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About IPRATROPIUM BROMIDE+SALBUTAMOL

IPRATROPIUM BROMIDE+SALBUTAMOL is a combination of medications primarily used to treat or prevent chronic obstructive pulmonary disease (COPD) symptoms, like shortness of breath, coughing, or wheezing (whistling sound while breathing). COPD is a group of lung diseases with emphysema (shortness of breath due to a damaged air sac) and chronic bronchitis (inflammation and narrowing of the lining of airways or bronchial tubes).

IPRATROPIUM BROMIDE+SALBUTAMOL contains Ipratropium bromide (anti-cholinergic) and Salbutamol (bronchodilator). Together, IPRATROPIUM BROMIDE+SALBUTAMOL works by relaxing muscles and widening the lungs' airways. Thereby allowing them to breathe easily and providing relief from symptoms such as shortness of breath, coughing, or wheezing (whistling sound while breathing).

IPRATROPIUM BROMIDE+SALBUTAMOL is for inhalation only. Your doctor will recommend how often you take IPRATROPIUM BROMIDE+SALBUTAMOL based on your medical condition. Some people may experience headaches, sore throat, dry mouth, runny or stuffy nose, pain, cough with mucus, sneezing, chest tightness, difficulty breathing, dizziness, nervousness, tiredness, irregular heartbeats, and vomiting. Most of these side effects of IPRATROPIUM BROMIDE+SALBUTAMOL do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to IPRATROPIUM BROMIDE+SALBUTAMOL or any other medicines, pregnant or breastfeeding, please inform your doctor before using IPRATROPIUM BROMIDE+SALBUTAMOL. If you experience difficulty breathing, please consult a doctor immediately to prescribe an alternative medicine. Do not use IPRATROPIUM BROMIDE+SALBUTAMOL to treat sudden severe breathing problems or as a rescue inhaler. Do not use IPRATROPIUM BROMIDE+SALBUTAMOL in more than the prescribed doses as it may lead to severe heart or lung problems. Regular monitoring of potassium levels is recommended, while taking a prolonged intake of IPRATROPIUM BROMIDE+SALBUTAMOL may cause low potassium levels in the blood. Please do not use or store IPRATROPIUM BROMIDE+SALBUTAMOL near open flame or heat as it may burst the container. If you have high blood pressure, diabetes fits, enlarged prostate, glaucoma, thyroid or heart problems, bladder obstruction, or other urinary problems, inform your doctor before taking IPRATROPIUM BROMIDE+SALBUTAMOL.

Uses of IPRATROPIUM BROMIDE+SALBUTAMOL

Chronic obstructive pulmonary disease (COPD)

Medicinal Benefits

IPRATROPIUM BROMIDE+SALBUTAMOL is a combination of two bronchodilators: Ipratropium bromide (anti-cholinergic) and Salbutamol (bronchodilator). Together, IPRATROPIUM BROMIDE+SALBUTAMOL works by relaxing muscles and widening the lungs' airways. Thereby allowing them to breathe easily and providing relief from symptoms such as shortness of breath, coughing, or wheezing (whistling sound while breathing).

Directions for Use

IPRATROPIUM BROMIDE+SALBUTAMOL should be used via inhalation with an inhaler. Your doctor or nurse will show you how to use the inhaler properly. Place the inhaler upright in your mouth and insert the mouthpiece between your teeth. Please do not bite it. When you begin to breathe in through your mouth, press the top of the inhaler to release a puff of air while continuing to inhale. After that, hold your breath. Remove the inhaler gently and hold your breath for as long as it feels comfortable. Breathe slowly out. If you require another puff, wait a minute before repeating the steps above. To avoid dust or fluff, close the mouthpiece with the cover after use.

Storage

Store in a cool and dry place away from sunlight

Side Effects of IPRATROPIUM BROMIDE+SALBUTAMOL

  • Headache
  • Dry mouth
  • Sore throat
  • Runny or stuffy nose
  • Cough with mucus
  • Sneezing
  • Chest tightness
  • Difficulty in breathing
  • Dizziness
  • Nervousness
  • Irregular heartbeat
  • Muscle cramps

In-Depth Precautions and Warning

Drug Warnings

Please tell your doctor if you are allergic to IPRATROPIUM BROMIDE+SALBUTAMOL or other ingredients. If you are pregnant or breastfeeding, please inform your doctor before using IPRATROPIUM BROMIDE+SALBUTAMOL. If you experience severe difficulty in breathing, please consult a doctor immediately. Do not use IPRATROPIUM BROMIDE+SALBUTAMOL in more than the prescribed doses as it may lead to severe heart or lung problems. If you have high blood pressure, diabetes, epilepsy (fits), enlarged prostate, glaucoma, thyroid or heart problems, bladder obstruction, or other urinary problems, inform your doctor before taking IPRATROPIUM BROMIDE+SALBUTAMOL. Regular monitoring of potassium levels is recommended while taking IPRATROPIUM BROMIDE+SALBUTAMOL as it may cause low potassium levels in the blood. However, if you experience irregular heartbeats, leg cramps, extreme thirst, constipation, increased urination, muscle weakness, numbness, or tingling, please consult a doctor immediately, as these might be signs of low potassium. Please do not use or store IPRATROPIUM BROMIDE+SALBUTAMOL near open flame or heat as it may burst the container. Bronchodilators like salbutamol in IPRATROPIUM BROMIDE+SALBUTAMOL can cause a rise in blood sugar levels; hence diabetic patients should monitor their blood glucose levels and use this medicine only with a doctor's advice.

Drug Interactions

Drug-Drug Interactions: IPRATROPIUM BROMIDE+SALBUTAMOL may interact with bronchodilators (salmeterol, vilanterol, formoterol, tiotropium), steroids (budesonide, prednisone, prednisolone), drugs used to lower high blood pressure (atenolol, metoprolol, propranolol, carvedilol, labetalol, sotalol, timolol), water pills (furosemide, amiloride, bumetanide), antidepressants (linezolid, rasagiline, selegiline, tranylcypromine, imipramine, amitriptyline), antifungals (itraconazole, ketoconazole), HIV medicines (atazanavir, ritonavir, nelfinavir, indinavir, cobicistat, saquinavir), medicines treating nausea and vomiting (ondansetron), antiparkinson drug (levodopa), heart-related medicines (atropine).

Drug-Food Interactions: IPRATROPIUM BROMIDE+SALBUTAMOL may interact with caffeine. Therefore, avoid or limit the intake of caffeinated beverages, foods, or dietary supplements with IPRATROPIUM BROMIDE+SALBUTAMOL as it may increase the risk of adverse effects.

Drug-Disease Interactions: If you have high blood pressure, diabetes, fits, enlarged prostate, glaucoma, thyroid or heart problems, bladder obstruction, or other urinary problems, inform your doctor before taking the IPRATROPIUM BROMIDE+SALBUTAMOL.

Drug-Drug Interactions Checker List:

  • SALMETEROL
  • FORMOTEROL
  • TIOTROPIUM
  • BUDESONIDE
  • PREDNISOLONE
  • PREDNISONE
  • ATENOLOL
  • METOPROLOL
  • PROPRANOLOL
  • CARVEDILOL
  • LABETALOL
  • SOTALOL
  • TIMOLOL
  • FUROSEMIDE
  • AMILORIDE
  • BUMETANIDE
  • LINEZOLID
  • RASAGILINE
  • SELEGILINE
  • TRANYLCYPROMINE
  • IMIPRAMINE
  • AMITRIPTYLINE
  • ITRACONAZOLE
  • KETOCONAZOLE
  • ATAZANAVIR
  • RITONAVIR
  • NELFINAVIR
  • INDINAVIR
  • COBICISTAT
  • SAQUINAVIR
  • ONDANSETRON
  • LEVODOPA
  • ATROPINE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      The interaction of IPRATROPIUM BROMIDE+SALBUTAMOL with alcohol is unknown. However, it is advisable to limit or avoid the consumption of alcohol.

    • Safety Warning

      Pregnancy

      caution

      IPRATROPIUM BROMIDE+SALBUTAMOL, a pregnancy category C drug may cause cleft palate and limb defects in newborns when used by pregnant women. Please consult your doctor if you are planning to become pregnant or already pregnant before starting IPRATROPIUM BROMIDE+SALBUTAMOL.

    • Safety Warning

      Breast Feeding

      caution

      Salbutamol, present in IPRATROPIUM BROMIDE+SALBUTAMOL, is excreted in human milk. So, it is advisable to avoid breastfeeding while using IPRATROPIUM BROMIDE+SALBUTAMOL. IPRATROPIUM BROMIDE+SALBUTAMOL should be given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

    • Safety Warning

      Driving

      caution

      IPRATROPIUM BROMIDE+SALBUTAMOL may cause blurred vision or dizziness in some people. Therefore, avoid driving if you notice any changes in vision or feel dizzy after taking IPRATROPIUM BROMIDE+SALBUTAMOL.

    • Safety Warning

      Liver

      caution

      Take IPRATROPIUM BROMIDE+SALBUTAMOL with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

    • Safety Warning

      Kidney

      caution

      IPRATROPIUM BROMIDE+SALBUTAMOL should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing IPRATROPIUM BROMIDE+SALBUTAMOL.

    • Safety Warning

      Children

      caution

      IPRATROPIUM BROMIDE+SALBUTAMOL is not recommended for children below 12 years of age. However, please consult a doctor before using IPRATROPIUM BROMIDE+SALBUTAMOL in children.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Eat foods rich in potassium, such as tomatoes, bananas, asparagus, oranges, potatoes, avocados, dark leafy greens, and beetroot, as potassium is important for lung function, and a potassium deficiency may cause breathing problems.
    • Drink plenty of fluids daily to thin mucus, making it easier to cough out.
    • Maintain a diet that includes complex carbohydrates such as lentils, beans, barley, oats, quinoa, bran, peas, and potatoes with skin.
    • Limit or avoid the intake of caffeinated drinks such as tea, coffee, soda, and energy drinks like red bull.
    • Eat protein-rich foods such as meat, fish (particularly salmon, sardines, and mackerel), eggs, and poultry.
    • Exercise regularly to strengthen your breathing muscles and boost your immune system. Learning breathing exercises will help you move more air in and out of your lungs.
    • Quit smoking may reduce the effectiveness of the IPRATROPIUM BROMIDE+SALBUTAMOL and irritate the lungs worsening breathing problems.

    Special Advise

    • Regularly monitor blood sugar levels while taking IPRATROPIUM BROMIDE+SALBUTAMOL, especially if you have diabetes, as IPRATROPIUM BROMIDE+SALBUTAMOL may increase blood sugar levels.
    • Monitor blood potassium levels while taking IPRATROPIUM BROMIDE+SALBUTAMOL, especially in asthma patients, as it may cause low potassium levels in the blood.
    • Avoid contact of IPRATROPIUM BROMIDE+SALBUTAMOL with eyes, especially if you have glaucoma (damaged eye nerve due to increased eye pressure), as it may worsen the condition and cause eye irritation or blurred vision.
    • The fungal infection might occur in your mouth and throat, so it is advisable to gargle with warm water after each inhalation of IPRATROPIUM BROMIDE+SALBUTAMOL.

    Patients Concern

    Disease/Condition Glossary

    Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases with emphysema (shortness of breath due to damaged air sacs) and chronic bronchitis (inflammation of the lining of bronchial tubes). The major cause of COPD is smoking tobacco and exposure to air pollutants like asbestos and chemicals/fumes. Also, long-term exposure to fumes and chemicals may lead to COPD. The symptoms include chronic cough, shortness of breath, or wheezing (whistle sound while breathing).

    FAQs

    How does IPRATROPIUM BROMIDE+SALBUTAMOL work?

    IPRATROPIUM BROMIDE+SALBUTAMOL is used to treat and prevent respiratory disorders like chronic obstructive pulmonary disease (COPD). IPRATROPIUM BROMIDE+SALBUTAMOL consists of Ipratropium bromide (anticholinergic) and Salbutamol (bronchodilator) that relax the airway's muscles and increases airflow to the lungs. It makes breathing easier by widening the airways.

    Does IPRATROPIUM BROMIDE+SALBUTAMOL cause hypokalaemia (low potassium levels in the blood)?

    IPRATROPIUM BROMIDE+SALBUTAMOL can cause hypokalaemia in some patients leading to cardiovascular effects. Please consult your doctor before taking IPRATROPIUM BROMIDE+SALBUTAMOL if you are a hypokalaemia patient or more susceptible to it.

    I am a patient with glucoma. Can I take IPRATROPIUM BROMIDE+SALBUTAMOL?

    Ipratropium bromide in IPRATROPIUM BROMIDE+SALBUTAMOL may increase intraocular pressure. This may result in precipitation or worsening of narrow-angle glaucoma (damaged eye nerve due to increased eye pressure). Therefore, IPRATROPIUM BROMIDE+SALBUTAMOL should be used with caution in patients with narrow-angle glaucoma. Inform your doctor if you have glaucoma before taking IPRATROPIUM BROMIDE+SALBUTAMOL. Your doctor will weigh the benefits and potential risks before prescribing IPRATROPIUM BROMIDE+SALBUTAMOL.

    Is it safe to use IPRATROPIUM BROMIDE+SALBUTAMOL if I have heart disease?

    Bronchodilators like salbutamol in IPRATROPIUM BROMIDE+SALBUTAMOL may cause rapid and irregular heartbeat, blood pressure changes, and electrocardiogram (ECG) changes. Please seek medical advice before using IPRATROPIUM BROMIDE+SALBUTAMOL if you are a heart disease patient.

    Can I take Atenolol (blood pressure lowering medications) with IPRATROPIUM BROMIDE+SALBUTAMOL?

    No, you are not recommended to take atenolol with IPRATROPIUM BROMIDE+SALBUTAMOL as it may reduce both the medicine's effectiveness. Also, atenolol may cause a narrowing of airways sometimes, which may trigger severe asthmatic attacks or worsen breathing problems. However, please consult a doctor before using other medicines with a IPRATROPIUM BROMIDE+SALBUTAMOL.

    Is IPRATROPIUM BROMIDE+SALBUTAMOL safe for diabetic patients?

    Salbutamol in IPRATROPIUM BROMIDE+SALBUTAMOL can cause a rise in blood glucose levels. Hence therapy with IPRATROPIUM BROMIDE+SALBUTAMOL is cautiously administered in patients with diabetes. Please monitor your blood glucose levels regularly and inform your doctor so the dose can be adjusted accordingly.

    Can IPRATROPIUM BROMIDE+SALBUTAMOL be used to relive sudden breathing problems?

    No, IPRATROPIUM BROMIDE+SALBUTAMOL is not useful in relieving sudden breathing problems. Consult your doctor for another rescue inhaler for sudden breathing problems.

    Available Medicines for

    IPRATROPIUM BROMIDE+SALBUTAMOL

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