Glibenclamide+metformin+pioglitazone
About Glibenclamide+metformin+pioglitazone
Glibenclamide+metformin+pioglitazone is used to treat type 2 diabetes mellitus. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels are more than normal. It occurs when the body does not produce enough insulin, or if produced, it cannot function properly in the body.
Glibenclamide+metformin+pioglitazone contains Glibenclamide, Metformin, and Pioglitazone, which increase insulin production by acting on the pancreas, lower liver glucose production and intestinal glucose uptake, and improve the sensitivity of tissues (muscles and fats) to insulin.
You may experience side effects such as nausea, vomiting, diarrhoea, stomach ache, respiratory infection, weight gain, numbness, and vision problems. If any of the side effects persist or worsen, consult your doctor.
Do not take Glibenclamide+metformin+pioglitazone if you are allergic to any of its contents. Before taking Glibenclamide+metformin+pioglitazone, inform your doctor if you are taking any other medicines, including prescription or non-prescription medicines. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Uses of Glibenclamide+metformin+pioglitazone
Medicinal Benefits
- Glibenclamide+metformin+pioglitazone is used to manage type 2 diabetes mellitus by effectively controlling high blood sugar levels.
- Glibenclamide helps increase insulin production from the pancreas.
- Metformin reduces glucose production in the liver and decreases glucose absorption from the intestine.
- Pioglitazone enhances insulin sensitivity in muscle and fat tissues, helping the body utilise glucose more efficiently.
- The combination provides better glycaemic control than using a single antidiabetic medicine alone.
- It helps reduce post-meal and fasting blood glucose levels, supporting overall metabolic balance.
- When combined with a proper diet and regular exercise, Glibenclamide+metformin+pioglitazone lowers the risk of diabetes-related complications such as nerve damage, kidney problems, and heart disease.
- It promotes stable energy levels and improved overall glucose metabolism.
Directions for Use
- Glibenclamide+metformin+pioglitazone is taken with food to prevent hypoglycemia or as advised by your doctor.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
- Swallow Glibenclamide+metformin+pioglitazone as a whole with a glass of water.
- Do not chew, crush, or break it.
Storage
Side Effects of Glibenclamide+metformin+pioglitazone
- Nausea (feeling sick)
- Vomiting (falling sick)
- Diarrhea
- Stomach ache
- Respiratory infection
- Weight gain
- Numbness
- Vision problems
Drug Warnings
- Do not take Glibenclamide+metformin+pioglitazone if you are allergic to any of its components.
- Inform your doctor if you have heart/liver/kidney problems, oedema (fluid build-up), diabetic ketoacidosis, bladder cancer or vitamin B12 deficiency.
- Glibenclamide+metformin+pioglitazone may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterised by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. Seek immediate medical attention if you notice any of these symptoms.
- Consult your doctor if you are pregnant or breastfeeding.
- Glibenclamide+metformin+pioglitazone is not recommended for use in children below 18 years of age.
- Let your doctor know if you are taking any other medicines, including supplements or herbal products.
Drug Interactions
Drug-Drug Interactions: Do not take the antifungal drug (miconazole and fluconazole) or iodine contrast agents (used for X-ray or scan) while using Glibenclamide+metformin+pioglitazone. Glibenclamide+metformin+pioglitazone may interact with medications used to treat high blood pressure like (ritodrine, salbutamol, and bosentan), bile acid sequestrants (lower cholesterol levels), drugs used to treat skin inflammation such as corticosteroids, pain killer (phenylbutazone), a medication used to treat mental illness (chlorpromazine), a medication used to reduce urine production (desmopressin), a medication used to treat endometriosis (danazol), antidiabetics (gemfibrozil), and antibiotics (rifampicin).
Drug-Food Interactions: Taking Glibenclamide+metformin+pioglitazone with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycemia.
Drug-Disease Interactions: Glibenclamide+metformin+pioglitazone should be avoided in patients with congestive heart failure (heart-related issues), type I diabetes, liver diseases, kidney diseases, hormonal problems, infectious illnesses, and oedema.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol may increase the risk of side effects and worsen the condition. Therefore, avoid alcohol consumption.
Pregnancy
unsafeGlibenclamide+metformin+pioglitazone is a category C drug and may cause harmful effects to the unborn baby. So, it is used only when the benefits of this medicine outweigh the risks.
Breast Feeding
unsafeGlibenclamide+metformin+pioglitazone should not be used in breastfeeding mothers as it may be secreted in the breast milk and cause unwanted effects in the nursing babies.
Driving
cautionGlibenclamide+metformin+pioglitazone may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using Glibenclamide+metformin+pioglitazone.
Liver
cautionGlibenclamide+metformin+pioglitazone should be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionGlibenclamide+metformin+pioglitazone should be taken with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.
Children
unsafeGlibenclamide+metformin+pioglitazone is not recommended for use in children below 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grains.
- Eat at regular intervals. Do not take a long gap between a meal or snack.
- Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
- Invest at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
- Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
- Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and veggies and other fibre-enriched foods.
- Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
- Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
- Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).
- Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.
Special Advise
- Glibenclamide+metformin+pioglitazone shows optimum effects when you follow healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc.
- Keep taking the drug even if you think your blood sugar levels are under control. If you miss a dose, do not take a larger dose; consult your treating physician for advice.
- Take short, frequent meals, and avoid prolonged fasting when taking this drug. Beware of symptoms of hypoglycemia, which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the above-mentioned symptoms, immediately consume 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and also get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.
- Avoid drinking alcohol while on this drug, as it increases the risk of hypoglycemia (a decrease in blood sugar, which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
- Try to quit smoking and reduce intake of carbohydrate-rich foods like potatoes, rice, mangoes, bread, sugar, etc.
Patients Concern
Disease/Condition Glossary
Type 2 diabetes mellitus: Type 2 diabetes mellitus is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilisation of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin, or in later stages, your body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite, and dry mouth. This condition may worsen over time and cause toxic effects if not properly treated.
FAQs
Glibenclamide+metformin+pioglitazone is used in the treatment of type 2 diabetes mellitus.
Glibenclamide+metformin+pioglitazone is a combination of three antidiabetic medicines, Glibenclamide, Metformin, and Pioglitazone. It works by increasing insulin production, helping restore your body's appropriate response to insulin, and thereby lowering your elevated blood sugar levels.
Glibenclamide+metformin+pioglitazone is used to treat type 2 diabetes. It is not recommended for the treatment of type 1 diabetes.
Glibenclamide+metformin+pioglitazone may cause hypoglycemia (low blood sugar levels). Hypoglycemia can occur if you miss or delay your food, drink alcohol, engage in intense exercise, or take other antidiabetic medicines along with this medicine. So, take your medicine as advised by your doctor to avoid any unwanted effects of this medicine.
You may experience symptoms such as increased thirst and hunger, frequent urination, weight loss, delayed wound healing, and frequent infections if you have diabetes. Consult a doctor to confirm the diagnosis.
If you feel that your blood sugar levels are dropping, eat glucose tablets or chocolate immediately. This will help to increase your sugar levels instantly. So, it is always advised to carry glucose tablets or sugar candies with you.
Stopping Glibenclamide+metformin+pioglitazone may cause a rise in blood sugar levels. Therefore, continue taking Glibenclamide+metformin+pioglitazone as directed even if your symptoms improve.
Regularly monitor your blood sugar levels and keep your doctor informed about any kidney or heart issues. If you have allergies, are pregnant, or are breastfeeding, consult your doctor before using this medication. Maintain a healthy lifestyle, including a balanced diet and regular exercise, and stay hydrated by drinking plenty of water. Also, be sure to disclose all medications you're taking to your doctor to avoid potential interactions. By following these guidelines, you'll be able to use this medication safely and effectively.
Before starting Glibenclamide+metformin+pioglitazone, share your medical history, including any existing conditions or allergies. If you're pregnant or breastfeeding, be sure to let your doctor know. Inform the doctor if you are taking any other medications, supplements, or herbal products.
Some individuals may feel tired and drowsy after taking Glibenclamide+metformin+pioglitazone. Drive or operate machinery only if you are alert. If you're experiencing any of these symptoms persistantly, it's crucial to consult your doctor.
No, Glibenclamide+metformin+pioglitazone does not contain steroids. Glibenclamide+metformin+pioglitazone is a medication specifically designed to manage type 2 diabetes. It's a combination therapy that helps regulate blood sugar levels.
Glibenclamide+metformin+pioglitazone may take around 2-3 months to reach its full effect, but you may start noticing improvements in your blood sugar control within the first few weeks.
It is generally safe to take Glibenclamide+metformin+pioglitazone and Fexofenadine together if it is prescribed by your doctor. Fexofenadine is an antihistamine used to treat allergies, and it doesn't typically interact with Glibenclamide+metformin+pioglitazone. However, it's always best to consult your doctor or pharmacist before combining any medications.
You should take Glibenclamide+metformin+pioglitazone for as long as it has been prescribed by the doctor to helps control your blood sugar levels This medication is usually taken for a long time, potentially many years, to manage type 2 diabetes effectively.
Taking Glibenclamide+metformin+pioglitazone daily for a long time is generally safe, but it's important to be aware of potential side effects. Common side effects include low blood sugar, stomach issues, headache, and dizziness. More serious side effects are rare but can include heart, kidney, and liver problems. To stay safe, take the medication as prescribed by the doctor, monitor your blood sugar, and have regular check-ups with your healthcare provider. They will help you manage any side effects and ensure the medication is working effectively for you.
The common side effects of Glibenclamide+metformin+pioglitazone include nausea, vomiting, and stomach issues. Consult the doctor if the side effects persist or worsen.
