About FOSNETUPITANT+PALONOSETRON
FOSNETUPITANT+PALONOSETRON belongs to a class of drugs called Antiemetics and antinauseants. It is used for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately and highly emetogenic cancer chemotherapy. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.
FOSNETUPITANT+PALONOSETRON contains fosnetupitant (prodrug of netupitant) and palonosetron, which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
FOSNETUPITANT+PALONOSETRON will be administered by a healthcare professional; do not self-administer. In some cases, you may experience headaches, constipation, and fatigue. Most of these side effects of FOSNETUPITANT+PALONOSETRON do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please inform your doctor.
Before taking FOSNETUPITANT+PALONOSETRON, inform your doctor about all your medical conditions, sensitivities, and medications you are using. FOSNETUPITANT+PALONOSETRON is not recommended for use in pregnant women. A pregnancy test should be performed on all pre-menopausal women before treatment. Breastfeeding should be discontinued during treatment with FOSNETUPITANT+PALONOSETRON and for one month after the last dose or as per doctor recommendation. Drive only if you are alert, as FOSNETUPITANT+PALONOSETRON may cause tiredness or dizziness.
Uses of FOSNETUPITANT+PALONOSETRON
Nausea and vomiting (associated with chemotherapy
Medicinal Benefits
FOSNETUPITANT+PALONOSETRON contains fosnetupitant (Prodrug of netupitant) and palonosetron, which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
Directions for Use
Storage
Side Effects of FOSNETUPITANT+PALONOSETRON
- Headache
- Constipation
- Fatigue (feel tired)
- Dyspepsia (indigestion)
- Erythema (skin redness)
In-Depth Precautions and Warning
Drug Warnings
FOSNETUPITANT+PALONOSETRON is not recommended for use in pregnant women or those who are hypersensitive to any component present in it. Breastfeeding should be discontinued during treatment with FOSNETUPITANT+PALONOSETRON and for one month after the last dose or as per doctor recommendation. As palonosetron in FOSNETUPITANT+PALONOSETRON may increase large bowel transit time, patients with a history of constipation or signs of subacute intestinal obstruction should be monitored following administration. So, let your doctor know about all your medical conditions, sensitives, and medications you are using. Drive only if alert, as FOSNETUPITANT+PALONOSETRON may cause fatigue or tiredness.
Drug Interactions
Drug-Drug Interaction: FOSNETUPITANT+PALONOSETRON may interact with antidepressants (e.g. citalopram, duloxetine, desvenlafaxine), antiarrhythmic drugs (e.g. quinidine, amiodarone), antibiotics (e.g. moxifloxacin), antipsychotic drugs (e.g. thioridazine, haloperidol).
Drug-Food Interaction: No interactions found.
Drug-Disease Interaction: If you have severe hepatic impairment or severe or end-stage renal disease, inform your doctor before taking FOSNETUPITANT+PALONOSETRON.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionThe interaction of alcohol with FOSNETUPITANT+PALONOSETRON is unknown. However, consumption of alcohol should be avoided while on chemotherapy and treatment with FOSNETUPITANT+PALONOSETRON.
Pregnancy
unsafeFOSNETUPITANT+PALONOSETRON is not recommended for use in pregnant women. So, a pregnancy test should be performed on all pre-menopausal women before treatment.
Breast Feeding
cautionBreastfeeding should be discontinued during treatment with FOSNETUPITANT+PALONOSETRON and for one month after the last dose or as per doctor recommendation.
Driving
cautionFOSNETUPITANT+PALONOSETRON may cause fatigue or tiredness in some people. Therefore, avoid driving or operating heavy machinery if you feel tired or dizzy after taking FOSNETUPITANT+PALONOSETRON.
Liver
cautionInform your doctor before receiving FOSNETUPITANT+PALONOSETRON if you have liver problems/disorder history. FOSNETUPITANT+PALONOSETRON is not recommended for use in patients with severe liver impairment.
Kidney
cautionInform your doctor before receiving FOSNETUPITANT+PALONOSETRON if you have kidney problems/disorder history. FOSNETUPITANT+PALONOSETRON is not recommended for use in patients with severe kidney impairment or end-stage kidney disease.
Children
cautionThe safety and efficacy of FOSNETUPITANT+PALONOSETRON in children have not yet been established.
Habit Forming
Diet & Lifestyle Advise
Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
Also, if you like to vomit at a specific time, avoid eating your favourite food at that particular time, as your taste for that food may get turned off.
Drink any other liquid at least 30 minutes after eating food.
If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.
Patients Concern
Disease/Condition Glossary
Nausea and vomiting: Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short, nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). There is a receptor located in our brain known as the chemoreceptor zone (CTZ) that controls vomiting.
