GLYBURIDE+METFORMIN belongs to a class of anti-diabetic drugs used in treating type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition affecting how the body processes glucose. People with type 2 diabetes either do not produce enough insulin, or the insulin produced cannot perform its function in the body (insulin resistance).
GLYBURIDE+METFORMIN is a combination of two anti-diabetic drugs: Glyburide and Metformin. Glyburide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Together, GLYBURIDE+METFORMIN helps treat type 2 diabetes.
Take GLYBURIDE+METFORMIN as prescribed by your doctor. You are advised to take GLYBURIDE+METFORMIN for as long as your doctor has prescribed it based on your medical condition. You may sometimes experience low blood sugar, nausea, diarrhoea, upset stomach and headache. Most of these side effects of GLYBURIDE+METFORMIN do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Please inform your doctor if you are allergic to GLYBURIDE+METFORMIN or other medicines. GLYBURIDE+METFORMIN is not recommended for children. Avoid breastfeeding while taking GLYBURIDE+METFORMIN as it may be excreted in human milk. Please inform your doctor before taking GLYBURIDE+METFORMIN if you are pregnant or planning pregnancy. Avoid alcohol consumption with GLYBURIDE+METFORMIN as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking GLYBURIDE+METFORMIN, as it may cause dizziness. Take short, frequent meals and avoid prolonged fasting while taking GLYBURIDE+METFORMIN.
Type 2 diabetes mellitus
GLYBURIDE+METFORMIN is a combination of two antidiabetic drugs: Glyburide and Metformin. GLYBURIDE+METFORMIN plays a vital role in decreasing the blood sugar level in the body. Metformin lowers glucose production in the liver, whereas Glyburide increases the insulin released by the pancreas. GLYBURIDE+METFORMIN also helps to prevent serious complications of diabetes, such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), and loss of sensation in hands and feet (diabetic neuropathy). Being a combination of two drugs GLYBURIDE+METFORMIN reduces the need to take multiple pills, making it easier to remember to take medicine.
Some diabetic patients taking GLYBURIDE+METFORMIN may develop a rare but serious condition called lactic acidosis. In this condition, there is too much lactic acid accumulated in the blood. Inform your doctor if you have/had kidney disease, diabetic ketoacidosis, heart attack, stroke, heart, liver problems or if you are older than 65years. If you are allergic to GLYBURIDE+METFORMIN or any other medicines, please tell your doctor. GLYBURIDE+METFORMIN is not recommended for children. Avoid breastfeeding while taking GLYBURIDE+METFORMIN as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking GLYBURIDE+METFORMIN. Avoid alcohol consumption with GLYBURIDE+METFORMIN as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking GLYBURIDE+METFORMIN as it may cause dizziness.
Drug-Drug Interactions: GLYBURIDE+METFORMIN may interact with high blood pressure-lowering pills (hydrochlorothiazide, amlodipine, metoprolol), water pills/diuretics (furosemide), heart failure-related medicines (digoxin), steroids (prednisolone), thyroid hormones etc. So, tell your doctor if you are using these drugs before taking GLYBURIDE+METFORMIN.
Drug-Food Interactions: Taking GLYBURIDE+METFORMIN with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycaemia.
Drug-Disease Interactions: GLYBURIDE+METFORMIN should be avoided in patients with vitamin B12 deficiency, kidney problems, liver problems, cardiovascular disease (heart-related issues), and low blood sugar level (hypoglycaemia) as it may worsen the condition.
Taking GLYBURIDE+METFORMIN with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycaemia.
It is highly recommended to consult your doctor before taking GLYBURIDE+METFORMIN in case you are pregnant.
Avoid breastfeeding while taking GLYBURIDE+METFORMIN. Talk to your doctor if you have any concerns.
GLYBURIDE+METFORMIN may cause hypoglycaemia (low blood sugar levels) and dizziness. This may affect your ability to drive. Use caution while driving or doing anything that requires concentration.
GLYBURIDE+METFORMIN to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
GLYBURIDE+METFORMIN to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.
The safety and efficacy of GLYBURIDE+METFORMIN in children have not been established. GLYBURIDE+METFORMIN is not recommended in children.
Diabetes Mellitus type 2: Diabetes Mellitus type 2 is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, excessive insulin is produced but fails to act on the body's organs. Symptoms of type 2 diabetes include feeling exhausted all time, feeling thirsty, having blurry vision, and having the urge to urinate (pee) more often. Complications of type 2 diabetes include skin infection, eye problems (retinopathy), nerve damage (neuropathy), delayed wound healing, diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke. Both low and high blood sugar levels can be dangerous and should be treated as soon as possible.