About FLUMAZENIL
FLUMAZENIL belongs to the benzodiazepine antagonist class of drugs. It is used to treat benzodiazepine overdose (sedative poisoning) in adults. Besides this, it is used to help you wake up after a surgery or medical procedure, acting as a reversal of conscious sedation and general anesthesia.
FLUMAZENIL contains Flumazenil, a benzodiazepine antagonist. It inhibits the activity of benzodiazepine and non-benzodiazepine compounds that bind with benzodiazepine receptors on the GABA/benzodiazepine receptor complex.
A qualified healthcare professional will administer FLUMAZENIL. You may experience mild to moderate pain at the injection site, nausea, vomiting, headache, dizziness, increased sweating, flushing (sudden warmth, redness, or tingly feeling), and vision problems. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Before taking FLUMAZENIL, let your doctor know about all your medical conditions (especially if you are suffering from seizures, drug abuse/dependence, psychosis, hepatic dysfunction), sensitivities (allergic to foods or medicines), and all medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. FLUMAZENIL may cause vision problems. It impacts your ability to drive or operate machinery.
Uses of FLUMAZENIL
Benzodiazepine overdose in adults.
Medicinal Benefits
FLUMAZENIL contains Flumazenil, a benzodiazepine antagonist. It is used to assist you in waking up after surgery or medical treatment, acting as a reversal of conscious sedation and general anesthesia. Aside from that, it can be used to treat benzodiazepine overdose in adults. It inhibits the activity of benzodiazepine and non-benzodiazepine compounds that bind with benzodiazepine receptors on the GABA/benzodiazepine receptor complex.
Directions for Use
Storage
Side Effects of FLUMAZENIL
Mild to moderate pain at the site of injection
Nausea
Vomiting
Headache
Dizziness
increased sweating
Flushing (sudden warmth, redness, or tingly feeling)
Vision problems
In-Depth Precautions and Warning
Drug Warnings
FLUMAZENIL is contraindicated in patients with a known hypersensitivity to flumazenil or benzodiazepines. Before taking FLUMAZENIL, inform your doctor of all your medical problems, sensitivities, and drugs. Also, let your doctor know if you are pregnant, want to become pregnant, or are breastfeeding. After you leave the hospital or surgery centre, avoid driving or doing any other activity that requires you to be awake and alert for at least 24 hours. Your ability to react might be compromised. Limit these activities further until they stop making you feel sedated (weak, drowsy, or dizzy). Additionally, wait at least 24 hours before taking any over-the-counter medications, especially if you are still feeling drowsy. If you are still feeling drowsy or for at least 24 hours after taking flumazenil, avoid drinking alcohol.
Drug Interactions
Drug-Drug Interactions: FLUMAZENIL may interact with antidepressant medications (e.g. amitriptyline, amoxapine, clomipramine, trimipramine),
Drug-Food Interactions: Alcohol consumption should be avoided.
Drug-Disease Interactions: FLUMAZENIL may interact with disease conditions, including seizures, drug abuse/dependence, psychosis and hepatic dysfunction
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIf you are still feeling drowsy or for at least 24 hours after taking FLUMAZENIL, avoid drinking alcohol.
Pregnancy
cautionThe use of FLUMAZENIL in pregnant women has not been adequately and carefully studied. During pregnancy, FLUMAZENIL should only be used if the possible advantages outweigh the possible risks to the developing foetus.
Breast Feeding
cautionIt is not known whether FLUMAZENIL passes into breastmilk. Hence, it should be used with caution in nursing mothers.
Driving
unsafeAvoid driving or doing any other activity that requires you to be awake and alert for at least 24 hours after taking FLUMAZENIL. Your ability to react might be compromised. Limit these activities further until they stop making you feel sedated (weak, drowsy, or dizzy).
Liver
cautionFLUMAZENIL should be given with caution by initial and/or repeated dosing to patients with liver disease.
Kidney
cautionThe effect of FLUMAZENIL was not significantly affected with renal impairment. However, inform the doctor if the patient has kidney problems.
Children
cautionThere was limited information about the usage of FLUMAZENIL in paediatric patients. Please seek medical advice. Only if the benefits exceed the risks, your doctor may prescribe.
Habit Forming
Patients Concern
Disease/Condition Glossary
Overdose and toxicity: Combining a benzodiazepine with another medication, such as another sedative, opioid, or alcohol, might result in overdose and death. Sedative overdose symptoms include Sedation to the extreme. Speech slurred.
