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About EVOGLIPTIN+METFORMIN

EVOGLIPTIN+METFORMIN belongs to the group of medications called 'antidiabetic agents' used as an adjunct to diet and exercise to improve glycaemic control in adult patients with type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to metformin alone. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than normal. 

EVOGLIPTIN+METFORMIN is a combination of two medicines: Metformin and Evogliptin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other side, Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces the fasting and post-meal sugar levels. Thereby, EVOGLIPTIN+METFORMIN reduces sugar levels in the body.

Take EVOGLIPTIN+METFORMIN as prescribed. You are advised to take EVOGLIPTIN+METFORMIN for as long as your doctor has advised. In some cases, EVOGLIPTIN+METFORMIN may cause nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, if the side effects persist or worsen, consult your doctor.

Do not take EVOGLIPTIN+METFORMIN if you are allergic to any of its contents. EVOGLIPTIN+METFORMIN may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycaemia). Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Uses of EVOGLIPTIN+METFORMIN

Type 2 Diabetes Mellitus

Medicinal Benefits

EVOGLIPTIN+METFORMIN is indicated for managing type 2 diabetes with the right diet and exercise. EVOGLIPTIN+METFORMIN is a combination of two medicines: Metformin (biguanide) and Evogliptin (dipeptidyl peptidase-4 inhibitor). Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces fasting and post-meal sugar levels. Thereby, EVOGLIPTIN+METFORMIN reduces sugar levels in the body.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of EVOGLIPTIN+METFORMIN

  • Nausea
  • Vomiting
  • Diarrhoea
  • Headache
  • Stomach ache
  • Respiratory infection
  • Indigestion

In-Depth Precautions and Warning

Drug Warnings

Do not take EVOGLIPTIN+METFORMIN if you are allergic to any of its contents. Do not use this medicine if you have heart failure, bladder cancer, or diabetic ketoacidosis (a complication of diabetes). EVOGLIPTIN+METFORMIN may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol with EVOGLIPTIN+METFORMIN as it may increase the risk of lactic acidosis or fast for prolonged periods as it might increase the risk of hypoglycaemia. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Drug Interactions

Drug-Drug Interactions: EVOGLIPTIN+METFORMIN may have interaction with antibiotic medicines (e.g. clarithromycin), steroid medicines ( e.g. prednisolone), diuretics medicines (e.g. furosemide), medicines to treat heart problems and high blood pressure (e.g. enalapril, perindopril), hormones (e.g. testosterone, oestrogen and progesterone) and other diabetes medicines.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: EVOGLIPTIN+METFORMIN may interact with uncontrolled diabetes, liver/kidney/heart problems, severe infection, severe circulation problems or breathing difficulties.

Drug-Drug Interactions Checker List:

  • CLARITHROMYCIN
  • PREDNISOLONE
  • FUROSEMIDE
  • ENALAPRIL
  • PERINDOPRIL
  • TESTOSTERONE
  • PROGESTERONE
  • OESTROGEN
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      It is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.

    • Safety Warning

      Pregnancy

      caution

      Limited information is available on the use of EVOGLIPTIN+METFORMIN in pregnant women. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

    • Safety Warning

      Breast Feeding

      caution

      Limited information on the use of EVOGLIPTIN+METFORMIN in breastfeeding mothers is available. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

    • Safety Warning

      Driving

      caution

      If your blood sugar is too low or too high, your driving ability may be affected. Do not drive if these symptoms appear.

    • Safety Warning

      Liver

      caution

      There is limited information available on the use of EVOGLIPTIN+METFORMIN in patients with liver disease. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.

    • Safety Warning

      Kidney

      caution

      Limited information is available on using EVOGLIPTIN+METFORMIN in patients with kidney disease. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

    • Safety Warning

      Children

      unsafe

      EVOGLIPTIN+METFORMIN is not recommended for people younger than 18 years of age.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Eat at regular intervals. Do not take a long gap between a meal or snack.
    • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
    • Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.
    • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
    • Replace refined carbohydrates-containing foods with whole-grain foods. Increase fruits, vegetables and other fibre-enriched foods in your diet.
    • Reduce saturated fat foods such as chips, crisps, pastries, biscuits, and samosas.
    • Choose omega-3 fatty acid-containing oils for daily cooking. 
    • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
    • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
    • Avoid drinking alcohol while on EVOGLIPTIN+METFORMIN. It increases the risk of hypoglycaemia (a decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts various organs).
    • Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar, etc.

    Special Advise

    • Keep taking EVOGLIPTIN+METFORMIN even if your blood sugar levels are controlled.
    • Take short, frequent meals, and avoid prolonged fasting when taking EVOGLIPTIN+METFORMIN. Beware of hypoglycaemia symptoms, including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the symptoms mentioned above, immediately consume 5-6 candies, three glucose biscuits, or three teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.

    Patients Concern

    Disease/Condition Glossary

    Type 2 diabetes mellitus: Type 2 diabetes mellitus is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilization of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin; in later stages, your body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite and dry mouth. If not properly treated, this condition may worsen over time and cause toxic effects.

    FAQs

    How does EVOGLIPTIN+METFORMIN work?

    EVOGLIPTIN+METFORMIN contains Metformin and Evogliptin. Metformin works by lowering glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. Altogether EVOGLIPTIN+METFORMIN reduces sugar levels in the body.

    What is hypoglycemia? Does EVOGLIPTIN+METFORMIN cause hypoglycemia?

    Hypoglycemia refers to low blood glucose levels. EVOGLIPTIN+METFORMIN may cause hypoglycemia. Hypoglycemia can occur if you miss or delay your food, drink alcohol, do intense exercise, or take other antidiabetic medicine along with EVOGLIPTIN+METFORMIN.

    What should I do if my blood sugar level suddenly decreases?

    If you feel that your blood sugar levels are dropping, eat glucose tablets or chocolate immediately. This will help to increase your sugar levels instantly. Always carry glucose tablets or sugar candies with you.

    Can I stop taking EVOGLIPTIN+METFORMIN on my own?

    Do not discontinue taking EVOGLIPTIN+METFORMIN without consulting your doctor. Take EVOGLIPTIN+METFORMIN for as long as it has been advised by the doctor. If you experience any difficulty while taking EVOGLIPTIN+METFORMIN, consult a doctor.

    What if I miss a dose of EVOGLIPTIN+METFORMIN?

    Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

    How is EVOGLIPTIN+METFORMIN useful in everyday life?

    EVOGLIPTIN+METFORMIN can assist in maintaining a consistent blood sugar level and lower your risk of diabetes-related issues in the future.

    Available Medicines for

    EVOGLIPTIN+METFORMIN