungs but can also spread to other body parts such as kidneys, brain, spine, and bone marrow. 

 

ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN contains Rifampicin, Ethambutol, Isoniazid, Pyridoxine and Pyrazinamide. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN works by killing the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis). Thus, it helps treat tuberculosis.

 

In some cases, ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN may cause side effects such as nausea, vomiting, stomach pain, headache, and diarrhoea. Most of these side effects may not require medical attention and will resolve gradually. However, you are advised to talk to the doctor if the side effects persist or worsen.

 

Consult the doctor before taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN if you are pregnant. Avoid breastfeeding while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN as it may pass into breast milk. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN is not recommended for use in children. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN may cause dizziness, so drive only if you are alert. Keep the doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of RIFAMPICIN+ETHAMBUTOL+ISONIAZID+PYRIDOXINE+PYRAZINAMIDE

Tuberculosis

Medicinal Benefits

ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat tuberculosis. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN contains Rifampicin, Ethambutol, Isoniazid, Pyridoxine and Pyrazinamide. Rifampicin inactivates the RNA-polymerase enzyme, which is necessary for the bacteria to reproduce and make essential proteins. Pyrazinamide and Ethambutol slow the growth of the bacteria. Isoniazid prevents the formation of bacterial protective covering. Pyridoxine prevents nerve damage that might be caused by Isoniazid. Together, it help treat tuberculosis.

Directions for Use

Take ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN 1 hour or 2 hours after food or as advised by the doctor. Swallow the medicine as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of RIFAMPICIN+ETHAMBUTOL+ISONIAZID+PYRIDOXINE+PYRAZINAMIDE

  • Nausea
  • Vomiting
  • Stomach pain
  • Headache
  • Diarrhoea

In-Depth Precautions and Warning

Drug Warnings

Do not take ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN if you are allergic to any of its components. Inform the doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult the doctor before taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN if you are pregnant. Avoid breastfeeding while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN as it may pass into breast milk. Let the doctor know if you take other medicines, including herbal products and supplements. 

Drug Interactions

Drug-Drug Interactions: Inform the doctor if you are taking an antibiotic (erythromycin), pain killer (acetaminophen), or anti-HIV (saquinavir, ritonavir).

Drug-Food Interactions: Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN as they might cause interaction.

Drug-Disease Interactions: Inform the doctor if you have colitis, peripheral neuropathy (numbness and pain in hands and feet), porphyria, diabetes, gout (high uric acid), or kidney or liver dysfunction.

Drug-Drug Interactions Checker List:

  • ERYTHROMYCIN
  • ACETAMINOPHEN
  • SAQUINAVIR
  • RITONAVIR
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      Avoid alcohol consumption while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN as it could lead to unpleasant side effects.

    • Safety Warning

      Pregnancy

      caution

      Please consult the doctor if you are pregnant; your doctor will prescribe ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN only if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      unsafe

      ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN may pass into breast milk. Do not breastfeed while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN.

    • Safety Warning

      Driving

      caution

      ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN may cause dizziness, numbness and tingling in hands and feet. Do not drive or operate machinery if you experience these symptoms.

    • Safety Warning

      Liver

      caution

      Dose adjustment may be needed. Please consult the doctor if you have liver impairment/liver disease before taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN.

    • Safety Warning

      Kidney

      caution

      Dose adjustment may be needed. Please consult the doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN.

    • Safety Warning

      Children

      unsafe

      ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN is not recommended for use in children.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
    • Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system. 
    • Avoid processed and fried foods.
    • Warm ginger tea or warm soup can help relieve a cough.
    • Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
    • Quit smoking and avoid alcohol consumption.

    Patients Concern

    Disease/Condition Glossary

    Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.

    FAQs

    How does ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN work?

    ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN works by killing the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis).

    Can I stop taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN on my own?

    Do not stop taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN despite symptomatic relief. To treat your condition effectually, continue taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN for as long as it has been prescribed for you.

    Does ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN affect contraception?

    ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN might decrease the effectiveness of oral contraceptives (birth control pills). Use a reliable barrier method of contraception such as condoms or the coil while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.

    Does ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN cause discolouration of teeth?

    ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time, even after you stop taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN. Do not worry, as it is a common side-effect of ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN. Also, ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lenses while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN.

    Available Medicines for

    ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE+RIFAMPICIN

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