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About INSULIN ASPART+INSULIN ASPART PROTAMINE

INSULIN ASPART+INSULIN ASPART PROTAMINE is a combination of rapid-acting human insulin and longer-acting insulin analogue to treat diabetes mellitus in children (above 2 years of age) and adults. It maintains blood sugar levels in adults and children. Diabetes mellitus is a condition that affects the way your body processes glucose. In Diabetes Mellitus Type 1, the body does not make enough insulin to control blood sugar levels. In Diabetes Mellitus type 2, either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood), or there is resistance to insulin action. As a result, insulin is produced in large amounts, but it cannot act on the organs of the body.

INSULIN ASPART+INSULIN ASPART PROTAMINE is a combination medicine that contains insulin aspart (rapid-acting), and the other is insulin aspart protamine (longer-acting). Insulin aspart has a fast onset of action, and insulin aspart protamine has a prolonged duration of action. Together, they ensure rapid and stable sugar control by enabling the reuptake of sugar in muscle and fat cells and decreasing sugar production in the liver.

Take INSULIN ASPART+INSULIN ASPART PROTAMINE as prescribed by your doctor. You are advised to take INSULIN ASPART+INSULIN ASPART PROTAMINE for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience weight gain, injection site allergic reaction, rash, lipodystrophy (skin thickening or pits at the injection site), hypoglycaemia (low blood glucose level), and itching. Most of these side effects of INSULIN ASPART+INSULIN ASPART PROTAMINE do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking INSULIN ASPART+INSULIN ASPART PROTAMINE of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take INSULIN ASPART+INSULIN ASPART PROTAMINE if you have liver disease, kidney, and low potassium levels in your blood. Inform your doctor if you are pregnant and breastfeeding while taking INSULIN ASPART+INSULIN ASPART PROTAMINE. Insulin is a cold chain medicine, so it must be stored in the refrigerator between 2-8 degrees Celsius or its efficiency might get lost. Do not store in the freezer. 

Uses of INSULIN ASPART+INSULIN ASPART PROTAMINE

Type 1 diabetes mellitus, Type 2 diabetes mellitus

Medicinal Benefits

INSULIN ASPART+INSULIN ASPART PROTAMINE works by ensuring rapid and stable sugar control. INSULIN ASPART+INSULIN ASPART PROTAMINE is combination of fast-acting and intermediate acting insulin that helps lower blood sugar levels after the intake of food. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver. INSULIN ASPART+INSULIN ASPART PROTAMINE helps in improving the glycaemic control which in turn decreases the risk of progression of complications of diabetes like damage of retina (retinopathy), damage of kidney (nephropathy), damage of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer and others.

Directions for Use

INSULIN ASPART+INSULIN ASPART PROTAMINE should be administered 15 minutes before taking the meal subcutaneously (SC) in the abdomen or thigh region. However, subcutaneous injection of INSULIN ASPART+INSULIN ASPART PROTAMINE in the abdomen region ensures a faster absorption than other injection sites. INSULIN ASPART+INSULIN ASPART PROTAMINE is usually given once or twice daily when both rapid and prolonged insulin effects are desired. Do not inject this medicine into a vein or a muscle. If you are not trained to self-administer INSULIN ASPART+INSULIN ASPART PROTAMINE, ask a healthcare professional to administer it. Procedure for self-injecting insulin: • You should wash your hand first before injecting insulin. • Then roll the insulin bottle and wipe the bottle top. • Now pull the syringe's plunger down to an appropriate number of units your doctor has prescribed. • Push the needle into the bottle and push the syringe plunger down. • Again pull the plunger down to an appropriate number of units prescribed by the doctor. • Pick the injection site and wipe it with an alcohol swab. Now, pinch up the skin, push the needle into the skin, and then push the plunger. • The needle should be kept under the skin for at least 6 seconds to ensure the entire dose is injected. • After injecting the insulin pull out the needle and dispose of the syringe safely. And then you can have a meal or snack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of INSULIN ASPART+INSULIN ASPART PROTAMINE

  • Injection site allergic reaction

  • Rash

  • Lipodystrophy (skin thickening or pits at the injection site)

  • Hypoglycemia (low blood glucose level)

  • Itching

  • Weight gain

In-Depth Precautions and Warning

Drug Warnings

INSULIN ASPART+INSULIN ASPART PROTAMINE is for subcutaneous (under the skin) use only and should never be administered intravenously (IV) or in the veins. If you are changing the insulin brand or need to inject your insulin by another method, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first hyperglycemia symptoms (high blood sugar level) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. INSULIN ASPART+INSULIN ASPART PROTAMINE may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take INSULIN ASPART+INSULIN ASPART PROTAMINE if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. 

Drug Interactions

Drug-Drug Interaction: INSULIN ASPART+INSULIN ASPART PROTAMINE may have an interaction with bleeding disorder drugs (octreotide), antibiotics (isoniazid, ciprofloxacin, gatifloxacin), blood pressure-lowering pills (metoprolol), lipid-lowering pills (reserpine, niacin, clonidine, fenofibrate, guanethidine), pain killers (aspirin), antidiabetic (pramlintide, pioglitazone), anti-asthmatics (albuterol, epinephrine, terbutaline).

Drug-Food Interaction: INSULIN ASPART+INSULIN ASPART PROTAMINE may interact with an ayurvedic, homoeopathy, Unani, herbal supplements, or OTC items. Tell your doctor if you are using these products. Try to avoid the intake of alcoholic beverages with INSULIN ASPART+INSULIN ASPART PROTAMINE as it may increase or decrease your blood sugar level.

Drug-Disease Interaction: INSULIN ASPART+INSULIN ASPART PROTAMINE should not be given to patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycaemia), and low potassium level (hypokalaemia).

Drug-Drug Interactions Checker List:

  • OCTREOTIDE
  • ISONIAZID
  • CIPROFLOXACIN
  • GATIFLOXACIN
  • METOPROLOL
  • RESERPINE
  • NIACIN
  • CLONIDINE
  • FENOFIBRATE
  • GUANETHIDINE
  • ASPIRIN
  • PRAMLINTIDE
  • PIOGLITAZONE
  • ALBUTEROL
  • EPINEPHRINE
  • TERBUTALINE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      You are recommended not to consume alcohol along with INSULIN ASPART+INSULIN ASPART PROTAMINE to avoid unpleasant side-effects. Alcohol may either decrease or increase the blood sugar level which can be fatal.

    • Safety Warning

      Pregnancy

      safe if prescribed

      If you are pregnant or become pregnant follow your doctor's advice about using insulin. During pregnancy controlling diabetes is very important and having high blood sugar may cause problems in both the mother and the baby.

    • Safety Warning

      Breast Feeding

      safe if prescribed

      INSULIN ASPART+INSULIN ASPART PROTAMINE can be given safely to nursing mothers but only under the supervision of a physician.

    • Safety Warning

      Driving

      unsafe

      Drive with caution, INSULIN ASPART+INSULIN ASPART PROTAMINE usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycemia (low blood sugar).

    • Safety Warning

      Liver

      caution

      INSULIN ASPART+INSULIN ASPART PROTAMINE to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      INSULIN ASPART+INSULIN ASPART PROTAMINE to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Children

      safe if prescribed

      INSULIN ASPART+INSULIN ASPART PROTAMINE can be given safely to children provided; dose has to be prescribed under the supervision of a doctor.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Exercise may lower your body’s need for insulin during and for some time after the physical activity.

    • Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of injection site (for example, the leg should not be used for injection just prior to running).

    • Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise. 

    • Avoid eating sugar food and prefer food cooked food low in calories.

    • When traveling across more than 2 time zones, you should talk to your doctor concerning adjustments in your insulin schedule.

    Special Advise

     

    • You should undergo a test called the HbA1C (A1C) every 2-3 months for closely monitoring your blood sugar level while taking INSULIN ASPART+INSULIN ASPART PROTAMINE. 

    • While using INSULIN ASPART+INSULIN ASPART PROTAMINE your blood sugar level might dip, which can result in seizure or unconsciousness, you should carry a quick source of sugar (glucose tablets or sugar candies) with you if you have symptoms of low blood sugar. 

    • Discard the used insulin pen after 14 days, even if there is slight insulin left in it.

    • Your doctor may tell you to have a regular potassium level as prolonged administration causes a life-threatening hypokalemia condition (low potassium). 

    Patients Concern

    Disease/Condition Glossary

    Type 1 diabetes mellitus: In type 1 diabetes mellitus, our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.

    Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin, or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amount but is unable to act on the tissues of the organs.

    FAQs

    In how much time does INSULIN ASPART+INSULIN ASPART PROTAMINE shows its effect?

    INSULIN ASPART+INSULIN ASPART PROTAMINE typically begins working after 10-20 minutes, and its effect will last for at least 24 hours.

    Which is the best area to inject INSULIN ASPART+INSULIN ASPART PROTAMINE?

    INSULIN ASPART+INSULIN ASPART PROTAMINE is to be injected below the skin (subcutaneously). The best areas to give INSULIN ASPART+INSULIN ASPART PROTAMINE are on your stomach, upper arm, upper thigh, or buttocks.

    What are the common signs of hypoglycaemia?

    Cold sweat; cool pale skin; headache; rapid heartbeat; feeling sick; feeling very hungry; temporary vision changes; drowsiness; unusual tiredness and weakness; nervousness or tremor; feeling anxious; feeling confused; difficulty in concentrating are some of the common signs of the low blood sugar level in an individual.

    What to do in case I experience low blood sugar?

    If you experience low blood sugar, eat glucose tablets, or another high sugar snack (e.g. sweets, biscuits, fruit juice). Measure your blood sugar if possible and rest. Always carry glucose tablets or high sugar snacks with you. You should give a call to any of your family members if you are feeling dizziness or drowsiness.

    Can I share injection pen/syringe with others?

    It is advisable do not share your insulin device with other persons, even if the needle has been changed. You may give other persons a serious infection or get a severe infection from them.

    Available Medicines for

    INSULIN ASPART+INSULIN ASPART PROTAMINE